BR112013002250A2 - composto, medicamento, método para a profilaxia ou tratamento de depressão, esquisofrenia, mal de alzheimer ou distúrbio de hiperatividade e déficit de atenção, e, uso de um composto. - Google Patents
composto, medicamento, método para a profilaxia ou tratamento de depressão, esquisofrenia, mal de alzheimer ou distúrbio de hiperatividade e déficit de atenção, e, uso de um composto.Info
- Publication number
- BR112013002250A2 BR112013002250A2 BR112013002250A BR112013002250A BR112013002250A2 BR 112013002250 A2 BR112013002250 A2 BR 112013002250A2 BR 112013002250 A BR112013002250 A BR 112013002250A BR 112013002250 A BR112013002250 A BR 112013002250A BR 112013002250 A2 BR112013002250 A2 BR 112013002250A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- schisophrenia
- depression
- disease
- attention deficit
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
composto, medicamento, método para a profilaxia ou tratamento de depressão, esquisofrenia, mal dealzheimer ou distúrbio de hiperatividade e déficit de atenção, e, uso de um composto - é fornecido um composto representado pela fórmula (i): em que cada símbolo é como definido no relatório descritivo, ou um sal deste, que tem uma ação potenciadora do receptor de ampa (ácido <244>-amido-3hidróxi-5-metil-4-isoxazolpropiônico). o composto da presente invenção é útil como um medicamento profilático ou terapêutico para a depressão, esquisofrenia, mal de alzheimer ou distúrbio de hiperatividade e déficit de atenção (adhd) e os semelhantes.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010179577 | 2010-08-10 | ||
| JP2010-179577 | 2010-08-10 | ||
| PCT/JP2011/068497 WO2012020848A1 (en) | 2010-08-10 | 2011-08-09 | Heterocyclic compound and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112013002250A2 true BR112013002250A2 (pt) | 2016-05-24 |
| BR112013002250B1 BR112013002250B1 (pt) | 2020-10-27 |
Family
ID=44534564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013002250-7A BR112013002250B1 (pt) | 2010-08-10 | 2011-08-09 | composto, composição farmacêutica, e, uso de um composto |
Country Status (38)
| Country | Link |
|---|---|
| US (10) | US9150591B2 (pt) |
| EP (1) | EP2603513B1 (pt) |
| JP (2) | JP5788496B2 (pt) |
| KR (1) | KR101852215B1 (pt) |
| CN (2) | CN103180326B (pt) |
| AR (1) | AR082618A1 (pt) |
| AU (1) | AU2011290126B2 (pt) |
| BR (1) | BR112013002250B1 (pt) |
| CA (1) | CA2807460C (pt) |
| CL (1) | CL2013000380A1 (pt) |
| CO (1) | CO6680700A2 (pt) |
| CR (1) | CR20130066A (pt) |
| CY (1) | CY1123507T1 (pt) |
| DK (1) | DK2603513T3 (pt) |
| DO (1) | DOP2013000030A (pt) |
| EA (1) | EA022078B1 (pt) |
| EC (1) | ECSP13012478A (pt) |
| ES (1) | ES2793723T3 (pt) |
| GE (1) | GEP20156216B (pt) |
| HR (1) | HRP20200844T1 (pt) |
| HU (1) | HUE049460T2 (pt) |
| IL (1) | IL224452A (pt) |
| LT (1) | LT2603513T (pt) |
| MA (1) | MA34509B1 (pt) |
| MX (1) | MX349470B (pt) |
| MY (1) | MY165908A (pt) |
| NZ (1) | NZ607593A (pt) |
| PE (1) | PE20131116A1 (pt) |
| PL (1) | PL2603513T3 (pt) |
| PT (1) | PT2603513T (pt) |
| RS (1) | RS60311B1 (pt) |
| SG (1) | SG187656A1 (pt) |
| SI (1) | SI2603513T1 (pt) |
| TW (1) | TWI504604B (pt) |
| UA (1) | UA111594C2 (pt) |
| UY (1) | UY33551A (pt) |
| WO (1) | WO2012020848A1 (pt) |
| ZA (1) | ZA201301120B (pt) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR082618A1 (es) * | 2010-08-10 | 2012-12-19 | Takeda Pharmaceutical | Derivados de tiadiazina, composiciones farmaceuticas y usos |
