BR112014019667A2 - formulação de anticorpo abeta - Google Patents
formulação de anticorpo abetaInfo
- Publication number
- BR112014019667A2 BR112014019667A2 BR112014019667A BR112014019667A BR112014019667A2 BR 112014019667 A2 BR112014019667 A2 BR 112014019667A2 BR 112014019667 A BR112014019667 A BR 112014019667A BR 112014019667 A BR112014019667 A BR 112014019667A BR 112014019667 A2 BR112014019667 A2 BR 112014019667A2
- Authority
- BR
- Brazil
- Prior art keywords
- abeta antibody
- antibody formulation
- approximately
- formulation
- abeta
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
resumo patente de invenção: "formulação de anticorpo abeta". a presente invenção refere-se a uma formulação farmacêutica que compreende aproximadamente 50 mg/ml-200 mg/ml de um anticorpo abeta, poloxâmero de aproximadamente 0,01%-0,1%, aproximadamente 5 mm-50 mm de um tampão, aproximadamente 100 mm-300 mm de um estabilizante em um ph de aproximadamente 4,5-7,0.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12158602 | 2012-03-08 | ||
EP12158602.8 | 2012-03-08 | ||
PCT/EP2013/054313 WO2013131866A1 (en) | 2012-03-08 | 2013-03-05 | Abeta antibody formulation |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112014019667A2 true BR112014019667A2 (pt) | 2017-06-27 |
BR112014019667B1 BR112014019667B1 (pt) | 2022-11-01 |
Family
ID=47780075
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014019667-2A BR112014019667B1 (pt) | 2012-03-08 | 2013-03-05 | Formulação farmacêutica líquida estável de anticorpo abeta |
Country Status (26)
Country | Link |
---|---|
US (1) | US20150030589A1 (pt) |
EP (1) | EP2822587B1 (pt) |
JP (1) | JP5859148B2 (pt) |
KR (1) | KR101666289B1 (pt) |
CN (1) | CN104159613B (pt) |
AR (2) | AR090272A1 (pt) |
AU (1) | AU2013229613B2 (pt) |
BR (1) | BR112014019667B1 (pt) |
CA (1) | CA2860543C (pt) |
CY (1) | CY1117363T1 (pt) |
DK (1) | DK2822587T3 (pt) |
ES (1) | ES2564281T3 (pt) |
HK (1) | HK1200717A1 (pt) |
HR (1) | HRP20160434T1 (pt) |
HU (1) | HUE028440T2 (pt) |
IL (1) | IL234120B (pt) |
MX (1) | MX351148B (pt) |
MY (1) | MY166045A (pt) |
NZ (1) | NZ626955A (pt) |
PL (1) | PL2822587T3 (pt) |
RS (1) | RS54644B1 (pt) |
RU (1) | RU2014140137A (pt) |
SG (1) | SG11201404481RA (pt) |
SI (1) | SI2822587T1 (pt) |
WO (1) | WO2013131866A1 (pt) |
ZA (1) | ZA201405103B (pt) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2592271T3 (es) | 2005-03-31 | 2016-11-29 | Chugai Seiyaku Kabushiki Kaisha | Métodos de producción de polipéptidos mediante la regulación de la asociación de los polipéptidos |
US9670269B2 (en) | 2006-03-31 | 2017-06-06 | Chugai Seiyaku Kabushiki Kaisha | Methods of modifying antibodies for purification of bispecific antibodies |
DK3056568T3 (da) | 2006-03-31 | 2021-11-01 | Chugai Pharmaceutical Co Ltd | Fremgangsmåder til kontrollering af antistoffers blodfarmakokinetik |
CN101874042B9 (zh) | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
EA034617B1 (ru) * | 2010-10-06 | 2020-02-27 | Ридженерон Фармасьютикалз, Инк. | Дозированная форма жидкой фармацевтической композиции, содержащей антитела к рецептору интерлейкина-4 (il-4r) |
KR102099580B1 (ko) | 2010-11-17 | 2020-04-10 | 추가이 세이야쿠 가부시키가이샤 | 혈액응고 제viii 인자의 기능을 대체하는 기능을 갖는 다중특이성 항원 결합 분자 |
AR087305A1 (es) | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
AU2014325063B2 (en) | 2013-09-27 | 2019-10-31 | Chugai Seiyaku Kabushiki Kaisha | Method for producing polypeptide heteromultimer |
TWI700300B (zh) | 2014-09-26 | 2020-08-01 | 日商中外製藥股份有限公司 | 中和具有第viii凝血因子(fviii)機能替代活性的物質之抗體 |
TWI701435B (zh) | 2014-09-26 | 2020-08-11 | 日商中外製藥股份有限公司 | 測定fviii的反應性之方法 |
WO2016159213A1 (ja) | 2015-04-01 | 2016-10-06 | 中外製薬株式会社 | ポリペプチド異種多量体の製造方法 |
PE20221007A1 (es) | 2015-06-24 | 2022-06-15 | Hoffmann La Roche | Anticuerpos anti-receptor de transferrina con afinidad disenada |
MX2018002000A (es) | 2015-08-18 | 2018-06-19 | Regeneron Pharma | Anticuerpos inhibidores de anti-pcsk9 para el tratamiento de pacientes con hiperlipidemia que se someten aferesis de lipoproteina. |
AR106189A1 (es) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO |
UA127887C2 (uk) | 2015-10-02 | 2024-02-07 | Ф. Хоффманн-Ля Рош Аг | Біспецифічне антитіло до людського cd20/людського рецептора трансферину та способи його застосування |
KR20180091918A (ko) | 2015-12-28 | 2018-08-16 | 추가이 세이야쿠 가부시키가이샤 | Fc 영역 함유 폴리펩타이드의 정제를 효율화하기 위한 방법 |
CR20180554A (es) | 2016-04-28 | 2019-01-10 | Chugai Pharmaceutical Co Ltd | Preparaciones que contienen anticuerpos |
