BR112018075310A2 - metódo de tratamento de esclerose múltipla empregando um inibidor de lsd1 - Google Patents

metódo de tratamento de esclerose múltipla empregando um inibidor de lsd1

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Publication number
BR112018075310A2
BR112018075310A2 BR112018075310-6A BR112018075310A BR112018075310A2 BR 112018075310 A2 BR112018075310 A2 BR 112018075310A2 BR 112018075310 A BR112018075310 A BR 112018075310A BR 112018075310 A2 BR112018075310 A2 BR 112018075310A2
Authority
BR
Brazil
Prior art keywords
multiple sclerosis
employing
treating multiple
lsd1 inhibitor
lsd1
Prior art date
Application number
BR112018075310-6A
Other languages
English (en)
Inventor
Maes Tamara
Mascaro Crusat Cristina
ROTLLANT POZO David
Original Assignee
Oryzon Genomics, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oryzon Genomics, S.A. filed Critical Oryzon Genomics, S.A.
Publication of BR112018075310A2 publication Critical patent/BR112018075310A2/pt

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Abstract

a presente invenção refere-se a, métodos para tratamento de esclerose múltipla utilizando (-) 5-((((trans)-2-(4-(benzilóxi)fenil)ciclopropil)amino)metil)-1,3,4-oxadiazol-2-amina, ou um sal ou solvato farmaceuticamente aceitável do mesmo.
BR112018075310-6A 2015-06-12 2017-06-09 metódo de tratamento de esclerose múltipla empregando um inibidor de lsd1 BR112018075310A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP15382310 2015-06-12
EP15382369 2015-07-17
PCT/EP2016/063368 WO2016198649A1 (en) 2015-06-12 2016-06-10 Biomarkers associated with lsd1 inhibitors and uses thereof
EPPCT/EP2016/063368 2016-06-10
PCT/EP2017/064206 WO2017212061A1 (en) 2015-06-12 2017-06-09 Method of treating multiple sclerosis employing a lsd1-inhibitor

Publications (1)

Publication Number Publication Date
BR112018075310A2 true BR112018075310A2 (pt) 2019-03-19

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018075310-6A BR112018075310A2 (pt) 2015-06-12 2017-06-09 metódo de tratamento de esclerose múltipla empregando um inibidor de lsd1

Country Status (22)

Country Link
US (1) US20180284095A1 (pt)
EP (1) EP3307909A1 (pt)
JP (3) JP6855466B2 (pt)
KR (2) KR20180011331A (pt)
CN (2) CN107849611A (pt)
AU (2) AU2016275702A1 (pt)
BR (1) BR112018075310A2 (pt)
CA (1) CA2987876A1 (pt)
CY (1) CY1121988T1 (pt)
DK (1) DK3307267T3 (pt)
HK (1) HK1253743A1 (pt)
HR (1) HRP20191121T1 (pt)
HU (1) HUE043954T2 (pt)
IL (2) IL256208A (pt)
LT (1) LT3307267T (pt)
MX (2) MX2017015922A (pt)
MY (1) MY190849A (pt)
PT (1) PT3307267T (pt)
RU (1) RU2768120C2 (pt)
SG (1) SG10201911989SA (pt)
TR (1) TR201909353T4 (pt)
WO (2) WO2016198649A1 (pt)

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Also Published As

Publication number Publication date
JP6411680B1 (ja) 2018-10-24
WO2016198649A1 (en) 2016-12-15
DK3307267T3 (da) 2019-07-01
MX2017015921A (es) 2018-12-11
PT3307267T (pt) 2019-07-04
JP6855466B2 (ja) 2021-04-07
CN107849611A (zh) 2018-03-27
KR20190016478A (ko) 2019-02-18
RU2768120C2 (ru) 2022-03-23
SG10201911989SA (en) 2020-02-27
JP2018522581A (ja) 2018-08-16
JP2019023202A (ja) 2019-02-14
RU2019100037A (ru) 2020-07-13
AU2016275702A1 (en) 2017-12-21
CY1121988T1 (el) 2020-10-14
IL256208A (en) 2018-02-28
AU2017277751B2 (en) 2018-03-01
TR201909353T4 (tr) 2019-07-22
HRP20191121T1 (hr) 2019-09-20
CN107921029A (zh) 2018-04-17
WO2017212061A1 (en) 2017-12-14
CA2987876A1 (en) 2016-12-15
KR20180011331A (ko) 2018-01-31
IL256207A (en) 2018-02-28
LT3307267T (lt) 2019-07-25
EP3307909A1 (en) 2018-04-18
US20180284095A1 (en) 2018-10-04
HUE043954T2 (hu) 2019-09-30
HK1253743A1 (zh) 2019-06-28
IL256207B (en) 2022-05-01
NZ738830A (en) 2018-12-21
AU2017277751A1 (en) 2018-02-01
MY190849A (en) 2022-05-12
RU2019100037A3 (pt) 2020-07-13
CN107921029B (zh) 2021-09-28
JP2018534234A (ja) 2018-11-22
MX2017015922A (es) 2018-12-11
KR102372194B1 (ko) 2022-03-08

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