BR112014015322A8 - compostos e composições para inibir a interação de bcl2 com parceiros de ligação - Google Patents
compostos e composições para inibir a interação de bcl2 com parceiros de ligaçãoInfo
- Publication number
- BR112014015322A8 BR112014015322A8 BR112014015322A BR112014015322A BR112014015322A8 BR 112014015322 A8 BR112014015322 A8 BR 112014015322A8 BR 112014015322 A BR112014015322 A BR 112014015322A BR 112014015322 A BR112014015322 A BR 112014015322A BR 112014015322 A8 BR112014015322 A8 BR 112014015322A8
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- bcl
- interaction
- formula
- compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
abstract the present invention relates to compounds of formula i: in which r1, r2, r3 and r4 are as defined in the summary of the invention. compounds of formula i are capable of disrupting the bcl-2 interations with proteins containing a bh3 domain. disrupting this interaction can restore the anti-apoptotic function of bcl-2 in cancer cells and tumor tissue expressing bcl-2. the invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancerous diseases. tradução do resumo resumo patente de invenção: "compostos e composições para inibir a interação de bcl2 com parceiros de ligação". a presente invenção refere-se aos compostos da fórmula i: na qual r1, r2, r3 e r4 são conforme definidos no sumário da invenção. os compostos da fórmula i são capazes de interferir nos processos de interação entre bcl-2 e proteínas contendo um domínio bh3. a interferência nesta interação pode restaurar a função apoptótica de bcl-2 em células cancerosas e no tecido tumoral que expressa bcl-2. a invenção provê ainda um processo para o preparo de compostos da invenção, de preparados farmacêuticos que compreendem tais compostos e de métodos para o uso de tais compostos no tratamento de doenças cancerosas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161579724P | 2011-12-23 | 2011-12-23 | |
| PCT/US2012/069270 WO2013096059A1 (en) | 2011-12-23 | 2012-12-12 | Compounds for inhibiting the interaction of bcl2 with binding partners |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112014015322A2 BR112014015322A2 (pt) | 2017-06-13 |
| BR112014015322A8 true BR112014015322A8 (pt) | 2017-06-13 |
Family
ID=47429052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014015322A BR112014015322A8 (pt) | 2011-12-23 | 2012-12-12 | compostos e composições para inibir a interação de bcl2 com parceiros de ligação |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9126979B2 (pt) |
| EP (1) | EP2794591A1 (pt) |
| JP (1) | JP2015503518A (pt) |
| KR (1) | KR20140104047A (pt) |
| CN (1) | CN104125954A (pt) |
| AU (1) | AU2012355623A1 (pt) |
| BR (1) | BR112014015322A8 (pt) |
| CA (1) | CA2859869A1 (pt) |
| EA (1) | EA201491264A1 (pt) |
| MX (1) | MX2014007730A (pt) |
| WO (1) | WO2013096059A1 (pt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140107573A (ko) | 2011-12-23 | 2014-09-04 | 노파르티스 아게 | Bcl2와 결합 파트너의 상호작용을 억제하기 위한 화합물 |
| FR3008978A1 (fr) * | 2013-07-23 | 2015-01-30 | Servier Lab | "nouveaux derives d'indole et de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent" |
| FR3008977A1 (fr) * | 2013-07-23 | 2015-01-30 | Servier Lab | Nouveaux derives d'isoindoline ou d'isoquinoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3008979B1 (fr) | 2013-07-23 | 2015-07-24 | Servier Lab | Nouveaux derives phosphates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3008976A1 (fr) | 2013-07-23 | 2015-01-30 | Servier Lab | "nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent" |
| US10195213B2 (en) | 2015-03-13 | 2019-02-05 | Unity Biotechnology, Inc. | Chemical entities that kill senescent cells for use in treating age-related disease |
| CA3073656C (en) | 2017-09-22 | 2024-03-05 | Jubilant Epipad LLC | Heterocyclic compounds as pad inhibitors |
| AU2018352142B2 (en) | 2017-10-18 | 2022-08-25 | Jubilant Epipad LLC | Imidazo-pyridine compounds as PAD inhibitors |
| SG11202004143XA (en) | 2017-11-06 | 2020-06-29 | Jubilant Prodel LLC | Pyrimidine derivatives as inhibitors of pd1/pd-l1 activation |
| CN111542523B (zh) | 2017-11-24 | 2024-03-29 | 朱比连特埃皮斯科瑞有限责任公司 | 作为prmt5抑制剂的杂环化合物 |
| CA3093527A1 (en) | 2018-03-13 | 2019-09-19 | Jubilant Prodel LLC | Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation |
| CA3098348A1 (en) | 2018-04-29 | 2019-11-07 | Beigene, Ltd. | Bcl-2 inhibitors |
| CN110746355B (zh) * | 2018-07-24 | 2023-08-11 | 中国科学院上海有机化学研究所 | 一种苯基吡唑类化合物、药物组合物、其制备方法及应用 |
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| US20140357633A1 (en) | 2011-12-23 | 2014-12-04 | Novartis Ag | Compounds for inhibiting the interaction of bcl2 with binding partners |
| KR20140107573A (ko) | 2011-12-23 | 2014-09-04 | 노파르티스 아게 | Bcl2와 결합 파트너의 상호작용을 억제하기 위한 화합물 |
-
2012
- 2012-12-12 US US14/366,857 patent/US9126979B2/en not_active Expired - Fee Related
- 2012-12-12 JP JP2014549138A patent/JP2015503518A/ja active Pending
- 2012-12-12 EA EA201491264A patent/EA201491264A1/ru unknown
- 2012-12-12 KR KR1020147020549A patent/KR20140104047A/ko not_active Application Discontinuation
- 2012-12-12 EP EP12805896.3A patent/EP2794591A1/en not_active Withdrawn
- 2012-12-12 WO PCT/US2012/069270 patent/WO2013096059A1/en active Application Filing
- 2012-12-12 AU AU2012355623A patent/AU2012355623A1/en not_active Abandoned
- 2012-12-12 CA CA2859869A patent/CA2859869A1/en not_active Abandoned
- 2012-12-12 CN CN201280070505.4A patent/CN104125954A/zh active Pending
- 2012-12-12 BR BR112014015322A patent/BR112014015322A8/pt not_active Application Discontinuation
- 2012-12-12 MX MX2014007730A patent/MX2014007730A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2859869A1 (en) | 2013-06-27 |
| MX2014007730A (es) | 2015-01-12 |
| US9126979B2 (en) | 2015-09-08 |
| KR20140104047A (ko) | 2014-08-27 |
| JP2015503518A (ja) | 2015-02-02 |
| WO2013096059A1 (en) | 2013-06-27 |
| EP2794591A1 (en) | 2014-10-29 |
| BR112014015322A2 (pt) | 2017-06-13 |
| AU2012355623A1 (en) | 2014-07-17 |
| US20140343093A1 (en) | 2014-11-20 |
| EA201491264A1 (ru) | 2014-11-28 |
| CN104125954A (zh) | 2014-10-29 |
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| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |