BR112017023269A2 - métodos para tratamento de câncer - Google Patents

métodos para tratamento de câncer

Info

Publication number
BR112017023269A2
BR112017023269A2 BR112017023269A BR112017023269A BR112017023269A2 BR 112017023269 A2 BR112017023269 A2 BR 112017023269A2 BR 112017023269 A BR112017023269 A BR 112017023269A BR 112017023269 A BR112017023269 A BR 112017023269A BR 112017023269 A2 BR112017023269 A2 BR 112017023269A2
Authority
BR
Brazil
Prior art keywords
methods
cancer treatment
subject
palbocyclib
rad1901
Prior art date
Application number
BR112017023269A
Other languages
English (en)
Portuguese (pt)
Inventor
Hattersley Gary
Original Assignee
Radius Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Radius Pharmaceuticals Inc filed Critical Radius Pharmaceuticals Inc
Publication of BR112017023269A2 publication Critical patent/BR112017023269A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
BR112017023269A 2015-04-29 2016-04-29 métodos para tratamento de câncer BR112017023269A2 (pt)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US201562154699P 2015-04-29 2015-04-29
US201562155451P 2015-04-30 2015-04-30
US201562158469P 2015-05-07 2015-05-07
US201562192944P 2015-07-15 2015-07-15
US201562192940P 2015-07-15 2015-07-15
US201562252085P 2015-11-06 2015-11-06
US201562252916P 2015-11-09 2015-11-09
US201562265696P 2015-12-10 2015-12-10
US201562265663P 2015-12-10 2015-12-10
US201562265774P 2015-12-10 2015-12-10
US201562265658P 2015-12-10 2015-12-10
US201662323572P 2016-04-15 2016-04-15
US201662323576P 2016-04-15 2016-04-15
PCT/US2016/030321 WO2016176666A1 (fr) 2015-04-29 2016-04-29 Méthodes de traitement du cancer

Publications (1)

Publication Number Publication Date
BR112017023269A2 true BR112017023269A2 (pt) 2018-11-06

Family

ID=57198783

Family Applications (3)

Application Number Title Priority Date Filing Date
BR112017023233A BR112017023233A2 (pt) 2015-04-29 2016-04-29 métodos para tratamento de câncer
BR112017023269A BR112017023269A2 (pt) 2015-04-29 2016-04-29 métodos para tratamento de câncer
BR112017023228A BR112017023228A2 (pt) 2015-04-29 2016-04-29 métodos para tratamento de câncer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR112017023233A BR112017023233A2 (pt) 2015-04-29 2016-04-29 métodos para tratamento de câncer

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR112017023228A BR112017023228A2 (pt) 2015-04-29 2016-04-29 métodos para tratamento de câncer

Country Status (14)

Country Link
US (10) US20180214393A1 (fr)
EP (4) EP4039253A1 (fr)
JP (7) JP6926065B2 (fr)
KR (3) KR20180043202A (fr)
CN (5) CN113750091A (fr)
AU (3) AU2016256470B2 (fr)
BR (3) BR112017023233A2 (fr)
CA (3) CA2984357A1 (fr)
HK (3) HK1251408A1 (fr)
IL (7) IL255261B2 (fr)
MX (6) MX2017013794A (fr)
RU (3) RU2747228C2 (fr)
SG (4) SG10202104177VA (fr)
WO (3) WO2016176665A1 (fr)

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TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
RS62660B1 (sr) * 2016-09-27 2021-12-31 Radius Pharmaceuticals Inc Rad1901 za upotrebu u lečenju karcinoma jajnika
CN112353796A (zh) 2016-10-11 2021-02-12 杜克大学 Er+乳腺癌的拉索昔芬治疗
AU2017362460B2 (en) 2016-11-17 2021-07-22 Sanofi Novel substituted N-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof
EP3565542B1 (fr) * 2017-01-05 2024-04-10 Radius Pharmaceuticals, Inc. Formes polymorphes de rad1901-2hcl
RU2764724C2 (ru) * 2017-03-16 2022-01-19 ЭИСАЙ Р энд Д МЕНЕДЖМЕНТ КО., ЛТД. Комбинированная терапия для лечения рака молочной железы
EP3434272A1 (fr) * 2017-07-25 2019-01-30 Sanofi Combinaison comprenant du palbociclib et 6-(2,4-dichlorophényl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulène-2-acide carboxylique
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CN112261937B (zh) * 2018-04-10 2023-11-14 杜克大学 乳腺癌的拉索昔芬治疗
CN110585429B (zh) * 2018-06-12 2022-10-21 江苏恒瑞医药股份有限公司 酪氨酸激酶抑制剂联合单克隆抗体以及紫杉醇类药物***疾病的用途
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AU2019335542A1 (en) 2018-09-07 2021-04-01 Sanofi Process for the preparation of methyl 6-(2,4-dichlorophenyl)-5-(4-((3s)-1-(3-fluoropropyl)pyrrolidin-3-yl)oxyphenyl)-8,9-dihydro-7H-benzo(7)annulene-2-carboxylate
CA3120368A1 (fr) * 2018-11-30 2020-06-04 Radius Pharmaceuticals, Inc. Elacestrant en combinaison avec de l'abemaciclib chez des femmes atteintes d'un cancer du sein
JOP20210138A1 (ar) * 2018-12-06 2023-01-30 Radius Pharmaceuticals Inc طرق علاج السرطان في نماذج تأوي طفرات esr1
MX2021006411A (es) * 2018-12-06 2021-07-21 Radius Pharmaceuticals Inc Metodos para el tratamiento del cancer resistente a inhibidores de cinasa 4 y cinasa 6 dependiente de ciclina (cdk4/6).
KR102341347B1 (ko) * 2019-11-28 2021-12-20 의료법인 성광의료재단 암 치료제에 대한 내성 암의 진단을 위한 조성물, 키트 및 방법
CN115175679A (zh) * 2020-03-06 2022-10-11 奥列马制药公司 治疗***受体相关疾病的方法
CN115551513A (zh) 2020-05-12 2022-12-30 基因泰克公司 使用包含gdc-9545和cdk4/6抑制剂的组合疗法治疗乳腺癌
CN113662942B (zh) * 2021-08-19 2023-02-07 中国人民解放军陆军军医大学第一附属医院 药物组合物及其在smo突变性髓母细胞瘤中的应用
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