JP7125932B2 (ja) | 2016-09-06 | 2022-08-25 | 中外製薬株式会社 | 凝固第ix因子および/または活性化凝固第ix因子ならびに凝固第x因子および/または活性化凝固第x因子を認識する二重特異性抗体の使用法 |
CN110691592A (zh) * | 2017-05-30 | 2020-01-14 | 森永乳业株式会社 | 脑功能改善用组合物 |
MX2020001855A (es) | 2017-08-22 | 2020-08-13 | Biogen Ma Inc | Composiciones farmacéuticas que contienen anticuerpos anti-beta-amiloides. |
CR20200158A (es) | 2017-09-29 | 2020-06-14 | Chugai Pharmaceutical Co Ltd | Molécula de unión al antígeno multiespecífica que tiene actividad de sustitución de la función de cofactor del factor viii de coagulación de sangre (fviii) y formulación farmacéutica que contiene tal molécula como ingrediente |
WO2022000046A1 (en) * | 2020-07-03 | 2022-01-06 | CSL Innovation Pty Ltd | High concentration formulation of factor xii antigen binding proteins |
WO2023115112A1 (en) * | 2021-12-20 | 2023-06-29 | CSL Innovation Pty Ltd | Protein formulations and uses thereof |
WO2023215267A1 (en) * | 2022-05-02 | 2023-11-09 | Regeneron Pharmaceuticals, Inc. | Anti-interleukin-4 receptor (il-4r) antibody formulations |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US5202238A (en) | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
US5204244A (en) | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
US5959177A (en) | 1989-10-27 | 1999-09-28 | The Scripps Research Institute | Transgenic plants expressing assembled secretory antibodies |
CA2116774C (en) | 1991-09-19 | 2003-11-11 | Paul J. Carter | Expression in e. coli antibody fragments having at least a cysteine present as a free thiol. use for the production of bifunctional f(ab') 2 antibodies |
US5789199A (en) | 1994-11-03 | 1998-08-04 | Genentech, Inc. | Process for bacterial production of polypeptides |
US5840523A (en) | 1995-03-01 | 1998-11-24 | Genetech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
US6040498A (en) | 1998-08-11 | 2000-03-21 | North Caroline State University | Genetically engineered duckweed |
NZ517906A (en) | 1999-10-04 | 2003-01-31 | Medicago Inc | Cloning of genomic sequences encoding nitrite reductase (NiR) for use in regulated expression of foreign genes in host plants |
US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
TWI382990B (zh) * | 2005-12-12 | 2013-01-21 | Hoffmann La Roche | 可變區域抗體之糖化 |
EP2094729A1 (en) * | 2006-12-11 | 2009-09-02 | F.Hoffmann-La Roche Ag | Abeta antibody parenteral formulation |
-
2013
- 2013-03-05 ES ES13707176.7T patent/ES2564281T3/es active Active
- 2013-03-05 DK DK13707176.7T patent/DK2822587T3/en active
- 2013-03-05 PL PL13707176T patent/PL2822587T3/pl unknown
- 2013-03-05 RS RS20160187A patent/RS54644B1/en unknown
- 2013-03-05 MX MX2014009662A patent/MX351148B/es active IP Right Grant
- 2013-03-05 BR BR112014019667-2A patent/BR112014019667B1/pt active IP Right Grant
- 2013-03-05 SG SG11201404481RA patent/SG11201404481RA/en unknown
- 2013-03-05 MY MYPI2014002221A patent/MY166045A/en unknown
- 2013-03-05 RU RU2014140137A patent/RU2014140137A/ru not_active Application Discontinuation
- 2013-03-05 EP EP13707176.7A patent/EP2822587B1/en active Active
- 2013-03-05 CA CA2860543A patent/CA2860543C/en active Active
- 2013-03-05 US US14/381,849 patent/US20150030589A1/en not_active Abandoned
- 2013-03-05 NZ NZ626955A patent/NZ626955A/en unknown
- 2013-03-05 KR KR1020147025086A patent/KR101666289B1/ko active IP Right Grant
- 2013-03-05 JP JP2014560323A patent/JP5859148B2/ja active Active
- 2013-03-05 SI SI201330150T patent/SI2822587T1/sl unknown
- 2013-03-05 HU HUE13707176A patent/HUE028440T2/en unknown
- 2013-03-05 AU AU2013229613A patent/AU2013229613B2/en active Active
- 2013-03-05 CN CN201380012493.4A patent/CN104159613B/zh active Active
- 2013-03-05 WO PCT/EP2013/054313 patent/WO2013131866A1/en active Application Filing
- 2013-03-07 AR ARP130100743A patent/AR090272A1/es not_active Application Discontinuation
-
2014
- 2014-07-11 ZA ZA2014/05103A patent/ZA201405103B/en unknown
- 2014-08-14 IL IL234120A patent/IL234120B/en active IP Right Grant
-
2015
- 2015-02-05 HK HK15101245.4A patent/HK1200717A1/xx unknown
-
2016
- 2016-04-12 CY CY20161100295T patent/CY1117363T1/el unknown
- 2016-04-21 HR HRP20160434TT patent/HRP20160434T1/hr unknown
-
2021
- 2021-06-25 AR ARP210101758A patent/AR122746A2/es unknown
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Legal Events
Date | Code | Title | Description |
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 05/03/2013, OBSERVADAS AS CONDICOES LEGAIS |