BR112016025849A2 - métodos e composições para o tratamento da doença de huntington - Google Patents

métodos e composições para o tratamento da doença de huntington

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Publication number
BR112016025849A2
BR112016025849A2 BR112016025849A BR112016025849A BR112016025849A2 BR 112016025849 A2 BR112016025849 A2 BR 112016025849A2 BR 112016025849 A BR112016025849 A BR 112016025849A BR 112016025849 A BR112016025849 A BR 112016025849A BR 112016025849 A2 BR112016025849 A2 BR 112016025849A2
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BR
Brazil
Prior art keywords
methods
compositions
subject
disease
huntington
Prior art date
Application number
BR112016025849A
Other languages
English (en)
Inventor
Steve Zhang H
Munoz-Sanjuan Ignacio
Kwak Seung
FROELICH Steven
Original Assignee
Chdi Foundation Inc
Sangamo Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Chdi Foundation Inc, Sangamo Biosciences Inc filed Critical Chdi Foundation Inc
Publication of BR112016025849A2 publication Critical patent/BR112016025849A2/pt

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    • A61K38/00—Medicinal preparations containing peptides
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    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12N2750/14011—Parvoviridae
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Abstract

são divulgados métodos e composições para tratar ou prevenir a doença de huntington (hd). especificamente, são fornecidos métodos e composições para reduzir e/ou eliminar agregados de huntingtina (htt), melhorar déficits motores, aumentar a atividade celular (por exemplo, atividade de atp) e/ou reduzir a apoptose em um sujeito com hd, os métodos compreendendo a administração de um repressor de um alelo da htt mutante (mhtt) ao sujeito. são divulgados ainda métodos de diagnóstico de hd e/ou monitoramento da progressão da doença compreendendo a detecção de mhtt em um sujeito.
BR112016025849A 2014-05-08 2015-05-07 métodos e composições para o tratamento da doença de huntington BR112016025849A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461990521P 2014-05-08 2014-05-08
US201462051724P 2014-09-17 2014-09-17
PCT/US2015/029748 WO2015171932A1 (en) 2014-05-08 2015-05-07 Methods and compositions for treating huntington's disease

Publications (1)

Publication Number Publication Date
BR112016025849A2 true BR112016025849A2 (pt) 2017-10-17

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BR112016025849A BR112016025849A2 (pt) 2014-05-08 2015-05-07 métodos e composições para o tratamento da doença de huntington

Country Status (13)

Country Link
US (1) US11110154B2 (pt)
EP (1) EP3139966B1 (pt)
JP (1) JP2017515819A (pt)
KR (1) KR102380324B1 (pt)
CN (1) CN106413760B (pt)
AU (1) AU2015255877B2 (pt)
BR (1) BR112016025849A2 (pt)
CA (1) CA2947035A1 (pt)
HK (1) HK1232141A1 (pt)
MX (1) MX2016014565A (pt)
NZ (1) NZ725542A (pt)
RU (1) RU2691102C2 (pt)
WO (1) WO2015171932A1 (pt)

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