BR112015031722A2 - método de preparação de 4-benzil-1-fenetil-piperazina-2,6-diona, e intermediário e método de preparação dos mesmos - Google Patents
método de preparação de 4-benzil-1-fenetil-piperazina-2,6-diona, e intermediário e método de preparação dos mesmosInfo
- Publication number
- BR112015031722A2 BR112015031722A2 BR112015031722A BR112015031722A BR112015031722A2 BR 112015031722 A2 BR112015031722 A2 BR 112015031722A2 BR 112015031722 A BR112015031722 A BR 112015031722A BR 112015031722 A BR112015031722 A BR 112015031722A BR 112015031722 A2 BR112015031722 A2 BR 112015031722A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- formula
- preparing
- dione
- benzyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
resumo método de preparação de 4-benzil-1-fenetil-piperazina-2,6-diona, e intermediário e método de preparação dos mesmos a presente invenção refere-se a um novo intermediário essencial (um composto de fórmula iii) de 4-benzil-1-fenetil-piperazina-2,6-diona (composto de fórmula iv), um sal farmaceuticamente aceitável do mesmo e um método de preparação dos mesmos. a presente invenção revela adicionalmente um método para preparar 4-benzil-1-fenetil-piperazina-2,6-diona (composto de fórmula iv) a partir do composto de fórmula iii, sendo que o dito método supera as deficiências dos métodos de preparação do composto de fórmula iv atuais, tais como baixos volumes de produção, baixa pureza, alto consumo de energia, custos elevados, e incapacidade de atingir a produção industrializada, e fornece um método de preparação do composto de fórmula iv que é simples, econômico, ambientalmente amigável e fácil de produzir industrialmente; o solvente de reação do método é facilmente reciclado e o método pode produzir o composto de fórmula iv em altas taxas de produção e com alta pureza. 1/1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310255096.1A CN104230743B (zh) | 2013-06-24 | 2013-06-24 | 一种4-苄基-1-苯乙基哌嗪-2,6-二酮的制备方法 |
CN201310255096.1 | 2013-06-24 | ||
PCT/CN2014/080498 WO2014206254A1 (zh) | 2013-06-24 | 2014-06-23 | 一种4-苄基-1-苯乙基哌嗪-2,6-二酮的制备方法、中间体及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112015031722A2 true BR112015031722A2 (pt) | 2017-07-25 |
BR112015031722B1 BR112015031722B1 (pt) | 2022-05-31 |
Family
ID=52141050
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015031722-7A BR112015031722B1 (pt) | 2013-06-24 | 2014-06-23 | Método de preparação de 4-benzil-1-fenetil-piperazina-2,6-diona, e intermediário e método de preparação dos mesmos |
Country Status (8)
Country | Link |
---|---|
US (1) | US9527804B2 (pt) |
EP (1) | EP3015455B1 (pt) |
JP (1) | JP6230703B2 (pt) |
KR (1) | KR101810515B1 (pt) |
CN (1) | CN104230743B (pt) |
BR (1) | BR112015031722B1 (pt) |
RU (1) | RU2631323C2 (pt) |
WO (1) | WO2014206254A1 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109232319A (zh) * | 2018-09-07 | 2019-01-18 | 山东金城柯瑞化学有限公司 | 二环己基碳二亚胺的制备方法 |
CN110903218A (zh) * | 2019-12-16 | 2020-03-24 | 山东金城柯瑞化学有限公司 | 一种二环己基碳二亚胺的制备方法 |
CN115466261A (zh) * | 2022-09-15 | 2022-12-13 | 诚弘制药(威海)有限责任公司 | 一种吡喹酮的新制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2425825C2 (ru) * | 2007-02-09 | 2011-08-10 | Пфайзер Лимитед | Амидоацетонитрильные производные, содержащие их фармацевтические композиции и их применение в изготовлении лекарственного средства |
US8268849B2 (en) * | 2007-09-25 | 2012-09-18 | Board Of Regents Of The University Of Nebraska | Multifunctional Antioxidants and methods of use thereof |
EP2371421A1 (en) | 2010-03-04 | 2011-10-05 | Université de Lille 2 Droit et Santé | Ligands of insulin degrading enzyme and their uses |
-
2013
- 2013-06-24 CN CN201310255096.1A patent/CN104230743B/zh active Active
-
2014
- 2014-06-23 RU RU2015152291A patent/RU2631323C2/ru active
- 2014-06-23 JP JP2016522214A patent/JP6230703B2/ja active Active
- 2014-06-23 EP EP14817699.3A patent/EP3015455B1/en active Active
- 2014-06-23 US US14/899,350 patent/US9527804B2/en active Active
- 2014-06-23 WO PCT/CN2014/080498 patent/WO2014206254A1/zh active Application Filing
- 2014-06-23 KR KR1020167000372A patent/KR101810515B1/ko active IP Right Grant
- 2014-06-23 BR BR112015031722-7A patent/BR112015031722B1/pt active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
KR20160018713A (ko) | 2016-02-17 |
EP3015455A1 (en) | 2016-05-04 |
EP3015455B1 (en) | 2018-01-10 |
JP2016527207A (ja) | 2016-09-08 |
CN104230743B (zh) | 2017-02-08 |
BR112015031722B1 (pt) | 2022-05-31 |
RU2631323C2 (ru) | 2017-09-21 |
JP6230703B2 (ja) | 2017-11-15 |
CN104230743A (zh) | 2014-12-24 |
RU2015152291A (ru) | 2017-07-28 |
US20160130218A1 (en) | 2016-05-12 |
US9527804B2 (en) | 2016-12-27 |
WO2014206254A1 (zh) | 2014-12-31 |
EP3015455A4 (en) | 2017-03-29 |
KR101810515B1 (ko) | 2017-12-19 |
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
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Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/06/2014, OBSERVADAS AS CONDICOES LEGAIS |