| WO2012137982A2 (en) * | 2011-04-05 | 2012-10-11 | Takeda Pharmaceutical Company Limited | Sulfonamide derivative and use thereof |
| WO2013118845A1 (ja) * | 2012-02-08 | 2013-08-15 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| CA2915405A1 (en) * | 2013-06-13 | 2014-12-18 | Veroscience Llc | Compositions and methods for treating metabolic disorders |
| CN105324376B (zh) | 2013-06-27 | 2017-06-23 | 辉瑞大药厂 | 杂芳族化合物及其作为多巴胺d1配体的用途 |
| US11589583B2 (en) | 2013-12-03 | 2023-02-28 | Fmc Corporation | Pyrrolidinones herbicides |
| SI3077374T1 (sl) | 2013-12-03 | 2020-07-31 | Fmc Corporation | Pirolidinoni kot herbicidi |
| AU2015284280C1 (en) | 2014-07-02 | 2020-02-13 | Fmc Corporation | Piperidinone herbicides |
| BR112017009701B1 (pt) | 2014-12-08 | 2021-09-08 | Fmc Corporation | Composto e métodos de preparação de compostos |
| BR112017017945B1 (pt) | 2015-04-10 | 2021-06-08 | Fmc Corporation | composto, composições herbicidas, mistura herbicida e método de controle do crescimento de vegetação indesejada |
| WO2016176082A1 (en) | 2015-04-27 | 2016-11-03 | E I Du Pont De Nemours And Company | Butyrolactones as herbicides |
| BR112017023038A2 (pt) * | 2015-04-29 | 2018-07-03 | Janssen Pharmaceutica Nv | imidazopirazinas e pirazolopirimidinas e seu uso como moduladores do receptor ampa |
| WO2016176460A1 (en) | 2015-04-29 | 2016-11-03 | Janssen Pharmaceutica Nv | Azabenzimidazoles and their use as ampa receptor modulators |
| CN107592862B (zh) | 2015-05-12 | 2021-06-15 | Fmc公司 | 作为除草剂的芳基取代的双环化合物 |
| US10906873B2 (en) | 2015-05-29 | 2021-02-02 | Fmc Corporation | Substituted cyclic amides as herbicides |
| EP3303321A1 (en) | 2015-06-02 | 2018-04-11 | E. I. du Pont de Nemours and Company | Substituted cyclic amides and their use as herbicides |
| AU2016303209B2 (en) | 2015-07-31 | 2021-04-01 | Fmc Corporation | Cyclic N-carboxamide compounds useful as herbicides |
| SI3331892T1 (sl) * | 2015-08-06 | 2019-10-30 | Hoffmann La Roche | Postopki za pripravo derivatov gaINAc kisline |
| TW201713774A (zh) | 2015-08-06 | 2017-04-16 | Kohjin Life Sciences Co Ltd | 含有β-菸鹼醯胺單核苷酸的酵母萃取物及其製造方法 |
| US20170181292A1 (en) * | 2015-12-16 | 2017-06-22 | Rohm And Haas Electronic Materials Llc | Method for forming organic coating on nickel surface |
| CN105669731B (zh) * | 2016-01-10 | 2017-06-30 | 沧州普瑞东方科技有限公司 | 一种4‑(4‑烷基环己氧基)苯硼酸的合成方法 |
| BR112019012910B1 (pt) | 2016-12-21 | 2023-10-17 | Fmc Corporation | Composto, composição herbicida, mistura herbicida e método para controlar o crescimento de vegetação indesejável |
| CN107892697B (zh) | 2016-12-26 | 2020-11-03 | 郑州泰基鸿诺医药股份有限公司 | 一种[1,3]噻嗪-2-胺类化合物及应用，药物组合物 |
| BR112019019605B1 (pt) | 2017-03-21 | 2023-03-07 | Fmc Corporation | Compostos e processo para preparar um composto de fórmula ii-a |
| CA3057300A1 (en) | 2017-03-21 | 2018-09-27 | Fmc Corporation | Herbicidal mixture, composition and method |
| AR111967A1 (es) | 2017-05-30 | 2019-09-04 | Fmc Corp | Amidas herbicidas |
| AR111839A1 (es) | 2017-05-30 | 2019-08-21 | Fmc Corp | Lactamas 3-sustituidas herbicidas |
| EP3693368B1 (en) * | 2017-10-06 | 2023-12-06 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| EP3693360B1 (en) * | 2017-10-06 | 2023-12-13 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds |
| EP4149478A1 (en) | 2020-05-15 | 2023-03-22 | Takeda Pharmaceutical Company Limited | Treatment for depression |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JPH0437742Y2 (pt) | 1986-10-22 | 1992-09-04 | ||
| JPH0285851A (ja) * | 1988-09-22 | 1990-03-27 | Konica Corp | 新規な写真用カプラー |
| JPH037742A (ja) | 1989-06-05 | 1991-01-14 | Toyo Tire & Rubber Co Ltd | ラバーチエーン用ゴム組成物 |
| JP2874960B2 (ja) * | 1990-06-03 | 1999-03-24 | コニカ株式会社 | 新規な染料を含有するハロゲン化銀写真感光材料 |
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| FR2801587B1 (fr) | 1999-11-30 | 2002-01-11 | Adir | Nouveaux derives de benzothiadiazines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| JP2005508352A (ja) * | 2001-10-10 | 2005-03-31 | ニューロサーチ、アクティーゼルスカブ | 新規ベンゾチアジン誘導体、その製造方法及びその使用方法 |
| FR2833955B1 (fr) * | 2001-12-21 | 2004-01-30 | Servier Lab | Nouveaux derives de benzothiazine et de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2854634B1 (fr) | 2003-05-05 | 2005-07-08 | Servier Lab | Nouveaux derives de thiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2865474B1 (fr) | 2004-01-26 | 2008-06-13 | Servier Lab | Nouveaux derives de benzothiazines fluorees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2879201B1 (fr) * | 2004-12-10 | 2007-02-16 | Servier Lab | Nouveaux derives de benzothiazine et benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| AU2007100527A4 (en) | 2006-06-23 | 2007-08-23 | Nufarm Australia Limited | Phenoxy alkanoate herbicidal composition and method of preparation and use |
| EP2102153A1 (en) * | 2006-12-11 | 2009-09-23 | Eli Lilly & Company | Ampa receptor potentiators |
| US20080167374A1 (en) | 2007-01-09 | 2008-07-10 | Loveland Products, Inc. | Pesticide composition and method of use |
| JP2011503002A (ja) * | 2007-11-05 | 2011-01-27 | シェーリング コーポレイション | γセクレターゼ調節剤 |
| WO2009086303A2 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| EP2269990A4 (en) | 2008-03-25 | 2012-04-18 | Takeda Pharmaceutical | HETEROCYCLIC COMPOUND |
| JP2009248543A (ja) * | 2008-04-11 | 2009-10-29 | Fujifilm Corp | 光情報記録媒体および情報記録方法 |
| TW201012803A (en) | 2008-06-06 | 2010-04-01 | Organon Nv | Heterocyclic derivatives |
| AU2009313527A1 (en) | 2008-11-06 | 2010-05-14 | Merck Sharp & Dohme Corp. | Gamma secretase modulators |
| TW201030002A (en) | 2009-01-16 | 2010-08-16 | Bristol Myers Squibb Co | Bicyclic compounds for the reduction of beta-amyloid production |
| JP2012051806A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | イミダゾリルピラジン誘導体 |
| FR2943342B1 (fr) | 2009-03-20 | 2011-03-04 | Servier Lab | Nouveaux derives de benzothiadiazepines,leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| WO2010140339A1 (ja) | 2009-06-01 | 2010-12-09 | 武田薬品工業株式会社 | 複素環化合物 |
| JPWO2011007756A1 (ja) | 2009-07-13 | 2012-12-27 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
| WO2011036889A1 (ja) | 2009-09-25 | 2011-03-31 | 武田薬品工業株式会社 | 複素環化合物 |
| WO2011036885A1 (ja) | 2009-09-25 | 2011-03-31 | 武田薬品工業株式会社 | 複素環化合物 |
| AR082618A1 (es) * | 2010-08-10 | 2012-12-19 | Takeda Pharmaceutical | Derivados de tiadiazina, composiciones farmaceuticas y usos |
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2011
- 2011-08-09 AR ARP110102905A patent/AR082618A1/es active IP Right Grant
- 2011-08-09 DK DK11749944.2T patent/DK2603513T3/da active
- 2011-08-09 MA MA35708A patent/MA34509B1/fr unknown
- 2011-08-09 ES ES11749944T patent/ES2793723T3/es active Active
- 2011-08-09 EP EP11749944.2A patent/EP2603513B1/en active Active
- 2011-08-09 GE GEAP201113021A patent/GEP20156216B/en unknown
- 2011-08-09 CN CN201180048970.3A patent/CN103180326B/zh active Active
- 2011-08-09 MX MX2013001614A patent/MX349470B/es active IP Right Grant
- 2011-08-09 BR BR112013002250-7A patent/BR112013002250B1/pt active IP Right Grant
- 2011-08-09 UY UY0001033551A patent/UY33551A/es not_active Application Discontinuation
- 2011-08-09 JP JP2013506362A patent/JP5788496B2/ja active Active
- 2011-08-09 US US13/816,137 patent/US9150591B2/en active Active
- 2011-08-09 AU AU2011290126A patent/AU2011290126B2/en active Active
- 2011-08-09 LT LTEP11749944.2T patent/LT2603513T/lt unknown
- 2011-08-09 TW TW100128311A patent/TWI504604B/zh active
- 2011-08-09 PL PL11749944T patent/PL2603513T3/pl unknown
- 2011-08-09 PT PT117499442T patent/PT2603513T/pt unknown
- 2011-08-09 SI SI201131887T patent/SI2603513T1/sl unknown
- 2011-08-09 CA CA2807460A patent/CA2807460C/en active Active
- 2011-08-09 SG SG2013007463A patent/SG187656A1/en unknown
- 2011-08-09 MY MYPI2013000428A patent/MY165908A/en unknown
- 2011-08-09 EA EA201390222A patent/EA022078B1/ru not_active IP Right Cessation
- 2011-08-09 RS RS20200574A patent/RS60311B1/sr unknown
- 2011-08-09 NZ NZ607593A patent/NZ607593A/en unknown
- 2011-08-09 WO PCT/JP2011/068497 patent/WO2012020848A1/en active Application Filing
- 2011-08-09 PE PE2013000244A patent/PE20131116A1/es active IP Right Grant
- 2011-08-09 CN CN201510259936.0A patent/CN104926837A/zh active Pending
- 2011-08-09 HU HUE11749944A patent/HUE049460T2/hu unknown
- 2011-08-09 KR KR1020137006113A patent/KR101852215B1/ko active IP Right Grant
- 2011-08-09 US US13/206,113 patent/US8575154B2/en active Active
- 2011-09-08 UA UAA201302884A patent/UA111594C2/uk unknown
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2013
- 2013-01-28 IL IL224452A patent/IL224452A/en active IP Right Grant
- 2013-02-05 DO DO2013000030A patent/DOP2013000030A/es unknown
- 2013-02-07 CL CL2013000380A patent/CL2013000380A1/es unknown
- 2013-02-12 ZA ZA2013/01120A patent/ZA201301120B/en unknown
- 2013-02-18 CR CR20130066A patent/CR20130066A/es unknown
- 2013-02-22 US US13/774,635 patent/US8778934B2/en active Active
- 2013-02-22 US US13/774,707 patent/US8916551B2/en active Active
- 2013-03-06 EC ECSP13012478 patent/ECSP13012478A/es unknown
- 2013-03-07 CO CO13046020A patent/CO6680700A2/es active IP Right Grant
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2014
- 2014-11-13 US US14/540,699 patent/US20150073137A1/en not_active Abandoned
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2015
- 2015-07-21 US US14/804,935 patent/US9499568B2/en active Active
- 2015-07-29 JP JP2015149216A patent/JP6113789B2/ja active Active
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2016
- 2016-10-10 US US15/289,650 patent/US9884875B2/en active Active
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2017
- 2017-12-18 US US15/845,621 patent/US20180162875A1/en not_active Abandoned
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2019
- 2019-01-24 US US16/256,773 patent/US10654874B2/en active Active
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2020
- 2020-03-23 US US16/827,316 patent/US11279713B2/en active Active
- 2020-05-25 CY CY20201100475T patent/CY1123507T1/el unknown
- 2020-05-25 HR HRP20200844TT patent/HRP20200844T1/hr unknown
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