BR112012014770A2 - derivados de etinila - Google Patents

derivados de etinila

Info

Publication number
BR112012014770A2
BR112012014770A2 BR112012014770A BR112012014770A BR112012014770A2 BR 112012014770 A2 BR112012014770 A2 BR 112012014770A2 BR 112012014770 A BR112012014770 A BR 112012014770A BR 112012014770 A BR112012014770 A BR 112012014770A BR 112012014770 A2 BR112012014770 A2 BR 112012014770A2
Authority
BR
Brazil
Prior art keywords
ethinyl
derivatives
ethinyl derivatives
Prior art date
Application number
BR112012014770A
Other languages
English (en)
Inventor
Eric Vieira
Georg Jaeschke
Heinz Stadler
Lothar Lindemann
Luke Green
Synese Jolidon
Wolfgang Guba
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43446449&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112012014770(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112012014770A2 publication Critical patent/BR112012014770A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BR112012014770A 2009-12-17 2010-12-14 derivados de etinila BR112012014770A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09179719 2009-12-17
PCT/EP2010/069593 WO2011073172A1 (en) 2009-12-17 2010-12-14 Ethynyl derivatives

Publications (1)

Publication Number Publication Date
BR112012014770A2 true BR112012014770A2 (pt) 2016-03-29

Family

ID=43446449

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012014770A BR112012014770A2 (pt) 2009-12-17 2010-12-14 derivados de etinila

Country Status (27)

Country Link
US (2) US8586581B2 (pt)
EP (1) EP2513102B1 (pt)
JP (1) JP5763094B2 (pt)
KR (1) KR101407856B1 (pt)
CN (1) CN102686589B (pt)
AR (1) AR079467A1 (pt)
AU (1) AU2010332987B2 (pt)
BR (1) BR112012014770A2 (pt)
CA (1) CA2780155A1 (pt)
CL (1) CL2012001596A1 (pt)
CO (1) CO6531478A2 (pt)
CR (1) CR20120269A (pt)
EC (1) ECSP12011977A (pt)
ES (1) ES2551582T3 (pt)
HK (1) HK1171225A1 (pt)
IL (1) IL219371A (pt)
MA (1) MA33802B1 (pt)
MX (1) MX2012006789A (pt)
MY (1) MY162998A (pt)
NZ (1) NZ599553A (pt)
PE (1) PE20121443A1 (pt)
RU (1) RU2553461C2 (pt)
SG (1) SG181779A1 (pt)
TW (1) TWI448465B (pt)
UA (1) UA107002C2 (pt)
WO (1) WO2011073172A1 (pt)
ZA (1) ZA201204429B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103201259B (zh) * 2010-11-05 2015-05-27 日本欧爱特农业科技株式会社 乙炔基苯脒化合物或其盐、其制备方法和用于农业和园艺的杀菌剂
WO2012146551A1 (en) 2011-04-26 2012-11-01 F. Hoffmann-La Roche Ag Ethynyl derivatives as positive allosteric modulators of the mglur5
US20130123254A1 (en) 2011-09-30 2013-05-16 Barbara Biemans Pharmaceutically acceptable mglur5 positive allosteric modulators and their methods of identification
UA110862C2 (uk) * 2011-10-07 2016-02-25 Ф. Хоффманн-Ля Рош Аг Похідні етинілу як алостеричні модулятори метаботропного рецептора глутамату mglur 5
EA025482B1 (ru) * 2012-09-27 2016-12-30 Ф. Хоффманн-Ля Рош Аг Производные арилэтинила
PE20150733A1 (es) * 2012-10-18 2015-05-17 Hoffmann La Roche Derivados de etinilo como moduladores de la actividad del receptor mglur5
BR112015009649A2 (pt) * 2012-11-07 2017-07-04 Hoffmann La Roche composto de triazolo
MX2017015043A (es) 2015-06-03 2018-02-26 Hoffmann La Roche Derivados de etinilo.
LT3322701T (lt) 2015-07-15 2019-07-10 F. Hoffmann-La Roche Ag Etinilo dariniai kaip metabotropinių glutamato receptorių moduliatoriai
CA3030788A1 (en) 2016-07-18 2018-01-25 F. Hoffmann-La Roche Ag Ethynyl derivatives

