BR112012031406A2 - processo para a preparação de derivados de di-hidropirrol - Google Patents

processo para a preparação de derivados de di-hidropirrol

Info

Publication number
BR112012031406A2
BR112012031406A2 BR112012031406A BR112012031406A BR112012031406A2 BR 112012031406 A2 BR112012031406 A2 BR 112012031406A2 BR 112012031406 A BR112012031406 A BR 112012031406A BR 112012031406 A BR112012031406 A BR 112012031406A BR 112012031406 A2 BR112012031406 A2 BR 112012031406A2
Authority
BR
Brazil
Prior art keywords
formula
compound
preparation
optionally substituted
dihydropyrrol
Prior art date
Application number
BR112012031406A
Other languages
English (en)
Inventor
Edouard Godineau
Helmars Smits
Jérome Yves Cassayre
Myriem El Qacemi
Nicholas Phillip Mulholland
Peter Renold
Thomas Pitterna
Original Assignee
Syngenta Ltd
Syngenta Participations Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2010/058207 external-priority patent/WO2010149506A1/en
Application filed by Syngenta Ltd, Syngenta Participations Ag filed Critical Syngenta Ltd
Publication of BR112012031406A2 publication Critical patent/BR112012031406A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/46—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom rings with more than six members
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

processo para a preparação de derivados de di-hidropirrol. a presente invenção refere-se a processos estereoseletivos para a preparação de compostos de fórmula (i) caracterizado pelo fato de que p ser fenil, naftil, um grupo heteroarilo de 6 membros contendo uma ou dois átomos de nitrogênio como membros do anel, ou um grupo heteroarilo bicíclico de 10 membros contendo uma ou dois átomos de nitrogênio como membros do anel, e em que os grupos fenil, nagtil e heteroaril são opcionalmente substituídos; r^ 1^é clorodifluoutometila ou trifluorometila; r^ 2^ é aril opcionalmente substituído ou heteroaril opcionalmente substituído; n é 0 ou 1; incluindo o processo compreendendo (a-i) fazer reagir um composto de fórmula ii em que p, r^ 1^ e r^ 2^são definidos para o composto de fórmula i; com nitrometano na presença de um catalisador quiral para dar um composto de fórmula iii em que p, r^ 1^ e r^ 2^ são definidos para o composto de fórmula i; e (a-ii) redutivamente ciclizar o composto de fórmula iii para dar o composto de fórmula i. a presente invenção também fornece intermediários úteis para processos de síntese dos compostos de fórmula (i).
BR112012031406A 2010-06-11 2011-06-14 processo para a preparação de derivados de di-hidropirrol BR112012031406A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/EP2010/058207 WO2010149506A1 (en) 2009-06-22 2010-06-11 Insecticidal compounds
EP10196633 2010-12-22
PCT/EP2011/059823 WO2011154555A1 (en) 2010-06-11 2011-06-14 Process for the preparation of dihydropyrrole derivatives

Publications (1)

Publication Number Publication Date
BR112012031406A2 true BR112012031406A2 (pt) 2015-09-22

Family

ID=44627703

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012031406A BR112012031406A2 (pt) 2010-06-11 2011-06-14 processo para a preparação de derivados de di-hidropirrol

Country Status (14)

Country Link
US (1) US9233920B2 (pt)
EP (1) EP2580211B1 (pt)
JP (2) JP2013529594A (pt)
KR (1) KR20130132726A (pt)
CN (1) CN102939288B (pt)
AU (1) AU2011263655B2 (pt)
BR (1) BR112012031406A2 (pt)
CA (1) CA2800114A1 (pt)
CL (1) CL2012003491A1 (pt)
CO (1) CO6640266A2 (pt)
MX (1) MX2012014410A (pt)
RU (1) RU2013100441A (pt)
TW (1) TW201211057A (pt)
WO (1) WO2011154555A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6030640B2 (ja) 2011-05-18 2016-11-24 シンジェンタ パーティシペーションズ アーゲー アリールチオアセトアミド誘導体をベースとする殺虫化合物
WO2013026929A1 (en) * 2011-08-25 2013-02-28 Syngenta Participations Ag Dihydropyrrole derivatives as insecticidal compounds
BR112014003730A2 (pt) * 2011-08-25 2017-03-14 Syngenta Participations Ag processo para a preparação de derivados de tietano
CN103764644A (zh) * 2011-08-25 2014-04-30 先正达参股股份有限公司 作为杀虫化合物的异噁唑啉衍生物
US9469633B2 (en) 2011-10-03 2016-10-18 Syngenta Participations Ag Processes for the preparation of pyrrolidine intermediates
EP3896058A3 (en) * 2011-10-03 2022-01-12 Syngenta Participations Ag Enantionselective processes to insecticidal 3-aryl-3-trifluoromethyl-substituted pyrrolidines
JP6049866B2 (ja) 2012-05-09 2016-12-21 ゾエティス・サービシーズ・エルエルシー 駆虫剤としてのアゼチジン誘導体
US20150189883A1 (en) 2012-08-03 2015-07-09 Syngenta Participations Ag Methods of controlling insects
CN103772233B (zh) * 2014-01-06 2015-06-10 华东师范大学 一种含多氟烷基五元环状硝酮衍生物及其制备方法
US11498899B2 (en) * 2016-12-21 2022-11-15 Fmc Corporation Nitrone herbicides
GB201800894D0 (en) * 2018-01-19 2018-03-07 Syngenta Participations Ag Improvements in or relating to organic compounds
CN118076600A (zh) * 2022-09-21 2024-05-24 青岛康乔药业集团有限公司 含五元杂环的化合物及其制备方法和应用

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US102011A (en) * 1870-04-19 Improvement in dovetailing-machine
US62009A (en) * 1867-02-12 Charles t
JP5007788B2 (ja) 2005-05-16 2012-08-22 日産化学工業株式会社 ジヒドロアゾール置換ベンズアミド化合物及び有害生物防除剤
UY30090A1 (es) 2006-01-16 2007-08-31 Syngenta Participations Ag Insecticidas novedosos
DE102006015467A1 (de) 2006-03-31 2007-10-04 Bayer Cropscience Ag Substituierte Enaminocarbonylverbindungen
JP5164525B2 (ja) * 2006-11-01 2013-03-21 日本曹達株式会社 含窒素へテロ環化合物および有害生物防除剤
WO2009005015A1 (ja) 2007-06-29 2009-01-08 Nissan Chemical Industries, Ltd. 置換イソキサゾリン又はエノンオキシム化合物および有害生物防除剤
TWI556741B (zh) * 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
WO2009072621A1 (ja) * 2007-12-07 2009-06-11 Nissan Chemical Industries, Ltd. 置換ジヒドロアゾール化合物及び有害生物防除剤
TWI411395B (zh) 2007-12-24 2013-10-11 Syngenta Participations Ag 殺蟲化合物
CN101939295B (zh) 2008-02-07 2013-04-24 拜尔农作物科学股份公司 杀虫的芳基吡咯啉
CN102131804B (zh) * 2008-08-22 2014-12-03 先正达参股股份有限公司 杀虫化合物
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JP2011219431A (ja) * 2010-04-13 2011-11-04 Bayer Cropscience Ag 新規アリールニトロアルカン誘導体

Also Published As

Publication number Publication date
CN102939288A (zh) 2013-02-20
EP2580211A1 (en) 2013-04-17
JP2013529594A (ja) 2013-07-22
KR20130132726A (ko) 2013-12-05
WO2011154555A1 (en) 2011-12-15
CN102939288B (zh) 2015-09-30
AU2011263655B2 (en) 2014-07-03
MX2012014410A (es) 2013-03-12
JP2016210779A (ja) 2016-12-15
CA2800114A1 (en) 2011-12-15
EP2580211B1 (en) 2015-08-19
US9233920B2 (en) 2016-01-12
RU2013100441A (ru) 2014-07-20
CO6640266A2 (es) 2013-03-22
AU2011263655A1 (en) 2012-12-13
US20130237583A1 (en) 2013-09-12
CL2012003491A1 (es) 2013-05-24
TW201211057A (en) 2012-03-16

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B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.