BR112012025590A2 - análogos de pirimidinilpiperidiniloxipiridinona como moduladores de gpr119 - Google Patents

análogos de pirimidinilpiperidiniloxipiridinona como moduladores de gpr119

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Publication number
BR112012025590A2
BR112012025590A2 BR112012025590A BR112012025590A BR112012025590A2 BR 112012025590 A2 BR112012025590 A2 BR 112012025590A2 BR 112012025590 A BR112012025590 A BR 112012025590A BR 112012025590 A BR112012025590 A BR 112012025590A BR 112012025590 A2 BR112012025590 A2 BR 112012025590A2
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BR
Brazil
Prior art keywords
gpr119
coupled receptor
pyrimidinylpiperidinyloxypyridinone
analogues
modulators
Prior art date
Application number
BR112012025590A
Other languages
English (en)
Inventor
Dean A Wacker
Stephen P O'connor
Zhenqiu Hong
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BR112012025590A2 publication Critical patent/BR112012025590A2/pt

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
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    • A61P27/06—Antiglaucoma agents or miotics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

análogos de pirimidinilpiperidiniloxipiridinona como moduladores de gpr119. a presente invenção refere-se a compostos de fórmula estrutural ou um enantiômero, um diastereômero, ou um sal farmaceuticamente aceitável dos mesmos, em que, n~ 1~, r^ 1^, r^ 2^, r^ 3^ e r^ 4^ são definidos aqui, são fornecidos os quais são moduladores de receptor acoplado à proteína g gpr119. moduladores de receptor acoplado à proteína g gpr119 são úteis no tratamento, prevenção, ou retardo da progressão de doenças que requerem terapia moduladora de receptor acoplado à proteína g gpr119. desse modo, a descrição também diz respeito a composições compreendendo estes novos compostos e métodos de tratar doenças ou condições relacionadas à atividade do receptor acoplado à proteína g gpr119 usando-se quaisquer destes novos compostos ou uma composição compreendendo quaisquer de tais novos compostos.
BR112012025590A 2010-04-08 2011-04-06 análogos de pirimidinilpiperidiniloxipiridinona como moduladores de gpr119 BR112012025590A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32194610P 2010-04-08 2010-04-08
PCT/US2011/031320 WO2011127106A1 (en) 2010-04-08 2011-04-06 Pyrimidinylpiperidinyloxypyridinone analogues as gpr119 modulators

Publications (1)

Publication Number Publication Date
BR112012025590A2 true BR112012025590A2 (pt) 2016-06-21

Family

ID=44021850

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012025590A BR112012025590A2 (pt) 2010-04-08 2011-04-06 análogos de pirimidinilpiperidiniloxipiridinona como moduladores de gpr119

Country Status (14)

Country Link
US (1) US8415367B2 (pt)
EP (1) EP2556069B1 (pt)
JP (1) JP2013523822A (pt)
CN (1) CN102933576A (pt)
AR (1) AR081819A1 (pt)
BR (1) BR112012025590A2 (pt)
CA (1) CA2795732A1 (pt)
EA (1) EA201270755A1 (pt)
IL (1) IL222220A0 (pt)
MX (1) MX2012011460A (pt)
SG (1) SG184168A1 (pt)
TW (1) TW201136917A (pt)
UY (1) UY33323A (pt)
WO (1) WO2011127106A1 (pt)

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Also Published As

Publication number Publication date
EP2556069A1 (en) 2013-02-13
IL222220A0 (en) 2012-12-31
US20110251221A1 (en) 2011-10-13
AR081819A1 (es) 2012-10-24
SG184168A1 (en) 2012-10-30
EA201270755A1 (ru) 2013-03-29
TW201136917A (en) 2011-11-01
US8415367B2 (en) 2013-04-09
WO2011127106A1 (en) 2011-10-13
UY33323A (es) 2011-10-31
MX2012011460A (es) 2012-11-23
EP2556069B1 (en) 2015-04-01
CA2795732A1 (en) 2011-10-13
JP2013523822A (ja) 2013-06-17
CN102933576A (zh) 2013-02-13

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