BR112015031277A2 - Moduladores do receptor de insulina de polipeptídeos estabilizados, análogos de insulina, composições farmacêuticas compreendendo os referidos polipeptídeos e métodos de preparação e usos dos mesmos - Google Patents

Moduladores do receptor de insulina de polipeptídeos estabilizados, análogos de insulina, composições farmacêuticas compreendendo os referidos polipeptídeos e métodos de preparação e usos dos mesmos

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Publication number
BR112015031277A2
BR112015031277A2 BR112015031277A BR112015031277A BR112015031277A2 BR 112015031277 A2 BR112015031277 A2 BR 112015031277A2 BR 112015031277 A BR112015031277 A BR 112015031277A BR 112015031277 A BR112015031277 A BR 112015031277A BR 112015031277 A2 BR112015031277 A2 BR 112015031277A2
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BR
Brazil
Prior art keywords
polypeptides
insulin
methods
pharmaceutical compositions
stabilized
Prior art date
Application number
BR112015031277A
Other languages
English (en)
Inventor
L Verdine Gregory
HILINSKI Gerard
Yue Liang Rebecca
Alice Nagel Yvonne
Zhou Minyun
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Publication of BR112015031277A2 publication Critical patent/BR112015031277A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

MODULADORES DO RECEPTOR DE INSULINA DE POLIPEPTÍDEOS ESTABILIZADOS, ANÁLOGOS DE INSULINA, COMPOSIÇÕES FARMACÊUTICAS COMPREENDENDO OS REFERIDOS POLIPEPTÍDEOS E MÉTODOS DE PREPARAÇÃO E USOS DOS MESMOS. São fornecidos aqui polipeptídeos (ALFA)-CT estabilizados que compreende um segmento alfa-helicoidal e em que o polipeptídeo é de Fórmula (I-1) ou Fórmula (I-2): Rf-[XAA]s-XA1-XA2-XA3-XA4-XA5-XA6-XA7-XA8-XA9-XA10-XA11-XA12-XA13-XA14-[XAA]t-Re (I-1) Rf-[XAA]s-XC1-XC2-XC3-XC4-XC5-XC6-XC7-XC8-XC9-XC10-XC11-XC12-XC13-XC14- XC15-XC16-XC17- XC18-XC19-XC20-[XAA]t-Re (I-2) em que o polipeptídeo Alfa-CT se liga ao receptor de insulina e em que o polipeptídeo Alfa-CT inclui pelo menos um grampo (isto é, dois aminoácidos com ligação cruzada) e/ou pelo menos uma costura (isto é, três aminoácidos com ligação cruzada). São ainda fornecidos análogos de insulina que incluem os polipeptídeos Alfa-CT grampeados ou costurados, composições farmacêuticas dos mesmos, métodos de uso, por exemplo, métodos de tratamento de uma condição diabética ou complicações da mesma.
BR112015031277A 2013-06-14 2014-06-13 Moduladores do receptor de insulina de polipeptídeos estabilizados, análogos de insulina, composições farmacêuticas compreendendo os referidos polipeptídeos e métodos de preparação e usos dos mesmos BR112015031277A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361835242P 2013-06-14 2013-06-14
PCT/US2014/042329 WO2014201370A1 (en) 2013-06-14 2014-06-13 Stabilized polypeptide insulin receptor modulators

Publications (1)

Publication Number Publication Date
BR112015031277A2 true BR112015031277A2 (pt) 2017-09-19

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015031277A BR112015031277A2 (pt) 2013-06-14 2014-06-13 Moduladores do receptor de insulina de polipeptídeos estabilizados, análogos de insulina, composições farmacêuticas compreendendo os referidos polipeptídeos e métodos de preparação e usos dos mesmos

Country Status (12)

Country Link
US (1) US10227390B2 (pt)
EP (1) EP3008081B1 (pt)
JP (1) JP2016523241A (pt)
KR (1) KR20160019547A (pt)
CN (1) CN105492460A (pt)
AU (2) AU2014278005B2 (pt)
BR (1) BR112015031277A2 (pt)
CA (1) CA2915354A1 (pt)
HK (1) HK1223945A1 (pt)
IL (1) IL243088B (pt)
MX (1) MX2015017274A (pt)
WO (1) WO2014201370A1 (pt)

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BR112019000991A2 (pt) * 2016-07-22 2019-07-02 University Of Utah Research Foundation análogo da insulina, composição farmacêutica, método para tratar e/ou prevenir uma afeção relacionada com insulina, método para decrescer níveis de glicose no sangue, uso do análogo da insulina, método de replanejamento ou modificação de um polipeptídeo que é conhecido por se ligar a um receptor da insulina, polipeptídeo, molécula isolada, método para identificar um composto que se liga ao receptor de insulina, método de base computacional para identificar um composto que imita a atividade da insulina, composto identificado usando um método, cristal do polipeptídeo, estrutura do polipeptídeo, uso da estrutura, uso do modelo estrutural, peptídeo, método para aumentar a ativação do receptor da insulina em um sujeito, método para diminuir o açúcar no sangue em um sujeito, método para tratar diabetes tipo 1 em um sujeito e proteína terapêutica
KR102003904B1 (ko) * 2016-08-17 2019-07-25 연세대학교 산학협력단 안정화된 알파-헬릭스 이차 구조를 갖는 펩타이드-고분자 결합체 제조방법 및 이를 이용해 제조된 펩타이드-고분자 결합체
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US11496462B2 (en) * 2017-11-29 2022-11-08 Jpmorgan Chase Bank, N.A. Secure multifactor authentication with push authentication
US11345725B2 (en) 2019-09-16 2022-05-31 Research Foundation Of The City University Of New York Bis-thioether stapled peptides as inhibitors of PRC2 function
CN116710116A (zh) * 2020-10-30 2023-09-05 Ｘｅｎｏ－Ｉｎｔｅｒｆａｃｅ株式会社 β折叠股桥肽
CN113527416A (zh) * 2021-08-11 2021-10-22 南开大学 一种硝基还原酶响应氨基酸及肿瘤乏氧荧光探针的制备方法

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