BR112012010537A2 - "clonagem, expressão e uso de fosfolipases ácidas" - Google Patents
"clonagem, expressão e uso de fosfolipases ácidas"Info
- Publication number
- BR112012010537A2 BR112012010537A2 BR112012010537A BR112012010537A BR112012010537A2 BR 112012010537 A2 BR112012010537 A2 BR 112012010537A2 BR 112012010537 A BR112012010537 A BR 112012010537A BR 112012010537 A BR112012010537 A BR 112012010537A BR 112012010537 A2 BR112012010537 A2 BR 112012010537A2
- Authority
- BR
- Brazil
- Prior art keywords
- sequence
- polypeptide
- dna
- dna sequence
- seq
- Prior art date
Links
- 102000015439 Phospholipases Human genes 0.000 title abstract 4
- 108010064785 Phospholipases Proteins 0.000 title abstract 4
- 239000002253 acid Substances 0.000 title abstract 2
- 238000010367 cloning Methods 0.000 title abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 13
- 229920001184 polypeptide Polymers 0.000 abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 7
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 7
- 239000002773 nucleotide Substances 0.000 abstract 4
- 125000003729 nucleotide group Chemical group 0.000 abstract 4
- 150000001413 amino acids Chemical class 0.000 abstract 3
- ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 abstract 2
- 230000000295 complement effect Effects 0.000 abstract 2
- 230000037430 deletion Effects 0.000 abstract 2
- 238000012217 deletion Methods 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 235000019626 lipase activity Nutrition 0.000 abstract 2
- 238000006467 substitution reaction Methods 0.000 abstract 2
- 241000228212 Aspergillus Species 0.000 abstract 1
- 241001225321 Aspergillus fumigatus Species 0.000 abstract 1
- 108091026890 Coding region Proteins 0.000 abstract 1
- 238000007792 addition Methods 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 229940091771 aspergillus fumigatus Drugs 0.000 abstract 1
- 230000007850 degeneration Effects 0.000 abstract 1
- 230000002068 genetic effect Effects 0.000 abstract 1
- 230000037431 insertion Effects 0.000 abstract 1
- 238000003780 insertion Methods 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
- A23D9/02—Other edible oils or fats, e.g. shortenings, cooking oils characterised by the production or working-up
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
- A23D9/02—Other edible oils or fats, e.g. shortenings, cooking oils characterised by the production or working-up
- A23D9/04—Working-up
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J7/00—Phosphatide compositions for foodstuffs, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/189—Enzymes
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B3/00—Refining fats or fatty oils
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B3/00—Refining fats or fatty oils
- C11B3/003—Refining fats or fatty oils by enzymes or microorganisms, living or dead
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
- C12Y301/01004—Phospholipase A2 (3.1.1.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
- C12Y301/01005—Lysophospholipase (3.1.1.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
- C12Y301/01032—Phospholipase A1 (3.1.1.32)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Polymers & Plastics (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Food Science & Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Husbandry (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Fats And Perfumes (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Fodder In General (AREA)
- Bakery Products And Manufacturing Methods Therefor (AREA)
Abstract
