BR112014019168A8 - Método capaz de detectar de forma não degenerada presença ou ausência de analitos em um único volume de amostra e método de detecção da presença ou ausência de cada analito dentre uma pluralidade de analitos - Google Patents
Método capaz de detectar de forma não degenerada presença ou ausência de analitos em um único volume de amostra e método de detecção da presença ou ausência de cada analito dentre uma pluralidade de analitosInfo
- Publication number
- BR112014019168A8 BR112014019168A8 BR112014019168A BR112014019168A BR112014019168A8 BR 112014019168 A8 BR112014019168 A8 BR 112014019168A8 BR 112014019168 A BR112014019168 A BR 112014019168A BR 112014019168 A BR112014019168 A BR 112014019168A BR 112014019168 A8 BR112014019168 A8 BR 112014019168A8
- Authority
- BR
- Brazil
- Prior art keywords
- analytes
- absence
- detecting
- analyte
- sample volume
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6851—Quantitative amplification
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B45/00—ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
- G16B25/20—Polymerase chain reaction [PCR]; Primer or probe design; Probe optimisation
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
- G06F17/10—Complex mathematical operations
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
- G06F17/10—Complex mathematical operations
- G06F17/11—Complex mathematical operations for solving equations, e.g. nonlinear equations, general mathematical optimization problems
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Medical Informatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Theoretical Computer Science (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physiology (AREA)
- Data Mining & Analysis (AREA)
- General Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Software Systems (AREA)
- Artificial Intelligence (AREA)
- Bioethics (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Databases & Information Systems (AREA)
- Epidemiology (AREA)
- Evolutionary Computation (AREA)
- Public Health (AREA)
Abstract
ENSAIO CAPAZ DE DETECTAR DE FORMA NÃO DEGENERADA PRESENÇA OU AUSÊNCIA DE ANALITOS EM UM ÚNICO VOLUME DE AMOSTRA, BEM COMO MÉTODO DE DETECÇÃO DA PRESENÇA OU AUSÊNCIA DE ANALITO DENTRE UMA PLURALIDADE DOS MESMOS. A presente invenção refere-se a um ensaio capaz de detectar de forma não degenerada a presença ou ausência de cada um dentre ao menos sete (7) analitos, em qualquer combinação de presença ou ausência, em um único volume de amostra sem imobilização dos ditos analitos, separação física dos ditos analitos, análise de curva de fusão ou espectrometria de massa. A presente invenção refere-se ainda a um método de detecção da presença ou ausência de cada analito dentre uma pluralidade de analitos.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261594480P | 2012-02-03 | 2012-02-03 | |
US61/594,480 | 2012-02-03 | ||
US201261703093P | 2012-09-19 | 2012-09-19 | |
US61/703,093 | 2012-09-19 | ||
PCT/US2013/024509 WO2013116780A1 (en) | 2012-02-03 | 2013-02-01 | Signal encoding and decoding in multiplexed biochemical assays |
Publications (3)
Publication Number | Publication Date |
---|---|
BR112014019168A8 true BR112014019168A8 (pt) | 2017-07-11 |
BR112014019168A2 BR112014019168A2 (pt) | 2021-06-01 |
BR112014019168B1 BR112014019168B1 (pt) | 2021-10-05 |
Family
ID=48905921
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014019168-9A BR112014019168B1 (pt) | 2012-02-03 | 2013-02-01 | Método capaz de detectar de forma não degenerada presença ou ausência de analitos em um único volume de amostra e método de detecção da presença ou ausência de cada analito dentre uma pluralidade de analitos |
Country Status (8)
Country | Link |
---|---|
US (9) | US8838394B2 (pt) |
EP (6) | EP4361609A3 (pt) |
JP (1) | JP6255353B2 (pt) |
KR (2) | KR102145677B1 (pt) |
CN (3) | CN114717296A (pt) |
BR (1) | BR112014019168B1 (pt) |
HK (1) | HK1205200A1 (pt) |
