BR112014014960A2 - métodos para o diagnóstico da doença de alzheimer - Google Patents
métodos para o diagnóstico da doença de alzheimerInfo
- Publication number
- BR112014014960A2 BR112014014960A2 BR112014014960A BR112014014960A BR112014014960A2 BR 112014014960 A2 BR112014014960 A2 BR 112014014960A2 BR 112014014960 A BR112014014960 A BR 112014014960A BR 112014014960 A BR112014014960 A BR 112014014960A BR 112014014960 A2 BR112014014960 A2 BR 112014014960A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- disease
- abstract
- diagnosing
- amyloidosis
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
abstract: front page image (en)the present invention relates to methods of diagnosing, monitoring, and assessing treatment effects for aß amyloidosis, early in the course of clinical disease or prior to the onset of brain damage and clinical symptoms. methods of measuring the in vivo metabolism of biomolecules produced in the cns in a subject are provided. tradução do resumo resumo patente de invenção: "métodos para o diagnóstico da doença de alzheimer". a presente invenção refere-se aos métodos de diagnóstico, mo-nitoramento e avaliação dos efeitos de tratamento para a aß amiloidose, no início do curso da doença clínica ou antes do começo das lesões cerebrais e sintomas clínicos. os métodos de medição do metabolismo in vivo das bio-moléculas produzidas no cns em um indivíduo são fornecidos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161577439P | 2011-12-19 | 2011-12-19 | |
PCT/US2012/070623 WO2013096451A2 (en) | 2011-12-19 | 2012-12-19 | Methods for diagnosing alzheimer's disease |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014014960A2 true BR112014014960A2 (pt) | 2017-06-13 |
Family
ID=48669694
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014014960A BR112014014960A2 (pt) | 2011-12-19 | 2012-12-19 | métodos para o diagnóstico da doença de alzheimer |
Country Status (8)
Country | Link |
---|---|
US (2) | US20140370619A1 (pt) |
EP (1) | EP2795325B9 (pt) |
JP (1) | JP6129868B2 (pt) |
AU (1) | AU2012359020B2 (pt) |
BR (1) | BR112014014960A2 (pt) |
CA (1) | CA2859808A1 (pt) |
WO (1) | WO2013096451A2 (pt) |
ZA (1) | ZA201404500B (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10267806B2 (en) | 2014-04-04 | 2019-04-23 | Mayo Foundation For Medical Education And Research | Isotyping immunoglobulins using accurate molecular mass |
EP3147668B1 (en) * | 2014-05-22 | 2019-12-11 | Shimadzu Corporation | Surrogate biomarker for evaluating intracerebral amyloid beta peptide accumulation and method for analysis thereof |
WO2016018978A1 (en) | 2014-07-29 | 2016-02-04 | Mayo Foundation For Medical Education And Research | Quantifying monoclonal antibody therapeutics by lc-ms/ms |
WO2016054247A1 (en) | 2014-09-30 | 2016-04-07 | Washington University | Tau kinetic measurements |
CN108027376B (zh) * | 2015-09-16 | 2021-04-02 | 株式会社岛津制作所 | 评价脑内的淀粉样蛋白β蓄积状态的多重生物标记物及其分析方法 |
CN108026164A (zh) | 2015-09-24 | 2018-05-11 | 梅约医学教育与研究基金会 | 通过质谱鉴定免疫球蛋白游离轻链 |
US11360098B2 (en) * | 2015-09-28 | 2022-06-14 | Quest Diagnostics Investments Llc | Amyloid beta detection by mass spectrometry |
CN109863395B (zh) | 2016-09-07 | 2023-05-23 | 梅约医学教育与研究基金会 | 分子量法鉴定和监测裂解免疫球蛋白 |
EP3532034A4 (en) | 2016-10-28 | 2020-12-02 | Washington University | ANTI-APOE ANTIBODIES |
US11085935B2 (en) | 2018-05-03 | 2021-08-10 | Washington University | Methods of treating based on site-specific tau phosphorylation |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003068919A2 (en) * | 2002-02-12 | 2003-08-21 | The Regents Of The University Of California | Non-invasive method for measuring rates of biosynthesis of biological molecules by label incorporation |
CN101374555B (zh) * | 2005-04-06 | 2013-04-17 | 圣路易斯华盛顿州立大学 | 神经衍生的生物分子体内代谢的检测方法 |
US20110143380A1 (en) * | 2006-03-14 | 2011-06-16 | The Washington University | Alzheimer's disease biomarkers and methods of use |
MX2009001079A (es) * | 2006-07-28 | 2009-02-10 | Adlyfe Inc | Sondas de peptido para diagnosis y terapeutica. |
US20090142766A1 (en) * | 2007-11-09 | 2009-06-04 | Washington University In St. Louis | Methods for measuring the metabolism of cns derived biomolecules in vivo |
JP2013511734A (ja) * | 2009-11-24 | 2013-04-04 | プロビオドルグ エージー | アルツハイマー病又は軽度認知障害の診断のための新規診断方法 |
US20130115716A1 (en) * | 2010-05-24 | 2013-05-09 | The Washington University | Methods of determining amyloid beta turnover in blood |
-
2012
- 2012-12-19 BR BR112014014960A patent/BR112014014960A2/pt not_active Application Discontinuation
- 2012-12-19 JP JP2014548837A patent/JP6129868B2/ja active Active
- 2012-12-19 US US14/366,831 patent/US20140370619A1/en not_active Abandoned
- 2012-12-19 WO PCT/US2012/070623 patent/WO2013096451A2/en active Application Filing
- 2012-12-19 CA CA2859808A patent/CA2859808A1/en not_active Abandoned
- 2012-12-19 AU AU2012359020A patent/AU2012359020B2/en not_active Ceased
- 2012-12-19 EP EP12859548.5A patent/EP2795325B9/en not_active Not-in-force
-
2014
- 2014-06-19 ZA ZA2014/04500A patent/ZA201404500B/en unknown
-
2016
- 2016-02-24 US US15/052,218 patent/US20160169916A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2013096451A2 (en) | 2013-06-27 |
WO2013096451A3 (en) | 2014-09-25 |
ZA201404500B (en) | 2017-09-27 |
US20160169916A1 (en) | 2016-06-16 |
EP2795325B9 (en) | 2017-11-15 |
CA2859808A1 (en) | 2013-06-27 |
EP2795325B1 (en) | 2017-09-13 |
EP2795325A2 (en) | 2014-10-29 |
JP6129868B2 (ja) | 2017-05-17 |
EP2795325A4 (en) | 2016-02-17 |
JP2015505365A (ja) | 2015-02-19 |
US20140370619A1 (en) | 2014-12-18 |
AU2012359020A1 (en) | 2014-07-10 |
AU2012359020B2 (en) | 2017-04-13 |
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Legal Events
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] |