BR112013000537A2 - composição aquosa contendo bromexina - Google Patents
composição aquosa contendo bromexinaInfo
- Publication number
- BR112013000537A2 BR112013000537A2 BR112013000537A BR112013000537A BR112013000537A2 BR 112013000537 A2 BR112013000537 A2 BR 112013000537A2 BR 112013000537 A BR112013000537 A BR 112013000537A BR 112013000537 A BR112013000537 A BR 112013000537A BR 112013000537 A2 BR112013000537 A2 BR 112013000537A2
- Authority
- BR
- Brazil
- Prior art keywords
- bromhexine
- composition
- containing aqueous
- aqueous composition
- aqueous
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/12—Mucolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
composição aquosa contendo bromexina. a presente invenção refere-se a uma composição aquosa contendo bromexina, em que a composição apresenta uma quantidade de álcoois de açúcar de menos de 10 g com base em 100 ml da composição, bem como seu uso para a terapia secretolítica em doenças broncopulmonares agudas e crônicas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10169236 | 2010-07-12 | ||
EP10169236.6 | 2010-07-12 | ||
PCT/EP2011/061527 WO2012007352A1 (de) | 2010-07-12 | 2011-07-07 | Wässrige zusammensetzung enthaltend bromhexin |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112013000537A2 true BR112013000537A2 (pt) | 2016-05-24 |
BR112013000537B1 BR112013000537B1 (pt) | 2021-07-27 |
Family
ID=43063562
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013000537-8A BR112013000537B1 (pt) | 2010-07-12 | 2011-07-07 | Composição aquosa contendo bromexina e seu uso |
Country Status (26)
Country | Link |
---|---|
US (1) | US9220693B2 (pt) |
EP (1) | EP2593094B1 (pt) |
JP (1) | JP5979763B2 (pt) |
KR (1) | KR101943812B1 (pt) |
CN (1) | CN103052384B (pt) |
AR (1) | AR082381A1 (pt) |
AU (1) | AU2011278451B2 (pt) |
BR (1) | BR112013000537B1 (pt) |
CA (1) | CA2803471C (pt) |
CL (1) | CL2012003625A1 (pt) |
CO (1) | CO6680609A2 (pt) |
CY (1) | CY1120079T1 (pt) |
DK (1) | DK2593094T3 (pt) |
EA (1) | EA025640B1 (pt) |
EC (1) | ECSP13012384A (pt) |
ES (1) | ES2661973T3 (pt) |
HR (1) | HRP20180396T1 (pt) |
HU (1) | HUE038399T2 (pt) |
LT (1) | LT2593094T (pt) |
MX (1) | MX337454B (pt) |
PE (1) | PE20131063A1 (pt) |
PL (1) | PL2593094T3 (pt) |
PT (1) | PT2593094T (pt) |
SG (1) | SG187016A1 (pt) |
SI (1) | SI2593094T1 (pt) |
WO (1) | WO2012007352A1 (pt) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112013000537B1 (pt) | 2010-07-12 | 2021-07-27 | Boehringer Ingelheim International Gmbh | Composição aquosa contendo bromexina e seu uso |
US9303038B2 (en) | 2011-09-06 | 2016-04-05 | Cellix Bio Private Limited | Compositions and methods for the treatment of epilepsy and neurological diseases |
US9399634B2 (en) | 2012-05-07 | 2016-07-26 | Cellix Bio Private Limited | Compositions and methods for the treatment of depression |
AU2013257706A1 (en) | 2012-05-07 | 2014-11-27 | Cellixbio Private Limited | Compositions and methods for the treatment of neurological disorders |
AU2013257742A1 (en) | 2012-05-07 | 2014-11-27 | Cellixbio Private Limited | Compositions and methods for treatment of neuromuscular disorders and neurodegenerative disorders |
US9403826B2 (en) | 2012-05-08 | 2016-08-02 | Cellix Bio Private Limited | Compositions and methods for the treatment of inflammatory disorders |
WO2013167991A1 (en) | 2012-05-08 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of metabolic disorders |
US9434704B2 (en) | 2012-05-08 | 2016-09-06 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological degenerative disorders |
WO2013168023A1 (en) | 2012-05-08 | 2013-11-14 | Mahesh Kandula | Compositions and methods for treatment of parkinson's disease |
US9309233B2 (en) | 2012-05-08 | 2016-04-12 | Cellix Bio Private Limited | Compositions and methods for the treatment of blood clotting disorders |
WO2013168000A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of severe pain |
US9273061B2 (en) | 2012-05-10 | 2016-03-01 | Cellix Bio Private Limited | Compositions and methods for the treatment of chronic pain |
WO2013168015A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of asthma and allergy |
US9242939B2 (en) | 2012-05-10 | 2016-01-26 | Cellix Bio Private Limited | Compositions and methods for the treatment of respiratory disorders |
WO2013168004A2 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of fibromyalgia pain |
US9315478B2 (en) | 2012-05-10 | 2016-04-19 | Cellix Bio Private Limited | Compositions and methods for the treatment of metabolic syndrome |
SG11201407318UA (en) | 2012-05-10 | 2014-12-30 | Cellix Bio Private Ltd | Compositions and methods for the treatment of metabolic syndrome |
US9321775B2 (en) | 2012-05-10 | 2016-04-26 | Cellix Bio Private Limited | Compositions and methods for the treatment of moderate to severe pain |
WO2013168033A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for treatment of neurologic diseases |
US9233161B2 (en) | 2012-05-10 | 2016-01-12 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological conditions |
WO2013168014A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of familial amyloid polyneuropathy |
US9315461B2 (en) | 2012-05-10 | 2016-04-19 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurologic diseases |
US9339484B2 (en) | 2012-05-10 | 2016-05-17 | Cellix Bio Private Limited | Compositions and methods for the treatment of restless leg syndrome and fibromyalgia |
WO2013175376A2 (en) | 2012-05-23 | 2013-11-28 | Mahesh Kandula | Compositions and methods for the treatment of local pain |
EP2852569B1 (en) | 2012-05-23 | 2020-10-14 | Cellixbio Private Limited | Compositions and methods for the treatment of multiple sclerosis |
WO2013175344A2 (en) | 2012-05-23 | 2013-11-28 | Mahesh Kandula | Compositions and methods for the treatment of periodontitis and rheumatoid arthritis |
US9227974B2 (en) | 2012-05-23 | 2016-01-05 | Cellex Bio Private Limited | Compositions and methods for the treatment of respiratory disorders |
NZ701832A (en) | 2012-05-23 | 2016-08-26 | Cellix Bio Private Ltd | Compositions and methods for treatment of inflammatory bowel disease |
SG11201407326XA (en) | 2012-05-23 | 2014-12-30 | Cellix Bio Private Ltd | Compositions and methods for treatment of mucositis |
US9108942B1 (en) | 2014-11-05 | 2015-08-18 | Mahesh Kandula | Compositions and methods for the treatment of moderate to severe pain |
WO2014020480A2 (en) | 2012-08-03 | 2014-02-06 | Mahesh Kandula | Compositions and methods for the treatment migraine and neurologic diseases |
US9624168B2 (en) | 2012-09-06 | 2017-04-18 | Cellix Bio Private Limited | Compositions and methods for the treatment inflammation and lipid disorders |
CA2873029A1 (en) | 2012-09-08 | 2014-03-13 | Cellixbio Private Limited | Compositions and methods for the treatment of inflammation and lipid disorders |
