BR112013018344A2 - substância probiótica microencapsulada e processo de fabricação - Google Patents
substância probiótica microencapsulada e processo de fabricaçãoInfo
- Publication number
- BR112013018344A2 BR112013018344A2 BR112013018344A BR112013018344A BR112013018344A2 BR 112013018344 A2 BR112013018344 A2 BR 112013018344A2 BR 112013018344 A BR112013018344 A BR 112013018344A BR 112013018344 A BR112013018344 A BR 112013018344A BR 112013018344 A2 BR112013018344 A2 BR 112013018344A2
- Authority
- BR
- Brazil
- Prior art keywords
- manufacturing process
- microencapsulated probiotic
- probiotic substance
- substance
- carrier phase
- Prior art date
Links
- 239000006041 probiotic Substances 0.000 title abstract 4
- 230000000529 probiotic effect Effects 0.000 title abstract 4
- 235000018291 probiotics Nutrition 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000000126 substance Substances 0.000 title abstract 2
- 239000002245 particle Substances 0.000 abstract 3
- 244000005700 microbiome Species 0.000 abstract 2
- 239000000843 powder Substances 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- 235000016709 nutrition Nutrition 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/256—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin from seaweeds, e.g. alginates, agar or carrageenan
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/275—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of animal origin, e.g. chitin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/275—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of animal origin, e.g. chitin
- A23L29/281—Proteins, e.g. gelatin or collagen
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
- A23P20/10—Coating with edible coatings, e.g. with oils or fats
- A23P20/12—Apparatus or processes for applying powders or particles to foodstuffs, e.g. for breading; Such apparatus combined with means for pre-moistening or battering
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
- A61K9/5057—Gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/175—Rhamnosus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/531—Lactis
Abstract
substância probiótica microencapsulada e processo de fabricação partículas sólidas em pó seco contendo um micro-organismo probiótico e uma fase de transportador em que o referido micro-organismo probiótico é encapsulado, a referida fase transportadora compreendendo ainda pelo menos uma fonte nutritiva, referidas partículas sólidas em pó seco apresentam uma distribuição de tamanho de partícula entre n e (n + 400) <109>m, em que n está compreendido entre 100 e 10000 <109>m, de preferência, entre 300 a 5000 <109>m, mais preferencialmente entre 400 e 1000 <100>m.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11151686 | 2011-01-21 | ||
LU91782A LU91782B1 (fr) | 2011-01-21 | 2011-01-21 | Substance probiotique microencapsulee |
US201161503307P | 2011-06-30 | 2011-06-30 | |
PCT/EP2012/050895 WO2012098239A1 (en) | 2011-01-21 | 2012-01-20 | Microencapsulated probiotic substance and process of manufacture |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112013018344A2 true BR112013018344A2 (pt) | 2017-06-13 |
Family
ID=45773666
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013018344A BR112013018344A2 (pt) | 2011-01-21 | 2012-01-20 | substância probiótica microencapsulada e processo de fabricação |
Country Status (12)
Country | Link |
---|---|
US (1) | US9554590B2 (pt) |
EP (1) | EP2665377B1 (pt) |
JP (1) | JP5950938B2 (pt) |
CN (1) | CN103458709B (pt) |
BE (1) | BE1019142A3 (pt) |
BR (1) | BR112013018344A2 (pt) |
