BR112014002674A2 - 3-(bifenil-3-il)-4-hidróxi-8-metóxi-1-azaspiro[4.5]dec-3-en-2-onas substituídas - Google Patents

3-(bifenil-3-il)-4-hidróxi-8-metóxi-1-azaspiro[4.5]dec-3-en-2-onas substituídas

Info

Publication number
BR112014002674A2
BR112014002674A2 BR112014002674A BR112014002674A BR112014002674A2 BR 112014002674 A2 BR112014002674 A2 BR 112014002674A2 BR 112014002674 A BR112014002674 A BR 112014002674A BR 112014002674 A BR112014002674 A BR 112014002674A BR 112014002674 A2 BR112014002674 A2 BR 112014002674A2
Authority
BR
Brazil
Prior art keywords
substituted
azaspiro
biphenyl
methoxy
dec
Prior art date
Application number
BR112014002674A
Other languages
English (en)
Inventor
Scholz Arne
Hilger Christoph-Stephan
Thede Kai
Liu Ningshu
Fischer Reiner
Bömer Ulf
Mönning Ursula
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of BR112014002674A2 publication Critical patent/BR112014002674A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

resumo patente de invenção: "3-(bifenil-3-il)-4-hidróxi-8-metóxi-1-azaspiro[4.5]dec-3-en-2-onas substituídas". a presente invenção refere-se às 3-( bifenil-3-il )-4-hidróxi-8-metóxi-1-azaspiro[ 4.5 ]dec-3-en -2-onas substituídas, em particular, para fins terapêuticos , a composições farmacêuticas e ao seu uso em terapia, em particular para a profilaxia e terapia de doenças neoplásicas.
BR112014002674A 2011-08-04 2012-07-31 3-(bifenil-3-il)-4-hidróxi-8-metóxi-1-azaspiro[4.5]dec-3-en-2-onas substituídas BR112014002674A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102011080406A DE102011080406A1 (de) 2011-08-04 2011-08-04 Substituierte 3-(Biphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro8[4.5]dec-3-en-2-one
PCT/EP2012/064974 WO2013017600A1 (de) 2011-08-04 2012-07-31 Substituierte 3-(biphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one

Publications (1)

Publication Number Publication Date
BR112014002674A2 true BR112014002674A2 (pt) 2017-04-11

Family

ID=46584054

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014002674A BR112014002674A2 (pt) 2011-08-04 2012-07-31 3-(bifenil-3-il)-4-hidróxi-8-metóxi-1-azaspiro[4.5]dec-3-en-2-onas substituídas

Country Status (21)

Country Link
US (1) US9278925B2 (pt)
EP (1) EP2739607A1 (pt)
JP (1) JP2014524413A (pt)
KR (1) KR20140051378A (pt)
CN (1) CN103842337A (pt)
AP (1) AP2014007469A0 (pt)
AU (1) AU2012292069A1 (pt)
BR (1) BR112014002674A2 (pt)
CA (1) CA2843809A1 (pt)
CO (1) CO6870039A2 (pt)
CR (1) CR20140063A (pt)
CU (1) CU20140012A7 (pt)
DE (1) DE102011080406A1 (pt)
DO (1) DOP2014000022A (pt)
EC (1) ECSP14013192A (pt)
HK (1) HK1198167A1 (pt)
IL (1) IL230609A0 (pt)
MX (1) MX2014001393A (pt)
SG (1) SG2014005235A (pt)
TN (1) TN2014000046A1 (pt)
WO (1) WO2013017600A1 (pt)

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TWI579260B (zh) * 2012-03-28 2017-04-21 拜耳智慧財產有限公司 用於製備順式－烷氧基－取代之螺環狀苯基乙醯基胺基酸酯及順式－烷氧基－取代之螺環狀１ｈ－吡咯啶－２，４－二酮衍生物之方法
BR112016004118A2 (pt) 2013-09-12 2017-10-17 Pfizer uso de inibidores da acetil-coa carboxilase para tratamento de acne vulgar
WO2015056782A1 (ja) 2013-10-17 2015-04-23 塩野義製薬株式会社 新規アルキレン誘導体
CN107207444B (zh) 2014-11-26 2020-07-24 武田药品工业株式会社 二环化合物
EP3279183B1 (en) 2015-03-31 2021-09-01 Takeda Pharmaceutical Company Limited Monocyclic compound
TWI767148B (zh) 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)
RU2733369C1 (ru) * 2020-01-15 2020-10-01 Федеральное государственное бюджетное учреждение науки Федеральный исследовательский центр "КОМИ научный центр Уральского отделения Российской академии наук" Хиральные трифторметилированные монотерпеновые тиоацетаты и тиолы пинанового ряда
RU2743302C1 (ru) * 2020-07-21 2021-02-16 Федеральное государственное бюджетное учреждение науки Федеральный исследовательский центр "КОМИ научный центр Уральского отделения Российской академии наук" Хиральные трифторметилированные монотерпеновые тиоацетаты и тиолы на основе миртеналя

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Also Published As

Publication number Publication date
WO2013017600A1 (de) 2013-02-07
HK1198167A1 (pt) 2015-03-13
IL230609A0 (en) 2014-03-31
AP2014007469A0 (en) 2014-02-28
CU20140012A7 (es) 2014-05-27
DOP2014000022A (es) 2014-03-31
TN2014000046A1 (en) 2015-07-01
DE102011080406A1 (de) 2013-02-07
US9278925B2 (en) 2016-03-08
SG2014005235A (en) 2014-06-27
CR20140063A (es) 2014-03-19
EP2739607A1 (de) 2014-06-11
CA2843809A1 (en) 2013-02-07
KR20140051378A (ko) 2014-04-30
AU2012292069A1 (en) 2014-02-13
CO6870039A2 (es) 2014-02-20
CN103842337A (zh) 2014-06-04
MX2014001393A (es) 2014-05-27
ECSP14013192A (es) 2014-03-31
US20140275199A1 (en) 2014-09-18
JP2014524413A (ja) 2014-09-22

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