BR112021026380A2 - Formas sólidas de (s)-2-((2s,3r)-1-amino-3-hidróxi-1-oxobutan-2-il)-1-oxo-2,5-diazaespiro[3.4]octano-5-carboxilato de terc-butila e métodos de preparação das mesmas - Google Patents

Formas sólidas de (s)-2-((2s,3r)-1-amino-3-hidróxi-1-oxobutan-2-il)-1-oxo-2,5-diazaespiro[3.4]octano-5-carboxilato de terc-butila e métodos de preparação das mesmas

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Publication number
BR112021026380A2
BR112021026380A2 BR112021026380A BR112021026380A BR112021026380A2 BR 112021026380 A2 BR112021026380 A2 BR 112021026380A2 BR 112021026380 A BR112021026380 A BR 112021026380A BR 112021026380 A BR112021026380 A BR 112021026380A BR 112021026380 A2 BR112021026380 A2 BR 112021026380A2
Authority
BR
Brazil
Prior art keywords
oxobutan
octane
oxo
hydroxy
diazaspiro
Prior art date
Application number
BR112021026380A
Other languages
English (en)
Inventor
T Ding Danny
Shaoxin Feng
R Perrault William
Xiaoda Yuan
Original Assignee
Naurex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Naurex Inc filed Critical Naurex Inc
Publication of BR112021026380A2 publication Critical patent/BR112021026380A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

formas sólidas de (s)-2-((2s,3r)-1-amino-3-hidróxi-1-oxobutan-2-il)-1-oxo-2,5-diazaespiro[3.4]octano-5-carboxilato de terc-butila e métodos de preparação das mesmas. a presente invenção refere-se a formas em estado sólido de (s)-2-((2s,3r)-1-amino-3-hidróxi-1-oxobutan-2-il)-1-oxo-2,5-diazaespiro[3.4]octano-5-carboxilato de terc-butila, composições farmacêuticas, preparação e usos dos mesmos.
BR112021026380A 2019-06-24 2020-06-23 Formas sólidas de (s)-2-((2s,3r)-1-amino-3-hidróxi-1-oxobutan-2-il)-1-oxo-2,5-diazaespiro[3.4]octano-5-carboxilato de terc-butila e métodos de preparação das mesmas BR112021026380A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962865826P 2019-06-24 2019-06-24
PCT/US2020/039163 WO2020263847A1 (en) 2019-06-24 2020-06-23 Solid forms of tert-butyl (s)-2-((2s,3r) -1-amino-3-hydroxy-1-oxobu tan-2-yl)-1-oxo-2, 5-diazaspiro [3.4] octan e-5-carboxylate and methods of preparing them

Publications (1)

Publication Number Publication Date
BR112021026380A2 true BR112021026380A2 (pt) 2022-05-10

Family

ID=74060350

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021026380A BR112021026380A2 (pt) 2019-06-24 2020-06-23 Formas sólidas de (s)-2-((2s,3r)-1-amino-3-hidróxi-1-oxobutan-2-il)-1-oxo-2,5-diazaespiro[3.4]octano-5-carboxilato de terc-butila e métodos de preparação das mesmas

Country Status (12)

Country Link
US (1) US20220267341A1 (pt)
EP (1) EP3986399A4 (pt)
JP (1) JP2022539342A (pt)
KR (1) KR20220061088A (pt)
CN (1) CN114364380A (pt)
AU (1) AU2020304001A1 (pt)
BR (1) BR112021026380A2 (pt)
CA (1) CA3144600A1 (pt)
IL (1) IL289198A (pt)
MA (1) MA56550A (pt)
MX (1) MX2022000069A (pt)
WO (1) WO2020263847A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3986400A4 (en) * 2019-06-24 2023-05-17 Naurex Inc. METHODS AND INTERMEDIATES FOR THE PRODUCTION OF DIAZASPIROLACTAM COMPOUNDS

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2613249A1 (en) * 2005-06-21 2006-12-28 Ajinomoto Co., Inc. Crystals of phenylalanine derivatives, production method thereof and use thereof
CN102186883B (zh) * 2008-09-18 2016-08-03 西北大学 Nmda受体调节剂和其用途
SG11201505934XA (en) * 2013-01-29 2015-09-29 Naurex Inc Spiro-lactam nmda receptor modulators and uses thereof
CA2898861C (en) * 2013-01-29 2021-07-20 Naurex, Inc. Spiro-lactam nmda receptor modulators and uses thereof
PT3436463T (pt) * 2016-03-28 2021-09-06 Takeda Pharmaceuticals Co Formas cristalinas de 2-[(2s)-1-azabiciclo[2.2.2]oct-2- il]-6-(3-metil-1h-pirazol-4-il)tieno[3,2-d]pirimidin-4(3h)- ona hemihidratada
CA3024606C (en) * 2016-05-19 2019-09-03 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
EP3986400A4 (en) * 2019-06-24 2023-05-17 Naurex Inc. METHODS AND INTERMEDIATES FOR THE PRODUCTION OF DIAZASPIROLACTAM COMPOUNDS

Also Published As

Publication number Publication date
CN114364380A (zh) 2022-04-15
KR20220061088A (ko) 2022-05-12
AU2020304001A1 (en) 2022-01-27
IL289198A (en) 2022-02-01
US20220267341A1 (en) 2022-08-25
EP3986399A1 (en) 2022-04-27
EP3986399A4 (en) 2023-06-07
MX2022000069A (es) 2022-05-24
MA56550A (fr) 2022-04-27
JP2022539342A (ja) 2022-09-08
WO2020263847A1 (en) 2020-12-30
CA3144600A1 (en) 2020-12-30

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