CA (1) | CA2825011C (pt) |
DK (1) | DK2665377T3 (pt) |
ES (1) | ES2627858T3 (pt) |
MY (1) | MY161543A (pt) |
RU (1) | RU2593327C2 (pt) |
WO (1) | WO2012098239A1 (pt) |
Families Citing this family (34)
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RS58325B1 (sr) * | 2013-04-23 | 2019-03-29 | Zx Pharma Llc | Enterosolventno obloženi višečestični preparat sa proteinskom sub-oblogom |
CN104642539B (zh) * | 2013-11-25 | 2018-02-09 | 内蒙古蒙牛乳业(集团)股份有限公司 | 一种益生菌颗粒,其制备方法,含有其的长保质期发酵乳及制备方法 |
US10624934B2 (en) * | 2014-03-06 | 2020-04-21 | Research Institute At Nationwide Children's Hospital | Prebiotic formulations |
EP3113630B1 (en) | 2014-03-06 | 2019-12-11 | The Research Institute at Nationwide Children's Hospital | Probiotic formulations and methods for use |
KR101640744B1 (ko) * | 2014-05-07 | 2016-07-19 | 일동제약주식회사 | 고분자 다당 바인더에 컨쥬게이트된 락토바실러스 람노서스 rht-3201, 및 이의 아토피 예방 및 치료 용도 |
JP6456377B2 (ja) * | 2014-06-10 | 2019-01-23 | ライオン株式会社 | 清酒酵母を含有する錠剤 |
EP3365027B1 (en) | 2015-10-14 | 2022-03-30 | Research Institute at Nationwide Children's Hospital | Hu specific antibodies and their use in inhibiting biofilm |
CN108066314A (zh) * | 2016-11-17 | 2018-05-25 | 中国科学院大连化学物理研究所 | 一种果胶为壁材的生物微球制备方法及应用 |
AU2018215216B2 (en) | 2017-01-31 | 2024-04-18 | Axiota U.S., Inc. | Microbial cells, methods of producing the same, and uses thereof |
US11191791B2 (en) | 2017-02-22 | 2021-12-07 | Praj Industries Limited | Preparation of dry formulations of dairy probiotics |
EP3600366A4 (en) * | 2017-03-27 | 2020-12-23 | Praj Industries Limited | PROCESS FOR THE PREPARATION OF PROBIOTIC POWDER FORMULATIONS FOR MONOGASTRIC ANIMALS |
WO2018181619A1 (ja) * | 2017-03-28 | 2018-10-04 | 味の素株式会社 | 腸内環境改善用食品 |
FR3065162B1 (fr) * | 2017-04-13 | 2019-06-28 | Universite De Bourgogne | Microcapsules de pectine, son procede de fabrication et ses utilisations |
US10514721B2 (en) * | 2017-05-08 | 2019-12-24 | International Business Machines Corporation | Validation of clock to provide security for time locked data |
WO2018230939A1 (ko) * | 2017-06-13 | 2018-12-20 | 부산대학교 산학협력단 | 산성 환경에서 프로바이오틱스를 보호하는 프로바이오틱스 전달용 하이드로겔 제제 및 이를 포함하는 프로바이오틱스 전달용 조성물 |
KR101999693B1 (ko) | 2017-06-13 | 2019-07-15 | 부산대학교 산학협력단 | 산성 환경에서 프로바이오틱스를 보호하는 프로바이오틱스 전달용 하이드로겔 제제 및 이를 포함하는 프로바이오틱스 전달용 조성물 |
CA3079562A1 (en) | 2017-10-20 | 2019-04-25 | Ms Biotech, Inc. | Methods of producing ensiled plant materials using megasphaera elsdenii |
CA3080442A1 (en) * | 2017-11-07 | 2019-05-16 | Purac Biochem B.V. | Acetate powder and method for the preparation thereof |
US20210015753A1 (en) * | 2017-11-27 | 2021-01-21 | Dsm Ip Assets B.V. | Freeze-dried multiparticulate solid dosage form |
BR112020016068A2 (pt) | 2018-02-08 | 2020-12-08 | Danisco Us Inc. | Partículas cera termicamente resistente matriz para encapsulamento de enzima |
CN108576371A (zh) * | 2018-03-30 | 2018-09-28 | 大连工业大学 | 一种微胶囊包埋的双蛋白肽及其制备方法 |
US20220273571A1 (en) * | 2019-08-07 | 2022-09-01 | Commonwealth Scientific And Industrial Research Organisation | Compositions of probiotics and biomass and methods for promoting health in a subject |
CN110522061B (zh) * | 2019-08-28 | 2021-09-14 | 青岛职业技术学院 | 一种微胶囊及其制备方法 |
WO2021061586A1 (en) * | 2019-09-24 | 2021-04-01 | Gpcp Ip Holdings Llc | Microencapsulated probiotic and compositions containing the same |
RU2740380C1 (ru) * | 2019-12-24 | 2021-01-13 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Биоинженерная конструкция на основе бактериального альгината и пробиотических бактерий и способ ее получения |
CN112273658A (zh) * | 2020-11-11 | 2021-01-29 | 郑州工业应用技术学院 | 一种基于内源乳化的双歧杆菌微胶囊的制备方法 |
