BR112012031232A2 - método, dispositivo e uso - Google Patents

método, dispositivo e uso

Info

Publication number
BR112012031232A2
BR112012031232A2 BR112012031232A BR112012031232A BR112012031232A2 BR 112012031232 A2 BR112012031232 A2 BR 112012031232A2 BR 112012031232 A BR112012031232 A BR 112012031232A BR 112012031232 A BR112012031232 A BR 112012031232A BR 112012031232 A2 BR112012031232 A2 BR 112012031232A2
Authority
BR
Brazil
Application number
BR112012031232A
Other languages
English (en)
Inventor
Clemens Schafmeyer
Dietrich Rein
Hennicke Kamp
Jens Fuhrmann
Jochen Hampe
Ulrike Rennefahrt
Original Assignee
Metanomics Health Gmbh
Universitätsklinikum Schleswig Holstein
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metanomics Health Gmbh, Universitätsklinikum Schleswig Holstein filed Critical Metanomics Health Gmbh
Publication of BR112012031232A2 publication Critical patent/BR112012031232A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G01N33/6812—Assays for specific amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/08—Hepato-biliairy disorders other than hepatitis
    • G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
BR112012031232A 2010-06-10 2011-06-10 método, dispositivo e uso BR112012031232A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35324910P 2010-06-10 2010-06-10
EP10165554 2010-06-10
PCT/EP2011/059650 WO2012000770A1 (en) 2010-06-10 2011-06-10 Methods to diagnose liver diseases

Publications (1)

Publication Number Publication Date
BR112012031232A2 true BR112012031232A2 (pt) 2016-10-25

Family

ID=42355394

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012031232A BR112012031232A2 (pt) 2010-06-10 2011-06-10 método, dispositivo e uso

Country Status (7)

Country Link
US (3) US9140686B2 (pt)
EP (3) EP2580596B1 (pt)
JP (3) JP5837581B2 (pt)
AU (1) AU2011273748A1 (pt)
BR (1) BR112012031232A2 (pt)
CA (1) CA2799032A1 (pt)
WO (1) WO2012000770A1 (pt)

