BR112018067721A2 - anticorpos específicos para tau hiperfosforilada para o tratamento de doenças oculares - Google Patents

anticorpos específicos para tau hiperfosforilada para o tratamento de doenças oculares

Info

Publication number
BR112018067721A2
BR112018067721A2 BR112018067721A BR112018067721A BR112018067721A2 BR 112018067721 A2 BR112018067721 A2 BR 112018067721A2 BR 112018067721 A BR112018067721 A BR 112018067721A BR 112018067721 A BR112018067721 A BR 112018067721A BR 112018067721 A2 BR112018067721 A2 BR 112018067721A2
Authority
BR
Brazil
Prior art keywords
treatment
specific antibodies
hyperphosphorylated tau
eye diseases
tau specific
Prior art date
Application number
BR112018067721A
Other languages
English (en)
Inventor
Abdur-Rasheed Asuni Ayodeji
Torleif Pedersen Jan
Claus Alfred Daechsel Justus
Østergaard Pedersen Lars
Helen Rosenqvist Nina
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of BR112018067721A2 publication Critical patent/BR112018067721A2/pt

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

a presente invenção baseia-se em anticorpos que são tanto altamente específicos para tau p-s396 hiperfosforilada patogênica como altamente específicos para as seções marcadas da retina humana, bem como a métodos de utilização destes anticorpos e seus fragmentos de ligação de tau no tratamento de amiloidose retinoide, degeneração macular relacionada com a idade (dmri) e glaucoma.
BR112018067721A 2017-01-04 2018-01-03 anticorpos específicos para tau hiperfosforilada para o tratamento de doenças oculares BR112018067721A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201700006 2017-01-04
PCT/EP2018/050149 WO2018127519A1 (en) 2017-01-04 2018-01-03 Antibodies specific for hyperphosphorylated tau for the treatment of ocular diseases

Publications (1)

Publication Number Publication Date
BR112018067721A2 true BR112018067721A2 (pt) 2019-01-08

Family

ID=62789197

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018067721A BR112018067721A2 (pt) 2017-01-04 2018-01-03 anticorpos específicos para tau hiperfosforilada para o tratamento de doenças oculares

Country Status (7)

Country Link
US (1) US10995137B2 (pt)
EP (1) EP3565836A1 (pt)
JP (1) JP7217710B2 (pt)
CN (1) CN110267985B (pt)
BR (1) BR112018067721A2 (pt)
MA (1) MA47205A (pt)
WO (1) WO2018127519A1 (pt)

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JO3711B1 (ar) 2015-07-13 2021-01-31 H Lundbeck As أجسام مضادة محددة لبروتين تاو وطرق استعمالها
LT3484916T (lt) 2016-07-12 2021-04-26 H. Lundbeck A/S Antikūnai, būdingi hiperfosforilintam tau, ir jų naudojimo būdai
WO2018152359A1 (en) 2017-02-17 2018-08-23 Denali Therapeutics Inc. Anti-tau antibodies and methods of use thereof
CN113631700A (zh) * 2019-03-18 2021-11-09 瑞泽恩制药公司 用于鉴定tau接种或聚集的基因修饰因子的CRISPR/Cas筛选平台
US11781131B2 (en) 2019-03-18 2023-10-10 Regeneron Pharmaceuticals, Inc. CRISPR/Cas dropout screening platform to reveal genetic vulnerabilities associated with tau aggregation
CN111349617B (zh) * 2020-05-25 2020-09-22 苏州仁端生物医药科技有限公司 一种分泌抗Tau或pTau-181/231/396单克隆抗体杂交瘤细胞株及其应用
WO2022140463A1 (en) * 2020-12-22 2022-06-30 Herzlinger Regina E Methods, systems, and apparatus for administering a monoclonal and/or polyclonal antibody treatment via rapid infusion
US11806507B2 (en) 2020-12-22 2023-11-07 Regina E. HERZLINGER Methods, systems, and apparatus for administering an antibody treatment via infusion
WO2023092004A1 (en) 2021-11-17 2023-05-25 Voyager Therapeutics, Inc. Compositions and methods for the treatment of tau-related disorders

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Also Published As

Publication number Publication date
MA47205A (fr) 2019-11-13
EP3565836A1 (en) 2019-11-13
US10995137B2 (en) 2021-05-04
WO2018127519A1 (en) 2018-07-12
CN110267985A (zh) 2019-09-20
CN110267985B (zh) 2023-05-23
JP7217710B2 (ja) 2023-02-03
US20190330320A1 (en) 2019-10-31
JP2020506954A (ja) 2020-03-05

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