BR112014017320A2 - método para determinar se um paciente é propenso a responder ao tratamento com um antagonista de vegf, método para otimizar a eficácia terapêutica de um antagonista de vegf, método para selecionar uma terapia, método para identificar um biomarcador e método para diagnosticar um distúrbio angiogênico - Google Patents

método para determinar se um paciente é propenso a responder ao tratamento com um antagonista de vegf, método para otimizar a eficácia terapêutica de um antagonista de vegf, método para selecionar uma terapia, método para identificar um biomarcador e método para diagnosticar um distúrbio angiogênico

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Publication number
BR112014017320A2
BR112014017320A2 BR112014017320A BR112014017320A BR112014017320A2 BR 112014017320 A2 BR112014017320 A2 BR 112014017320A2 BR 112014017320 A BR112014017320 A BR 112014017320A BR 112014017320 A BR112014017320 A BR 112014017320A BR 112014017320 A2 BR112014017320 A2 BR 112014017320A2
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BR
Brazil
Prior art keywords
vegf antagonist
biomarker
diagnosing
prone
optimizing
Prior art date
Application number
BR112014017320A
Other languages
English (en)
Inventor
Bais Carlos
Schmidt Maike
Singh Mallika
Brauer Matthew
Original Assignee
Genentech Inc
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Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of BR112014017320A2 publication Critical patent/BR112014017320A2/pt

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    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • G—PHYSICS
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    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
BR112014017320A 2012-01-13 2013-01-11 método para determinar se um paciente é propenso a responder ao tratamento com um antagonista de vegf, método para otimizar a eficácia terapêutica de um antagonista de vegf, método para selecionar uma terapia, método para identificar um biomarcador e método para diagnosticar um distúrbio angiogênico BR112014017320A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261586660P 2012-01-13 2012-01-13
PCT/US2013/021306 WO2013106765A1 (en) 2012-01-13 2013-01-11 Biological markers for identifying patients for treatment with vegf antagonists

Publications (1)

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BR112014017320A2 true BR112014017320A2 (pt) 2018-05-29

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BR112014017320A BR112014017320A2 (pt) 2012-01-13 2013-01-11 método para determinar se um paciente é propenso a responder ao tratamento com um antagonista de vegf, método para otimizar a eficácia terapêutica de um antagonista de vegf, método para selecionar uma terapia, método para identificar um biomarcador e método para diagnosticar um distúrbio angiogênico

Country Status (16)

Country Link
US (2) US20130216533A1 (pt)
EP (1) EP2802346B1 (pt)
JP (2) JP6529261B2 (pt)
KR (1) KR20140114415A (pt)
CN (1) CN104203268A (pt)
AU (2) AU2013207778B2 (pt)
BR (1) BR112014017320A2 (pt)
CA (1) CA2862835A1 (pt)
HK (1) HK1204933A1 (pt)
IL (2) IL233467B (pt)
MX (1) MX356802B (pt)
NZ (1) NZ627443A (pt)
RU (1) RU2659173C2 (pt)
SG (1) SG11201403927XA (pt)
WO (1) WO2013106765A1 (pt)
ZA (1) ZA201405305B (pt)

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US20130216533A1 (en) 2013-08-22
US10364466B2 (en) 2019-07-30
RU2014133164A (ru) 2016-03-10
IL233467B (en) 2018-07-31
EP2802346A4 (en) 2015-10-21
ZA201405305B (en) 2015-11-25
CA2862835A1 (en) 2013-07-18
EP2802346A1 (en) 2014-11-19
AU2013207778A1 (en) 2014-08-21
JP6529261B2 (ja) 2019-06-12
MX2014008463A (es) 2014-08-27
IL257141A (en) 2018-03-29
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IL233467A0 (en) 2014-08-31
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