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EP3502707A1 (en) 2010-01-29 2019-06-26 metanomics GmbH Means and methods for diagnosing heart failure in a subject
EP2580596B1 (en) * 2010-06-10 2015-02-25 Metanomics Health GmbH Methods to diagnose liver diseases
WO2012037365A1 (en) * 2010-09-16 2012-03-22 Quest Diagnostics Investments Incorporated Mass spectrometric determination of eicosapentaenoic acid and docosahexaenoic acid
WO2013113992A1 (en) * 2012-01-31 2013-08-08 Teknologian Tutkimuskeskus Vtt Method for determining liver fat amount and method for diagnosing nafld
EP2815237A4 (en) * 2012-02-15 2015-11-04 Basf Se MEANS AND METHODS FOR ASSESSING NEURONAL TOXICITY
EP2822457A4 (en) * 2012-03-09 2015-11-11 Basf Se MEANS AND METHODS FOR ASSESSING HYPERTHYROIDISM
WO2015089102A1 (en) 2013-12-10 2015-06-18 The Regents Of The University Of California Differential diagnosis of liver disease
JP2018502286A (ja) * 2014-11-19 2018-01-25 メタボロン，インコーポレイテッド 脂肪肝疾患のバイオマーカーおよびその使用方法
WO2016130961A1 (en) * 2015-02-13 2016-08-18 The Regents Of The University Of California Methods and compositions for identifying non-alcoholic fatty liver disease
JP7036805B2 (ja) * 2016-05-29 2022-03-15 深▲じぇん▼市▲絵▼云生物科技有限公司 肝疾患関連バイオマーカーおよびその使用方法
CN109313246A (zh) 2016-06-13 2019-02-05 国立大学法人九州大学 自由基消耗速度信息的获取方法以及nash的判定方法
WO2018007422A1 (en) * 2016-07-05 2018-01-11 One Way Liver,S.L. Identification of human non-alcoholic fatty liver disease (nafld) subtypes
EP3267199A1 (en) * 2016-07-06 2018-01-10 One Way Liver S.L. Diagnostic methods based on lipid profiles
US20200096524A1 (en) * 2017-02-03 2020-03-26 École Polytechnique Fédérale De Lausanne (Epfl) Plasma and liver lipid species as biomarkers of fatty liver
US20200348316A1 (en) * 2017-11-20 2020-11-05 Zora Biosciences Oy Methods for prediction and early detection of diabetes
EP3502703A1 (en) 2017-12-22 2019-06-26 Metanomics Health GmbH Method for the assessment of nafld
EP3759500A4 (en) * 2018-02-26 2021-12-08 Arizona Board of Regents on behalf of the University of Arizona EZETIMIB-METABOLIT AS A NON-INVASIVE BIOMARKER FOR NON-ALCOHOLIC STEATOHEPATITIS (NASH)
US11536726B2 (en) 2018-04-04 2022-12-27 Metabolon, Inc. Mass spectrometry assay method for detection and quantitation of liver function metabolites
CN109060977A (zh) * 2018-07-13 2018-12-21 深圳市绘云生物科技有限公司 用于肝纤维化和肝硬化诊断的生物标志物和试剂盒及使用方法
WO2020066162A1 (ja) * 2018-09-26 2020-04-02 株式会社島津製作所 非アルコール性脂肪肝疾患の検出方法、非アルコール性脂肪肝疾患検出用キットおよび非アルコール性脂肪肝疾患検出用バイオマーカー
KR102105880B1 (ko) * 2018-10-26 2020-04-29 서울대학교병원 비알코올 지방간 질환의 조직학적 중증도 진단 또는 예후 측정에 관한 정보 제공 방법
KR102280261B1 (ko) * 2019-07-16 2021-07-20 이화여자대학교 산학협력단 대사체 분석을 이용한 간질환의 진단 방법
KR102171243B1 (ko) * 2019-08-05 2020-10-28 한국과학기술연구원 행위 중독의 진단용 조성물, 키트 및 이를 이용한 행위 중독의 진단을 위한 인돌-3-락트산의 검출 방법
WO2023238881A1 (ja) * 2022-06-07 2023-12-14 日東電工株式会社 非アルコール性脂肪性肝疾患（ｎａｆｌｄ）または非アルコール性脂肪肝炎（ｎａｓｈ）を診断するためのマーカー
GB202214670D0 (en) * 2022-10-06 2022-11-23 Owlstone Med Ltd Detection of liver disease

Family Cites Families (30)

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US4540884A (en) 1982-12-29 1985-09-10 Finnigan Corporation Method of mass analyzing a sample by use of a quadrupole ion trap
US5397894A (en) 1993-05-28 1995-03-14 Varian Associates, Inc. Method of high mass resolution scanning of an ion trap mass spectrometer
ATE275728T1 (de) * 1999-01-12 2004-09-15 Ebara Corp Verfahren und biosensor zum nachweis von antigenen
WO2003073464A1 (de) 2002-02-28 2003-09-04 Metanomics Gmbh & Co. Kgaa Massenspektrometrisches verfahren zur analyse von substanzgemischen
ES2226549B1 (es) * 2002-12-18 2006-07-16 One Way Liver Genomics, S.L. Metodo para el diagnostico de esteatohepatitis no alcoholica (nash) mediante el empleo de marcadores moleculares.
EP1626279B1 (en) * 2004-08-12 2008-04-16 Roche Diagnostics GmbH Method for diagnosing liver fibrosis
EP1887362A4 (en) * 2005-05-30 2010-01-27 Ajinomoto Kk HEPATHOPATHY EVALUATION APPARATUS, HEPATHOPATHY EVALUATION METHOD, HEPATHOPATHY EVALUATION SYSTEM, HEPATHOPATHY EVALUATION PROGRAM, AND RECORDING MEDIUM
WO2007136822A2 (en) * 2006-05-19 2007-11-29 George Mason Intellectual Properties, Inc. Methods to diagnose non-alcoholic steatohepatitis
BRPI0715402A2 (pt) * 2006-08-08 2013-11-26 Lipomics Technologies Inc Marcadores de doença hepática gordurosa não alcoólica (nafld) e esteatohepatite não alcoólica (nash) e métodos de uso dos mesmos
US20100197028A1 (en) 2007-02-22 2010-08-05 Tethys Bioscience, Inc. Metabolic markers of diabetic conditions and methods of use thereof
WO2008156662A1 (en) * 2007-06-14 2008-12-24 George Mason Intellectual Properties, Inc. Methods of diagnosing non-alcoholic steatohepatitis (nash)
EP2212946B1 (en) * 2007-10-12 2013-02-27 Toray Battery Separator Film Co., Ltd. Microporous membranes and methods for making and using such membranes
WO2009059150A2 (en) 2007-11-02 2009-05-07 Metabolon, Inc. Biomarkers for fatty liver disease and methods using the same
US9186343B2 (en) * 2007-12-26 2015-11-17 Nanoveson, Llc Nanoveso™: treatment, biomarkers and diagnostic tests for liver diseases and comorbid diseases
EP3059592A1 (en) * 2008-05-28 2016-08-24 Basf Se Methods for assessing liver toxicity
DE112009001245T5 (de) * 2008-05-28 2012-03-15 Basf Se Mittel und Verfahren für die Beurteilung der Leberenzyminduktion
WO2009151125A1 (ja) * 2008-06-13 2009-12-17 持田製薬株式会社 肝障害の診断及び治療
JP2011524877A (ja) 2008-06-18 2011-09-08 ビーエーエスエフ ソシエタス・ヨーロピア 有害生物の防除に有用な１，２−ベンゾイソチアゾール化合物
EP2313773A1 (en) 2008-07-15 2011-04-27 Metanomics Health GmbH Means and methods diagnosing gastric bypass and conditions related thereto
EP2157431A1 (en) * 2008-08-11 2010-02-24 One Way Liver Genomics, S.L. Method for the diagnosis of NASH using metabolic profiles
ES2621838T3 (es) * 2008-11-18 2017-07-05 Universite D'angers Método in vitro no invasivo para la cuantificación de lesiones hepáticas
US10241093B2 (en) * 2009-05-28 2019-03-26 The Cleveland Clinic Foundation Trimethylamine-containing compounds for diagnosis and prediction of disease
CN102472744B (zh) 2009-08-13 2015-11-25 巴斯夫欧洲公司 诊断甲状腺疾病的手段和方法
JP2013508835A (ja) 2009-10-21 2013-03-07 ビーエーエスエフ プラント サイエンス カンパニー ゲーエムベーハー バイオマーカー参照パターンを作成する方法
AU2010326737A1 (en) 2009-12-01 2012-06-07 Metanomics Health Gmbh Means and methods for diagnosing multiple sclerosis
EP3502707A1 (en) 2010-01-29 2019-06-26 metanomics GmbH Means and methods for diagnosing heart failure in a subject
EP2580596B1 (en) * 2010-06-10 2015-02-25 Metanomics Health GmbH Methods to diagnose liver diseases
US20130295692A1 (en) 2010-12-23 2013-11-07 Metanomics Health Gmbh Means and methods for predicting diabetes
EP2498195A1 (en) * 2011-03-11 2012-09-12 Centre Hospitalier Universitaire d'Angers Non-invasive method for assessing the presence or severity of liver fibrosis based on a new detailed classification
EP2715361A1 (en) 2011-05-31 2014-04-09 Metanomics Health GmbH Methods for diagnosing multiple sclerosis

Also Published As

Publication number Publication date
AU2011273748A1 (en) 2012-12-06
WO2012000770A1 (en) 2012-01-05
JP5837581B2 (ja) 2015-12-24
CA2799032A1 (en) 2012-01-05
JP2013533471A (ja) 2013-08-22
US20130126722A1 (en) 2013-05-23
EP2580596B1 (en) 2015-02-25
US10001468B2 (en) 2018-06-19
EP2863227A1 (en) 2015-04-22
EP2580596A1 (en) 2013-04-17
US20150355197A1 (en) 2015-12-10
EP3273247A1 (en) 2018-01-24
JP6141387B2 (ja) 2017-06-07
US20180267018A1 (en) 2018-09-20
JP2017167153A (ja) 2017-09-21
US9140686B2 (en) 2015-09-22
EP2863227B1 (en) 2017-09-27
JP2016065873A (ja) 2016-04-28

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]