JP6017249B2 (ja) * | 2012-09-28 | 2016-10-26 | 小林製薬株式会社 | 経口投与用液体医薬組成物 |
US9333187B1 (en) | 2013-05-15 | 2016-05-10 | Cellix Bio Private Limited | Compositions and methods for the treatment of inflammatory bowel disease |
SG11201509782TA (en) | 2013-06-04 | 2015-12-30 | Cellix Bio Private Ltd | Compositions and methods for the treatment of diabetes and pre-diabetes |
US9096537B1 (en) | 2014-12-31 | 2015-08-04 | Mahesh Kandula | Compositions and methods for the treatment of mucositis |
CN103893116B (zh) * | 2014-04-17 | 2015-12-09 | 河北仁合益康药业有限公司 | 一种盐酸溴己新口服液组合物 |
WO2015177147A1 (de) * | 2014-05-23 | 2015-11-26 | Boehringer Ingelheim International Gmbh | Hustensaft enthaltend ambroxol hydrochlorid |
EP3240779B1 (en) | 2014-09-26 | 2020-10-28 | Cellixbio Private Limited | Compositions and methods for the treatment of epilepsy and neurological disorders |
WO2016051420A1 (en) | 2014-09-29 | 2016-04-07 | Cellix Bio Private Limited | Compositions and methods for the treatment of multiple sclerosis |
EP3212626B1 (en) | 2014-10-27 | 2018-11-07 | Cellix Bio Private Limited | Three component salts of fumaric acid monomethyl ester with piperazine or ethylene diamine for the treatment of multiple sclerosis |
US9290486B1 (en) | 2014-11-05 | 2016-03-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of epilepsy |
US9173877B1 (en) | 2014-11-05 | 2015-11-03 | Cellix Bio Private Limited | Compositions and methods for the treatment of local pain |
US9321716B1 (en) | 2014-11-05 | 2016-04-26 | Cellix Bio Private Limited | Compositions and methods for the treatment of metabolic syndrome |
US9150557B1 (en) | 2014-11-05 | 2015-10-06 | Cellix Bio Private Limited | Compositions and methods for the treatment of hyperglycemia |
US9175008B1 (en) | 2014-11-05 | 2015-11-03 | Cellix Bio Private Limited | Prodrugs of anti-platelet agents |
US10208014B2 (en) | 2014-11-05 | 2019-02-19 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological disorders |
US9284287B1 (en) | 2014-11-05 | 2016-03-15 | Cellix Bio Private Limited | Compositions and methods for the suppression of carbonic anhydrase activity |
US9932294B2 (en) | 2014-12-01 | 2018-04-03 | Cellix Bio Private Limited | Compositions and methods for the treatment of multiple sclerosis |
US9206111B1 (en) | 2014-12-17 | 2015-12-08 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological diseases |
SG11201705524SA (en) | 2015-01-06 | 2017-08-30 | Cellix Bio Private Ltd | Compositions and methods for the treatment of inflammation and pain |
CN111568861A (zh) * | 2020-05-25 | 2020-08-25 | 河北科星药业有限公司 | 畜禽用盐酸溴己新口服液及其制备方法和应用 |
CN111714477B (zh) * | 2020-07-23 | 2021-06-15 | 山东迅达康兽药有限公司 | 祛痰组合物及其口服液制备方法 |
CN113109463B (zh) * | 2021-03-16 | 2022-11-25 | 浙江工业大学 | 一种复方氯丙那林溴己新胶囊中有关物质的检测方法 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH085784B2 (ja) | 1987-06-17 | 1996-01-24 | 興和株式会社 | シロツプ剤 |
US5624906A (en) * | 1994-12-08 | 1997-04-29 | Lever Brothers Company, Division Of Conopco, Inc. | Oral hygiene compositions comprising heteroatom containing alkyl aldonamide compounds |
US6231890B1 (en) | 1996-05-02 | 2001-05-15 | Taisho Pharmaceutical Co., Ltd. | Suspension of sparingly water-soluble acidic drug |
JP3800437B2 (ja) | 1996-07-24 | 2006-07-26 | 大正製薬株式会社 | 苦味が軽減された液剤 |
JPH10101581A (ja) | 1996-09-26 | 1998-04-21 | Taisho Pharmaceut Co Ltd | 塩酸ブロムヘキシンの安定化製剤及び安定化方法 |
JPH10306038A (ja) | 1997-05-07 | 1998-11-17 | Taisho Pharmaceut Co Ltd | ブロムヘキシン含有液剤 |
JP2000281562A (ja) * | 1999-03-30 | 2000-10-10 | Taisho Pharmaceut Co Ltd | ゲル状組成物 |
JP2001106639A (ja) * | 1999-10-04 | 2001-04-17 | Taisho Pharmaceut Co Ltd | 経口用組成物 |
EP1121940A1 (en) | 2000-01-31 | 2001-08-08 | New Pharma Research Sweden AB | Pharmaceutical compositions comprising an antibiotic and bromhexine, and process for their preparation |
JP2002081562A (ja) | 2000-09-05 | 2002-03-22 | Kayaba Ind Co Ltd | リリーフ弁 |
US6692725B2 (en) * | 2001-02-19 | 2004-02-17 | Daicel Chemical Industries, Ltd. | Composition for oral care |
US7138133B2 (en) * | 2001-10-10 | 2006-11-21 | The Procter & Gamble Company | Orally administered liquid compositions |
JP5134802B2 (ja) | 2005-09-29 | 2013-01-30 | 第一三共ヘルスケア株式会社 | 塩酸ブロムヘキシン含有量低下の防止方法 |
US10022339B2 (en) * | 2006-04-21 | 2018-07-17 | The Procter & Gamble Company | Compositions and methods useful for treatment of respiratory illness |
JP2008013542A (ja) * | 2006-06-07 | 2008-01-24 | Daiichi Sankyo Healthcare Co Ltd | 去痰又は気道杯細胞過形成抑制のための医薬組成物 |
CN100409835C (zh) * | 2007-04-06 | 2008-08-13 | 张嵩 | 含有溴己新盐的组合物及大容量注射剂和注射剂制备方法 |
KR101025498B1 (ko) * | 2008-05-02 | 2011-03-31 | (주)이엘티사이언스 | 염산브롬헥신 경구용 액제 복합조성물 및 그 제조방법 |
BR112013000537B1 (pt) | 2010-07-12 | 2021-07-27 | Boehringer Ingelheim International Gmbh | Composição aquosa contendo bromexina e seu uso |
-
2011
- 2011-07-07 BR BR112013000537-8A patent/BR112013000537B1/pt active IP Right Grant
- 2011-07-07 PL PL11733637T patent/PL2593094T3/pl unknown
- 2011-07-07 EP EP11733637.0A patent/EP2593094B1/de active Active
- 2011-07-07 PE PE2013000041A patent/PE20131063A1/es not_active Application Discontinuation
- 2011-07-07 US US13/808,417 patent/US9220693B2/en active Active
- 2011-07-07 EA EA201201659A patent/EA025640B1/ru not_active IP Right Cessation
- 2011-07-07 CN CN201180033796.5A patent/CN103052384B/zh active Active
- 2011-07-07 PT PT117336370T patent/PT2593094T/pt unknown
- 2011-07-07 MX MX2013000417A patent/MX337454B/es active IP Right Grant
- 2011-07-07 SG SG2013002019A patent/SG187016A1/en unknown
- 2011-07-07 AU AU2011278451A patent/AU2011278451B2/en active Active
- 2011-07-07 DK DK11733637.0T patent/DK2593094T3/en active
- 2011-07-07 JP JP2013519036A patent/JP5979763B2/ja active Active
- 2011-07-07 WO PCT/EP2011/061527 patent/WO2012007352A1/de active Application Filing
- 2011-07-07 SI SI201131443T patent/SI2593094T1/en unknown
- 2011-07-07 LT LTEP11733637.0T patent/LT2593094T/lt unknown
- 2011-07-07 CA CA2803471A patent/CA2803471C/en not_active Expired - Fee Related
- 2011-07-07 KR KR1020137000722A patent/KR101943812B1/ko active IP Right Grant
- 2011-07-07 ES ES11733637.0T patent/ES2661973T3/es active Active
- 2011-07-07 HU HUE11733637A patent/HUE038399T2/hu unknown
- 2011-07-11 AR ARP110102491A patent/AR082381A1/es not_active Application Discontinuation
-
2012
- 2012-12-20 CL CL2012003625A patent/CL2012003625A1/es unknown
-
2013
- 2013-01-11 CO CO13004940A patent/CO6680609A2/es not_active Application Discontinuation
- 2013-01-12 EC ECSP13012384 patent/ECSP13012384A/es unknown
-
2018
- 2018-03-06 CY CY20181100277T patent/CY1120079T1/el unknown
- 2018-03-06 HR HRP20180396TT patent/HRP20180396T1/hr unknown
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Legal Events
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07E | Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 07/07/2011, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO. |