BR112012009584A2 - formas sólidas de n-(4-(7-azabiciclo[2.2.1]heptan-7-il)-2-(trifluorometil)fenil)-4-oxo-5-(trifluorometil)-1,4-di-hidroquinolina-3-carboxamida - Google Patents

formas sólidas de n-(4-(7-azabiciclo[2.2.1]heptan-7-il)-2-(trifluorometil)fenil)-4-oxo-5-(trifluorometil)-1,4-di-hidroquinolina-3-carboxamida

Info

Publication number: BR112012009584A2
Authority: BR; Brazil
Prior art keywords: trifluoromethyl; dihydroquinoline; heptan; azabicyclo; carboxamide
Prior art date: 2009-10-23

Application number

BR112012009584A

Other languages

English (en)

Inventor

Medek Ales

Zhang Beili

Luisi Brian

Krawiec Mariusz

Original Assignee

Vertex Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-10-23

Filing date

2010-10-21

Publication date

2019-09-24

2010-10-21 Application filed by Vertex Pharma filed Critical Vertex Pharma

2019-09-24 Publication of BR112012009584A2 publication Critical patent/BR112012009584A2/pt

Links

-1 4- (7-azabicyclo [2.2.1] heptan-7-yl) -2- (trifluoromethyl) phenyl Chemical group 0.000 title 1
239000007787 solid Substances 0.000 title 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- C07B2200/13—Crystalline forms, e.g. polymorphs

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Pharmacology & Pharmacy (AREA)
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BR112012009584A 2009-10-23 2010-10-21 formas sólidas de n-(4-(7-azabiciclo[2.2.1]heptan-7-il)-2-(trifluorometil)fenil)-4-oxo-5-(trifluorometil)-1,4-di-hidroquinolina-3-carboxamida BR112012009584A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US25461409P	2009-10-23	2009-10-23
PCT/US2010/053633 WO2011050220A1 (en)	2009-10-23	2010-10-21	Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide

Publications (1)

Publication Number	Publication Date
BR112012009584A2 true BR112012009584A2 (pt)	2019-09-24

Family

ID=43334525

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR112012009584A BR112012009584A2 (pt)	2009-10-23	2010-10-21	formas sólidas de n-(4-(7-azabiciclo[2.2.1]heptan-7-il)-2-(trifluorometil)fenil)-4-oxo-5-(trifluorometil)-1,4-di-hidroquinolina-3-carboxamida

Country Status (19)

