BR112015012841A2 - composição imunogênica, vacina, e, uso de uma composição imunogênica - Google Patents

composição imunogênica, vacina, e, uso de uma composição imunogênica

Info

Publication number
BR112015012841A2
BR112015012841A2 BR112015012841A BR112015012841A BR112015012841A2 BR 112015012841 A2 BR112015012841 A2 BR 112015012841A2 BR 112015012841 A BR112015012841 A BR 112015012841A BR 112015012841 A BR112015012841 A BR 112015012841A BR 112015012841 A2 BR112015012841 A2 BR 112015012841A2
Authority
BR
Brazil
Prior art keywords
immunogenic composition
vaccine
immunogenic
composition
difficile
Prior art date
Application number
BR112015012841A
Other languages
English (en)
Other versions
BR112015012841B1 (pt
Inventor
Boutriau Dominique
Wallemacq Hugues
Marie Jeanne Valentine Germain Sophie
Original Assignee
Glaxosmithkline Biologicals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Biologicals Sa filed Critical Glaxosmithkline Biologicals Sa
Publication of BR112015012841A2 publication Critical patent/BR112015012841A2/pt
Publication of BR112015012841B1 publication Critical patent/BR112015012841B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

1 / 105 1 / 1 resumo “composiã‡ãƒo imunogãšnica, vacina, e, uso de uma composiã‡ãƒo imunogãšnica” a presente invenã§ã£o refere-se a composiã§ãµes imunogãªnicas compreendendo um polipeptã­deo de clostridium difficile (c. difficile) e um adjuvante sem alumã­nio.
BR112015012841-6A 2012-12-05 2013-12-03 Composição imunogênica e uso de uma composição imunogênica BR112015012841B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1221875.6 2012-12-05
GB201221875 2012-12-05
PCT/EP2013/075405 WO2014086787A1 (en) 2012-12-05 2013-12-03 Immunogenic composition

Publications (2)

Publication Number Publication Date
BR112015012841A2 true BR112015012841A2 (pt) 2017-09-26
BR112015012841B1 BR112015012841B1 (pt) 2022-05-03

Family

ID=49724573

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015012841-6A BR112015012841B1 (pt) 2012-12-05 2013-12-03 Composição imunogênica e uso de uma composição imunogênica

Country Status (22)

Country Link
US (2) US9694064B2 (pt)
EP (2) EP3513806B1 (pt)
JP (2) JP6290918B2 (pt)
CN (2) CN112807422A (pt)
AR (1) AR093712A1 (pt)
AU (1) AU2013354186A1 (pt)
BR (1) BR112015012841B1 (pt)
CA (1) CA2893435A1 (pt)
CY (1) CY1121560T1 (pt)
DK (2) DK2928489T3 (pt)
ES (2) ES2939307T3 (pt)
FI (1) FI3513806T3 (pt)
HR (2) HRP20230359T1 (pt)
HU (2) HUE061273T2 (pt)
LT (2) LT3513806T (pt)
PL (2) PL2928489T3 (pt)
PT (2) PT2928489T (pt)
SG (1) SG11201503861UA (pt)
SI (2) SI2928489T1 (pt)
TR (1) TR201905272T4 (pt)
WO (1) WO2014086787A1 (pt)
ZA (1) ZA201503927B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
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PT2351578T (pt) * 2005-06-27 2017-04-07 Glaxosmithkline Biologicals Sa Processo para o fabrico de vacinas
DK2753352T4 (da) 2010-09-03 2022-09-12 Valneva Austria Gmbh Isoleret polypeptid af toxin a og toxin b proteinerne fra c. difficile og anvendelser deraf
PT3549949T (pt) 2011-04-22 2024-02-02 Wyeth Llc Composições relacionadas com uma toxina de clostridium difficile mutante e métodos da mesma
BR122016023101B1 (pt) * 2012-10-21 2022-03-22 Pfizer Inc Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
PT2928489T (pt) * 2012-12-05 2019-05-28 Glaxosmithkline Biologicals Sa Composição imunogénica
SI3160500T1 (sl) * 2014-06-25 2019-11-29 Glaxosmithkline Biologicals Sa Imunogeni sestavek proti Clostridium difficile
CA2954087C (en) * 2014-07-25 2023-09-19 Biosynth S.R.L. Glycoconjugate vaccines comprising basic units of a molecular construct expressing built-in multiple epitopes for the formulation of a broad-spectrum vaccine against infections due to enteropathogenic bacteria
US10533036B2 (en) 2015-02-19 2020-01-14 Immune Biosolutions Inc Clostridium difficile toxins a and/or B antigen and epitope antibody, and pharmaceutical uses thereof
CN109311950A (zh) 2016-03-21 2019-02-05 儿童医学中心公司 用于抑制wnt信号传导的组合物和方法
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
CA3056090A1 (en) * 2017-03-15 2018-09-20 Novavax, Inc. Methods and compositions for inducing immune responses against clostridium difficile
CN107397956A (zh) * 2017-08-08 2017-11-28 南开大学 一种铜绿假单胞菌外膜蛋白疫苗的制备方法及应用
US10933126B2 (en) 2018-05-03 2021-03-02 The Board Of Regents Of The University Of Oklahoma Clostridium difficile immunogenic compositions and methods of use
WO2021255690A2 (en) * 2020-06-19 2021-12-23 Pfizer Inc. Immunogenic compositions against clostridioides (clostridium) difficile and methods thereof