WO (1) | WO2013116780A1 (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4361609A3 (en) | 2012-02-03 | 2024-07-17 | California Institute of Technology | Signal encoding and decoding in multiplexed biochemical assays |
EP2880184B1 (en) | 2012-08-03 | 2021-03-31 | California Institute of Technology | Multiplexing and quantification in pcr with reduced hardware and requirements |
US10077475B2 (en) | 2013-01-24 | 2018-09-18 | California Institute Of Technology | FRET-based analytes detection and related methods and systems |
CA2897474A1 (en) | 2013-01-24 | 2014-07-31 | California Institute Of Technology | Chromophore-based characterization and detection methods |
KR101789079B1 (ko) | 2014-09-22 | 2017-10-24 | 건국대학교 산학협력단 | 마이크로알엔에이 검지를 위한 핵산 다중 접합체 및 그 제조방법 |
WO2016120396A1 (en) * | 2015-01-29 | 2016-08-04 | Instituut Voor Tropische Geneeskunde | Combined plasmodium-rna virus detection method |
WO2016161325A1 (en) * | 2015-04-02 | 2016-10-06 | University Of Washington | Optical painting and fluorescence-activated sorting of adherent cells |
CN108351352B (zh) * | 2015-10-05 | 2021-09-10 | 北卡罗来纳-查佩尔山大学 | 用于多路测定的解码方法及相关流体设备、试剂盒和固体支持物 |
WO2017173035A1 (en) | 2016-04-01 | 2017-10-05 | Chromacode Inc. | Competitive probes for engineering signal generation |
WO2017209563A1 (en) * | 2016-06-02 | 2017-12-07 | Seegene, Inc. . | Method for detecting a target analyte in a sample using a signal change-amount data set |
EP3472354A4 (en) | 2016-06-17 | 2020-01-01 | California Institute of Technology | NUCLEIC ACID ACTIONS AND RELATED PROCEDURES AND COMPOSITIONS |
JP6846636B2 (ja) * | 2017-02-28 | 2021-03-24 | パナソニックIpマネジメント株式会社 | 核酸検出用オリゴヌクレオチド |
WO2019006023A1 (en) * | 2017-06-28 | 2019-01-03 | ChromaCode, Inc. | MULTIPLEXED FLUORIMETRIC MEASUREMENTS WITH DROPLET PCR SYSTEMS |
JP2019154246A (ja) * | 2018-03-08 | 2019-09-19 | 株式会社リコー | プローブセット、及びそれを用いた核酸検出方法 |
WO2019236447A1 (en) * | 2018-06-04 | 2019-12-12 | ChromaCode, Inc. | Methods for watermarking and identifying chemical compositions |
US20200010876A1 (en) * | 2018-07-03 | 2020-01-09 | ChromaCode, Inc. | Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays |
EP3821034A4 (en) * | 2018-07-11 | 2022-04-27 | Chromacode, Inc. | METHODS FOR QUANTIFYING ANALYTES IN MULTIPLEXED BIOCHEMICAL REACTIONS |
USD975312S1 (en) | 2020-02-14 | 2023-01-10 | Beckman Coulter, Inc. | Reagent cartridge |
Family Cites Families (156)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE88761T1 (de) | 1986-01-10 | 1993-05-15 | Amoco Corp | Kompetitiver homogener test. |
US5618711A (en) | 1986-08-22 | 1997-04-08 | Hoffmann-La Roche Inc. | Recombinant expression vectors and purification methods for Thermus thermophilus DNA polymerase |
US6127155A (en) | 1986-08-22 | 2000-10-03 | Roche Molecular Systems, Inc. | Stabilized thermostable nucleic acid polymerase compositions containing non-ionic polymeric detergents |
US5079351A (en) | 1986-11-26 | 1992-01-07 | Cetus Corporation | Oligonucleotides and kits for detection of htlvi and htlvii viruses by hybridization |
US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
US5994056A (en) | 1991-05-02 | 1999-11-30 | Roche Molecular Systems, Inc. | Homogeneous methods for nucleic acid amplification and detection |
DK0519338T3 (da) | 1991-06-20 | 1996-10-28 | Hoffmann La Roche | Forbedrede fremgangsmåder til nukleinsyreamplifikation |
CA2130562A1 (en) | 1992-02-19 | 1993-09-02 | Alexander B. Chetverin | Novel oligonucleotide arrays and their use for sorting, isolating, sequencing, and manipulating nucleic acids |
US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
US5948360A (en) * | 1994-07-11 | 1999-09-07 | Tekmar Company | Autosampler with robot arm |
AU709045B2 (en) | 1995-02-02 | 1999-08-19 | Chugai Seiyaku Kabushiki Kaisha | Method for assay of analyte by adjustment of chemiluminescence |
CA2216645A1 (en) * | 1995-04-25 | 1996-11-21 | Irori | Remotely programmable matrices with memories and uses thereof |
AU693023B2 (en) | 1995-05-05 | 1998-06-18 | Applied Biosystems, Llc | Methods and reagents for combined PCR amplification and hybridization probing assay |
US5882856A (en) | 1995-06-07 | 1999-03-16 | Genzyme Corporation | Universal primer sequence for multiplex DNA amplification |
US5773258A (en) | 1995-08-25 | 1998-06-30 | Roche Molecular Systems, Inc. | Nucleic acid amplification using a reversibly inactivated thermostable enzyme |
US20050112637A1 (en) | 1995-09-08 | 2005-05-26 | Chatterjee Deb K. | Mutant DNA polymerases and uses thereof |
US5981180A (en) | 1995-10-11 | 1999-11-09 | Luminex Corporation | Multiplexed analysis of clinical specimens apparatus and methods |
US6007994A (en) | 1995-12-22 | 1999-12-28 | Yale University | Multiparametric fluorescence in situ hybridization |
US6156504A (en) | 1996-03-15 | 2000-12-05 | The Penn State Research Foundation | Detection of extracellular tumor-associated nucleic acid in blood plasma or serum using nucleic acid amplification assays |
WO1997035589A1 (en) | 1996-03-26 | 1997-10-02 | Kopreski Michael S | Method enabling use of extracellular rna extracted from plasma or serum to detect, monitor or evaluate cancer |
ATE428801T1 (de) | 1996-06-04 | 2009-05-15 | Univ Utah Res Found | Überwachung der hybridisierung während pcr |
US5834203A (en) | 1997-08-25 | 1998-11-10 | Applied Spectral Imaging | Method for classification of pixels into groups according to their spectra using a plurality of wide band filters and hardwire therefore |
AU1080999A (en) | 1997-10-14 | 1999-05-03 | Luminex Corporation | Precision fluorescently dyed particles and methods of making and using same |
US6235480B1 (en) | 1998-03-13 | 2001-05-22 | Promega Corporation | Detection of nucleic acid hybrids |
AU3555599A (en) | 1998-04-13 | 1999-11-01 | Luminex Corporation | Liquid labeling with fluorescent microparticles |
US7060431B2 (en) | 1998-06-24 | 2006-06-13 | Illumina, Inc. | Method of making and decoding of array sensors with microspheres |
AU762728B2 (en) | 1998-07-02 | 2003-07-03 | Gen-Probe Incorporated | Molecular torches |
US6642062B2 (en) | 1998-09-03 | 2003-11-04 | Trellis Bioinformatics, Inc. | Multihued labels |
EP1171636A2 (en) | 1999-04-22 | 2002-01-16 | Albert Einstein College Of Medicine Of Yeshiva University | Assay of gene expression patterns by multi-fluor fish |
DE60035691T2 (de) | 1999-07-23 | 2008-04-30 | Forensic Science Service Ltd. | Verfahren zur Erkennung von Einzel-Nukleotid-Polymorphismen |
ATE336591T1 (de) | 1999-10-22 | 2006-09-15 | New York Health Res Inst | Nachweisverfahren für kurze sequenzvarianten |
US20040053230A1 (en) | 2001-03-07 | 2004-03-18 | Schaffer Michael Edward | Real time quantitative pcr with intercalating dye for single and multiplex target dna |
EP1278889B1 (en) | 2000-03-29 | 2006-07-26 | LGC Limited | Hybridisation beacon and method of rapid sequence detection and discrimination |
US6734420B2 (en) | 2000-04-06 | 2004-05-11 | Quantum Dot Corporation | Differentiable spectral bar code methods and systems |
WO2002004680A2 (en) * | 2000-07-07 | 2002-01-17 | Visigen Biotechnologies, Inc. | Real-time sequence determination |
US7608683B2 (en) * | 2000-08-09 | 2009-10-27 | The Regents Of The University Of California | Stress proteins and peptides and methods of use thereof |
CA2314398A1 (en) * | 2000-08-10 | 2002-02-10 | Edward Shipwash | Microarrays and microsystems for amino acid analysis and protein sequencing |
US20020142345A1 (en) | 2000-12-22 | 2002-10-03 | Nelsen Anita J. | Methods for encoding and decoding complex mixtures in arrayed assays |
US20020146734A1 (en) * | 2001-02-21 | 2002-10-10 | Amnis Corporation | Method and apparatus for labeling and analyzing cellular components |
CA2439402A1 (en) | 2001-03-02 | 2002-09-12 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Pcr method |
WO2009003492A1 (en) | 2007-07-03 | 2009-01-08 | Dako Denmark A/S | Mhc multimers, methods for their generation, labeling and use |
