BR112021012685A2 - Métodos para tratar câncer, para aumentar o nível de citocinas th1 nas células mononucleares de sangue periférico humanas, para realçar uma resposta imune antitumoral e para estimular e/ou amplificar uma resposta imune em um sujeito mamífero sofrendo de ou em risco de desenvolver câncer ou metástase de câncer, e, composição farmacêutica - Google Patents

Métodos para tratar câncer, para aumentar o nível de citocinas th1 nas células mononucleares de sangue periférico humanas, para realçar uma resposta imune antitumoral e para estimular e/ou amplificar uma resposta imune em um sujeito mamífero sofrendo de ou em risco de desenvolver câncer ou metástase de câncer, e, composição farmacêutica

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Publication number
BR112021012685A2
BR112021012685A2 BR112021012685A BR112021012685A BR112021012685A2 BR 112021012685 A2 BR112021012685 A2 BR 112021012685A2 BR 112021012685 A BR112021012685 A BR 112021012685A BR 112021012685 A BR112021012685 A BR 112021012685A BR 112021012685 A2 BR112021012685 A2 BR 112021012685A2
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Brazil
Prior art keywords
cancer
immune response
methods
cytokines
enhancing
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BR112021012685A
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English (en)
Inventor
Alexander Gragerov
A Gaitanaris George
A Demopulos Gregory
A Gavin Marc
Michael Cicirelli
S Cutshall Neil
Rene Onrust
L Little Thomas
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Omeros Corp
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Publication of BR112021012685A2 publication Critical patent/BR112021012685A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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Abstract

métodos para tratar câncer, para aumentar o nível de citocinas th1 nas células mononucleares de sangue periférico humanas e para realçar uma resposta imune antitumoral, e, composição farmacêutica. esta descrição está direcionada aos compostos, composições, e métodos para o tratamento de várias doenças e/ou condições relacionadas com o receptor 174 acoplado à proteína g (por exemplo, cânceres).
BR112021012685A 2019-01-11 2020-01-10 Métodos para tratar câncer, para aumentar o nível de citocinas th1 nas células mononucleares de sangue periférico humanas, para realçar uma resposta imune antitumoral e para estimular e/ou amplificar uma resposta imune em um sujeito mamífero sofrendo de ou em risco de desenvolver câncer ou metástase de câncer, e, composição farmacêutica BR112021012685A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962791591P 2019-01-11 2019-01-11
US201962886235P 2019-08-13 2019-08-13
US201962936223P 2019-11-15 2019-11-15
US201962946631P 2019-12-11 2019-12-11
PCT/US2020/013183 WO2020146795A1 (en) 2019-01-11 2020-01-10 Methods and compositions for treating cancer

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BR112021012685A2 true BR112021012685A2 (pt) 2021-12-28

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BR112021012685A BR112021012685A2 (pt) 2019-01-11 2020-01-10 Métodos para tratar câncer, para aumentar o nível de citocinas th1 nas células mononucleares de sangue periférico humanas, para realçar uma resposta imune antitumoral e para estimular e/ou amplificar uma resposta imune em um sujeito mamífero sofrendo de ou em risco de desenvolver câncer ou metástase de câncer, e, composição farmacêutica

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US (1) US20200345725A1 (pt)
EP (1) EP3908601A4 (pt)
JP (1) JP2022517978A (pt)
KR (1) KR20210114963A (pt)
CN (1) CN113727999A (pt)
AU (1) AU2020205753A1 (pt)
BR (1) BR112021012685A2 (pt)
CA (1) CA3126735A1 (pt)
CL (1) CL2021001818A1 (pt)
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AU2019301283A1 (en) * 2018-07-10 2021-02-04 Sanofi Combination therapies against cancer targeting CD38 and TGF-beta
AU2020394514A1 (en) * 2019-11-26 2022-07-07 Astrazeneca Ab Methods of treating cancer
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