Country	Link
US (2)	US8389727B2 (pt)
EP (1)	EP2491042A1 (pt)
JP (1)	JP5877157B2 (pt)
KR (1)	KR20120102645A (pt)
CN (1)	CN102666546B (pt)
AR (1)	AR078766A1 (pt)
AU (1)	AU2010310617A1 (pt)
BR (1)	BR112012009584A2 (pt)
CA (1)	CA2778493A1 (pt)
CL (1)	CL2012001007A1 (pt)
HK (1)	HK1173151A1 (pt)
IL (1)	IL219327A0 (pt)
MX (1)	MX2012004791A (pt)
NZ (1)	NZ599703A (pt)
RU (1)	RU2568608C2 (pt)
TW (1)	TWI507409B (pt)
UA (1)	UA108087C2 (pt)
WO (1)	WO2011050220A1 (pt)
ZA (1)	ZA201202919B (pt)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20100074949A1 (en)	2008-08-13	2010-03-25	William Rowe	Pharmaceutical composition and administration thereof
EP1664006A2 (en)	2003-09-06	2006-06-07	Vertex Pharmaceuticals Incorporated	Modulators of atp-binding cassette transporters
US7977322B2 (en)	2004-08-20	2011-07-12	Vertex Pharmaceuticals Incorporated	Modulators of ATP-binding cassette transporters
CA2810655C (en)	2004-06-24	2013-12-10	Vertex Pharmaceuticals Incorporated	Modulators of atp-binding cassette transporters
EP1912983B1 (en)	2005-08-11	2011-06-08	Vertex Pharmaceuticals, Inc.	Modulators of cystic fibrosis transmembrane conductance regulator
SI2395002T1 (sl)	2005-11-08	2014-10-30	Vertex Pharmaceuticals Incorporated	Farmacevtski sestavek, vsebujoč heterociklični modulator prenašalcev z ATP-vezavno kaseto
CN103214450B (zh)	2005-12-28	2016-10-05	弗特克斯药品有限公司	作为atp-结合盒转运蛋白调节剂的1-(苯并[d][1,3]间二氧杂环戊烯-5-基)-n-(苯基)环丙烷-甲酰胺衍生物
EP3708564A1 (en)	2005-12-28	2020-09-16	Vertex Pharmaceuticals Incorporated	A solid form of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
EP2007756B1 (en)	2006-04-07	2015-08-26	Vertex Pharmaceuticals Incorporated	Modulators of atp-binding cassette transporters
US7645789B2 (en)	2006-04-07	2010-01-12	Vertex Pharmaceuticals Incorporated	Indole derivatives as CFTR modulators
US10022352B2 (en)	2006-04-07	2018-07-17	Vertex Pharmaceuticals Incorporated	Modulators of ATP-binding cassette transporters
US8563573B2 (en)	2007-11-02	2013-10-22	Vertex Pharmaceuticals Incorporated	Azaindole derivatives as CFTR modulators
JP5497633B2 (ja)	2007-05-09	2014-05-21	バーテックスファーマシューティカルズインコーポレイテッド	Ｃｆｔｒのモジュレーター
CA2696298C (en)	2007-08-24	2016-09-06	Vertex Pharmaceuticals Incorporated	Modulators of cystic fibrosis transmembrane conductance regulator
ES2658064T3 (es)	2007-11-16	2018-03-08	Vertex Pharmaceuticals Incorporated	Moduladores de isoquinolina de transportadores de casete de unión a ATP
US20100036130A1 (en)	2007-12-07	2010-02-11	Vertex Pharmaceuticals Incorporated	Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
SI2225230T1 (sl)	2007-12-07	2017-03-31	Vertex Pharmaceuticals Incorporated	Trdne oblike 3-(6-(1-2,2-difluorobenzo(d)(1,3)dioxol-5-il)ciklopropan- karboksamido)-3-metilpiridin-2-il) benzojske kisline
EA201070699A1 (ru) *	2007-12-07	2011-02-28	Вертекс Фармасьютикалз Инкорпорейтед	Композиции 3-(6-(1-2,2-дифторбензо[d][1,3]диоксол-5-ил)циклопропанкарбоксамидо)-3-метилпиридин-2-ил)бензойной кислоты
PL2639223T3 (pl)	2007-12-07	2017-09-29	Vertex Pharmaceuticals Incorporated	Sposób wytwarzania kwasów cykloalkilokarboksyamido-pirydyno-benzoesowych
CA2931134C (en)	2008-02-28	2019-07-30	Vertex Pharmaceuticals Incorporated	Heteroaryl derivatives as cftr modulators
EP2980077B1 (en)	2008-03-31	2020-05-06	Vertex Pharmaceuticals Incorporated	Pyridyl derivatives as cftr modulators
WO2010037066A2 (en)	2008-09-29	2010-04-01	Vertex Pharmaceuticals Incorporated	Dosage units of 3-(6-(1-(2,2-difluorobenzo [d] [1,3] dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
SI2349263T1 (sl) *	2008-10-23	2014-09-30	Vertex Pharmaceuticals Incorporated	Modulatorji cistiäśno-fibroznega transmembranskega regulatorja prevodnosti
NZ592504A (en) *	2008-10-23	2013-04-26	Vertex Pharma	Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide
KR101852173B1 (ko)	2009-03-20	2018-04-27	버텍스 파마슈티칼스 인코포레이티드	낭성 섬유증 막횡단 전도도 조절자의 조정자의 제조 방법
KR20120083416A (ko) *	2009-09-17	2012-07-25	버텍스 파마슈티칼스 인코포레이티드	아자비시클릭 화합물의 제조 방법
CA2778492A1 (en) *	2009-10-23	2011-04-28	Vertex Pharmaceuticals Incorporated	Process for preparing modulators of cystic fibrosis transmembrane conductance regulator
WO2011050220A1 (en) *	2009-10-23	2011-04-28	Vertex Pharmaceuticals Incorporated	Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide
US8802868B2 (en)	2010-03-25	2014-08-12	Vertex Pharmaceuticals Incorporated	Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
JP2013523833A (ja)	2010-04-07	2013-06-17	バーテックスファーマシューティカルズインコーポレイテッド	３−（６−（１−（２，２−ジフルオロベンゾ［ｄ］［１，３］ジオキソール−５−イル）シクロプロパンカルボキサミド）−３−メチルピリジン−２−イル）安息香酸の医薬組成物およびその投与
CN102933206A (zh)	2010-04-07	2013-02-13	弗特克斯药品有限公司	3-(6-(1-(2，2-二氟苯并[d][1，3]二氧杂环戊烯-5-基)环丙烷甲酰胺基)-3-甲基吡啶-2-基)苯甲酸的固体形式
MX342288B (es)	2010-04-22	2016-09-23	Vertex Pharma	Proceso para producir compuestos de cicloalquilcarboxamido-indol.
AR081920A1 (es) *	2010-05-20	2012-10-31	Vertex Pharma	Procesos de produccion de moduladores del regulador de conductancia transmembrana de fibrosis quistica
US8563593B2 (en)	2010-06-08	2013-10-22	Vertex Pharmaceuticals Incorporated	Formulations of (R)-1-(2,2-difluorobenzo[D] [1,3] dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide
IN2014KN00885A (pt)	2011-11-08	2015-10-02	Vertex Pharma
CN104470518A (zh)	2012-02-27	2015-03-25	沃泰克斯药物股份有限公司	药物组合物及其施用
US8674108B2 (en)	2012-04-20	2014-03-18	Vertex Pharmaceuticals Incorporated	Solid forms of N-[2,4-bis(1,1-dimethylethy)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US9012496B2 (en)	2012-07-16	2015-04-21	Vertex Pharmaceuticals Incorporated	Pharmaceutical compositions of (R)-1-(2,2-difluorobenzo[D][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide and administration thereof
RU2016122882A (ru)	2013-11-12	2017-12-19	Вертекс Фармасьютикалз Инкорпорейтед	Способ получения фармацевтических композиций для лечения опосредованных cftr заболеваний
ES2957761T3 (es)	2014-04-15	2024-01-25	Vertex Pharma	Composiciones farmacéuticas para el tratamiento de enfermedades mediadas por el regulador de la conductancia transmembrana de fibrosis quística
JP6746569B2 (ja)	2014-10-07	2020-08-26	バーテックスファーマシューティカルズインコーポレイテッドＶｅｒｔｅｘＰｈａｒｍａｃｅｕｔｉｃａｌｓＩｎｃｏｒｐｏｒａｔｅｄ	嚢胞性線維症膜貫通コンダクタンス制御因子のモジュレーターの共結晶
RU2691136C2 (ru)	2014-11-18	2019-06-11	Вертекс Фармасьютикалз Инкорпорейтед	Способ проведения высокопроизводительной тестовой высокоэффективной жидкостной хроматографии

