BR112016022868A2 - método para preparação de amg 416. - Google Patents

método para preparação de amg 416.

Info

Publication number
BR112016022868A2
BR112016022868A2 BR112016022868-5A BR112016022868A BR112016022868A2 BR 112016022868 A2 BR112016022868 A2 BR 112016022868A2 BR 112016022868 A BR112016022868 A BR 112016022868A BR 112016022868 A2 BR112016022868 A2 BR 112016022868A2
Authority
BR
Brazil
Prior art keywords
amg
preparing
preparing amg
Prior art date
Application number
BR112016022868-5A
Other languages
English (en)
Inventor
BEZEMER Jeroen
Chen Ying
Crockett Richard
CROSSLEY Kevin
Cui Sheng
Huang Liang
Jones Sian
LOWER Asher
RANGANATHAN Krishnakumar
Original Assignee
Amgen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54241346&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112016022868(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc. filed Critical Amgen Inc.
Publication of BR112016022868A2 publication Critical patent/BR112016022868A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
BR112016022868-5A 2014-04-03 2015-04-03 método para preparação de amg 416. BR112016022868A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461974899P 2014-04-03 2014-04-03
US61/974,899 2014-04-03
PCT/US2015/024347 WO2015154031A1 (en) 2014-04-03 2015-04-03 Method for preparing amg 416

Publications (1)

Publication Number Publication Date
BR112016022868A2 true BR112016022868A2 (pt) 2018-07-03

Family

ID=54241346

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016022868-5A BR112016022868A2 (pt) 2014-04-03 2015-04-03 método para preparação de amg 416.

Country Status (27)

Country Link
US (3) US10407464B2 (pt)
EP (3) EP3708576B1 (pt)
JP (1) JP6710158B2 (pt)
KR (1) KR102397271B1 (pt)
CN (1) CN106795201A (pt)
AU (1) AU2015240527B2 (pt)
BR (1) BR112016022868A2 (pt)
CA (1) CA2944194C (pt)
CL (1) CL2016002513A1 (pt)
CY (1) CY1123100T1 (pt)
DK (1) DK3126373T3 (pt)
EA (1) EA032597B1 (pt)
ES (2) ES2786225T3 (pt)
HR (1) HRP20200527T1 (pt)
HU (1) HUE048489T2 (pt)
IL (1) IL248059B2 (pt)
LT (1) LT3126373T (pt)
MA (2) MA39628B1 (pt)
ME (1) ME03781B (pt)
MX (1) MX2016012965A (pt)
PL (1) PL3126373T3 (pt)
PT (1) PT3126373T (pt)
RS (1) RS60187B1 (pt)
SG (1) SG11201608176VA (pt)
SI (1) SI3126373T1 (pt)
WO (1) WO2015154031A1 (pt)
ZA (1) ZA201606844B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE034209T2 (en) 2013-06-28 2018-02-28 Amgen Inc AMG 416 stable liquid preparation (velcalcetide)
EP3708576B1 (en) 2014-04-03 2023-02-22 Amgen Inc. Method for preparing amg 416
CN106928320B (zh) * 2015-12-31 2021-01-15 深圳翰宇药业股份有限公司 一种合成Etelcalcetide的方法
CN106928321B (zh) * 2015-12-31 2019-07-26 深圳翰宇药业股份有限公司 一种合成Etelcalcetide的方法
US11117946B2 (en) * 2016-03-23 2021-09-14 Bachem Holding Ag Method for preparing glucagon-like peptides
US10858390B2 (en) * 2016-09-02 2020-12-08 Cem Corporation Use of excess carbodiimide for peptide synthesis at elevated temperatures
CN108101959B (zh) * 2016-11-24 2021-07-09 四川科伦药物研究院有限公司 一种制备高纯度多肽或其类似物的方法
CN106928171B (zh) * 2017-05-03 2019-08-13 成都郑源生化科技有限公司 Fmoc-Arg（Pbf）-OH的合成方法
TW201915009A (zh) * 2017-10-03 2019-04-16 中化合成生技股份有限公司 合成依特卡肽（Ｅｔｅｌｃａｌｃｅｔｉｄｅ）或其鹽類之方法
CN110498835B (zh) * 2018-05-17 2021-06-08 深圳翰宇药业股份有限公司 一种合成etelcalcetide的方法
CN109280078B (zh) * 2018-10-30 2019-06-25 成都诺和晟泰生物科技有限公司 一种制备维拉卡肽的方法
CN112062811B (zh) * 2019-06-10 2022-03-25 深圳翰宇药业股份有限公司 一种维拉卡肽的合成方法
US20220298206A1 (en) * 2019-08-26 2022-09-22 Auro Peptides Ltd An improved process for the preparation of Etelcalcetide Hydrochloride
EP3875466A1 (en) * 2020-03-05 2021-09-08 Fresenius Kabi iPSUM S.r.l. Process for the synthesis of etelcalcetide
TW202210498A (zh) 2020-06-03 2022-03-16 日商中外製藥股份有限公司 高難度序列之有效率的胜肽縮合法
CN111925415A (zh) * 2020-08-10 2020-11-13 海南中和药业股份有限公司 一种维拉卡肽杂质的制备方法
TWI792442B (zh) * 2021-07-23 2023-02-11 建誼生技股份有限公司 依特卡肽鹽酸鹽之製造方法
CN114524860A (zh) * 2021-12-29 2022-05-24 深圳翰宇药业股份有限公司 一种Etelcalcetide的合成方法及其应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3941763A (en) 1975-03-28 1976-03-02 American Home Products Corporation PGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 and intermediates
EP0339695A3 (en) 1988-04-29 1990-05-30 Stichting Voor De Technische Wetenschappen A process for preparing an antigenic or immunogenic conjugate as well as the use of such conjugates
SE9603465D0 (sv) 1996-09-23 1996-09-23 Astra Ab New compounds
NO311807B1 (no) * 1999-03-04 2002-01-28 Bionor Immuno As HIV-peptider, antigener, vaksinepreparater, immunoassay- testsett og en metode for påvisning av antistoffer fremkalt av HIV
JP5473925B2 (ja) 2007-10-27 2014-04-16 コーデン ファーマ コロラド インコーポレイテッド 固相および溶液相の組み合わせ技法を使用するインスリン分泌性ペプチドの合成
CN101250172B (zh) 2008-03-07 2012-05-02 上海瀚鸿化工科技有限公司 精氨酸双保护制备工艺
US8742028B2 (en) 2009-05-06 2014-06-03 Mallinckrodt Llc Solid support for Fmoc-solid phase synthesis of peptide acids
ES2607954T3 (es) * 2009-07-29 2017-04-04 Kai Pharmaceuticals, Inc. Agentes terapéuticos para reducir los niveles de hormona paratiroidea
EP2560491A1 (en) * 2010-04-21 2013-02-27 Signature Therapeutics, Inc. Peripheral opioid agonists and peripheral opioid antagonists
AU2011301147A1 (en) * 2010-09-08 2013-04-18 Howard Florey Institute Of Experimental Physiology And Medicine Modified relaxin polypeptides
WO2013042129A1 (en) 2011-09-23 2013-03-28 Natco Pharma Limited Improved process for preparation of bivalirudin
HUE034209T2 (en) 2013-06-28 2018-02-28 Amgen Inc AMG 416 stable liquid preparation (velcalcetide)
EP3708576B1 (en) 2014-04-03 2023-02-22 Amgen Inc. Method for preparing amg 416
CN105504012A (zh) * 2014-09-30 2016-04-20 深圳翰宇药业股份有限公司 一种多肽的制备方法
CN107434820A (zh) * 2017-08-07 2017-12-05 南京工业大学 一种维拉卡肽的合成方法

Also Published As

Publication number Publication date
JP2017511332A (ja) 2017-04-20
MA39628B1 (fr) 2020-05-29
KR102397271B1 (ko) 2022-05-16
CL2016002513A1 (es) 2018-03-23
CN106795201A (zh) 2017-05-31
RS60187B1 (sr) 2020-06-30
MX2016012965A (es) 2017-07-06
IL248059B2 (en) 2023-10-01
CY1123100T1 (el) 2021-10-29
HUE048489T2 (hu) 2020-07-28
EP3708576A1 (en) 2020-09-16
LT3126373T (lt) 2020-05-11
EA032597B1 (ru) 2019-06-28
DK3126373T3 (da) 2020-05-04
KR20170026326A (ko) 2017-03-08
ZA201606844B (en) 2018-07-25
SG11201608176VA (en) 2016-10-28
JP6710158B2 (ja) 2020-06-17
US20170190739A1 (en) 2017-07-06
EP3126373A4 (en) 2018-06-20
US11377474B2 (en) 2022-07-05
US10407464B2 (en) 2019-09-10
AU2015240527B2 (en) 2019-09-26
ES2943671T3 (es) 2023-06-15
CA2944194A1 (en) 2015-10-08
EP4219526A2 (en) 2023-08-02
SI3126373T1 (sl) 2020-06-30
HRP20200527T1 (hr) 2020-06-26
PL3126373T3 (pl) 2020-07-27
WO2015154031A1 (en) 2015-10-08
US20230099078A1 (en) 2023-03-30
EA201692001A1 (ru) 2017-02-28
EP3126373A1 (en) 2017-02-08
CA2944194C (en) 2022-04-19
EP4219526A3 (en) 2023-08-30
IL248059B1 (en) 2023-06-01
ME03781B (me) 2021-04-20
ES2786225T3 (es) 2020-10-09
EP3708576B1 (en) 2023-02-22
MA52906A (fr) 2021-04-21
PT3126373T (pt) 2020-04-24
AU2015240527A1 (en) 2016-10-20
US20190352336A1 (en) 2019-11-21
IL248059A0 (en) 2016-11-30
EP3126373B1 (en) 2020-03-04

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NAO 10196/2001, QUE MODIFICOU A LEI NAO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUAANCIA PRA VIA DA ANVISA. CONSIDERANDO A APROVAA AO DOS TERMOS DO PARECER NAO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NAO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDAANCIAS CABA-VEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]