AU2002322457A1 (en) * | 2001-06-28 | 2003-03-03 | Illumina, Inc. | Multiplex decoding of array sensors with microspheres |
AU2002322348A1 (en) * | 2001-06-28 | 2003-03-03 | Advanced Research And Technology Institute, Inc. | Methods of preparing multicolor quantum dot tagged beads and conjugates thereof |
US7473767B2 (en) | 2001-07-03 | 2009-01-06 | The Institute For Systems Biology | Methods for detection and quantification of analytes in complex mixtures |
EP1288308A1 (en) | 2001-08-28 | 2003-03-05 | Roche Diagnostics GmbH | A method for the determination of multiple analytes |
US6852491B2 (en) | 2001-09-04 | 2005-02-08 | Abbott Laboratories | Amplification and detection reagents for HIV-1 |
US20030134320A1 (en) | 2002-01-15 | 2003-07-17 | Myriad Genetics, Incorporated | Method system and computer program product for quality assurance in detecting biochemical markers |
EP1426448A1 (en) | 2002-12-03 | 2004-06-09 | bioMérieux BV | Method for lowering the effects of sequence variations in a diagnostic hybridization assay, probe for use in the assay and assay |
EP2284278A1 (en) * | 2003-04-04 | 2011-02-16 | Roche Diagnostics GmbH | Improved system for multi color real time PCR |
US7385043B1 (en) | 2003-04-30 | 2008-06-10 | The Public Health Research Institute Of The City Of New York, Inc. | Homogeneous multiplex screening assays and kits |
US7070786B2 (en) | 2003-06-06 | 2006-07-04 | Centocor, Inc. | RSV proteins, antibodies, compositions, methods and uses |
US20050053950A1 (en) | 2003-09-08 | 2005-03-10 | Enrique Zudaire Ubani | Protocol and software for multiplex real-time PCR quantification based on the different melting temperatures of amplicons |
US20050064435A1 (en) | 2003-09-24 | 2005-03-24 | Xing Su | Programmable molecular barcodes |
TWI232934B (en) | 2003-11-19 | 2005-05-21 | Ind Tech Res Inst | A biochip containing splitable reaction confinement and method for producing same and application thereof |
WO2005051967A2 (en) | 2003-11-19 | 2005-06-09 | Allelogic Biosciences Corp. | Oligonucleotides labeled with a plurality of fluorophores |
US7601821B2 (en) * | 2004-03-24 | 2009-10-13 | Applied Biosystems, Llc | Encoding and decoding reactions for determining target molecules |
EP1740711A2 (en) | 2004-04-01 | 2007-01-10 | Bio-Rad Laboratories, Inc. | Quantitative amplification with a labeled probe and 3' to 5' exonuclease activity |
ES2527426T3 (es) | 2004-05-07 | 2015-01-23 | Cepheid | Detección combinada de agentes biológicos |
US7575864B2 (en) | 2004-05-27 | 2009-08-18 | E.I. Du Pont De Nemours And Company | Method for the direct detection of diagnostic RNA |
DE102004043870B4 (de) | 2004-09-10 | 2009-11-19 | Eppendorf Ag | Verfahren zur Erweiterung des dynamischen Erfassungsbereich bei Mikroarrays |
AU2005287517A1 (en) | 2004-09-24 | 2006-03-30 | Universitaet Bern | Molecular beacons |
ES2529204T3 (es) | 2004-10-18 | 2015-02-17 | Brandeis University | Métodos para la amplificación de ácido nucleico |
WO2006047777A2 (en) | 2004-10-27 | 2006-05-04 | Cepheid | Closed-system multi-stage nucleic acid amplification reactions |
CA2595729A1 (en) | 2005-01-21 | 2006-07-27 | Third Wave Technologies, Inc. | Methods and compositions for increased dynamic range detection of nucleic acid molecules |
US8168602B2 (en) * | 2005-02-17 | 2012-05-01 | Dana-Farber Cancer Institute, Inc. | Compositions, kits and methods for identification, assessment, prevention and therapy of cancer |
US7709249B2 (en) | 2005-04-01 | 2010-05-04 | 3M Innovative Properties Company | Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector |
US7507575B2 (en) | 2005-04-01 | 2009-03-24 | 3M Innovative Properties Company | Multiplex fluorescence detection device having removable optical modules |
US7919244B2 (en) | 2005-06-16 | 2011-04-05 | Biotools Biotechnological & Medical Laboratories, S.A. | Nucleic acid detection method involving the direct generation of a measurable signal |
US8067208B2 (en) | 2005-06-30 | 2011-11-29 | Roche Molecular Systems, Inc. | Probes and methods for hepatitis C virus typing using multidimensional probe analysis |