patente de invenção: "clonagem, expressão e uso de fosfolipases ácidas". a presente invenção refere-se a uma nova sequência de dna, que codifica um polipeptídeo com atividade de fosfolipase essencialmente sem atividade de lipase, caracterizada pelo fato de que a sequência de dna é selecionada de a) sequência de dna que compreendem uma sequência de nucleotídeos de acordo com seq id no: 1, b) sequência de dna, que compreendem a sequência codificante de acordo com seq id no: 1, c) sequência de dna, que codificam a sequência de proteína de acordo com seq id no: 2, d) sequência de dna, que são codificadas pelo plasmídeo ppl3949-topo2.5 com a carta de restrição de acordo com a figura 7 e depositada sob o número de depósito dsm 22741, e) sequência de dna, que hibridizam em condições rigorosas com uma das sequências de dna de acordo com a),b) ou d), f) sequências de dna, que devido à degeneração do código genético são análogas às sequências de dna de acordo com a), b),c),d) ou e) e g) filamentos complementares às sequências de acordo com a) até f), em que a sequência de dna é preferencialmente derivada de aspergillus e de modo ainda mais preferido, de aspergillus fumigatus, bem com um polipeptídeo com atividade de fosfolipase essencialmente sem atividade de lipase selecionado de a) um polipeptídeo, que é codificado pela parte codificante de uma sequência de dna de acordo com uma das reivindicaçãoes 1 a 2, b) um polipeptídeo com a sequência de acordo com a seq id no: 2 ou de uma sequência derivada dessa, que pode ser obtido através de substituição, adição, deleção de um ou mais aminoácidos, c) um polipeptídeo com uma sequência, que apresenta uma identidade de pelo menos 83% para os aminoácidos 1 a 299 de seq id no: 2, d) um polipeptídeo, que é codificado por uma sequência de ácido nucleico, que hibridiza em condições rigorosas com (i) os nucleotídeos 55 a 1106 da seq id no: 1, (ii) a sequência de cdna contida nos nucleotídeos 55 a 1106 da seq id no: 1, (iii) uma sequência parcial de (i) ou (ii) de pelo menos 100 nucleotídeos ou (iv) um filamento complementar de (i), (ii) ou (iii), e) uma variante do polipeptídeo com seq id no: 2 compreendendo uma substituição, deleção e/ou inserção de um ou mais aminoácidos, f) variantes alélicas para as sequências de aminoácido a) até e).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009051013A DE102009051013A1 (de) | 2009-10-28 | 2009-10-28 | Klonierung, Expression und Verwendung saurer Phospholipasen |
| PCT/EP2010/066234 WO2011051322A1 (de) | 2009-10-28 | 2010-10-27 | Klonierung, expression und verwendung saurer phospholipasen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012010537A2 true BR112012010537A2 (pt) | 2016-11-29 |
Family
ID=43530076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012010537A BR112012010537A2 (pt) | 2009-10-28 | 2010-10-27 | "clonagem, expressão e uso de fosfolipases ácidas" |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9045713B2 (pt) |
| EP (1) | EP2494015B1 (pt) |
| JP (1) | JP5918141B2 (pt) |
| CN (1) | CN102803455B (pt) |
| AU (1) | AU2010311491B2 (pt) |
| BR (1) | BR112012010537A2 (pt) |
| CA (1) | CA2778668A1 (pt) |
| DE (1) | DE102009051013A1 (pt) |
| DK (1) | DK2494015T3 (pt) |
| MX (1) | MX2012004725A (pt) |
| MY (1) | MY178796A (pt) |
| RU (1) | RU2567659C2 (pt) |
| WO (1) | WO2011051322A1 (pt) |
| ZA (1) | ZA201202808B (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102009051013A1 (de) | 2009-10-28 | 2011-06-09 | Ab Enzymes Gmbh | Klonierung, Expression und Verwendung saurer Phospholipasen |
| CN106047732B (zh) * | 2016-05-26 | 2019-09-03 | 江南大学 | 一种高分泌型耐热酵母基因工程菌及其应用 |
| RU2676321C1 (ru) * | 2018-03-07 | 2018-12-27 | Общество с ограниченной ответственностью "Инновационный центр "Бирюч-новые технологии" (ООО "ИЦ "Бирюч-НТ") | Способ получения ферментного препарата фосфолипазы А2 с применением рекомбинантного штамма-продуцента Pichia pastoris X-33/ pPICZαA-PhoA2-StV |
| US11999923B2 (en) | 2018-05-07 | 2024-06-04 | Dsm Ip Assets B.V. | Process for enzymatic oil degumming |
| CN108841741B (zh) * | 2018-07-11 | 2021-07-06 | 四川润格生物科技有限公司 | 一种产耐酸耐高温型木聚糖酶的基因工程菌及应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL97645A (en) | 1990-03-23 | 1997-03-18 | Gist Brocades Nv | Production of enzymes in seeds and their use |
| DE4115938A1 (de) | 1991-05-16 | 1992-11-19 | Metallgesellschaft Ag | Enzymatisches verfahren zur verminderung des gehaltes an phosphorhaltigen bestandteilen in pflanzlichen und tierischen oelen |
