BR112016015818A2 - Compostos e respectivos usos para tratar pacientes com células cancerosas mutantes em relação a ros1 - Google Patents
Compostos e respectivos usos para tratar pacientes com células cancerosas mutantes em relação a ros1Info
- Publication number
- BR112016015818A2 BR112016015818A2 BR112016015818A BR112016015818A BR112016015818A2 BR 112016015818 A2 BR112016015818 A2 BR 112016015818A2 BR 112016015818 A BR112016015818 A BR 112016015818A BR 112016015818 A BR112016015818 A BR 112016015818A BR 112016015818 A2 BR112016015818 A2 BR 112016015818A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- treatment
- patients
- cancer cells
- ros1
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
COMPOSTOS E RESPECTIVOS USOS PARA TRATAR PACIENTES COM CÉLULAS CANCEROSAS MUTANTES EM RELAÇÃO A ROS1. São divulgados derivados de indazol da fórmula (I) ou da fórmula 2.(I) substi-tuídos e sais farmaceuticamente aceitáveis dos mesmos, que são definidos no Relatório Descritivo, processo para a preparação dos mesmos e composi-ções farmacêuticas que compreendem os mesmos; os compostos da inven-ção podem ser úteis em terapia no tratamento de doenças associadas a uma atividade desregulada de proteínas quinases, como câncer.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461942287P | 2014-02-20 | 2014-02-20 | |
US201462052994P | 2014-09-19 | 2014-09-19 | |
US201462055450P | 2014-09-25 | 2014-09-25 | |
US201462069999P | 2014-10-29 | 2014-10-29 | |
PCT/EP2015/053544 WO2015124697A1 (en) | 2014-02-20 | 2015-02-19 | Compounds for treating patients with ros1 mutant cancer cells |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112016015818A2 true BR112016015818A2 (pt) | 2017-08-08 |
Family
ID=52544499
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016015818A BR112016015818A2 (pt) | 2014-02-20 | 2015-02-19 | Compostos e respectivos usos para tratar pacientes com células cancerosas mutantes em relação a ros1 |
Country Status (20)
Country | Link |
---|---|
US (4) | US10231965B2 (pt) |
EP (2) | EP3107541B1 (pt) |
JP (1) | JP6636933B2 (pt) |
KR (2) | KR102634514B1 (pt) |
CN (1) | CN106029073A (pt) |
AU (1) | AU2015220832B2 (pt) |
BR (1) | BR112016015818A2 (pt) |
CA (1) | CA2933623C (pt) |
CL (1) | CL2016001507A1 (pt) |
EA (1) | EA033457B1 (pt) |
ES (1) | ES2856231T3 (pt) |
IL (1) | IL246544B (pt) |
MX (1) | MX2016010519A (pt) |
NL (1) | NL301111I2 (pt) |
PH (1) | PH12016501394A1 (pt) |
PL (1) | PL3107541T3 (pt) |
SG (1) | SG11201605816TA (pt) |
TW (1) | TWI672141B (pt) |
UA (1) | UA118773C2 (pt) |
WO (1) | WO2015124697A1 (pt) |
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JP2019527231A (ja) * | 2016-08-01 | 2019-09-26 | イグナイタ インコーポレイテッド | がんを治療するための組み合わせ |
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TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
JP6888101B2 (ja) | 2017-01-18 | 2021-06-16 | アレイ バイオファーマ インコーポレイテッド | RETキナーゼ阻害剤としての置換ピラゾロ[1,5−a]ピラジン化合物 |
JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
BR112020000793A2 (pt) | 2017-07-19 | 2020-07-14 | Ignyta, Inc. | composições farmacêuticas e formas de dosagem |
US10180422B1 (en) | 2017-08-22 | 2019-01-15 | Scripps Health | Methods of treating a neuroendocrine tumor |
TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
TWI812649B (zh) | 2017-10-10 | 2023-08-21 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
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KR102545594B1 (ko) | 2018-07-31 | 2023-06-21 | 록쏘 온콜로지, 인코포레이티드 | (s)-5-아미노-3-(4-((5-플루오로-2-메톡시벤즈아미도)메틸)페닐)-1-(1,1,1-트리플루오로프로판-2-일)-1h-피라졸-4-카르복스아미드의 분무-건조된 분산물 및 제제 |
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2015
- 2015-02-17 TW TW104105734A patent/TWI672141B/zh active
- 2015-02-17 US US14/623,904 patent/US10231965B2/en active Active
- 2015-02-19 EA EA201691151A patent/EA033457B1/ru not_active IP Right Cessation
- 2015-02-19 MX MX2016010519A patent/MX2016010519A/es active IP Right Grant
- 2015-02-19 PL PL15705613T patent/PL3107541T3/pl unknown
- 2015-02-19 CA CA2933623A patent/CA2933623C/en active Active
- 2015-02-19 KR KR1020227041235A patent/KR102634514B1/ko active IP Right Grant
- 2015-02-19 US US15/114,367 patent/US20170007599A1/en not_active Abandoned
- 2015-02-19 KR KR1020167025693A patent/KR20160117611A/ko not_active Application Discontinuation
- 2015-02-19 SG SG11201605816TA patent/SG11201605816TA/en unknown
- 2015-02-19 EP EP15705613.6A patent/EP3107541B1/en active Active
- 2015-02-19 WO PCT/EP2015/053544 patent/WO2015124697A1/en active Application Filing
- 2015-02-19 UA UAA201607296A patent/UA118773C2/uk unknown
- 2015-02-19 JP JP2016553608A patent/JP6636933B2/ja active Active
- 2015-02-19 EP EP20207234.4A patent/EP3834827A1/en not_active Withdrawn
- 2015-02-19 CN CN201580004225.7A patent/CN106029073A/zh active Pending
- 2015-02-19 BR BR112016015818A patent/BR112016015818A2/pt not_active Application Discontinuation
- 2015-02-19 AU AU2015220832A patent/AU2015220832B2/en active Active
- 2015-02-19 ES ES15705613T patent/ES2856231T3/es active Active
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2016
- 2016-06-15 CL CL2016001507A patent/CL2016001507A1/es unknown
- 2016-06-30 IL IL246544A patent/IL246544B/en active IP Right Grant
- 2016-07-14 PH PH12016501394A patent/PH12016501394A1/en unknown
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2018
- 2018-07-31 US US16/050,516 patent/US10561651B2/en active Active
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2019
- 2019-01-16 US US16/249,703 patent/US10682348B2/en active Active
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2021
- 2021-06-22 NL NL301111C patent/NL301111I2/nl unknown
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