BR112017023540A2 - síntese de derivados de 1 h-pirrolo[2,3-b]piridin que modulam quinases - Google Patents

síntese de derivados de 1 h-pirrolo[2,3-b]piridin que modulam quinases

Info

Publication number
BR112017023540A2
BR112017023540A2 BR112017023540-4A BR112017023540A BR112017023540A2 BR 112017023540 A2 BR112017023540 A2 BR 112017023540A2 BR 112017023540 A BR112017023540 A BR 112017023540A BR 112017023540 A2 BR112017023540 A2 BR 112017023540A2
Authority
BR
Brazil
Prior art keywords
pyrrolo
synthesis
pyridin derivatives
modulate kinases
kinases
Prior art date
Application number
BR112017023540-4A
Other languages
English (en)
Other versions
BR112017023540B1 (pt
Inventor
N. Ibrahim Prabha
Jin Masayoshi
Matsuura Shinji
Original Assignee
Plexxikon, Inc.
Daiichi Sankyo Company, Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Plexxikon, Inc., Daiichi Sankyo Company, Limited filed Critical Plexxikon, Inc.
Publication of BR112017023540A2 publication Critical patent/BR112017023540A2/pt
Publication of BR112017023540B1 publication Critical patent/BR112017023540B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

a presente invenção refere-se a processos para a preparação de um composto de fórmula (i): ou um sal do mesmo, ativo sobre as quinases de proteína receptora c-kit e/ou c-fms e/ou flt3. a divulgação também proporciona compostos e processos para a preparação dos compostos que são intermediários sintéticos para o composto de fórmula (i).
BR112017023540-4A 2015-05-06 2016-05-05 Processos de preparação de derivados de 1h-pirrolo[2,3-b]piridina que modulam quinases BR112017023540B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562157902P 2015-05-06 2015-05-06
US62/157,902 2015-05-06
US201562241040P 2015-10-13 2015-10-13
US62/241,040 2015-10-13
PCT/US2016/031022 WO2016179412A1 (en) 2015-05-06 2016-05-05 Synthesis of 1 h-pyrrolo[2,3-b]pyridin derivatives that modulate kinases

Publications (2)

Publication Number Publication Date
BR112017023540A2 true BR112017023540A2 (pt) 2018-07-24
BR112017023540B1 BR112017023540B1 (pt) 2023-04-04

Family

ID=56008879

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017023540-4A BR112017023540B1 (pt) 2015-05-06 2016-05-05 Processos de preparação de derivados de 1h-pirrolo[2,3-b]piridina que modulam quinases

Country Status (13)

Country Link
US (4) US9745298B2 (pt)
EP (2) EP3581573B1 (pt)
JP (4) JP6530826B2 (pt)
KR (1) KR102637844B1 (pt)
CN (2) CN112574196A (pt)
BR (1) BR112017023540B1 (pt)
CA (1) CA2984899C (pt)
ES (2) ES2923943T3 (pt)
HK (1) HK1248675A1 (pt)
HU (1) HUE047657T2 (pt)
IL (1) IL255305B (pt)
TW (1) TWI660956B (pt)
WO (1) WO2016179412A1 (pt)

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CN112119072A (zh) 2018-03-20 2020-12-22 普莱希科公司 用于ido和tdo调节的化合物和方法，以及其适应症
CN111349043B (zh) * 2018-12-20 2022-09-27 上海医药工业研究院 用于制备派西尼布的中间体及其制备方法和应用
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CN113444083A (zh) * 2020-03-25 2021-09-28 上海天慈国际药业有限公司 一种小分子酪氨酸激酶抑制剂的制备方法
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SG11201504754QA (en) 2012-12-21 2015-07-30 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
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WO2015134536A1 (en) 2014-03-04 2015-09-11 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
AU2015318233B2 (en) 2014-09-15 2020-03-12 Plexxikon Inc. Heterocyclic compounds and uses thereof
US10160755B2 (en) 2015-04-08 2018-12-25 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
SI3292123T1 (sl) * 2015-05-06 2020-10-30 Plexxikon Inc. Trdne oblike spojine, ki modulira kinaze
CN112574196A (zh) * 2015-05-06 2021-03-30 普莱希科公司 调节激酶的1H-吡咯并[2,3-b]吡啶衍生物的合成
CN107771178B (zh) 2015-05-22 2021-04-06 普莱希科公司 杂环化合物的合成
BR112017025045A2 (pt) 2015-05-22 2018-08-07 Plexxikon Inc plx-8394 ou plx-7904 para uso no tratamento de doenças relacionadas a braf-v600
US10829484B2 (en) 2015-07-28 2020-11-10 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
MY195977A (en) 2015-09-21 2023-02-27 Plexxikon Inc Heterocyclic Compounds and uses Thereof
KR20180086247A (ko) 2015-12-07 2018-07-30 플렉시콘 인코퍼레이티드 키나제 조절을 위한 화합물 및 방법과 이들에 대한 징후
AU2017232610B2 (en) 2016-03-16 2021-07-22 Plexxikon Inc. Compounds and methods for kinase modulation and indications therefore
TW201815766A (zh) 2016-09-22 2018-05-01 美商普雷辛肯公司 用於ｉｄｏ及ｔｄｏ調節之化合物及方法以及其適應症
AU2017395023B2 (en) 2016-12-23 2022-04-07 Plexxikon Inc. Compounds and methods for CDK8 modulation and indications therefor
JP2020511467A (ja) 2017-03-20 2020-04-16 プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． ブロモドメインを阻害する４−（１−（１，１−ジ（ピリジン−２−イル）エチル）−６−（３，５−ジメチルイソオキサゾール−４−イル）−１Ｈ−ピロロ［３，２−ｂ］ピリジン−３−イル）安息香酸の結晶形
US10428067B2 (en) 2017-06-07 2019-10-01 Plexxikon Inc. Compounds and methods for kinase modulation
TWI805599B (zh) 2017-07-25 2023-06-21 美商第一三共公司 激酶調節化合物之調配物
CA3079029A1 (en) 2017-10-13 2019-04-18 Plexxikon Inc. Solid forms of a compound for modulating kinases
BR112020007972A2 (pt) 2017-10-27 2020-10-20 Plexxikon, Inc. formulações de composto que modula quinases
CN112119072A (zh) 2018-03-20 2020-12-22 普莱希科公司 用于ido和tdo调节的化合物和方法，以及其适应症

Also Published As

Publication number Publication date
IL255305B (en) 2020-05-31
WO2016179412A1 (en) 2016-11-10
EP3581573A1 (en) 2019-12-18
ES2774178T3 (es) 2020-07-17
JP2021185163A (ja) 2021-12-09
CN112574196A (zh) 2021-03-30
US10730876B2 (en) 2020-08-04
JP2024056918A (ja) 2024-04-23
EP3292122B1 (en) 2020-01-15
US20170334909A1 (en) 2017-11-23
JP6530826B2 (ja) 2019-06-12
JP2018516880A (ja) 2018-06-28
BR112017023540B1 (pt) 2023-04-04
US20180305358A1 (en) 2018-10-25
EP3292122A1 (en) 2018-03-14
CN107531706A (zh) 2018-01-02
US20160326169A1 (en) 2016-11-10
KR20180015142A (ko) 2018-02-12
US10040792B2 (en) 2018-08-07
JP6986045B2 (ja) 2021-12-22
US10399975B2 (en) 2019-09-03
HK1248675A1 (zh) 2018-10-19
ES2923943T3 (es) 2022-10-03
IL255305A0 (en) 2017-12-31
EP3581573B1 (en) 2022-07-06
US9745298B2 (en) 2017-08-29
KR102637844B1 (ko) 2024-02-19
HUE047657T2 (hu) 2020-05-28
US20190337943A1 (en) 2019-11-07
TWI660956B (zh) 2019-06-01
TW201706271A (zh) 2017-02-16
CA2984899C (en) 2021-06-15
CA2984899A1 (en) 2016-11-10
JP2019147828A (ja) 2019-09-05

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