BR112017008799A2 - composições de apilimod e métodos de uso das mesmas no tratamento de câncer renal - Google Patents

composições de apilimod e métodos de uso das mesmas no tratamento de câncer renal

Info

Publication number
BR112017008799A2
BR112017008799A2 BR112017008799A BR112017008799A BR112017008799A2 BR 112017008799 A2 BR112017008799 A2 BR 112017008799A2 BR 112017008799 A BR112017008799 A BR 112017008799A BR 112017008799 A BR112017008799 A BR 112017008799A BR 112017008799 A2 BR112017008799 A2 BR 112017008799A2
Authority
BR
Brazil
Prior art keywords
methods
kidney cancer
treating kidney
apilimod
compositions
Prior art date
Application number
BR112017008799A
Other languages
English (en)
Inventor
Conrad Chris
Lichenstein Henri
M Rothberg Jonathan
BEEHARRY Neil
Beckett Paul
LANDRETTE Sean
Gayle Sophia
Xu Tian
Original Assignee
Lam Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lam Therapeutics Inc filed Critical Lam Therapeutics Inc
Publication of BR112017008799A2 publication Critical patent/BR112017008799A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

a presente invenção refere-se a métodos para o tratamento de câncer renal com apilimod e composições e métodos relacionados.
BR112017008799A 2014-11-07 2015-11-06 composições de apilimod e métodos de uso das mesmas no tratamento de câncer renal BR112017008799A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462077127P 2014-11-07 2014-11-07
PCT/US2015/059512 WO2016073877A1 (en) 2014-11-07 2015-11-06 Apilimod for use in the treatment of renal cancer

Publications (1)

Publication Number Publication Date
BR112017008799A2 true BR112017008799A2 (pt) 2017-12-19

Family

ID=54548302

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017008799A BR112017008799A2 (pt) 2014-11-07 2015-11-06 composições de apilimod e métodos de uso das mesmas no tratamento de câncer renal

Country Status (16)

Country Link
US (3) US10206910B2 (pt)
EP (2) EP3215158B1 (pt)
JP (1) JP6705828B2 (pt)
KR (1) KR20170098812A (pt)
CN (1) CN107249638B (pt)
AU (1) AU2015342869A1 (pt)
BR (1) BR112017008799A2 (pt)
CA (1) CA2966359A1 (pt)
ES (1) ES2741399T3 (pt)
HU (1) HUE044557T2 (pt)
IL (1) IL251905B (pt)
MX (1) MX2017006015A (pt)
PL (1) PL3215158T3 (pt)
PT (1) PT3215158T (pt)
RU (1) RU2727802C2 (pt)
WO (1) WO2016073877A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2937655C (en) 2014-01-24 2022-06-28 Lam Therapeutics, Inc. Apilimod compositions for cancer treatment
EP3215158B1 (en) 2014-11-07 2019-05-08 AI Therapeutics, Inc. Apilimod for use in the treatment of renal cancer
US20190209576A1 (en) * 2014-11-07 2019-07-11 AI Therapeutics, Inc. Apilimod for use in the treatment of colorectal cancer
JP2019502707A (ja) * 2016-01-21 2019-01-31 ラム・セラピューティクス，インコーポレーテッド 癌をアピリモドで処置するためのバイオマーカー
CN109952113A (zh) * 2016-08-25 2019-06-28 人工智能治疗公司 包含pikfyve抑制剂的组合物和与rank信号传导的抑制相关的方法
CN110167559A (zh) * 2016-10-12 2019-08-23 人工智能治疗公司 阿匹莫德组合物和将其用于治疗阿尔茨海默病中的方法
CN110662544A (zh) 2017-03-24 2020-01-07 纳诺森公司 具有有用的药学应用的稠合***并嘧啶化合物
US11524053B2 (en) 2018-01-26 2022-12-13 The Regents Of The University Of California Methods and compositions for treatment of angiogenic disorders using anti-VEGF agents
MX2020008680A (es) * 2018-02-21 2020-09-25 Ai Therapeutics Inc Terapia de combinacion con apilimod y agentes glutamatergicos.
AU2020393842A1 (en) 2019-11-25 2022-06-16 The Regents Of The University Of California Long-acting VEGF inhibitors for intraocular neovascularization
CN114306370A (zh) * 2021-12-31 2022-04-12 北京悦康科创医药科技股份有限公司 反义寡核苷酸在制备治疗肾癌药物中的应用

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
PT1921169E (pt) 1993-11-12 2012-05-23 Phri Properties Inc Sondas de hibridação para detecção de ácidos nucleicos, troncos universais, métodos e estojos
US6693097B2 (en) 2001-11-30 2004-02-17 Synta Pharmaceuticals Corp. Pyrimidine compounds
US20050255118A1 (en) 2004-02-06 2005-11-17 Nancy Wehner Methods and composition for treating tumors and metastatic disease
EP1737845A4 (en) 2004-04-13 2010-07-21 Synta Pharmaceuticals Corp DISPLAY HEMMER OF IL-12 PRODUCTION
JP2008512490A (ja) 2004-09-08 2008-04-24 チェルシー・セラピューティクス，インコーポレイテッド 異常細胞増殖および炎症の障害を治療するための代謝的に不活性な葉酸拮抗剤
TW200630363A (en) 2004-11-10 2006-09-01 Synta Pharmaceuticals Corp Process for preparing trisubstituted pyrimidine compounds
WO2006124662A1 (en) 2005-05-13 2006-11-23 Synta Pharmaceuticals Corp. Il-12 modulatory compounds
WO2006128129A2 (en) * 2005-05-26 2006-11-30 Synta Pharmaceuticals Corp. Method for treating cancer
PT1951724E (pt) 2005-11-17 2011-08-02 Osi Pharm Inc Inibidores mtor fundidos bicíclicos
AR057960A1 (es) 2005-12-02 2007-12-26 Osi Pharm Inc Inhibidores de proteina quinasa biciclicos
JP5156644B2 (ja) 2006-01-25 2013-03-06 オーエスアイ・フアーマシユーテイカルズ・エル・エル・シー 不飽和ｍＴＯＲ阻害剤
EP2038252B1 (en) 2006-07-12 2016-11-02 University of Tennessee Research Foundation Substituted acylanilides and methods of use thereof
AU2008213808B2 (en) 2007-02-06 2011-11-10 Novartis Ag PI 3-kinase inhibitors and methods of their use
RU2438664C2 (ru) 2007-05-15 2012-01-10 Пирамал Лайф Сайнсиз Лимитед Синергическая фармацевтическая комбинация для лечения рака
DE102007036076A1 (de) * 2007-08-01 2009-02-05 Bayer Healthcare Aktiengesellschaft Dipeptoid-Produgs und ihre Verwendung
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
JP5258331B2 (ja) 2008-03-03 2013-08-07 ロート製薬株式会社 光安定性が改善されたニューキノロン系抗菌剤含有医薬組成物
WO2010006072A2 (en) 2008-07-08 2010-01-14 The Regents Of The University Of California Mtor modulators and uses thereof
EP2318406B1 (en) 2008-07-17 2016-01-27 Critical Outcome Technologies, Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods
US9180105B2 (en) 2010-03-08 2015-11-10 Sloan-Kettering Institute For Cancer Research CDC7 kinase inhibitors and uses thereof
CN102905707A (zh) * 2010-03-29 2013-01-30 味之素株式会社 含有苯基丙氨酸衍生物的医药制剂
US8402515B2 (en) 2010-05-06 2013-03-19 Jonathan Weizman Apparatus and method for establishing a peer-to-peer communication session with a client device
WO2011146727A1 (en) 2010-05-19 2011-11-24 Philip Bosch Methods of treating interstitial cystitis
US8709419B2 (en) * 2010-08-17 2014-04-29 Hoffmann-La Roche, Inc. Combination therapy
EP2640712B1 (en) 2010-11-19 2018-07-11 Ecole Polytechnique Fédérale de Lausanne (EPFL) 2-piperazin-1-yl-4h-1,3-benzothiazin-4-one derivatives and their use for the treatment of mammalian infections
WO2013152342A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Anti-cancer mtor inhibitor and anti-androgen combination
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CA2873402C (en) 2012-05-15 2023-10-24 Bristol-Myers Squibb Company Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
EP2903644A4 (en) 2012-10-05 2016-03-09 Cerulean Pharma Inc TREATMENT OF CANCER
US9295731B2 (en) 2013-04-01 2016-03-29 Mark Quang Nguyen Cleavable drug conjugates, compositions thereof and methods of use
CA2937655C (en) * 2014-01-24 2022-06-28 Lam Therapeutics, Inc. Apilimod compositions for cancer treatment
EP3215158B1 (en) 2014-11-07 2019-05-08 AI Therapeutics, Inc. Apilimod for use in the treatment of renal cancer
US20190209576A1 (en) 2014-11-07 2019-07-11 AI Therapeutics, Inc. Apilimod for use in the treatment of colorectal cancer
KR101761573B1 (ko) 2014-12-29 2017-07-26 주식회사 인트론바이오테크놀로지 신규한 장출혈성 대장균 박테리오파지 Ｅｓｃ-ＣＨＰ-1 및 이의 장출혈성 대장균 증식 억제 용도
US20180015098A1 (en) 2015-02-03 2018-01-18 Lam Therapeutics, Inc. Apilimod compositions and methods for using same
US20180078561A1 (en) 2015-03-31 2018-03-22 Lam Therapeutics, Inc. Active metabolites of apilimod and uses thereof
TWI746449B (zh) 2015-07-20 2021-11-21 美商Ａｉ治療公司 使用阿吡莫德治療癌症之方法
AU2019299234A1 (en) 2018-07-05 2021-01-14 Mayo Foundation For Medical Education And Research PIKfyve inhibitors
US20210077500A1 (en) 2019-09-12 2021-03-18 Al Therapeutics, Inc. Pikfyve inhibitors for cancer therapy