PL1937834T3 (pl) | 2005-09-01 | 2014-11-28 | Mtpcr Pty Ltd | Sposoby wzmacniania, kwantyfikacji i identyfikacji kwasów nukleinowych |
US7553955B2 (en) | 2005-09-01 | 2009-06-30 | The Trustees Of The University Of Pennsylvania | Molecular beacons, methods and kits for detecting DNA damage response |
CN1936019B (zh) * | 2005-10-18 | 2013-01-30 | 厦门大学 | 用于多重实时核酸扩增检测的探针编码方法 |
AU2006330834B2 (en) | 2005-12-23 | 2013-09-12 | Nanostring Technologies, Inc. | Compositions comprising oriented, immobilized macromolecules and methods for their preparation |
ES2374788T3 (es) | 2005-12-23 | 2012-02-22 | Nanostring Technologies, Inc. | Nanoinformadores y métodos para su producción y uso. |
WO2007080583A2 (en) | 2006-01-10 | 2007-07-19 | Applied Spectral Imaging Ltd. | Methods and systems for analyzing biological samples |
US8455184B2 (en) | 2006-04-18 | 2013-06-04 | The United States Of America As Represented By The Secretary Of The Air Force | Differential multiplexing with pattern recognition |
WO2007121489A2 (en) * | 2006-04-19 | 2007-10-25 | Applera Corporation | Reagents, methods, and libraries for gel-free bead-based sequencing |
US7941279B2 (en) | 2006-05-22 | 2011-05-10 | Nanostring Technologies, Inc. | Systems and methods for analyzing nanoreporters |
EP2210955A3 (en) | 2006-05-23 | 2010-09-15 | Molecular Detection, Inc. | Ambient temperature stable kits for molecular diagnostics |
US7608399B2 (en) | 2006-06-26 | 2009-10-27 | Blood Cell Storage, Inc. | Device and method for extraction and analysis of nucleic acids from biological samples |
WO2008005248A2 (en) * | 2006-06-30 | 2008-01-10 | Canon U.S. Life Sciences, Inc. | Real-time pcr in micro-channels |
WO2008014485A2 (en) | 2006-07-28 | 2008-01-31 | California Institute Of Technology | Multiplex q-pcr arrays |
WO2008036614A1 (en) * | 2006-09-18 | 2008-03-27 | California Institute Of Technology | Apparatus for detecting target molecules and related methods |
US8993256B2 (en) | 2006-09-28 | 2015-03-31 | The Regents Of The University Of California | Fusion proteins and polynucleotide constructs to measure protein turn-over |
EP2061901A2 (en) | 2006-10-31 | 2009-05-27 | Noxxon Pharma AG | Methods for detection of a single- or double-stranded nucleic acid molecule |
US9201063B2 (en) | 2006-11-16 | 2015-12-01 | General Electric Company | Sequential analysis of biological samples |
EP2102773B1 (en) | 2006-11-30 | 2012-08-01 | Gen-Probe Incorporated | Quantitative method employing adjustment of pre-defined master calibration curves |
AU2007333040B2 (en) | 2006-12-13 | 2013-02-07 | Luminex Corporation | Systems and methods for multiplex analysis of PCR in real time |
CA2580589C (en) * | 2006-12-19 | 2016-08-09 | Fio Corporation | Microfluidic detection system |
US20090042735A1 (en) | 2007-03-05 | 2009-02-12 | Blair Steven M | Methods and Compositions Related to Nucleic Acid Detection |
WO2008118998A2 (en) | 2007-03-27 | 2008-10-02 | Primera Biosystems Inc. | Method for multiplex detection and quantitation of nucleic acids |
EP2155899A2 (en) | 2007-04-10 | 2010-02-24 | Nanostring Technologies, Inc. | Methods and computer systems for identifying target-specific sequences for use in nanoreporters |
WO2009027102A2 (en) | 2007-08-29 | 2009-03-05 | Eppendorf Ag | Device and method for radiometric measurement of a plurality of samples |
EP2195453A4 (en) | 2007-09-20 | 2011-02-02 | Molecular Plant Breeding Nominees Ltd | METHOD FOR AMPLIFYING NUCLEIC ACID |
CN101646786A (zh) | 2007-12-26 | 2010-02-10 | 爱科来株式会社 | 目标核酸序列的扩增方法和用于该方法的探针 |
EP2116614A1 (en) | 2008-05-06 | 2009-11-11 | Qiagen GmbH | Simultaneous detection of multiple nucleic acid sequences in a reaction |
SG182951A1 (en) * | 2008-06-25 | 2012-08-30 | Baylor Res Inst | Blood transcriptional signature of mycobacterium tuberculosis infection |
GB0812862D0 (en) | 2008-07-14 | 2008-08-20 | Lumora Ltd | Nucleic acid amplification |