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US4751180A (en) 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
US4935233A (en) 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US4877611A (en) 1986-04-15 1989-10-31 Ribi Immunochem Research Inc. Vaccine containing tumor antigens and adjuvants
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AU685443B2 (en) 1993-03-23 1998-01-22 Smithkline Beecham Biologicals (Sa) Vaccine compositions containing 3-O deacylated monophosphoryl lipid A
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Also Published As

Publication number Publication date
FI3513806T3 (fi) 2023-04-26
CN104884081A (zh) 2015-09-02
US10130694B2 (en) 2018-11-20
EP2928489A1 (en) 2015-10-14
EP3513806B1 (en) 2023-01-25
ES2721930T3 (es) 2019-08-06
US20170340719A1 (en) 2017-11-30
LT2928489T (lt) 2019-04-10
SG11201503861UA (en) 2015-06-29
TR201905272T4 (tr) 2019-05-21
JP2016502551A (ja) 2016-01-28
AR093712A1 (es) 2015-06-17
JP6290918B2 (ja) 2018-03-07
SI2928489T1 (sl) 2019-05-31
LT3513806T (lt) 2023-04-11
CN112807422A (zh) 2021-05-18
DK3513806T3 (da) 2023-02-27
AU2013354186A1 (en) 2014-06-12
CA2893435A1 (en) 2014-06-12
PT2928489T (pt) 2019-05-28
JP2018104446A (ja) 2018-07-05
US9694064B2 (en) 2017-07-04
PL2928489T3 (pl) 2019-07-31
WO2014086787A1 (en) 2014-06-12
BR112015012841B1 (pt) 2022-05-03
HRP20230359T1 (hr) 2023-06-09
ES2939307T3 (es) 2023-04-20
JP6626521B2 (ja) 2019-12-25
DK2928489T3 (en) 2019-04-23
ZA201503927B (en) 2017-11-29
HRP20190711T1 (hr) 2019-05-31
EP2928489B1 (en) 2019-02-27
SI3513806T1 (sl) 2023-04-28
HUE043091T2 (hu) 2019-08-28
PT3513806T (pt) 2023-03-02
US20150313984A1 (en) 2015-11-05
EP3513806A1 (en) 2019-07-24
CY1121560T1 (el) 2020-05-29
HUE061273T2 (hu) 2023-06-28
PL3513806T3 (pl) 2023-05-15

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 03/12/2013, OBSERVADAS AS CONDICOES LEGAIS.