CN112375703A (zh) * | 2020-11-12 | 2021-02-19 | 安徽燕婉健康科技有限公司 | 一种治疗型乳源性复合益生菌及其制备方法与应用 |
KR20230169127A (ko) * | 2021-04-13 | 2023-12-15 | 일루미나 케임브리지 리미티드 | 캡슐화된 동결건조 미소구체를 제조 및 사용하는 조성물, 시스템, 및 방법 |
CN117242177A (zh) * | 2021-05-11 | 2023-12-15 | 大日本印刷株式会社 | 干燥微载体及其制造方法 |
CN113730250B (zh) * | 2021-07-19 | 2023-08-25 | 珠海凤凰高科生物制药有限公司 | 一种益生菌粉末再处理方法 |
KR102464572B1 (ko) * | 2022-03-22 | 2022-11-10 | 대한켐텍 주식회사 | 프로바이오틱스 캡슐제 |
WO2023209224A1 (en) | 2022-04-29 | 2023-11-02 | Université Libre de Bruxelles | Probiotics for the prevention or treatment of viral respiratory infections |
CN115777937B (zh) * | 2023-01-30 | 2023-05-16 | 山东瑞安泰医疗技术有限公司 | 一种内嵌多元营养微球的减节食胶囊及其制备方法 |
CN117586930B (zh) * | 2024-01-19 | 2024-04-16 | 北京市农林科学院 | 一种用于降解展青霉素的微囊材料及其制备方法和应用 |
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JPS60221078A (ja) | 1984-04-18 | 1985-11-05 | Morinaga Milk Ind Co Ltd | 有用微生物粉末の粒状製品およびその製造法 |
KR100387245B1 (ko) * | 1997-10-17 | 2003-08-19 | 일양약품주식회사 | 유산균의안정화를위한미세장용성코팅과립 |
PT1065936E (pt) | 1998-03-23 | 2009-09-24 | Gen Mills Inc | Encapsulação de componentes em produtos comestíveis |
EP1344458A1 (en) * | 2002-03-12 | 2003-09-17 | Société des Produits Nestlé S.A. | Probiotic delivery system |
US20050266069A1 (en) * | 2002-09-06 | 2005-12-01 | Simmons Donald L | Stable probiotic microsphere compositions and their methods of preparation |
US20040247580A1 (en) | 2003-06-06 | 2004-12-09 | Myung-Jun Chung | Process for preparing double-coated lactic acid bacteria powder using protein and polysaccharide and product by the same |
CN1613455A (zh) * | 2003-11-04 | 2005-05-11 | 北京东方百信生物技术有限公司 | 靶向益生菌微胶囊及其制备方法 |
US20060099247A1 (en) * | 2004-11-10 | 2006-05-11 | Byrd-Walsh, Llc. | Liquid, gas and/or vapor phase delivery systems |
ATE515198T1 (de) * | 2005-05-18 | 2011-07-15 | Dsm Ip Assets Bv | Zusammensetzung für die enterale verabreichung von mikroorganismen |
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CN101323850B (zh) * | 2008-07-28 | 2011-05-04 | 天津科技大学 | 瑞士乳杆菌微胶囊及其制备与应用 |
-
2011
- 2011-11-02 BE BE2011/0633A patent/BE1019142A3/fr active
-
2012
- 2012-01-20 CN CN201280005852.9A patent/CN103458709B/zh not_active Expired - Fee Related
- 2012-01-20 WO PCT/EP2012/050895 patent/WO2012098239A1/en active Application Filing
- 2012-01-20 US US13/980,526 patent/US9554590B2/en active Active
- 2012-01-20 JP JP2013549833A patent/JP5950938B2/ja not_active Expired - Fee Related
- 2012-01-20 DK DK12700703.7T patent/DK2665377T3/en active
- 2012-01-20 RU RU2013138291/13A patent/RU2593327C2/ru not_active IP Right Cessation
- 2012-01-20 MY MYPI2013002688A patent/MY161543A/en unknown
- 2012-01-20 BR BR112013018344A patent/BR112013018344A2/pt not_active Application Discontinuation
- 2012-01-20 CA CA2825011A patent/CA2825011C/en not_active Expired - Fee Related
- 2012-01-20 ES ES12700703.7T patent/ES2627858T3/es active Active
- 2012-01-20 EP EP12700703.7A patent/EP2665377B1/en active Active
Also Published As
Publication number | Publication date |
---|---|
BE1019142A3 (fr) | 2012-03-06 |
RU2593327C2 (ru) | 2016-08-10 |
CN103458709B (zh) | 2017-10-03 |
MY161543A (en) | 2017-04-28 |
EP2665377B1 (en) | 2017-03-08 |
CA2825011C (en) | 2019-09-03 |
DK2665377T3 (en) | 2017-06-19 |
CA2825011A1 (en) | 2012-07-26 |
JP5950938B2 (ja) | 2016-07-13 |
WO2012098239A1 (en) | 2012-07-26 |
US20140010918A1 (en) | 2014-01-09 |
US9554590B2 (en) | 2017-01-31 |
JP2014502989A (ja) | 2014-02-06 |
RU2013138291A (ru) | 2015-02-27 |
EP2665377A1 (en) | 2013-11-27 |
CN103458709A (zh) | 2013-12-18 |
ES2627858T3 (es) | 2017-07-31 |
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