US9234232B2 (en) | 2008-07-31 | 2016-01-12 | Oxitec Limited | Multiplex amplification and detection |
CA2733186A1 (en) | 2008-08-08 | 2010-02-11 | Smiths Detection Inc. | Detection algorithm for pcr assay |
JP5836803B2 (ja) | 2008-08-14 | 2015-12-24 | ナノストリング テクノロジーズ, インコーポレイテッド | 安定したナノレポーター |
US8951939B2 (en) | 2011-07-12 | 2015-02-10 | Bio-Rad Laboratories, Inc. | Digital assays with multiplexed detection of two or more targets in the same optical channel |
US9921154B2 (en) | 2011-03-18 | 2018-03-20 | Bio-Rad Laboratories, Inc. | Multiplexed digital assays |
CN102232118B (zh) | 2008-12-01 | 2015-07-08 | 恰根有限公司 | 用于核酸检测的新型荧光染料组合物 |
EP2376659B1 (en) | 2008-12-17 | 2015-12-02 | Life Technologies Corporation | Methods, compositions, and kits for detecting allelic variants |
US8361738B2 (en) | 2009-03-06 | 2013-01-29 | California Institute Of Technology | Methods for quantitative target detection and related devices and systems |
US8039215B2 (en) | 2009-03-10 | 2011-10-18 | Roche Molecular Systems, Inc. | Multiplex quantitative nucleic acid amplification and melting assay |
CN101570782B (zh) * | 2009-03-20 | 2012-01-11 | 曹际娟 | 乳制品中8种致病菌检测试剂盒及其检测方法 |
FI20095514A0 (fi) | 2009-05-07 | 2009-05-07 | Expression Analytics Oy | Menetelmä, laitteisto ja tietokoneohjelmatuote PCR-tuotteiden kvantifioimiseksi |
WO2010130877A2 (en) | 2009-05-12 | 2010-11-18 | Abacus Diagnostica Oy | Method for detecting nucleic acids |
CN102449167B (zh) | 2009-05-26 | 2014-12-17 | 厦门大学 | 一种检测核酸序列变异的方法 |
EP2439283B1 (en) | 2009-05-26 | 2014-12-31 | Xiamen University | Method for the detection of multiple single nucleotide variations or single nucleotide polymorphisms in a single tube |
EP2280080A1 (en) | 2009-07-31 | 2011-02-02 | Qiagen GmbH | Method of normalized quantification of nucleic acids using anchor oligonucleotides and adapter oligonucleotides |
US9938569B2 (en) | 2009-09-10 | 2018-04-10 | Diasorin S.P.A. | Compensation for spectral crosstalk in multiplex nucleic acid amplification |
WO2011037306A1 (en) | 2009-09-24 | 2011-03-31 | Seegene, Inc. | Detection of target nucleic acid sequences by cyclic exonucleolytic reactions |
US8962251B2 (en) | 2009-10-08 | 2015-02-24 | Medical Service Consultation International, Llc | Methods and compositions for identifying sulfur and iron modifying bacteria |
CA2775613C (en) | 2009-10-13 | 2018-06-12 | Nanostring Technologies, Inc. | Protein detection via nanoreporters |
US9752187B2 (en) | 2009-12-11 | 2017-09-05 | Nucleix | Categorization of DNA samples |
US9220743B2 (en) | 2010-01-22 | 2015-12-29 | Nuovo Biologics, Llc | Pan-antiviral peptides for protein kinase inhibition |
AU2011215753B2 (en) | 2010-02-11 | 2015-09-03 | Bruker Spatial Biology, Inc. | Compositions and methods for the detection of small RNAs |
US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
EP3392349A1 (en) | 2010-02-12 | 2018-10-24 | Raindance Technologies, Inc. | Digital analyte analysis |
US20110229888A1 (en) | 2010-03-16 | 2011-09-22 | Hengen Paul N | Compositions and Methods for the Detection of Genomic Features |
CA2799200A1 (en) | 2010-05-19 | 2011-11-24 | Qiagen Gaithersburg, Inc. | Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids |
US9822397B2 (en) | 2010-06-30 | 2017-11-21 | Gen-Probe Incorporated | Method and apparatus for identifying analyte-containing samples using single-read determination of analyte and process control signals |
US8877464B2 (en) | 2010-07-29 | 2014-11-04 | Roche Molecular Systems, Inc. | Qualitative and quantitative detection of microbial nucleic acids |
EP2633080B1 (en) | 2010-10-29 | 2018-12-05 | President and Fellows of Harvard College | Method of detecting targets using fluorescently labelled nucleic acid nanotube probes |
CN107502660B (zh) | 2011-01-20 | 2021-08-10 | 华盛顿大学商业中心 | 进行数字测量的方法和*** |
US20150140554A1 (en) | 2011-02-03 | 2015-05-21 | Richard O. Snyder | Detection Methods for Target DNA |
US9493825B2 (en) | 2011-03-18 | 2016-11-15 | University Of South Florida | Materials and methods for profiling microRNAs |