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5304121A (en)	1990-12-28	1994-04-19	Boston Scientific Corporation	Drug delivery system making use of a hydrogel polymer coating
US5716981A (en)	1993-07-19	1998-02-10	Angiogenesis Technologies, Inc.	Anti-angiogenic compositions and methods of use
ITMI941099A1 (it) *	1994-05-27	1995-11-27	Smithkline Beecham Farma	Derivati chinolinici
US6099562A (en)	1996-06-13	2000-08-08	Schneider (Usa) Inc.	Drug coating with topcoat
CA2810655C (en) *	2004-06-24	2013-12-10	Vertex Pharmaceuticals Incorporated	Modulators of atp-binding cassette transporters
EP3708564A1 (en) *	2005-12-28	2020-09-16	Vertex Pharmaceuticals Incorporated	A solid form of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
PT2444120T (pt)	2007-12-10	2018-01-03	Novartis Ag	Análogos da amilorida espirocíclicos como bloqueadores de enac
NZ592504A (en) *	2008-10-23	2013-04-26	Vertex Pharma	Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide
SI2349263T1 (sl)	2008-10-23	2014-09-30	Vertex Pharmaceuticals Incorporated	Modulatorji cistiäśno-fibroznega transmembranskega regulatorja prevodnosti
US20110257223A1 (en) *	2008-10-23	2011-10-20	Vertex Pharmaceuticals Incorporated	Modulators of Cystic Fibrosis Transmembrane Conductance Regulator
CA2778492A1 (en) *	2009-10-23	2011-04-28	Vertex Pharmaceuticals Incorporated	Process for preparing modulators of cystic fibrosis transmembrane conductance regulator
WO2011050220A1 (en) *	2009-10-23	2011-04-28	Vertex Pharmaceuticals Incorporated	Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide

2010
- 2010-10-21 WO PCT/US2010/053633 patent/WO2011050220A1/en active Application Filing
- 2010-10-21 CN CN201080053379.2A patent/CN102666546B/zh not_active Expired - Fee Related
- 2010-10-21 UA UAA201206183A patent/UA108087C2/uk unknown
- 2010-10-21 KR KR1020127013139A patent/KR20120102645A/ko not_active Application Discontinuation
- 2010-10-21 JP JP2012535394A patent/JP5877157B2/ja not_active Expired - Fee Related
- 2010-10-21 RU RU2012121168/04A patent/RU2568608C2/ru not_active IP Right Cessation
- 2010-10-21 AU AU2010310617A patent/AU2010310617A1/en not_active Abandoned
- 2010-10-21 EP EP10774360A patent/EP2491042A1/en not_active Withdrawn
- 2010-10-21 MX MX2012004791A patent/MX2012004791A/es active IP Right Grant
- 2010-10-21 NZ NZ599703A patent/NZ599703A/en not_active IP Right Cessation
- 2010-10-21 US US12/909,789 patent/US8389727B2/en active Active
- 2010-10-21 BR BR112012009584A patent/BR112012009584A2/pt not_active IP Right Cessation
- 2010-10-21 CA CA2778493A patent/CA2778493A1/en not_active Abandoned
- 2010-10-22 TW TW099136177A patent/TWI507409B/zh not_active IP Right Cessation
- 2010-10-25 AR ARP100103915A patent/AR078766A1/es unknown
2012
- 2012-04-20 ZA ZA2012/02919A patent/ZA201202919B/en unknown
- 2012-04-20 CL CL2012001007A patent/CL2012001007A1/es unknown
- 2012-04-22 IL IL219327A patent/IL219327A0/en unknown
2013
- 2013-01-11 HK HK13100461.5A patent/HK1173151A1/zh not_active IP Right Cessation
- 2013-01-28 US US13/751,656 patent/US8741922B2/en active Active

Also Published As

Publication number	Publication date
MX2012004791A (es)	2013-02-01
WO2011050220A1 (en)	2011-04-28
CA2778493A1 (en)	2011-04-28
US20110123449A1 (en)	2011-05-26
CL2012001007A1 (es)	2012-09-07
RU2012121168A (ru)	2013-11-27
NZ599703A (en)	2014-06-27
KR20120102645A (ko)	2012-09-18
CN102666546B (zh)	2015-09-09
IL219327A0 (en)	2012-06-28
ZA201202919B (en)	2013-06-26
RU2568608C2 (ru)	2015-11-20
CN102666546A (zh)	2012-09-12
UA108087C2 (uk)	2015-03-25
US20130137722A1 (en)	2013-05-30
AU2010310617A1 (en)	2012-05-24
EP2491042A1 (en)	2012-08-29
AR078766A1 (es)	2011-11-30
JP2013508407A (ja)	2013-03-07
US8741922B2 (en)	2014-06-03
HK1173151A1 (zh)	2013-07-05
US8389727B2 (en)	2013-03-05
TW201121976A (en)	2011-07-01
TWI507409B (zh)	2015-11-11
JP5877157B2 (ja)	2016-03-02

