BR112014019459A8 - Proteínas de ligação à cdim e usos das mesmas - Google Patents

Proteínas de ligação à cdim e usos das mesmas

Info

Publication number
BR112014019459A8
BR112014019459A8 BR112014019459A BR112014019459A BR112014019459A8 BR 112014019459 A8 BR112014019459 A8 BR 112014019459A8 BR 112014019459 A BR112014019459 A BR 112014019459A BR 112014019459 A BR112014019459 A BR 112014019459A BR 112014019459 A8 BR112014019459 A8 BR 112014019459A8
Authority
BR
Brazil
Prior art keywords
binding proteins
cdim
dim
cells
diagnostic assays
Prior art date
Application number
BR112014019459A
Other languages
English (en)
Other versions
BR112014019459A2 (pt
BR112014019459B1 (pt
Inventor
N H Teng Nelson
M Bhat Neelirna
M Bieber Marcia
A Keyt Bruce
Original Assignee
Igm Biosciences Inc
Igm Biosciences As
Mcure Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Igm Biosciences Inc, Igm Biosciences As, Mcure Biosciences Inc filed Critical Igm Biosciences Inc
Publication of BR112014019459A2 publication Critical patent/BR112014019459A2/pt
Publication of BR112014019459A8 publication Critical patent/BR112014019459A8/pt
Publication of BR112014019459B1 publication Critical patent/BR112014019459B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

PROTEÍNAS DE LIGAÇÃO À CDIM E USOS DAS MESMAS. A presente divulgação refere-se às proteínas de ligação à molécula de indução de morte celular ("CDIM") e às composições farmacêuticas da mesma. Particularmente, a divulgação fornece proteínas de ligação à CDIM que são úteis para o seletivo esgotamento e morte das células B, incluindo células B neoplásicas e células neoplásicas que não são originárias de células B e que expressam antígenos tipo CDIM. Além disso, a divulgação abrange polinucleotídeos que codificam as proteínas de ligação ao antígeno divulgadas, e sistemas de expressão para produzir as mesmas. Além disso, a presente divulgação engloba métodos de tratamento de pacientes com doenças mediadas e proliferativas de células B pela administração de proteínas de ligação à CDIM, bem como ensaios de diagnósticos para a identificação de proteínas que se ligam à CDIM. A divulgação contempla adicionalmente ensaios de diagnóstico para identificar populações de pacientes que podem ser tratadas com as proteínas de ligação à CDIM.
BR112014019459-9A 2012-02-08 2013-02-08 Proteínas de ligação à cdim e usos das mesmas BR112014019459B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261633330P 2012-02-08 2012-02-08
US61/633,330 2012-02-08
PCT/US2013/025430 WO2013120012A2 (en) 2012-02-08 2013-02-08 Cdim binding proteins and uses thereof

Publications (3)

Publication Number Publication Date
BR112014019459A2 BR112014019459A2 (pt) 2017-06-27
BR112014019459A8 true BR112014019459A8 (pt) 2023-01-10
BR112014019459B1 BR112014019459B1 (pt) 2023-04-18

Family

ID=48045015

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014019459-9A BR112014019459B1 (pt) 2012-02-08 2013-02-08 Proteínas de ligação à cdim e usos das mesmas

Country Status (15)

Country Link
US (1) US9409976B2 (pt)
EP (1) EP2812356B1 (pt)
JP (1) JP6335796B2 (pt)
KR (1) KR102102111B1 (pt)
CN (1) CN104254544B (pt)
AU (1) AU2013200903B2 (pt)
BR (1) BR112014019459B1 (pt)
CA (1) CA2863714C (pt)
DK (1) DK2812356T3 (pt)
ES (1) ES2735289T3 (pt)
HK (1) HK1205136A1 (pt)
IN (1) IN2014MN01781A (pt)
MX (1) MX363819B (pt)
TW (1) TWI606064B (pt)
WO (1) WO2013120012A2 (pt)

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SG11201707144VA (en) * 2015-03-04 2017-09-28 Igm Biosciences Inc Cd20 binding molecules and uses thereof
AU2016238246B2 (en) 2015-03-25 2021-05-13 Igm Biosciences, Inc. Multi-valent hepatitis B virus antigen binding molecules and uses thereof
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CN116635064A (zh) 2020-12-18 2023-08-22 世纪治疗股份有限公司 具有适应性受体特异性的嵌合抗原受体***
CN114181318B (zh) * 2021-11-08 2023-08-01 四川大学 一种组织特异性表达穿透血脑屏障的idua融合蛋白的重组腺相关病毒及应用

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Also Published As

Publication number Publication date
EP2812356A2 (en) 2014-12-17
JP2015511817A (ja) 2015-04-23
US9409976B2 (en) 2016-08-09
MX2014009628A (es) 2015-03-19
ES2735289T3 (es) 2019-12-17
CN104254544A (zh) 2014-12-31
HK1205136A1 (en) 2015-12-11
CN104254544B (zh) 2017-04-26
WO2013120012A2 (en) 2013-08-15
IN2014MN01781A (pt) 2015-07-03
CA2863714A1 (en) 2013-08-15
JP6335796B2 (ja) 2018-06-06
TW201345921A (zh) 2013-11-16
AU2013200903B2 (en) 2015-05-14
AU2013200903A1 (en) 2013-08-22
BR112014019459A2 (pt) 2017-06-27
CA2863714C (en) 2022-07-05
KR102102111B1 (ko) 2020-04-20
BR112014019459B1 (pt) 2023-04-18
US20140044739A1 (en) 2014-02-13
KR20150001728A (ko) 2015-01-06
MX363819B (es) 2019-04-03
EP2812356B1 (en) 2019-03-27
TWI606064B (zh) 2017-11-21
DK2812356T3 (da) 2019-07-08
WO2013120012A3 (en) 2013-11-07

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