JP2014509865A (ja) | 2011-03-18 | 2014-04-24 | バイオ−ラッド・ラボラトリーズ・インコーポレーテッド | シグナルの組合せ使用による多重化デジタルアッセイ |
WO2012135340A2 (en) | 2011-03-28 | 2012-10-04 | Nanostring Technologies, Inc. | Compositions and methods for diagnosing cancer |
AU2012272763B2 (en) | 2011-06-24 | 2016-11-03 | Nanostring Technologies, Inc. | Multivariate diagnostic assays and methods for using same |
US10196681B2 (en) | 2011-10-06 | 2019-02-05 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US8858623B2 (en) | 2011-11-04 | 2014-10-14 | Valtech Cardio, Ltd. | Implant having multiple rotational assemblies |
EP4249605A3 (en) * | 2011-12-22 | 2023-11-15 | President And Fellows Of Harvard College | Methods for analyte detection |
EP4361609A3 (en) | 2012-02-03 | 2024-07-17 | California Institute of Technology | Signal encoding and decoding in multiplexed biochemical assays |
BR112014032677A2 (pt) | 2012-06-27 | 2019-01-15 | Univ Rutgers | ensaios rápido para ativação de célula t por medições de rna usando citometria de fluxo |
EP2880184B1 (en) | 2012-08-03 | 2021-03-31 | California Institute of Technology | Multiplexing and quantification in pcr with reduced hardware and requirements |
GB201218909D0 (en) | 2012-10-22 | 2012-12-05 | Univ Singapore | Assay for the parallel detection of biological material based on PCR |
CA2897474A1 (en) | 2013-01-24 | 2014-07-31 | California Institute Of Technology | Chromophore-based characterization and detection methods |
WO2014165210A2 (en) | 2013-03-12 | 2014-10-09 | Life Technologies Corporation | Universal reporter-based genotyping methods and materials |
EP2873740A1 (en) | 2013-11-19 | 2015-05-20 | Oncodiag | Methods for the surveillance, diagnosis and screening of bladder cancer |
US9670530B2 (en) | 2014-01-30 | 2017-06-06 | Illumina, Inc. | Haplotype resolved genome sequencing |
WO2015147370A1 (en) | 2014-03-28 | 2015-10-01 | Seegene, Inc. | Detection of target nucleic acid sequences using different detection temperatures |
MA39951A (fr) | 2014-05-09 | 2017-03-15 | Lifecodexx Ag | Détection de l'adn provenant d'un type spécifique de cellule et méthodes associées |
ES2954456T3 (es) | 2015-03-25 | 2023-11-22 | Massachusetts Gen Hospital | Análisis digital de células tumorales circulantes en muestras de sangre |
CN114196746A (zh) | 2016-02-10 | 2022-03-18 | 密歇根大学董事会 | 核酸的检测 |
WO2017173035A1 (en) | 2016-04-01 | 2017-10-05 | Chromacode Inc. | Competitive probes for engineering signal generation |
EP3472354A4 (en) | 2016-06-17 | 2020-01-01 | California Institute of Technology | NUCLEIC ACID ACTIONS AND RELATED PROCEDURES AND COMPOSITIONS |
AU2017348009B2 (en) | 2016-10-24 | 2019-10-10 | Ontera Inc. | Fractional abundance of polynucleotide sequences in a sample |
WO2019006023A1 (en) | 2017-06-28 | 2019-01-03 | ChromaCode, Inc. | MULTIPLEXED FLUORIMETRIC MEASUREMENTS WITH DROPLET PCR SYSTEMS |
US20190112636A1 (en) | 2017-10-16 | 2019-04-18 | ChromaCode, Inc. | Methods and compositions for nucleic acid detection |
WO2019169043A1 (en) | 2018-02-28 | 2019-09-06 | ChromaCode, Inc. | Molecular targets for fetal nucleic acid analysis |
US20200010876A1 (en) | 2018-07-03 | 2020-01-09 | ChromaCode, Inc. | Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays |
-
2013
- 2013-02-01 EP EP24161844.6A patent/EP4361609A3/en active Pending
- 2013-02-01 KR KR1020187030476A patent/KR102145677B1/ko active IP Right Grant
- 2013-02-01 US US13/756,760 patent/US8838394B2/en active Active
- 2013-02-01 EP EP24161817.2A patent/EP4361606A3/en active Pending
- 2013-02-01 CN CN202210389347.4A patent/CN114717296A/zh active Pending
- 2013-02-01 EP EP18181686.9A patent/EP3544015A1/en active Pending
- 2013-02-01 WO PCT/US2013/024509 patent/WO2013116780A1/en active Application Filing
- 2013-02-01 CN CN201710674587.8A patent/CN107326085B/zh active Active
- 2013-02-01 CN CN201380018760.9A patent/CN104271767B/zh active Active
- 2013-02-01 EP EP24161820.6A patent/EP4361607A3/en active Pending