Also Published As

Publication number Publication date
RU2017119065A (ru) 2018-12-07
PL3215158T3 (pl) 2019-11-29
PT3215158T (pt) 2019-08-23
CA2966359A1 (en) 2016-05-12
IL251905B (en) 2021-03-25
MX2017006015A (es) 2017-11-17
RU2017119065A3 (pt) 2019-06-05
IL251905A0 (en) 2017-06-29
EP3581184A1 (en) 2019-12-18
WO2016073877A1 (en) 2016-05-12
US20200297706A1 (en) 2020-09-24
CN107249638B (zh) 2021-05-14
EP3215158A1 (en) 2017-09-13
JP2017535601A (ja) 2017-11-30
US20170333408A1 (en) 2017-11-23
EP3215158B1 (en) 2019-05-08
ES2741399T3 (es) 2020-02-10
EP3581184B1 (en) 2021-02-24
JP6705828B2 (ja) 2020-06-03
RU2727802C2 (ru) 2020-07-24
HUE044557T2 (hu) 2019-11-28
US11166944B2 (en) 2021-11-09
AU2015342869A1 (en) 2017-06-15
KR20170098812A (ko) 2017-08-30
CN107249638A (zh) 2017-10-13
US20190201385A1 (en) 2019-07-04
US10206910B2 (en) 2019-02-19

Similar Documents

Publication Publication Date Title
BR112017008799A2 (pt) composições de apilimod e métodos de uso das mesmas no tratamento de câncer renal
CL2018002782A1 (es) Apósito modificado
EA201791029A1 (ru) Антитела против интерлейкина-33 и их применение
BR112019006160A2 (pt) composições e métodos para o tratamento das condições oftálmicas
BR112016017112A2 (pt) Composições de apilimod e métodos de uso das mesmas
BR112017006664A2 (pt) terapias de combinação
BR112017011771A2 (pt) métodos e composições para o tratamento de câncer
DK3119808T3 (da) Antistofsammensætninger til tumorbehandling
EA201790380A1 (ru) Ингибиторы mk2 и их применения
BR112018000776A2 (pt) métodos para tratamento de câncer usando apilimod
BR112015028115A2 (pt) métodos e composições para o tratamento de câncer
DK3380086T3 (da) Cyp26-resistente rar-alpha-selektive agonister i behandling af cancer
BR112017009265A2 (pt) apilimode para uso no tratamento do câncer colorretal
BR112018012313A2 (pt) composições que compreendem 15-hepe e métodos para uso das mesmas
DK3456330T3 (da) Cortexolon-17alpha-valerat til anvendelse ved behandling af tumorer
CL2016003074A1 (es) Compuestos derivados de 2-oxi-2-fenil-n-5-pirrolidin-3-ilamino-1,3,4-tiadiazol-2-ilacetamida, inhibidores gls1 composición farmacéutica y su uso para tratar el cáncer.
PH12016501422A1 (en) Functionalised benzopyran compounds and use thereof
DK3253208T3 (da) Kombinationsterapier til anvendelse i behandlingen af brystcancer
DK3374497T3 (da) Modificerede makrofager til anvendelse i behandlingen af kræft
BR112017000303A2 (pt) métodos para o tratamento de hipotensão
EP3148526A4 (en) Use of eribulin in the treatment of cancer
PH12016501838A1 (en) Compounds and their methods of use
EA201591709A1 (ru) 5-бром-индирубины
MX2016005473A (es) Metodos y composiciones para mejorar la funcion renal.
BR112017011685A2 (pt) composições compreendendo 15-hepe e métodos de tratamento ou prevenção da fibrose usando as mesmas

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B25D Requested change of name of applicant approved

Owner name: AI THERAPEUTICS, INC. (US)

B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO EM FUNCAO DA REVOGACAO DO ART. 229-C DA LEI NO 9.279, DE 1996, POR FORCA DA LEI NO 14.195, DE 2021

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements