BR112013023609A8 - Método para a redução de sintomas parecidos com a gripe associado com a administração intramuscular de interferon ao usar um regime de dosagem escalonado de titulação rápida - Google Patents
Método para a redução de sintomas parecidos com a gripe associado com a administração intramuscular de interferon ao usar um regime de dosagem escalonado de titulação rápidaInfo
- Publication number
- BR112013023609A8 BR112013023609A8 BR112013023609A BR112013023609A BR112013023609A8 BR 112013023609 A8 BR112013023609 A8 BR 112013023609A8 BR 112013023609 A BR112013023609 A BR 112013023609A BR 112013023609 A BR112013023609 A BR 112013023609A BR 112013023609 A8 BR112013023609 A8 BR 112013023609A8
- Authority
- BR
- Brazil
- Prior art keywords
- symptoms associated
- interferon
- titer
- stepped
- rapid
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/215—IFN-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicinal Preparation (AREA)
Abstract
MÉTODO PARA A REDUÇÃO DE SINTOMAS PARECIDOS COM A GRIPE ASSOCIADO COM A ADMINISTRAÇÃO INTRAMUSCULAR DE INTERFERON AO USAR UM REGIME DE DOSAGEM ESCALONADO DE TITULAÇÃO RÁPIDA. A presente invenção refere-se a um método para o tratamento de esclerose múltipla (MS) e para a redução de sintomas parecidos com a gripe associado com a administração de interferon a um paciente com MS. O método envolve a administração intramuscular de interferon ao paciente com MS de acordo com um regime de dosagem escalonado na s semanas 1 a 3, e uma dose total terapeuticamente eficaz de interferon na semana 4. Em uma modalidade da invenção, o regime de dosagem escalonado compreende a administração de um quarto da dose terapeuticamente eficaz na semana 1, metade da dose terapeuticamente eficaz na semana 2 e três quatros da dose terapeuticamente eficaz na semana 3. Também são apresentados pacotes de titulação para permitir a conformidade com um regime de dosagem variável de um interferon por um período de tempo.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161452807P | 2011-03-15 | 2011-03-15 | |
| US201161476930P | 2011-04-19 | 2011-04-19 | |
| PCT/US2012/029201 WO2012125809A1 (en) | 2011-03-15 | 2012-03-15 | Method for reducing flu-like symptoms associated with intramuscular administration of interferon using a fast titration escalating dosing regimen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112013023609A2 BR112013023609A2 (pt) | 2016-12-06 |
| BR112013023609A8 true BR112013023609A8 (pt) | 2018-04-03 |
Family
ID=46045072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013023609A BR112013023609A8 (pt) | 2011-03-15 | 2012-03-15 | Método para a redução de sintomas parecidos com a gripe associado com a administração intramuscular de interferon ao usar um regime de dosagem escalonado de titulação rápida |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US9198955B2 (pt) |
| EP (1) | EP2686002B1 (pt) |
| JP (2) | JP6279905B2 (pt) |
| KR (1) | KR102050339B1 (pt) |
| CN (1) | CN103702680A (pt) |
| AU (1) | AU2012229104B2 (pt) |
| BR (1) | BR112013023609A8 (pt) |
| CA (1) | CA2846786C (pt) |
| CY (1) | CY1120176T1 (pt) |
| DK (1) | DK2686002T3 (pt) |
| EA (1) | EA028448B1 (pt) |
| ES (1) | ES2666850T3 (pt) |
| HR (1) | HRP20180621T1 (pt) |
| HU (1) | HUE036931T2 (pt) |
| IL (1) | IL228425A (pt) |
| LT (1) | LT2686002T (pt) |
| MX (1) | MX359947B (pt) |
| PL (1) | PL2686002T3 (pt) |
| PT (1) | PT2686002T (pt) |
| RS (1) | RS57175B1 (pt) |
| SG (1) | SG193446A1 (pt) |
| SI (1) | SI2686002T1 (pt) |
| WO (1) | WO2012125809A1 (pt) |
| ZA (1) | ZA201306933B (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102050339B1 (ko) * | 2011-03-15 | 2019-11-29 | 바이오젠 엠에이 인코포레이티드 | 빠른 적정 단계식 증가 투여 요법을 이용한 인터페론의 근육내 투여와 관련된 독감 유사 증상의 감소 방법 |
| US10106775B2 (en) | 2014-01-09 | 2018-10-23 | Kyushu University, National University Corporation | Method of producing microglial cells |
| WO2018056584A1 (ko) | 2016-09-21 | 2018-03-29 | 삼성전자 주식회사 | 피부 상태 측정 방법 및 이를 위한 전자 장치 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4456748A (en) | 1981-02-23 | 1984-06-26 | Genentech, Inc. | Hybrid human leukocyte interferons |
| DE3273787D1 (en) | 1981-02-04 | 1986-11-20 | Japan Found Cancer | Human interferon-beta gene |
| US4695543A (en) | 1982-03-23 | 1987-09-22 | Bristol-Myers Company | Alpha Interferon GX-1 |
| CA1302320C (en) | 1984-06-11 | 1992-06-02 | Hideo Niwa | Expression of human cromosomal interferon-_ in animal cells |
| US5231176A (en) | 1984-08-27 | 1993-07-27 | Genentech, Inc. | Distinct family DNA encoding of human leukocyte interferons |
| FI90990C (fi) | 1984-12-18 | 1994-04-25 | Boehringer Ingelheim Int | Rekombinantti-DNA-molekyyli, transformoitu isäntäorganismi ja menetelmä interferonin valmistamiseksi |
| EP0205404B1 (en) | 1985-06-11 | 1992-07-15 | Ciba-Geigy Ag | Hybrid interferons |
| US5641656A (en) | 1993-10-22 | 1997-06-24 | University Of Connecticut | Nucleic acids encoding avian interferon (IFN) proteins and recombinant methods using them |
| SK284989B6 (sk) * | 1996-12-24 | 2006-04-06 | Biogen, Inc. | Kvapalná kompozícia obsahujúca interferón a spôsob stabilizácie interferónu |
| JP2001104482A (ja) * | 1999-10-07 | 2001-04-17 | Terumo Corp | ２室型プレフィルドシリンジ |
| US8932265B2 (en) * | 2003-01-30 | 2015-01-13 | Becton, Dickinson And Company | Holder with safety shield for a drug delivery device |
| CN1993139B (zh) * | 2004-06-01 | 2011-02-16 | 阿雷斯贸易股份有限公司 | 稳定的干扰素液体制剂 |
| US20060089593A1 (en) * | 2004-10-26 | 2006-04-27 | Sergio Landau | Needle-free injection device for individual users |
| EP1923085A1 (en) * | 2006-11-17 | 2008-05-21 | Sanofi-Aventis Deutschland GmbH | Dosing and drive mechanism for drug delivery device |
| EP2120869A2 (en) | 2006-12-18 | 2009-11-25 | Altus Pharmaceuticals Inc. | Human growth hormone formulations |
| US9044378B2 (en) * | 2007-05-31 | 2015-06-02 | Safety Syringes, Inc. | Anti-needle stick safety device or system for use with drugs requiring reconstitution |
| JP5549048B2 (ja) * | 2007-08-16 | 2014-07-16 | 味の素株式会社 | 薬剤バイアルとプレフィルドシリンジの接続構造 |
| EP2442798A4 (en) * | 2009-06-18 | 2013-03-13 | Wyeth Llc | LYOPHILIZED FORMULATIONS FOR SMALL-SCALE MODULAR IMMUNOPHARMACEUTICAL AGENTS |
| KR102050339B1 (ko) * | 2011-03-15 | 2019-11-29 | 바이오젠 엠에이 인코포레이티드 | 빠른 적정 단계식 증가 투여 요법을 이용한 인터페론의 근육내 투여와 관련된 독감 유사 증상의 감소 방법 |
-
2012
- 2012-03-15 KR KR1020137027053A patent/KR102050339B1/ko active IP Right Grant
- 2012-03-15 RS RS20180455A patent/RS57175B1/sr unknown
- 2012-03-15 SG SG2013069018A patent/SG193446A1/en unknown
- 2012-03-15 HU HUE12719487A patent/HUE036931T2/hu unknown
- 2012-03-15 EA EA201301024A patent/EA028448B1/ru unknown
- 2012-03-15 PT PT127194876T patent/PT2686002T/pt unknown
- 2012-03-15 ES ES12719487.6T patent/ES2666850T3/es active Active
- 2012-03-15 US US13/421,197 patent/US9198955B2/en active Active
- 2012-03-15 EP EP12719487.6A patent/EP2686002B1/en active Active
- 2012-03-15 PL PL12719487T patent/PL2686002T3/pl unknown
- 2012-03-15 JP JP2013558168A patent/JP6279905B2/ja active Active
- 2012-03-15 LT LTEP12719487.6T patent/LT2686002T/lt unknown
- 2012-03-15 SI SI201231281T patent/SI2686002T1/en unknown
- 2012-03-15 WO PCT/US2012/029201 patent/WO2012125809A1/en active Application Filing
- 2012-03-15 BR BR112013023609A patent/BR112013023609A8/pt not_active Application Discontinuation
- 2012-03-15 DK DK12719487.6T patent/DK2686002T3/en active
- 2012-03-15 AU AU2012229104A patent/AU2012229104B2/en active Active
- 2012-03-15 CN CN201280019863.2A patent/CN103702680A/zh active Pending
- 2012-03-15 CA CA2846786A patent/CA2846786C/en active Active
- 2012-03-15 MX MX2013010507A patent/MX359947B/es active IP Right Grant
-
2013
- 2013-09-12 ZA ZA2013/06933A patent/ZA201306933B/en unknown
- 2013-09-12 IL IL228425A patent/IL228425A/en active IP Right Grant
-
2015
- 2015-11-09 US US14/936,228 patent/US20160101157A1/en not_active Abandoned
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2017
- 2017-09-05 JP JP2017170640A patent/JP6522069B2/ja active Active
- 2017-09-05 US US15/695,587 patent/US10500254B2/en active Active
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2018
- 2018-04-18 HR HRP20180621TT patent/HRP20180621T1/hr unknown
- 2018-04-23 CY CY20181100424T patent/CY1120176T1/el unknown
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2019
- 2019-10-22 US US16/660,038 patent/US20200046804A1/en not_active Abandoned
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2022
- 2022-05-27 US US17/827,282 patent/US20220280610A1/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B25D | Requested change of name of applicant approved |
Owner name: BIOGEN INC. (GB) |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B12B | Appeal against refusal [chapter 12.2 patent gazette] |