- 2013-02-01 JP JP2014555800A patent/JP6255353B2/ja active Active
- 2013-02-01 BR BR112014019168-9A patent/BR112014019168B1/pt active IP Right Grant
- 2013-02-01 EP EP13744261.2A patent/EP2809813B1/en active Active
- 2013-02-01 KR KR1020147023833A patent/KR101912401B1/ko active IP Right Grant
- 2013-02-01 EP EP24161841.2A patent/EP4361608A3/en active Pending
-
2014
- 2014-08-05 US US14/451,876 patent/US10068051B2/en active Active
-
2015
- 2015-06-09 HK HK15105486.3A patent/HK1205200A1/xx unknown
-
2018
- 2018-03-07 US US15/914,356 patent/US10770170B2/en active Active
-
2020
- 2020-05-01 US US16/864,744 patent/US11827921B2/en active Active
- 2020-07-23 US US16/937,464 patent/US11866768B2/en active Active
-
2022
- 2022-08-10 US US17/885,037 patent/US20230086246A1/en active Pending
-
2023
- 2023-07-13 US US18/352,080 patent/US20240182954A1/en active Pending
- 2023-07-13 US US18/352,112 patent/US20240018573A1/en active Pending
- 2023-11-21 US US18/516,842 patent/US20240093273A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112014019168A8 (pt) | Método capaz de detectar de forma não degenerada presença ou ausência de analitos em um único volume de amostra e método de detecção da presença ou ausência de cada analito dentre uma pluralidade de analitos | |
IL256307B (en) | Methods and systems for the detection of an analyte or for the classification of a sample | |
CA2873099C (en) | Aptamer-based multiplexed assays | |
BR112017025097A2 (pt) | método para quantificação espectrométrica de massa de analitos extraídos de um dispositivo de microamostragem | |
BR112013022735A2 (pt) | aparelho para processamento de uma amostra, aparelho para processamento de uma pluralidade de amostras, método para detectar a presença ou ausência de um analito em uma amostra e método para detectar a presença ou ausência de um analito em uma pluralidade de amostras | |
BR112014031365A2 (pt) | métodos de detectar doenças ou condições | |
BR112014018831A2 (pt) | método para otimizar sensibilidade e/ou seletividade de um sensor para um ou mais analitos, método para formar um sensor para um ou mais analitos, kit para a detecção de um ou mais analitos, método de identificação de um aptâmero, composição de matéria e aptâmeros. | |
BR112014010955A2 (pt) | sistema e método para processar amostras | |
CA2864035C (en) | A method for determining the presence of an analyte using an aptamer | |
EP3004385A4 (en) | Nanopore-based nucleic acid analysis with mixed fret detection | |
EP2576833A4 (en) | METHOD AND DEVICE FOR THE POINT-OF-CARE DETECTION OF NUCLEIC ACID IN A SAMPLE | |
WO2014028378A3 (en) | Methods and systems for detecting biological components | |
BR112015005887A2 (pt) | quantificação de tiroglobulina por espectroscopia de massa | |
BR112015009901A2 (pt) | elementos de ensaio , material reagente e método para a determinação dos primeiro e segundo analitos em uma amostra. | |
BR112012021590A2 (pt) | detecção de capacitância em ensaio eletroquímico | |
WO2013166444A3 (en) | Biomarker analysis using scodaphoresis | |
BR112015023769A2 (pt) | sistemas de instrumento analítico | |
GB201206977D0 (en) | An enzyme detection device | |
GB2515944A (en) | Peptide arrays | |
ZA201402460B (en) | Assembly for determining the presence or absence of an analyte in a blood sample and analysis unit comprising such an assembly | |
EA201500377A1 (ru) | Способ обнаружения анализируемого вещества и определение его концентрации с использованием намагничиваемых гранул | |
WO2012103260A3 (en) | High-throughput methods to produce, validate and characterize mmabs | |
WO2015023503A3 (en) | Compositions and methods for multimodal analysis of cmet nucleic acids | |
WO2015042326A3 (en) | Methods for detection and treatment of neurodegenerative diseases | |
BR112016003058A2 (pt) | composições e métodos para análise multiplex de ácidos nucleicos nras e braf |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 01/02/2013, OBSERVADAS AS CONDICOES LEGAIS. |