BR112016003454A2 - Uso de composto de metil bardoxolona - Google Patents

Uso de composto de metil bardoxolona

Info

Publication number
BR112016003454A2
BR112016003454A2 BR112016003454A BR112016003454A BR112016003454A2 BR 112016003454 A2 BR112016003454 A2 BR 112016003454A2 BR 112016003454 A BR112016003454 A BR 112016003454A BR 112016003454 A BR112016003454 A BR 112016003454A BR 112016003454 A2 BR112016003454 A2 BR 112016003454A2
Authority
BR
Brazil
Prior art keywords
compound
methyl bardoxolone
bardoxolone
methyl
bardoxolone compound
Prior art date
Application number
BR112016003454A
Other languages
English (en)
Other versions
BR112016003454B1 (pt
Inventor
Pei-Heng Chin Melanie
J Meyer Colin
Original Assignee
Reata Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reata Pharmaceuticals Inc filed Critical Reata Pharmaceuticals Inc
Publication of BR112016003454A2 publication Critical patent/BR112016003454A2/pt
Publication of BR112016003454B1 publication Critical patent/BR112016003454B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
BR112016003454-6A 2013-08-23 2014-08-22 Uso de composto de metil bardoxolona BR112016003454B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361869527P 2013-08-23 2013-08-23
US61/869,527 2013-08-23
PCT/US2014/052382 WO2015027206A1 (en) 2013-08-23 2014-08-22 Methods of treating and preventing endothelial dysfunction using bardoxololone methyl or analogs thereof

Publications (2)

Publication Number Publication Date
BR112016003454A2 true BR112016003454A2 (pt) 2017-08-01
BR112016003454B1 BR112016003454B1 (pt) 2023-02-14

Family

ID=51794949

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016003454-6A BR112016003454B1 (pt) 2013-08-23 2014-08-22 Uso de composto de metil bardoxolona

Country Status (19)

Country Link
US (3) US20150080465A1 (pt)
EP (1) EP3035937A1 (pt)
JP (3) JP6564372B2 (pt)
KR (1) KR102322057B1 (pt)
CN (2) CN105517554B (pt)
AU (2) AU2014308600B2 (pt)
BR (1) BR112016003454B1 (pt)
CA (1) CA2921386A1 (pt)
CL (1) CL2016000405A1 (pt)
EA (1) EA201690456A1 (pt)
HK (1) HK1223015A1 (pt)
IL (3) IL285832B2 (pt)
MX (2) MX2016002375A (pt)
MY (1) MY198522A (pt)
NZ (4) NZ756256A (pt)
PH (1) PH12016500358A1 (pt)
SG (2) SG10201906113RA (pt)
TW (2) TWI716341B (pt)
WO (1) WO2015027206A1 (pt)

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EA030468B1 (ru) 2012-04-27 2018-08-31 Рита Фармасьютикалз, Инк. 2,2-дифторпропионамидные производные бардоксолон-метила, их полиморфные формы и способы применения
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BR112021005919A2 (pt) * 2018-09-28 2021-07-27 Sichuan Haisco Pharmaceutical Co., Ltd. composto, composição farmacêutica e método para tratar uma doença em um mamífero
TW202028748A (zh) * 2018-10-17 2020-08-01 日商資生堂股份有限公司 檢定根據血液中之胱蛋白c含量之腎功能檢查結果之妥當性之方法
JP2023504428A (ja) * 2019-11-27 2023-02-03 ▲魯▼南制▲薬▼集▲団▼股▲フン▼有限公司 オレアナンシンナムアミド誘導体及びその製造方法と用途
WO2021126884A1 (en) * 2019-12-16 2021-06-24 Tenax Therapeutics, Inc. LEVOSIMENDAN FOR TREATING PULMONARY HYPERTENSION WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION (PH-HF-pEF)
CN115697319A (zh) * 2020-04-01 2023-02-03 四川海思科制药有限公司 三萜系化合物nrf2抑制剂的用途
MX2022014034A (es) * 2020-05-09 2023-01-11 Reata Pharmaceuticals Holdings Llc Métodos para tratar covid-19 con el uso de bardoxolona metilo o análogos de esta.
CN111704647B (zh) * 2020-06-15 2021-10-22 中国人民解放军海军军医大学 一类三萜类衍生物及其作为程序性细胞坏死抑制剂的用途
AU2021397631A1 (en) 2020-12-11 2023-07-20 Reata Pharmaceuticals Holdings, LLC Synthetic triterpenoids for use in therapy
US20220401396A1 (en) * 2021-06-22 2022-12-22 Asklepion Pharmaceuticals, Llc Action of l-citrulline to prevent or treat endothelial dysfunction
CN114097807B (zh) * 2021-11-25 2023-05-05 兰州大学 巴多索隆类化合物在抗农业病原真菌中的用途
CN116509874A (zh) * 2023-02-01 2023-08-01 潍坊医学院附属医院 甲基巴多索隆在制备改善病毒性心肌炎或病毒性心肌损伤的药物中的用途

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Also Published As

Publication number Publication date
IL285832B1 (en) 2023-09-01
KR20160061994A (ko) 2016-06-01
MX2021002897A (es) 2021-06-08
JP6564372B2 (ja) 2019-08-21
WO2015027206A1 (en) 2015-02-26
NZ744036A (en) 2020-09-25
IL285832A (en) 2021-09-30
JP2019131599A (ja) 2019-08-08
AU2020203510B2 (en) 2023-05-11
IL285832B2 (en) 2024-01-01
CN105517554A (zh) 2016-04-20
JP6701407B2 (ja) 2020-05-27
KR102322057B1 (ko) 2021-11-05
WO2015027206A8 (en) 2015-06-11
AU2014308600A1 (en) 2016-03-03
CN112870202A (zh) 2021-06-01
MY198522A (en) 2023-09-04
NZ756256A (en) 2021-07-30
SG11201601202WA (en) 2016-03-30
TW202026003A (zh) 2020-07-16
TWI717026B (zh) 2021-01-21
PH12016500358A1 (en) 2016-05-16
IL244171A0 (en) 2016-04-21
US20240115542A1 (en) 2024-04-11
IL272242B (en) 2021-09-30
TWI716341B (zh) 2021-01-21
NZ774222A (en) 2023-01-27
IL244171B (en) 2020-02-27
JP6526306B2 (ja) 2019-06-05
IL272242A (en) 2020-02-27
NZ630951A (en) 2018-09-28
CL2016000405A1 (es) 2017-02-24
CA2921386A1 (en) 2015-02-26
BR112016003454B1 (pt) 2023-02-14
MX2016002375A (es) 2016-12-20
EP3035937A1 (en) 2016-06-29
AU2014308600B2 (en) 2020-03-05
TW201542211A (zh) 2015-11-16
JP2019048873A (ja) 2019-03-28
US20150080465A1 (en) 2015-03-19
CN105517554B (zh) 2021-01-15
SG10201906113RA (en) 2019-08-27
EA201690456A1 (ru) 2016-06-30
JP2016528300A (ja) 2016-09-15
HK1223015A1 (zh) 2017-07-21
AU2020203510A1 (en) 2020-06-18
US20190091194A1 (en) 2019-03-28

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 22/08/2014, OBSERVADAS AS CONDICOES LEGAIS

B25A Requested transfer of rights approved

Owner name: REATA PHARMACEUTICALS HOLDINGS, LLC (US)