| TW362115B (en) * | 1992-06-16 | 1999-06-21 | Sankyo Lifetech Co Ltd | Novel phospholipase A1, process for its preparation and the use thereof |
| FI932521A0 (fi) | 1993-06-02 | 1993-06-02 | Alko Ab Oy | Nytt endoglukanasenzym |
| DK76893D0 (pt) | 1993-06-28 | 1993-06-28 | Novo Nordisk As | |
| DE19620649A1 (de) | 1996-05-22 | 1997-11-27 | Roehm Gmbh | Rekombinant hergestellte Lysophospholipase aus Aspergillus |
| DE19701348A1 (de) | 1997-01-16 | 1998-07-23 | Roehm Gmbh | Protein mit Phospholipaseaktivität |
| DE69835112T2 (de) | 1997-04-09 | 2007-01-04 | Danisco A/S | Verwendung von Lipase zur Verbesserung von Teigen Und Backwaren |
| US20030082595A1 (en) * | 2001-08-03 | 2003-05-01 | Bo Jiang | Nucleic acids of aspergillus fumigatus encoding industrial enzymes and methods of use |
| CA2467415C (en) * | 2002-01-16 | 2014-03-11 | Novozymes A/S | Lipolytic enzyme variants and method for their production |
| PL373887A1 (en) | 2002-05-21 | 2005-09-19 | Dsm Ip Assets B.V. | Novel phospholipases and uses thereof |
| ES2409682T3 (es) | 2003-12-19 | 2013-06-27 | Bunge Oils, Inc | Proceso para mejorar el desgomado enzimático de aceites vegetales y reducir el ensuciamiento del equipo posterior de procesado |
| EP1788080A1 (en) | 2005-11-22 | 2007-05-23 | Süd-Chemie Ag | Use of a thermostable phospholipase in the degumming of an oil or fat, and a method for obtaining a thermostable phopholipase |
| DE102006046719A1 (de) * | 2006-10-02 | 2008-04-03 | Ab Enzymes Gmbh | Klonierung, Expression und Verwendung saurer Phospholipasen |
| DE102006046857A1 (de) | 2006-10-02 | 2008-04-03 | Ab Enzymes Gmbh | Klonierung, Expression und Verwendung saurer Lysophospholipasen |
| CN105038978B (zh) | 2007-01-30 | 2017-09-29 | 邦奇油类公司 | 使用pla和plc磷脂酶混合物进行的酶法脱胶 |
| DE102009051013A1 (de) | 2009-10-28 | 2011-06-09 | Ab Enzymes Gmbh | Klonierung, Expression und Verwendung saurer Phospholipasen |
-
2009
- 2009-10-28 DE DE102009051013A patent/DE102009051013A1/de not_active Withdrawn
-
2010
- 2010-10-27 US US13/502,945 patent/US9045713B2/en active Active
- 2010-10-27 EP EP10774185.2A patent/EP2494015B1/de active Active
- 2010-10-27 RU RU2012120571/10A patent/RU2567659C2/ru active
- 2010-10-27 CN CN201080059893.7A patent/CN102803455B/zh active Active
- 2010-10-27 WO PCT/EP2010/066234 patent/WO2011051322A1/de active Application Filing
- 2010-10-27 JP JP2012535804A patent/JP5918141B2/ja not_active Expired - Fee Related
- 2010-10-27 CA CA2778668A patent/CA2778668A1/en not_active Abandoned
- 2010-10-27 AU AU2010311491A patent/AU2010311491B2/en not_active Ceased
- 2010-10-27 BR BR112012010537A patent/BR112012010537A2/pt not_active Application Discontinuation
- 2010-10-27 MY MYPI2012001885A patent/MY178796A/en unknown
- 2010-10-27 DK DK10774185.2T patent/DK2494015T3/en active
- 2010-10-27 MX MX2012004725A patent/MX2012004725A/es active IP Right Grant
-
2012
- 2012-04-17 ZA ZA2012/02808A patent/ZA201202808B/en unknown
-
2015
- 2015-04-21 US US14/692,230 patent/US9322003B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2494015A1 (de) | 2012-09-05 |
| US20150299680A1 (en) | 2015-10-22 |
| US9322003B2 (en) | 2016-04-26 |
| RU2012120571A (ru) | 2013-12-10 |
| DK2494015T3 (en) | 2018-05-28 |
| CA2778668A1 (en) | 2011-05-05 |
| CN102803455A (zh) | 2012-11-28 |
| MX2012004725A (es) | 2012-05-29 |
| MY178796A (en) | 2020-10-20 |
| CN102803455B (zh) | 2014-09-03 |
| JP2013509165A (ja) | 2013-03-14 |
| US20120213888A1 (en) | 2012-08-23 |
| AU2010311491B2 (en) | 2013-09-19 |
| RU2567659C2 (ru) | 2015-11-10 |
| ZA201202808B (en) | 2013-09-25 |
| DE102009051013A1 (de) | 2011-06-09 |
| JP5918141B2 (ja) | 2016-05-18 |
| US9045713B2 (en) | 2015-06-02 |
| WO2011051322A1 (de) | 2011-05-05 |
| AU2010311491A1 (en) | 2012-05-17 |
| EP2494015B1 (de) | 2018-03-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06G | Technical and formal requirements: other requirements [chapter 6.7 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL |