BR112019007433A2 - sistemas de replicon de vírus recombinante e usos dos mesmos - Google Patents
sistemas de replicon de vírus recombinante e usos dos mesmosInfo
- Publication number
- BR112019007433A2 BR112019007433A2 BR112019007433A BR112019007433A BR112019007433A2 BR 112019007433 A2 BR112019007433 A2 BR 112019007433A2 BR 112019007433 A BR112019007433 A BR 112019007433A BR 112019007433 A BR112019007433 A BR 112019007433A BR 112019007433 A2 BR112019007433 A2 BR 112019007433A2
- Authority
- BR
- Brazil
- Prior art keywords
- recombinant virus
- interest
- disclosure relates
- virus replicon
- replicon systems
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36141—Use of virus, viral particle or viral elements as a vector
- C12N2770/36143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
a presente divulgação refere-se de forma geral a sistemas de expressão com base em vírus adequados para a produção de moléculas de interesse. a divulgação refere-se a construções de ácido nucleico, tais como vetores de expressão, que contêm um replicon de rna modificado que inclui uma região não traduzida a 5? (5?-utr) modificada e, opcionalmente, pelo menos parte de sua sequência viral original que codifica proteínas estruturais que foram deletadas. também são divulgados métodos para produção de polipeptídeos de interesse.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662409228P | 2016-10-17 | 2016-10-17 | |
PCT/US2017/054928 WO2018075235A1 (en) | 2016-10-17 | 2017-10-03 | Recombinant virus replicon systems and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112019007433A2 true BR112019007433A2 (pt) | 2019-07-02 |
Family
ID=60153459
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112019007433A BR112019007433A2 (pt) | 2016-10-17 | 2017-10-03 | sistemas de replicon de vírus recombinante e usos dos mesmos |
Country Status (10)
Country | Link |
---|---|
US (2) | US11364310B2 (pt) |
EP (1) | EP3526332B1 (pt) |
JP (2) | JP7382230B2 (pt) |
KR (1) | KR20190082226A (pt) |
CN (1) | CN110073002B (pt) |
AU (1) | AU2017347725B2 (pt) |
BR (1) | BR112019007433A2 (pt) |
CA (1) | CA3040264A1 (pt) |
MX (1) | MX2019004499A (pt) |
WO (1) | WO2018075235A1 (pt) |
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CN111542340B (zh) | 2017-11-16 | 2023-12-19 | 华盛顿大学 | 治疗性乙型肝炎病毒(hbv)疫苗 |
AU2018389787A1 (en) | 2017-12-19 | 2020-06-25 | Janssen Sciences Ireland Unlimited Company | Hepatitis B virus (HBV) vaccines and uses thereof |
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2017
- 2017-10-03 CN CN201780075817.7A patent/CN110073002B/zh active Active
- 2017-10-03 BR BR112019007433A patent/BR112019007433A2/pt unknown
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AU2017347725A1 (en) | 2019-05-09 |
CA3040264A1 (en) | 2018-04-26 |
AU2017347725B2 (en) | 2024-01-04 |
US20230126773A1 (en) | 2023-04-27 |
WO2018075235A1 (en) | 2018-04-26 |
US20180104359A1 (en) | 2018-04-19 |
CN110073002A (zh) | 2019-07-30 |
JP7382230B2 (ja) | 2023-11-16 |
EP3526332B1 (en) | 2024-06-26 |
US11364310B2 (en) | 2022-06-21 |
EP3526332A1 (en) | 2019-08-21 |
MX2019004499A (es) | 2019-11-18 |
CN110073002B (zh) | 2024-06-11 |
JP2019530466A (ja) | 2019-10-24 |
JP2023134488A (ja) | 2023-09-27 |
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