BR112021022960A2 - Derivados de heterociclo fundidos como moduladores da montagem do capsídeo - Google Patents
Derivados de heterociclo fundidos como moduladores da montagem do capsídeoInfo
- Publication number
- BR112021022960A2 BR112021022960A2 BR112021022960A BR112021022960A BR112021022960A2 BR 112021022960 A2 BR112021022960 A2 BR 112021022960A2 BR 112021022960 A BR112021022960 A BR 112021022960A BR 112021022960 A BR112021022960 A BR 112021022960A BR 112021022960 A2 BR112021022960 A2 BR 112021022960A2
- Authority
- BR
- Brazil
- Prior art keywords
- modulators
- capsid assembly
- fused heterocycle
- heterocycle derivatives
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
derivados de heterociclo fundidos como moduladores da montagem do capsídeo. são divulgados compostos, composições e métodos para tratamento de doenças, síndromes, condições e disfunções que são afetadas pela modulação de cam1. tais compostos são representados pela fórmula (i) como se segue em que r1, r1a, r2, r3, r4, het, n, x, y, z1 e z2 são definidos aqui.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962853528P | 2019-05-28 | 2019-05-28 | |
PCT/EP2020/064751 WO2020239864A1 (en) | 2019-05-28 | 2020-05-27 | Fused heterocycle derivatives as capsid assembly modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112021022960A2 true BR112021022960A2 (pt) | 2022-01-04 |
Family
ID=70968930
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021022960A BR112021022960A2 (pt) | 2019-05-28 | 2020-05-27 | Derivados de heterociclo fundidos como moduladores da montagem do capsídeo |
Country Status (10)
Country | Link |
---|---|
US (1) | US20220153754A1 (pt) |
EP (1) | EP3976619A1 (pt) |
JP (1) | JP2022535216A (pt) |
KR (1) | KR20220015426A (pt) |
CN (1) | CN113906031A (pt) |
AU (1) | AU2020285314A1 (pt) |
BR (1) | BR112021022960A2 (pt) |
CA (1) | CA3136519A1 (pt) |
MX (1) | MX2021014580A (pt) |
WO (1) | WO2020239864A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024032409A1 (zh) * | 2022-08-09 | 2024-02-15 | 成都百裕制药股份有限公司 | 哌嗪类化合物在联合放疗***中的用途 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6713465B2 (ja) * | 2014-12-30 | 2020-06-24 | ノヴィラ・セラピューティクス・インコーポレイテッド | B型肝炎感染症治療のための誘導体及び方法 |
WO2018005881A1 (en) | 2016-06-29 | 2018-01-04 | Novira Therapeutics, Inc. | Oxadiazepinone derivatives and their use in the treatment of hepatitis b infections |
EP3478683B1 (en) * | 2016-06-29 | 2021-07-21 | Novira Therapeutics Inc. | Diazepinone derivatives and their use in the treatment of hepatitis b infections |
-
2020
- 2020-05-27 KR KR1020217042206A patent/KR20220015426A/ko unknown
- 2020-05-27 US US17/595,819 patent/US20220153754A1/en active Pending
- 2020-05-27 CN CN202080040337.9A patent/CN113906031A/zh active Pending
- 2020-05-27 JP JP2021570398A patent/JP2022535216A/ja active Pending
- 2020-05-27 WO PCT/EP2020/064751 patent/WO2020239864A1/en unknown
- 2020-05-27 MX MX2021014580A patent/MX2021014580A/es unknown
- 2020-05-27 AU AU2020285314A patent/AU2020285314A1/en not_active Abandoned
- 2020-05-27 CA CA3136519A patent/CA3136519A1/en active Pending
- 2020-05-27 BR BR112021022960A patent/BR112021022960A2/pt not_active Application Discontinuation
- 2020-05-27 EP EP20729989.2A patent/EP3976619A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
CA3136519A1 (en) | 2020-12-03 |
EP3976619A1 (en) | 2022-04-06 |
CN113906031A (zh) | 2022-01-07 |
KR20220015426A (ko) | 2022-02-08 |
MX2021014580A (es) | 2022-01-11 |
US20220153754A1 (en) | 2022-05-19 |
WO2020239864A1 (en) | 2020-12-03 |
AU2020285314A1 (en) | 2021-11-25 |
JP2022535216A (ja) | 2022-08-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |