BR112019008048A2 - método para preparar rebaudiosídeo n com o uso de método enzimático - Google Patents
método para preparar rebaudiosídeo n com o uso de método enzimáticoInfo
- Publication number
- BR112019008048A2 BR112019008048A2 BR112019008048A BR112019008048A BR112019008048A2 BR 112019008048 A2 BR112019008048 A2 BR 112019008048A2 BR 112019008048 A BR112019008048 A BR 112019008048A BR 112019008048 A BR112019008048 A BR 112019008048A BR 112019008048 A2 BR112019008048 A2 BR 112019008048A2
- Authority
- BR
- Brazil
- Prior art keywords
- rebaudioside
- enzymatic
- preparing rebaudioside
- preparing
- glycosyltransferase
- Prior art date
Links
- 229930188195 rebaudioside Natural products 0.000 title abstract 3
- 238000006911 enzymatic reaction Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000000758 substrate Substances 0.000 abstract 2
- 239000001512 FEMA 4601 Substances 0.000 abstract 1
- HELXLJCILKEWJH-SEAGSNCFSA-N Rebaudioside A Natural products O=C(O[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)[C@@]1(C)[C@@H]2[C@](C)([C@H]3[C@@]4(CC(=C)[C@@](O[C@H]5[C@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@H](O)[C@@H](CO)O5)(C4)CC3)CC2)CCC1 HELXLJCILKEWJH-SEAGSNCFSA-N 0.000 abstract 1
- HINSNOJRHFIMKB-DJDMUFINSA-N [(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl] (1R,4S,5R,9S,10R,13S)-13-[(2S,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3,4-bis[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]oxan-2-yl]oxy-5,9-dimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylate Chemical compound [H][C@@]1(O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]2OC(=O)[C@]2(C)CCC[C@@]3(C)[C@]4([H])CC[C@@]5(C[C@]4(CC5=C)CC[C@]23[H])O[C@]2([H])O[C@H](CO)[C@@H](O)[C@H](O[C@]3([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@H]2O[C@]2([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O HINSNOJRHFIMKB-DJDMUFINSA-N 0.000 abstract 1
- 238000006555 catalytic reaction Methods 0.000 abstract 1
- HELXLJCILKEWJH-UHFFFAOYSA-N entered according to Sigma 01432 Natural products C1CC2C3(C)CCCC(C)(C(=O)OC4C(C(O)C(O)C(CO)O4)O)C3CCC2(C2)CC(=C)C21OC(C1OC2C(C(O)C(O)C(CO)O2)O)OC(CO)C(O)C1OC1OC(CO)C(O)C(O)C1O HELXLJCILKEWJH-UHFFFAOYSA-N 0.000 abstract 1
- 239000000348 glycosyl donor Substances 0.000 abstract 1
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 abstract 1
- 235000019203 rebaudioside A Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
- C12P19/08—Dextran
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01017—Glucuronosyltransferase (2.4.1.17)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
a presente invenção se refere a um método para preparar rebaudiosídeo n com o uso de um método enzimático que compreende o uso de rebaudiosídeo a ou rebaudiosídeo j como um substrato e fazer com que o substrato, na presença de um doador de glicosil, reaja sob a catálise de uma célula recombinante contendo udp-glicosiltransferase e/ou udp-glicosiltransferase para gerar rebaudiosídeo n.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2016/102948 WO2018072213A1 (zh) | 2016-10-21 | 2016-10-21 | 一种酶法制备瑞鲍迪甙n的方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112019008048A2 true BR112019008048A2 (pt) | 2019-07-02 |
Family
ID=62018053
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112019008048A BR112019008048A2 (pt) | 2016-10-21 | 2016-10-21 | método para preparar rebaudiosídeo n com o uso de método enzimático |
Country Status (10)
Country | Link |
---|---|
US (2) | US11352653B2 (pt) |
EP (1) | EP3530745A4 (pt) |
JP (1) | JP6972123B2 (pt) |
CN (2) | CN116515929A (pt) |
AU (1) | AU2016427130B2 (pt) |
BR (1) | BR112019008048A2 (pt) |
CA (1) | CA3041152A1 (pt) |
MX (1) | MX2019004628A (pt) |
RU (1) | RU2737118C2 (pt) |
WO (1) | WO2018072213A1 (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2016427120B2 (en) | 2016-10-21 | 2022-08-18 | Pepsico, Inc. | Method for preparing rebaudioside C using enzymatic method |
CA3041147A1 (en) | 2016-10-21 | 2018-04-26 | Pepsico, Inc. | Method for preparing rebaudioside j using enzymatic method |
US20210246156A1 (en) * | 2018-06-08 | 2021-08-12 | Purecircle Usa, Inc. | High-purity steviol glycosides |
CA3131818A1 (en) * | 2019-03-29 | 2020-10-08 | Guohong MAO | Biosynthetic production of udp-rhamnose |
EP4086237A1 (en) | 2021-05-05 | 2022-11-09 | Hypex Bio Explosives Technology AB | Composition for forming a hydrogen peroxide based emulsion explosive |
KR102628374B1 (ko) * | 2021-10-19 | 2024-01-24 | 씨제이제일제당 주식회사 | 신규한 당전이효소 및 이의 용도 |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8937168B2 (en) | 2007-01-22 | 2015-01-20 | Cargill, Incorporated | Method of producing purified rebaudioside A compositions using solvent/antisolvent crystallization |
CN101225424B (zh) | 2007-09-13 | 2013-05-29 | 天津药物研究院 | 环黄芪醇的单葡萄糖苷、其制备方法、药物组合物和应用 |
KR102061165B1 (ko) | 2008-10-03 | 2019-12-31 | 모리타 가가쿠 고교 가부시키가이샤 | 신규 스테비올 배당체 |
ES2457641T3 (es) | 2009-10-15 | 2014-04-28 | Purecircle Sdn Bhd | Procedimiento para preparar rebaudiósido D de pureza elevada |
BR112012030836B8 (pt) | 2010-06-02 | 2024-02-06 | Evolva Nutrition Inc | Hospedeiro recombinante que compreende genes recombinantes para produção de esteviol ou glicosídeo de esteviol, método para produzir esteviol, glicosídeo de esteviol ou composição de glicosídeo de esteviol e método para sintetizar esteviol ou glicosídeo de esteviol |
US8962698B2 (en) | 2011-01-28 | 2015-02-24 | Tate & Lyle Ingredients Americas Llc | Rebaudioside-mogroside V blends |
BR122021015509B1 (pt) | 2011-08-08 | 2022-03-29 | Evolva Sa | Método para produzir um glicosídeo de esteviol alvo |
CN103031283B (zh) | 2011-10-08 | 2015-07-08 | 成都华高瑞甜科技有限公司 | 甜叶菊酶vi及莱鲍迪苷a转化为莱鲍迪苷d的方法 |
CN103159808B (zh) * | 2011-12-09 | 2017-03-29 | 上海泓博智源医药股份有限公司 | 一种制备天然甜味剂的工艺方法 |
ES2787899T3 (es) | 2011-12-19 | 2020-10-19 | Purecircle Sdn Bhd | Métodos para purificar glucósidos de esteviol |
DK2806754T3 (en) | 2012-01-23 | 2019-02-18 | Dsm Ip Assets Bv | Diterpene PREPARATION |
BR112014028819A2 (pt) | 2012-05-22 | 2017-07-25 | Purecircle Sdn Bhd | glicosídeos de esteviol de pureza elevada |
US9752174B2 (en) | 2013-05-28 | 2017-09-05 | Purecircle Sdn Bhd | High-purity steviol glycosides |
EP2928321A1 (en) | 2012-12-05 | 2015-10-14 | Evolva SA | Steviol glycoside compositions sensory properties |
CN103088041B (zh) | 2013-01-29 | 2015-01-07 | 江南大学 | 一种可用于高效生产角质酶的角质酶基因及其应用 |
CA2899276C (en) | 2013-02-06 | 2022-11-01 | Evolva Sa | Methods for improved production of rebaudioside d and rebaudioside m |
US9717267B2 (en) | 2013-03-14 | 2017-08-01 | The Coca-Cola Company | Beverages containing rare sugars |
CN103397064B (zh) | 2013-08-14 | 2015-04-15 | 苏州汉酶生物技术有限公司 | 一种酶法制备瑞鲍迪甙m的方法 |
CN105611844A (zh) * | 2013-08-15 | 2016-05-25 | 嘉吉公司 | 掺入了莱苞迪苷n的甜味剂组合物和经甜化的组合物 |
RU2706789C2 (ru) | 2013-11-01 | 2019-11-21 | Конаджен Инк. | Рекомбинантное получение стевиол-гликозидов |
SG2013092820A (en) | 2013-12-16 | 2015-07-30 | Ngee Ann Polytechnic | Xylose isomerase genes for xylose-fermenting yeast construction |
CN103757074B (zh) | 2014-01-16 | 2015-12-02 | 苏州汉酶生物技术有限公司 | 一种酶法制备瑞鲍迪甙m的方法 |
EP3101139A4 (en) | 2014-01-28 | 2017-08-30 | Pepsico, Inc. | Rebaudioside m enzymatic preparation method |
US9522929B2 (en) | 2014-05-05 | 2016-12-20 | Conagen Inc. | Non-caloric sweetener |
EP3183349B1 (en) | 2014-08-19 | 2020-03-25 | Purecircle SDN BHD | Method for preparing rebaudioside i |
KR102536036B1 (ko) | 2014-10-03 | 2023-05-23 | 코나겐 인크. | 비칼로리 감미료 및 합성 방법 |
CA2973674A1 (en) * | 2015-01-30 | 2016-08-04 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
AU2016271125A1 (en) | 2015-05-29 | 2017-12-21 | Cargill, Incorporated | Heat treatment to produce glycosides |
CN105200098A (zh) | 2015-06-30 | 2015-12-30 | 苏州汉酶生物技术有限公司 | 一种利用酿酒酵母酶法制备瑞鲍迪甙m的方法 |
WO2017031424A1 (en) | 2015-08-20 | 2017-02-23 | Pepsico, Inc. | Preparation of rebaudioside m in a single reaction vessel |
CA3041147A1 (en) | 2016-10-21 | 2018-04-26 | Pepsico, Inc. | Method for preparing rebaudioside j using enzymatic method |
AU2016427120B2 (en) | 2016-10-21 | 2022-08-18 | Pepsico, Inc. | Method for preparing rebaudioside C using enzymatic method |
-
2016
- 2016-10-21 US US16/343,335 patent/US11352653B2/en active Active
- 2016-10-21 CN CN202310412340.4A patent/CN116515929A/zh active Pending
- 2016-10-21 WO PCT/CN2016/102948 patent/WO2018072213A1/zh unknown
- 2016-10-21 CA CA3041152A patent/CA3041152A1/en active Pending
- 2016-10-21 AU AU2016427130A patent/AU2016427130B2/en active Active
- 2016-10-21 JP JP2019520995A patent/JP6972123B2/ja active Active
- 2016-10-21 CN CN201680089986.1A patent/CN109890973B/zh active Active
- 2016-10-21 EP EP16919469.3A patent/EP3530745A4/en active Pending
- 2016-10-21 RU RU2019112909A patent/RU2737118C2/ru active
- 2016-10-21 BR BR112019008048A patent/BR112019008048A2/pt not_active Application Discontinuation
- 2016-10-21 MX MX2019004628A patent/MX2019004628A/es unknown
-
2022
- 2022-05-16 US US17/663,631 patent/US11976313B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN116515929A (zh) | 2023-08-01 |
US11976313B2 (en) | 2024-05-07 |
AU2016427130B2 (en) | 2022-08-18 |
CN109890973B (zh) | 2023-05-23 |
WO2018072213A1 (zh) | 2018-04-26 |
US20220275415A1 (en) | 2022-09-01 |
CN109890973A (zh) | 2019-06-14 |
RU2019112909A (ru) | 2020-11-23 |
US20210214761A1 (en) | 2021-07-15 |
JP2019531083A (ja) | 2019-10-31 |
CA3041152A1 (en) | 2018-04-26 |
AU2016427130A1 (en) | 2019-05-30 |
EP3530745A1 (en) | 2019-08-28 |
JP6972123B2 (ja) | 2021-11-24 |
EP3530745A4 (en) | 2020-07-22 |
RU2019112909A3 (pt) | 2020-11-23 |
MX2019004628A (es) | 2019-06-06 |
US11352653B2 (en) | 2022-06-07 |
RU2737118C2 (ru) | 2020-11-24 |
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B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] |