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1117403E (pt) * 1998-10-02 2004-04-30 Sibia Neurosciences Inc Antagonistas de mglurs para o tratamento da dor e ansiedade
AR029803A1 (es) 2000-02-21 2003-07-16 Smithkline Beecham Plc Imidazoles sustituidos con piridilo y composiciones farmaceuticas que las comprenden
GB0027987D0 (en) 2000-11-16 2001-01-03 Smithkline Beecham Plc Compounds
US6910976B2 (en) 2001-06-26 2005-06-28 Stx, Llc Multi-component lacrosse stick head
GB0127430D0 (en) * 2001-11-15 2002-01-09 Smithkline Beecham Corp Compounds
GB0127433D0 (en) * 2001-11-15 2002-01-09 Smithkline Beecham Corp Compounds
TWI292318B (en) * 2003-03-10 2008-01-11 Hoffmann La Roche Imidazol-4-yl-ethynyl-pyridine derivatives
GB0325956D0 (en) 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
GB0413605D0 (en) 2004-06-17 2004-07-21 Addex Pharmaceuticals Sa Novel compounds
WO2006048771A1 (en) 2004-11-04 2006-05-11 Addex Pharmaceuticals Sa Novel tetrazole derivatives as positive allosteric modulators of metabotropic glutamate receptors
GB0510139D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B1
EP1912966A2 (en) * 2005-06-01 2008-04-23 Ucb, S.A. 2-oxo-1-pyrrolidine derivatives and their therapeutic use on the central nervous system
ATE446294T1 (de) 2005-11-15 2009-11-15 Array Biopharma Inc N4-phenyl-chinazolin-4-aminderivate und verwandte verbindungen als inhibitoren der erbb-typ-i- rezeptortyrosinkinase zur behandlung hyperproliferativer krankheiten
UY30444A1 (es) 2006-06-30 2008-01-31 Astrazeneca Ab Derivados de pirimidina, procesos para su preparacinn, composiciones farmaccuticos y usos de los mismos.
EP1972628A1 (en) 2007-03-21 2008-09-24 Schwarz Pharma Ag Indolizines and aza-analog derivatives thereof as CNS active compounds
CN101720327A (zh) * 2007-04-30 2010-06-02 雅培制药有限公司 二酰甘油o-酰基转移酶1型酶的抑制剂
WO2008151184A1 (en) 2007-06-03 2008-12-11 Vanderbilt University Benzamide mglur5 positive allosteric modulators and methods of making and using same
TW201116532A (en) * 2009-08-05 2011-05-16 Merz Pharma Gmbh & Co Kgaa Metabotropic glutamate receptor modulators

Also Published As

Publication number Publication date
CA2780155A1 (en) 2011-06-23
JP5763094B2 (ja) 2015-08-12
SG181779A1 (en) 2012-07-30
TWI448465B (zh) 2014-08-11
RU2553461C2 (ru) 2015-06-20
KR101407856B1 (ko) 2014-06-16
PE20121443A1 (es) 2012-10-26
CN102686589B (zh) 2014-12-10
AU2010332987B2 (en) 2015-08-13
US20110152257A1 (en) 2011-06-23
ES2551582T3 (es) 2015-11-20
WO2011073172A1 (en) 2011-06-23
ECSP12011977A (es) 2012-07-31
EP2513102A1 (en) 2012-10-24
CR20120269A (es) 2012-07-04
RU2012128551A (ru) 2014-01-27
MY162998A (en) 2017-07-31
US8586581B2 (en) 2013-11-19
NZ599553A (en) 2014-05-30
CL2012001596A1 (es) 2013-01-04
ZA201204429B (en) 2013-02-27
US8933094B2 (en) 2015-01-13
KR20120095472A (ko) 2012-08-28
TW201144314A (en) 2011-12-16
US20140073638A1 (en) 2014-03-13
MX2012006789A (es) 2012-07-10
EP2513102B1 (en) 2015-08-19
CO6531478A2 (es) 2012-09-28
MA33802B1 (fr) 2012-12-03
AU2010332987A1 (en) 2012-06-07
IL219371A (en) 2015-02-26
HK1171225A1 (en) 2013-03-22
AR079467A1 (es) 2012-01-25
IL219371A0 (en) 2012-06-28
CN102686589A (zh) 2012-09-19
JP2013514305A (ja) 2013-04-25
UA107002C2 (uk) 2014-11-10

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06T Formal requirements before examination [chapter 6.20 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal of application maintained [chapter 11.20 patent gazette]