Legal Events

Date	Code	Title	Description
2019-10-01	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
2020-01-21	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

Publication	Publication Date	Title
BR112012009584A2 (pt)	2019-09-24	formas sólidas de n-(4-(7-azabiciclo[2.2.1]heptan-7-il)-2-(trifluorometil)fenil)-4-oxo-5-(trifluorometil)-1,4-di-hidroquinolina-3-carboxamida
BRPI0920598A2 (pt)	2015-12-29	formas sólidas de n-(4(7-azabiciclo[2.2.1]heptan-7-il)-2-(triflúor-metil)fenil)-4-oxo-5-(triflúor-metil)-1,4-di-hidroquinolina-3-carboxamida
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SMAP201000115A (it)	2011-01-19	Nuovi composti eterociclici e loro usi.
AP2010005364A0 (en)	2010-08-31	Novel heterocyclic compounds.
IL215732A0 (en)	2012-01-31	Novel compounds of reverse-turn mimetics, method for manufacturing the same and use thereof
BRPI0923048A2 (pt)	2018-09-25	"composto de aminopirazol".
FR2963728B1 (fr)	2012-08-17	Table pliante, portable, en particulier table de massage.
BRPI0907108A2 (pt)	2016-07-26	escova de dentes.
EA201000258A1 (ru)	2010-08-30	Новые гербициды
BRPI0916688A2 (pt)	2015-11-17	destilado intermediário, e, produto acabado
BR112012016786A2 (pt)	2015-09-01	Processos para preparar 7-metil-5-(3-piperazin-1-ilmetil-[1,2,4]oxadiazol-5-il)-2-(4- trifluorometoxibenzil)-2
SMT201600421B (it)	2017-01-10	7-metil-2-[4-metil-6-[4-(trifluorometil)-fenil]pirimidin-2-il]-1,7-diazaspiro[4.4]nonan-6-one
BRPI0823093A2 (pt)	2015-06-16	Luva e acessórios para ela.
DK2792662T3 (da)	2016-07-25	Morphinanforbindelser
BR112012030895A2 (pt)	2016-11-08	devirados antifúngicos de 5,6-di-hidro-4-[(difluoroetil)fenil]-4h-pirrolo[1,2-a][1,4]benzodiazepina e de 4-(difluoroetil)fenil-6h-pirrolo[1,2-a][1,4]benzodiazepina
BRPI0822637A2 (pt)	2015-06-16	Uso de lanosta-8, 24-dien-3-óis
BRPI0912193A2 (pt)	2015-10-06	compostos terapêuticos.
BR112013011094A2 (pt)	2016-08-23	formas sólidas de dimetilcarbamato de 3-(4-(aminometil)-1-(5-metil-7h-pirrolo[2,3-d] pirimidin-4-il) piperina-4- carboxamido) fenila
ES1066103Y (es)	2008-03-16	Asador de mesa
ES1059446Y (es)	2005-08-01	Mesa redonda ampliable de extension radial
SI2358680T1 (sl)	2013-08-30	Trdne obllike n-(4-(7-azabiciklo(2.2.1)heptan-7-il)-2-(trifluorometil) fenil)-4-okso-5-(trifluorometil)-1,4-dihidrokinolin-3-karboksamida
ITRG20090005U1 (it)	2011-04-24	Cric manuale universale, richiudibile.
IT1392870B1 (it)	2012-04-02	Tavolo multifunzione, particolarmente per piccoli ambienti.
ITTO20080006U1 (it)	2009-07-18	Gruppo maniglia perfezionato