BR112015010314A8 - Composto ou sais farmaceuticamente aceitáveis ou isômeros dos mesmos, composição farmacêutica, secretagogo de insulina ou agente hipoglicêmico, e, agonista do receptor gpr40 - Google Patents
Composto ou sais farmaceuticamente aceitáveis ou isômeros dos mesmos, composição farmacêutica, secretagogo de insulina ou agente hipoglicêmico, e, agonista do receptor gpr40Info
- Publication number
- BR112015010314A8 BR112015010314A8 BR112015010314A BR112015010314A BR112015010314A8 BR 112015010314 A8 BR112015010314 A8 BR 112015010314A8 BR 112015010314 A BR112015010314 A BR 112015010314A BR 112015010314 A BR112015010314 A BR 112015010314A BR 112015010314 A8 BR112015010314 A8 BR 112015010314A8
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical composition
- receptor agonist
- isomers
- compound
- pharmaceutically acceptable
- Prior art date
Links
- 102100026148 Free fatty acid receptor 1 Human genes 0.000 title abstract 2
- 101000912510 Homo sapiens Free fatty acid receptor 1 Proteins 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000000018 receptor agonist Substances 0.000 title abstract 2
- 229940044601 receptor agonist Drugs 0.000 title abstract 2
- 229940122199 Insulin secretagogue Drugs 0.000 title 1
- 239000003472 antidiabetic agent Substances 0.000 title 1
- 229940126904 hypoglycaemic agent Drugs 0.000 title 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 230000003914 insulin secretion Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
COMPOSTO OU SAIS FARMACEUTICAMENTE ACEITÁVEIS OU ISÔMEROS DOS MESMOS, COMPOSIÇÃO FARMACÊUTICA, SECRETAGOGO DE INSULINA OU AGENTE HIPOGLICÊMICO, AGONISTA DO RECEPTOR GPR40, E, MÉTODO PARA TRATAR DOENÇAS OU DISTÚRBIOS. A presente invenção refere-se a um composto novo tendo atividade do agonista do receptor GPR40 que promove secreção de insulina e inibe a elevação de açúcar no sangue após carga de glicose, e é assim utilizável para o tratamento de diabetes e complicações da mesma, o método de preparação do mesmo e composição farmacêutica contendo o mesmo como um ingrediente ativo.
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KR20120127005 | 2012-11-09 | ||
KR10-2012-0127005 | 2012-11-09 | ||
PCT/KR2013/010135 WO2014073904A1 (en) | 2012-11-09 | 2013-11-08 | Gpr40 receptor agonist, methods of preparing the same, and pharmaceutical compositions containing the same as an active ingredient |
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BR112015010314A2 BR112015010314A2 (pt) | 2017-07-11 |
BR112015010314A8 true BR112015010314A8 (pt) | 2018-08-14 |
BR112015010314B1 BR112015010314B1 (pt) | 2021-11-16 |
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US (1) | US9988379B2 (pt) |
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CN (2) | CN110003169A (pt) |
AU (1) | AU2013341945B2 (pt) |
BR (1) | BR112015010314B1 (pt) |
CA (1) | CA2889505C (pt) |
MX (1) | MX2015005418A (pt) |
RU (1) | RU2650506C2 (pt) |
TW (1) | TWI692469B (pt) |
WO (1) | WO2014073904A1 (pt) |
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EP2917180A1 (en) | 2015-09-16 |
US9988379B2 (en) | 2018-06-05 |
JP2018184454A (ja) | 2018-11-22 |
AU2013341945A1 (en) | 2015-05-14 |
KR20140060242A (ko) | 2014-05-19 |
EP2917180A4 (en) | 2016-04-27 |
CA2889505A1 (en) | 2014-05-15 |
WO2014073904A1 (en) | 2014-05-15 |
CA2889505C (en) | 2020-12-29 |
TWI692469B (zh) | 2020-05-01 |
CN110003169A (zh) | 2019-07-12 |
RU2015121948A (ru) | 2017-01-10 |
JP2016503409A (ja) | 2016-02-04 |
US20150291584A1 (en) | 2015-10-15 |
TW201427943A (zh) | 2014-07-16 |
AU2013341945B2 (en) | 2018-07-12 |
BR112015010314A2 (pt) | 2017-07-11 |
MX2015005418A (es) | 2015-07-23 |
RU2650506C2 (ru) | 2018-04-16 |
JP6442787B2 (ja) | 2018-12-26 |
KR101984629B1 (ko) | 2019-05-31 |
BR112015010314B1 (pt) | 2021-11-16 |
CN104837816A (zh) | 2015-08-12 |
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