BR112018001640A2 - combinação de antagonista da pd-1 com um inibidor de egfr - Google Patents

combinação de antagonista da pd-1 com um inibidor de egfr

Info

Publication number
BR112018001640A2
BR112018001640A2 BR112018001640A BR112018001640A BR112018001640A2 BR 112018001640 A2 BR112018001640 A2 BR 112018001640A2 BR 112018001640 A BR112018001640 A BR 112018001640A BR 112018001640 A BR112018001640 A BR 112018001640A BR 112018001640 A2 BR112018001640 A2 BR 112018001640A2
Authority
BR
Brazil
Prior art keywords
combination
antagonist
egfr inhibitor
present
medicament
Prior art date
Application number
BR112018001640A
Other languages
English (en)
Inventor
Howard Danny Jr
Cameron John
Bilic Sanela
Kasibhatla Shailaja
Jia Yong
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR112018001640A2 publication Critical patent/BR112018001640A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

a presente invenção refere-se a uma composição farmacêutica compreendendo um antagonista de pd-1 e um inibidor de egfr. a presente combinação pode ser administrada de forma independente ou separada, em uma quantidade que seja conjunta e terapeuticamente efetiva para o tratamento de câncer. a invenção também proporciona o uso de tal combinação para a fabricação de um medicamento; o uso de tal combinação como um medicamento; um kit de partes compreendendo tal combinação; e um método de tratamento de tal combinação.
BR112018001640A 2015-07-29 2016-07-27 combinação de antagonista da pd-1 com um inibidor de egfr BR112018001640A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562198390P 2015-07-29 2015-07-29
US201662331371P 2016-05-03 2016-05-03
PCT/IB2016/054488 WO2017017624A1 (en) 2015-07-29 2016-07-27 Combination of pd-1 antagonist with an egfr inhibitor

Publications (1)

Publication Number Publication Date
BR112018001640A2 true BR112018001640A2 (pt) 2018-09-18

Family

ID=56682137

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018001640A BR112018001640A2 (pt) 2015-07-29 2016-07-27 combinação de antagonista da pd-1 com um inibidor de egfr

Country Status (15)

Country Link
US (1) US20180177872A1 (pt)
EP (1) EP3328407A1 (pt)
JP (1) JP2018523652A (pt)
KR (1) KR20180030911A (pt)
CN (1) CN108235685A (pt)
AU (1) AU2016298823A1 (pt)
BR (1) BR112018001640A2 (pt)
CA (1) CA2993908A1 (pt)
CL (1) CL2018000223A1 (pt)
HK (1) HK1247850A1 (pt)
IL (1) IL256775A (pt)
MX (1) MX2018001268A (pt)
PH (1) PH12018500097A1 (pt)
RU (1) RU2018105846A (pt)
WO (1) WO2017017624A1 (pt)

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Also Published As

Publication number Publication date
WO2017017624A1 (en) 2017-02-02
US20180177872A1 (en) 2018-06-28
IL256775A (en) 2018-03-29
EP3328407A1 (en) 2018-06-06
JP2018523652A (ja) 2018-08-23
CL2018000223A1 (es) 2018-07-13
CA2993908A1 (en) 2017-02-02
CN108235685A (zh) 2018-06-29
KR20180030911A (ko) 2018-03-26
MX2018001268A (es) 2018-07-06
RU2018105846A (ru) 2019-08-28
HK1247850A1 (zh) 2018-10-05
AU2016298823A1 (en) 2018-02-08
PH12018500097A1 (en) 2018-07-23

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