BR112013029203A2 - método para a preparação de um ou mais oligossacarídeos de leite humano, e, uso de oligossacarídeos de leite humano - Google Patents
método para a preparação de um ou mais oligossacarídeos de leite humano, e, uso de oligossacarídeos de leite humanoInfo
- Publication number
- BR112013029203A2 BR112013029203A2 BR112013029203A BR112013029203A BR112013029203A2 BR 112013029203 A2 BR112013029203 A2 BR 112013029203A2 BR 112013029203 A BR112013029203 A BR 112013029203A BR 112013029203 A BR112013029203 A BR 112013029203A BR 112013029203 A2 BR112013029203 A2 BR 112013029203A2
- Authority
- BR
- Brazil
- Prior art keywords
- human milk
- milk oligosaccharides
- preparing
- oligosaccharides
- human
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/12—Disaccharides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Dairy Products (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11166137 | 2011-05-13 | ||
| PCT/IB2012/051314 WO2012127410A1 (en) | 2011-03-18 | 2012-03-19 | Synthesis of new fucose-containing carbohydrate derivatives |
| PCT/IB2012/052401 WO2012156898A1 (en) | 2011-05-13 | 2012-05-14 | DIVERSIFICATION OF HUMAN MILK OLIGOSACCHARIDES (HMOs) OR PRECURSORS THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112013029203A2 true BR112013029203A2 (pt) | 2016-08-09 |
Family
ID=47176364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013029203A BR112013029203A2 (pt) | 2011-05-13 | 2012-05-14 | método para a preparação de um ou mais oligossacarídeos de leite humano, e, uso de oligossacarídeos de leite humano |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9382564B2 (pt) |
| EP (2) | EP2707380B1 (pt) |
| JP (1) | JP6106160B2 (pt) |
| KR (1) | KR20140036226A (pt) |
| CN (1) | CN103562214B9 (pt) |
| BR (1) | BR112013029203A2 (pt) |
| CA (1) | CA2835989A1 (pt) |
| DK (1) | DK2707380T3 (pt) |
| ES (1) | ES2820429T3 (pt) |
| IL (1) | IL229047A0 (pt) |
| MX (1) | MX349153B (pt) |
| PL (1) | PL2707380T3 (pt) |
| RU (1) | RU2013155453A (pt) |
| WO (1) | WO2012156898A1 (pt) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140001198A (ko) | 2010-07-16 | 2014-01-06 | 글리콤 에이/에스 | 신규 시알로올리고당 유도체들의 합성 |
| WO2013091660A1 (en) * | 2011-12-23 | 2013-06-27 | Glycom A/S | A method for obtaining crystalline lacto-n-tetraose and lacto-n-neotetraose precursors and mixtures thereof |
| WO2014090261A1 (en) * | 2012-12-14 | 2014-06-19 | Glycom A/S | Mixture of fucosylate lactoses |
| GB201306689D0 (en) | 2013-04-12 | 2013-05-29 | Glycom As | Synthesis of sialylated/fucosylated human milk oligosaccharides |
| CN105246911B (zh) * | 2013-04-12 | 2019-10-01 | 丹麦科技大学 | 用于产生唾液酸化聚糖之具有转唾液酸酶活性的突变体唾液酸酶 |
| ES2891731T3 (es) | 2013-05-22 | 2022-01-31 | Glycom As | Mezcla sintética de oligosacáridos para el tratamiento de la microbiota de un mamífero |
| EP3041947A4 (en) | 2013-09-06 | 2017-07-26 | Glycom A/S | Fermentative production of oligosaccharides |
| EP2857410A1 (en) * | 2013-10-04 | 2015-04-08 | Jennewein Biotechnologie GmbH | Process for purification of 2´-fucosyllactose using simulated moving bed chromatography |
| PL3209673T5 (pl) * | 2014-10-24 | 2023-10-23 | Glycom A/S | Mieszaniny hmo |
| WO2016063261A1 (en) * | 2014-10-24 | 2016-04-28 | Glycom A/S | Mutated fucosidase |
| US11040049B2 (en) | 2014-10-29 | 2021-06-22 | Glycom A/S | Composition comprising HMSs/HMOs and use thereof |
| US11040050B2 (en) | 2014-10-29 | 2021-06-22 | Glycom A/S | Composition comprising HMSs/HMOs and use thereof |
| EP3212198B1 (en) | 2014-10-29 | 2020-12-23 | Glycom A/S | Synthetic composition and method for promoting mucosal healing |
| JP7182872B2 (ja) | 2014-10-29 | 2022-12-05 | グリコム・アクティーゼルスカブ | 過敏性腸症候群の治療のための合成組成物および方法 |
| US10835544B2 (en) | 2014-12-08 | 2020-11-17 | Glycom A/S | Synthetic composition for regulating satiety |
| US10881674B2 (en) | 2014-12-08 | 2021-01-05 | Glycom A/S | Synthetic composition for treating metabolic disorders |
| CN107106584A (zh) | 2014-12-08 | 2017-08-29 | 格礼卡姆股份公司 | 用于治疗代谢障碍的合成组合物 |
| US10987368B2 (en) | 2014-12-08 | 2021-04-27 | Glycom A/S | Synthetic composition for preventing or treating CVD |
| CN115300517A (zh) * | 2015-03-31 | 2022-11-08 | 格礼卡姆股份公司 | 包含3’-o-唾液乳糖的人乳寡糖的混合物 |
| ES2870973T3 (es) * | 2015-06-09 | 2021-10-28 | Glycom As | Mezclas ternarias de 6'-SL, LNnT y LST c |
| DK3307882T3 (da) * | 2015-06-09 | 2020-05-18 | Glycom As | Mutated photobacterium transsialidases |
| ES2772685T3 (es) | 2015-08-04 | 2020-07-08 | Nestle Sa | Composiciones nutricionales con 2FL y LNNT para inducir una microbiota intestinal similar a la de los bebés lactantes |
| US10751354B2 (en) | 2015-09-14 | 2020-08-25 | Glycom A/S | Synthetic composition for microbiota modulation |
| EP3368046B1 (en) | 2015-10-28 | 2022-07-27 | Glycom A/S | Synthetic composition and method for modulating brain function and behaviour |
| ES2950489T3 (es) | 2015-10-28 | 2023-10-10 | Glycom As | Composición sintética y método para modular los trastornos de la emoción y del ánimo |
| CN108348536B (zh) | 2015-11-17 | 2021-09-24 | 格礼卡姆股份公司 | 治疗抗生素相关性并发症的合成组合物 |
| EP3389668A4 (en) | 2015-12-15 | 2019-08-21 | Glycom A/S | MIX OF HMO |
| EP3419630A4 (en) | 2016-02-24 | 2019-11-06 | Glycom A/S | SYNTHETIC COMPOSITION OF MICROBIOTIC MODULATION |
| WO2017190755A1 (en) | 2016-05-05 | 2017-11-09 | Glycom A/S | Composition comprising hmos for use in the treatment of mast cell mediated visceral hypersensitivity and/or pain |
| PL3452050T3 (pl) | 2016-05-05 | 2023-06-12 | Glycom A/S | Kompozycja zawierająca hmo do leczenia biegunki niezakaźnej |
| WO2017198276A1 (en) | 2016-05-19 | 2017-11-23 | Glycom A/S | Synthetic composition |
| EP3474861A4 (en) | 2016-06-24 | 2020-04-15 | Glycom A/S | COMPOUNDS COMPRISING HMOS FOR THE PREVENTION AND / OR TREATMENT OF VIRAL AND / OR BACTERIAL INFECTIONS. |
| EP3490567A4 (en) | 2016-07-28 | 2020-03-18 | Fonterra Co-Operative Group Limited | DAIRY PRODUCT AND DAIRY PROCESS |
| US11278558B2 (en) | 2017-03-01 | 2022-03-22 | Glycom A/S | Synthetic composition for microbiota modulation |
| EP3634429A4 (en) | 2017-05-09 | 2020-11-04 | Glycom A/S | SYNTHETIC COMPOSITION FOR MICROBIOTE MODULATION |
| WO2018215960A1 (en) | 2017-05-24 | 2018-11-29 | Glycom A/S | Synthetic composition comprising one or more human milk oligosaccharides (hmos) |
| WO2018215961A1 (en) | 2017-05-24 | 2018-11-29 | Glycom A/S | Synthetic composition comprising oligosaccharides and its use in medical treatment. |
| EP3645545A4 (en) | 2017-06-30 | 2021-05-05 | Glycom A/S | PURIFICATION OF OLIGOSACCHARIDES |
| EP3672600A4 (en) | 2017-08-21 | 2021-05-19 | Glycom A/S | SYNTHETIC COMPOSITION TO REDUCE ALLERGY SYMPTOMS |
| EP3450443A1 (en) * | 2017-08-29 | 2019-03-06 | Jennewein Biotechnologie GmbH | Process for purifying sialylated oligosaccharides |
| CA3081496A1 (en) | 2017-11-02 | 2019-05-09 | Glycom A/S | Mixture of hmos for reducing or preventing fatigue |
| BR112020010863A2 (pt) | 2017-11-30 | 2020-11-10 | Glycom A/S | mistura de hmos para tratamento da sensibilidade ao trigo |
| CN111556755A (zh) | 2017-12-05 | 2020-08-18 | 格礼卡姆股份公司 | 用于治疗偏头痛的人乳寡糖 |
| US11566219B2 (en) * | 2017-12-08 | 2023-01-31 | Morinaga Milk Industry Co., Ltd. | Bifidobacterium bacteria and composition including novel bifidobacterium bacteria |
| WO2019123316A1 (en) | 2017-12-22 | 2019-06-27 | Glycom A/S | Composition comprising hmos for preventing or reducing nociception |
| EP3801558A4 (en) | 2018-05-31 | 2022-03-09 | Glycom A/S | HMOS BLEND FOR THE TREATMENT OF AUTOIMMUNE DISEASES |
| CN113194960A (zh) | 2018-12-19 | 2021-07-30 | 格礼卡姆股份公司 | 用于治疗使用低fodmap饮食的人的组合物和方法 |
| CN110016066B (zh) * | 2019-04-02 | 2021-11-02 | 江西师范大学 | 一种i型n-聚糖天线的合成方法 |
| CN114350640B (zh) * | 2019-12-13 | 2023-09-08 | 中国科学院天津工业生物技术研究所 | 一株表达几丁质酶重组菌的构建及高酶活突变体的筛选 |
| WO2022089707A1 (en) | 2020-10-30 | 2022-05-05 | Mille International Aps | A method of producing a human milk oligosaccharide (hmo) |
| CN112795583A (zh) * | 2020-11-16 | 2021-05-14 | 上海大学 | 重组唾液酸外切酶的制备方法、表达基因、重组表达载体及构建方法 |
| WO2022223430A1 (en) | 2021-04-19 | 2022-10-27 | Dsm Ip Assets B.V. | A composition of enzymes and human milk oligosaccharides |
| CN113960232B (zh) * | 2021-10-28 | 2024-02-20 | 苏州大学 | 一种基于唾液特异性岩藻糖基化结构糖谱及其检测方法和应用 |
| DK202200588A1 (en) | 2022-06-20 | 2024-02-23 | Dsm Ip Assets Bv | Mixture of fucosylated HMOs |
| WO2024042235A1 (en) | 2022-08-25 | 2024-02-29 | Dsm Ip Assets B.V. | Hybrid method for producing complex hmos |
| WO2024110667A1 (en) | 2022-11-25 | 2024-05-30 | Dsm Ip Assets B.V. | Two-strain system for producing oligosaccharides |
| DK202201151A1 (en) | 2022-12-14 | 2024-07-02 | Dsm Ip Assets Bv | Mutated lacto-n-biosidase |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993018787A1 (en) * | 1992-03-25 | 1993-09-30 | New York University | Trans-sialidase and methods of use and making thereof |
| JPH0686684A (ja) | 1992-05-26 | 1994-03-29 | Monsanto Co | シアロ抱合体の合成 |
| US5409817A (en) * | 1993-05-04 | 1995-04-25 | Cytel, Inc. | Use of trans-sialidase and sialyltransferase for synthesis of sialylα2→3βgalactosides |
| EP0820520B1 (en) | 1995-04-11 | 2002-08-14 | Neose Technologies, Inc. | Improved enzymatic synthesis of oligosaccharides |
| US6323008B1 (en) | 1997-08-14 | 2001-11-27 | Neose Technologies, Inc. | Methods for producing sialyloligosaccharides in a dairy source |
| US20050032742A1 (en) | 2001-08-17 | 2005-02-10 | Defrees Shawn | Chemo-enzymatic synthesis of sialylated oligosaccharides |
| WO2005055944A2 (en) * | 2003-12-05 | 2005-06-23 | Cincinnati Children's Hospital Medical Center | Oligosaccharide compositions and use thereof in the treatment of infection |
| US8591981B2 (en) * | 2005-02-21 | 2013-11-26 | Nestec S.A. | Oligosaccharide mixture |
| JP4937288B2 (ja) | 2009-03-02 | 2012-05-23 | シャープ株式会社 | 画像読取装置及び画像形成装置 |
| WO2011100980A1 (en) | 2010-02-19 | 2011-08-25 | Glycom A/S | A method for preparation of the tetrasaccharide lacto-n-neotetraose (lnnt) containing n-acetyllactosamine |
| KR20140001198A (ko) | 2010-07-16 | 2014-01-06 | 글리콤 에이/에스 | 신규 시알로올리고당 유도체들의 합성 |
| RU2013146524A (ru) | 2011-03-18 | 2015-04-27 | Глюком А/С | Синтез новых фукозо-содержащих производных углеводородов |
-
2012
- 2012-05-14 JP JP2014510920A patent/JP6106160B2/ja active Active
- 2012-05-14 WO PCT/IB2012/052401 patent/WO2012156898A1/en active Application Filing
- 2012-05-14 EP EP12785572.4A patent/EP2707380B1/en active Active
- 2012-05-14 PL PL12785572T patent/PL2707380T3/pl unknown
- 2012-05-14 KR KR1020137032961A patent/KR20140036226A/ko not_active Application Discontinuation
- 2012-05-14 CN CN201280023818.4A patent/CN103562214B9/zh active Active
- 2012-05-14 DK DK12785572.4T patent/DK2707380T3/da active
- 2012-05-14 ES ES12785572T patent/ES2820429T3/es active Active
- 2012-05-14 MX MX2013013027A patent/MX349153B/es active IP Right Grant
- 2012-05-14 RU RU2013155453/04A patent/RU2013155453A/ru not_active Application Discontinuation
- 2012-05-14 BR BR112013029203A patent/BR112013029203A2/pt not_active IP Right Cessation
- 2012-05-14 CA CA2835989A patent/CA2835989A1/en not_active Abandoned
- 2012-05-14 EP EP20182361.4A patent/EP3744725A1/en active Pending
- 2012-05-14 US US14/117,332 patent/US9382564B2/en active Active
-
2013
- 2013-10-24 IL IL229047A patent/IL229047A0/en unknown
-
2016
- 2016-05-23 US US15/161,887 patent/US9963729B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20140212930A1 (en) | 2014-07-31 |
| US9963729B2 (en) | 2018-05-08 |
| JP2014513986A (ja) | 2014-06-19 |
| US20160289721A1 (en) | 2016-10-06 |
| EP3744725A1 (en) | 2020-12-02 |
| CA2835989A1 (en) | 2012-11-22 |
| ES2820429T3 (es) | 2021-04-21 |
| MX349153B (es) | 2017-07-14 |
| CN103562214B9 (zh) | 2016-12-14 |
| DK2707380T3 (da) | 2020-10-12 |
| PL2707380T3 (pl) | 2021-01-11 |
| KR20140036226A (ko) | 2014-03-25 |
| EP2707380A4 (en) | 2014-10-08 |
| WO2012156898A1 (en) | 2012-11-22 |
| RU2013155453A (ru) | 2015-06-20 |
| US9382564B2 (en) | 2016-07-05 |
| JP6106160B2 (ja) | 2017-03-29 |
| EP2707380A1 (en) | 2014-03-19 |
| CN103562214A (zh) | 2014-02-05 |
| EP2707380B1 (en) | 2020-07-08 |
| CN103562214B (zh) | 2016-10-19 |
| IL229047A0 (en) | 2013-12-31 |
| MX2013013027A (es) | 2013-12-02 |
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