BR112012011274A2 - formulação de metformina de massa reduzida e sua combinação - Google Patents

formulação de metformina de massa reduzida e sua combinação

Info

Publication number
BR112012011274A2
BR112012011274A2 BR112012011274A BR112012011274A BR112012011274A2 BR 112012011274 A2 BR112012011274 A2 BR 112012011274A2 BR 112012011274 A BR112012011274 A BR 112012011274A BR 112012011274 A BR112012011274 A BR 112012011274A BR 112012011274 A2 BR112012011274 A2 BR 112012011274A2
Authority
BR
Brazil
Prior art keywords
reduced mass
combination
mass metformin
metformin formulation
formulation
Prior art date
Application number
BR112012011274A
Other languages
English (en)
Inventor
Admassu Abebe
Jatin M Patel
Kyle Martin
Peter Timmins
Original Assignee
Astrazeneca Uk Ltd
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Uk Ltd, Bristol Myers Squibb Co filed Critical Astrazeneca Uk Ltd
Publication of BR112012011274A2 publication Critical patent/BR112012011274A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

formulações de metformina de massa reduzida. a presente invenção refere-se ás formulações de liberação prolongada de metformina (xr) com compactibilidade melhorada para prover comprimidos, granulações, e cápsulas de massa reduzida.
BR112012011274A 2009-11-13 2010-11-12 formulação de metformina de massa reduzida e sua combinação BR112012011274A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26104909P 2009-11-13 2009-11-13
PCT/US2010/056525 WO2011060255A1 (en) 2009-11-13 2010-11-12 Reduced mass metformin formulations

Publications (1)

Publication Number Publication Date
BR112012011274A2 true BR112012011274A2 (pt) 2016-04-12

Family

ID=43430616

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012011274A BR112012011274A2 (pt) 2009-11-13 2010-11-12 formulação de metformina de massa reduzida e sua combinação

Country Status (10)

Country Link
US (2) US20120294936A1 (pt)
EP (1) EP2498757A1 (pt)
JP (1) JP5798123B2 (pt)
CN (1) CN102711738A (pt)
AU (1) AU2010319438B2 (pt)
BR (1) BR112012011274A2 (pt)
CA (1) CA2780938A1 (pt)
MX (1) MX2012005425A (pt)
RU (1) RU2564901C2 (pt)
WO (1) WO2011060255A1 (pt)

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CN103399112B (zh) * 2013-07-24 2015-07-15 上海交通大学 一种盐酸二甲双胍含量的测定方法
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EA023747B1 (ru) * 2014-11-13 2016-07-29 Промомед Холдингс Лимитед Фармацевтическая композиция для профилактики и лечения нарушений, связанных с избыточным весом или ожирением (варианты), наборы (варианты), их применение и способ профилактики и лечения нарушений, связанных с избыточным весом или ожирением
CN104324033A (zh) * 2014-11-20 2015-02-04 哈尔滨圣吉药业股份有限公司 一种西格列汀二甲双胍缓释片及其制备方法
CN105476995A (zh) * 2015-12-23 2016-04-13 青岛海之源智能技术有限公司 一种二甲双胍阿昔莫司复方缓释胶囊及制备方法
CN106924208A (zh) * 2015-12-30 2017-07-07 深圳翰宇药业股份有限公司 一种复方达格列净二甲双胍缓释片及其制备方法
BR112018073688A2 (pt) * 2016-05-20 2019-02-26 Center Laboratories, Inc. método de tratamento de hiperglicemia
FR3053892A1 (fr) * 2016-07-12 2018-01-19 Urgo Recherche Innovation Et Developpement Pansement permettant la liberation controlee et prolongee de la metformine
US10639292B2 (en) 2018-04-20 2020-05-05 Center Laboratories, Inc. Method of treating hyperglycemia
SG11202011883RA (en) * 2018-05-31 2020-12-30 Hua Medicine Shanghai Ltd Pharmaceutical combination, composition, and combination formulation containing glucokinase activator and ppar receptor activator, and preparation methods and uses thereof
JP2023518645A (ja) * 2020-01-16 2023-05-08 上海仁会生物制▲やく▼股▲ふん▼有限公司 Ｇｌｐ－１の投薬レジメン

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Also Published As

Publication number Publication date
AU2010319438A1 (en) 2012-07-05
CN102711738A (zh) 2012-10-03
US20140335170A1 (en) 2014-11-13
CA2780938A1 (en) 2011-05-19
JP5798123B2 (ja) 2015-10-21
EP2498757A1 (en) 2012-09-19
WO2011060255A1 (en) 2011-05-19
RU2012124239A (ru) 2013-12-20
AU2010319438B2 (en) 2015-05-21
US20120294936A1 (en) 2012-11-22
JP2013510872A (ja) 2013-03-28
MX2012005425A (es) 2012-06-14
RU2564901C2 (ru) 2015-10-10

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