BR112018008388A2 - composição compreendendo uma matriz para transferência melhorada de moléculas osteoindutoras em reparo ósseo, implante ósseo, kit e uso - Google Patents
composição compreendendo uma matriz para transferência melhorada de moléculas osteoindutoras em reparo ósseo, implante ósseo, kit e usoInfo
- Publication number
- BR112018008388A2 BR112018008388A2 BR112018008388A BR112018008388A BR112018008388A2 BR 112018008388 A2 BR112018008388 A2 BR 112018008388A2 BR 112018008388 A BR112018008388 A BR 112018008388A BR 112018008388 A BR112018008388 A BR 112018008388A BR 112018008388 A2 BR112018008388 A2 BR 112018008388A2
- Authority
- BR
- Brazil
- Prior art keywords
- bone
- kit
- matrix
- composition
- improved transfer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0036—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/10—Ceramics or glasses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Materials Engineering (AREA)
- Surgery (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Composite Materials (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Ceramic Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Physical Education & Sports Medicine (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Prostheses (AREA)
Abstract
a presente invenção refere-se a sistemas e métodos para preparo de enxertos ósseos sintéticos osteoindutores em que um grânulo cerâmico poroso, que pode ser incorporado em um material de matriz biocompatível, é carregado com um agente osteoindutor. o carregamento de grânulos é facilitado em alguns casos pelo uso de tampões e pré-tratamentos de baixo ph.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562248861P | 2015-10-30 | 2015-10-30 | |
PCT/US2016/059782 WO2017075613A1 (en) | 2015-10-30 | 2016-10-31 | Matrix for enhanced delivery of osteoinductive molecules in bone repair |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018008388A2 true BR112018008388A2 (pt) | 2018-10-23 |
Family
ID=57281306
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018008388A BR112018008388A2 (pt) | 2015-10-30 | 2016-10-31 | composição compreendendo uma matriz para transferência melhorada de moléculas osteoindutoras em reparo ósseo, implante ósseo, kit e uso |
Country Status (9)
Country | Link |
---|---|
US (1) | US10300172B2 (pt) |
EP (1) | EP3368094B1 (pt) |
JP (1) | JP2018537158A (pt) |
KR (1) | KR20180079368A (pt) |
CN (1) | CN108601864A (pt) |
AU (1) | AU2016344024B2 (pt) |
BR (1) | BR112018008388A2 (pt) |
CA (1) | CA3002565A1 (pt) |
WO (1) | WO2017075613A1 (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL3697459T3 (pl) * | 2017-10-19 | 2023-03-06 | Genera Istrazivanja D.O.O. | Autologiczny substytut przeszczepu kości |
KR102094987B1 (ko) * | 2019-07-12 | 2020-03-31 | 주식회사 휴덴스 | 합성골 이식재 제조장치 |
US11433159B2 (en) * | 2019-07-26 | 2022-09-06 | Warsaw Orthopedic, Inc. | Hydratable and flowable implantable compositions and methods of making and using them |
US11498880B2 (en) | 2019-07-26 | 2022-11-15 | Warsaw Orthopedic, Inc. | Calcium phosphate granules and methods of making them |
US11311647B2 (en) * | 2019-07-26 | 2022-04-26 | Warsaw Orthopedic, Inc. | Implantable calcium phosphate compositions and methods |
CN114569732B (zh) * | 2022-01-24 | 2023-09-01 | 国家纳米科学中心 | 一种纳米药物及其制备方法和应用 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4394370A (en) | 1981-09-21 | 1983-07-19 | Jefferies Steven R | Bone graft material for osseous defects and method of making same |
US5385887A (en) | 1993-09-10 | 1995-01-31 | Genetics Institute, Inc. | Formulations for delivery of osteogenic proteins |
EP0823687B1 (de) | 1996-08-09 | 2001-01-31 | Hans Dipl.-Ing. Seib | Computernetzwerk und Verfahren zur Freigabe von Bau- und Konstruktionsplänen |
EP1344538A1 (en) * | 2002-03-14 | 2003-09-17 | Degradable Solutions AG | Porous biodegradable implant material and method for its fabrication |
JP4540969B2 (ja) | 2003-11-27 | 2010-09-08 | Hoya株式会社 | リン酸カルシウムセラミックス多孔体及びその製造方法 |
US7722895B1 (en) * | 2004-09-20 | 2010-05-25 | Warsaw Orthopedic, Inc. | Osteogenic implants with combined implant materials, and materials and methods for same |
GB0502493D0 (en) * | 2005-02-07 | 2005-03-16 | Orthogem Ltd | Bone cement |
WO2007097710A1 (en) | 2006-02-27 | 2007-08-30 | Agency For Science, Technology And Research | Curable bone cement |
GB2440721A (en) * | 2006-08-11 | 2008-02-13 | Univ Cambridge Tech | Composite biomaterial formed by cooling a fluid composition on a porous solid and removing solidified crystals of the liquid carrier |
US8048857B2 (en) * | 2006-12-19 | 2011-11-01 | Warsaw Orthopedic, Inc. | Flowable carrier compositions and methods of use |
WO2012028620A1 (en) | 2010-08-31 | 2012-03-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Porous polysaccharide scaffold comprising nano-hydroxyapatite and use for bone formation |
BR112013014686A2 (pt) | 2010-12-13 | 2016-10-04 | Biomimetic Therapeutics Llc | composições e métodos para procedimentos de fusão da espinha |
BR112013021369B1 (pt) | 2011-02-25 | 2019-04-16 | Synthes Gmbh | Implante e sistema de formação de um implante para promover crescimento ósseo |
GB201113054D0 (en) | 2011-07-29 | 2011-09-14 | Rolls Royce Plc | Flap seal and sealing apparatus |
CN110464701A (zh) | 2012-04-11 | 2019-11-19 | 感应生物制品股份有限公司 | 用于生长因子多相释放的体系和方法 |
-
2016
- 2016-10-31 KR KR1020187014811A patent/KR20180079368A/ko unknown
- 2016-10-31 JP JP2018521871A patent/JP2018537158A/ja active Pending
- 2016-10-31 CN CN201680063582.5A patent/CN108601864A/zh not_active Withdrawn
- 2016-10-31 AU AU2016344024A patent/AU2016344024B2/en not_active Ceased
- 2016-10-31 BR BR112018008388A patent/BR112018008388A2/pt not_active Application Discontinuation
- 2016-10-31 EP EP16794490.9A patent/EP3368094B1/en active Active
- 2016-10-31 WO PCT/US2016/059782 patent/WO2017075613A1/en active Application Filing
- 2016-10-31 US US15/339,834 patent/US10300172B2/en active Active
- 2016-10-31 CA CA3002565A patent/CA3002565A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR20180079368A (ko) | 2018-07-10 |
CA3002565A1 (en) | 2017-05-04 |
AU2016344024B2 (en) | 2018-11-22 |
US10300172B2 (en) | 2019-05-28 |
US20170209623A1 (en) | 2017-07-27 |
CN108601864A (zh) | 2018-09-28 |
WO2017075613A1 (en) | 2017-05-04 |
JP2018537158A (ja) | 2018-12-20 |
EP3368094B1 (en) | 2021-03-10 |
AU2016344024A1 (en) | 2018-05-10 |
EP3368094A1 (en) | 2018-09-05 |
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Legal Events
Date | Code | Title | Description |
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B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired |