BR112015008347A2 - molécula de anticorpo isolada, uso de dita molécula de anticorpo, composição, ácido nucleico isolado, célula hospedeira, métodos para produção de uma molécula de anticorpo, para produzir um domínio de ligação de antígeno ao anticorpo para a?1-42 humano e para produzir um membro de ligação que se liga a a?1-42 humana. - Google Patents

molécula de anticorpo isolada, uso de dita molécula de anticorpo, composição, ácido nucleico isolado, célula hospedeira, métodos para produção de uma molécula de anticorpo, para produzir um domínio de ligação de antígeno ao anticorpo para a?1-42 humano e para produzir um membro de ligação que se liga a a?1-42 humana.

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Publication number
BR112015008347A2
BR112015008347A2 BR112015008347A BR112015008347A BR112015008347A2 BR 112015008347 A2 BR112015008347 A2 BR 112015008347A2 BR 112015008347 A BR112015008347 A BR 112015008347A BR 112015008347 A BR112015008347 A BR 112015008347A BR 112015008347 A2 BR112015008347 A2 BR 112015008347A2
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BR
Brazil
Prior art keywords
producing
antibody molecule
human
antibody
isolated
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BR112015008347A
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English (en)
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BR112015008347B1 (pt
Inventor
Nickson Adrian
Niva Camiilla
Lloyd Chris
Lowne David
Höglund Kina
Groves Maria
Gustavsson Suzanne
Simon Sylvia
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Medimmune Ltd
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49765450&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112015008347(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Medimmune Ltd filed Critical Medimmune Ltd
Publication of BR112015008347A2 publication Critical patent/BR112015008347A2/pt
Publication of BR112015008347B1 publication Critical patent/BR112015008347B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1716—Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

1 / 1 resumo “molã‰cula de anticorpo isolada, composiã‡ãƒo, mã‰todo para reduã‡ãƒo da amiloidose, tratamento da doenã‡a de alzheimer, melhoria da cogniã‡ãƒo ou reduã‡ãƒo do declãnio cognitivo em um paciente com doenã‡a de alzheimer ou sãndrome de down e/ou tratamento da degeneraã‡ãƒo macular num indivãduo, ãcido nucleico isolado, cã‰lula hospedeira, mã‰todos para produã‡ãƒo de uma molã‰cula de anticorpo, para produzir um domãnio de ligaã‡ãƒo de antãgeno ao anticorpo para a 1-42 humano e para produzir um membro de ligaã‡ãƒo que se liga a a 1-42 humana” anticorpos para beta-amilã³ides humanos. o anticorpo liga-se seletivamente ao pã©ptido beta-amilã³ide 42 humano em relaã§ã£o ao pã©ptido 40. anticorpos especã­ficos para a beta-amilã³ide 42, como agentes terapãªuticos, para a ligaã§ã£o ao pã©ptido beta-amilã³ide 42 e o tratamento de condiã§ãµes associadas com amiloidose, tal como a doenã§a de alzheimer.
BR112015008347-1A 2012-10-15 2013-10-15 Molécula de anticorpo, uso de dita molécula de anticorpo, composição para uso no tratamento de uma doença associada com betaamilóide, uso de uma composição, ácido nucleico, célula hospedeira e método para produção de uma molécula de anticorpo BR112015008347B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261713996P 2012-10-15 2012-10-15
US61/713,996 2012-10-15
PCT/EP2013/071567 WO2014060444A1 (en) 2012-10-15 2013-10-15 Antibodies to amyloid beta

Publications (2)

Publication Number Publication Date
BR112015008347A2 true BR112015008347A2 (pt) 2017-12-05
BR112015008347B1 BR112015008347B1 (pt) 2023-12-26

Family

ID=49765450

Family Applications (1)

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BR112015008347-1A BR112015008347B1 (pt) 2012-10-15 2013-10-15 Molécula de anticorpo, uso de dita molécula de anticorpo, composição para uso no tratamento de uma doença associada com betaamilóide, uso de uma composição, ácido nucleico, célula hospedeira e método para produção de uma molécula de anticorpo

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US (4) US9834598B2 (pt)
EP (2) EP2906597B1 (pt)
JP (5) JP6343615B2 (pt)
KR (2) KR102450670B1 (pt)
CN (2) CN110294804B (pt)
AU (3) AU2013333948B2 (pt)
BR (1) BR112015008347B1 (pt)
CA (1) CA2888322A1 (pt)
CY (1) CY1122987T1 (pt)
DK (1) DK2906597T3 (pt)
ES (1) ES2802873T3 (pt)
HK (1) HK1213906A1 (pt)
HR (1) HRP20200936T1 (pt)
HU (1) HUE051127T2 (pt)
LT (1) LT2906597T (pt)
ME (1) ME03751B (pt)
MX (2) MX370725B (pt)
PL (1) PL2906597T3 (pt)
PT (1) PT2906597T (pt)
RS (1) RS60388B1 (pt)
RU (2) RU2689674C2 (pt)
SI (1) SI2906597T1 (pt)
WO (1) WO2014060444A1 (pt)

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JP2022025078A (ja) 2022-02-09
JP2023116770A (ja) 2023-08-22
US9834598B2 (en) 2017-12-05
RU2018110064A (ru) 2019-02-28
EP2906597B1 (en) 2020-04-08
MX2019015602A (es) 2020-02-26
JP7301924B2 (ja) 2023-07-03
AU2018256498A1 (en) 2018-11-22
LT2906597T (lt) 2020-07-10
RU2018110064A3 (pt) 2019-02-28
RS60388B1 (sr) 2020-07-31
BR112015008347B1 (pt) 2023-12-26
US11286297B2 (en) 2022-03-29
AU2020256414A1 (en) 2020-11-12
KR102450670B1 (ko) 2022-10-04
CN110294804A (zh) 2019-10-01
MX370725B (es) 2019-12-20
ME03751B (me) 2021-04-20
AU2013333948A1 (en) 2015-05-14
JP2015536645A (ja) 2015-12-24
RU2689674C2 (ru) 2019-05-28
RU2651486C2 (ru) 2018-04-19
CN105164156B (zh) 2019-04-02
EP2906597A1 (en) 2015-08-19
US20150299299A1 (en) 2015-10-22
RU2015118180A (ru) 2016-12-10
US20210009665A1 (en) 2021-01-14
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