BR112012005280B8 - Polímero e composição farmacêutica - Google Patents

Polímero e composição farmacêutica

Info

Publication number
BR112012005280B8
BR112012005280B8 BR112012005280A BR112012005280A BR112012005280B8 BR 112012005280 B8 BR112012005280 B8 BR 112012005280B8 BR 112012005280 A BR112012005280 A BR 112012005280A BR 112012005280 A BR112012005280 A BR 112012005280A BR 112012005280 B8 BR112012005280 B8 BR 112012005280B8
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
polymer
cr2r3
monomer
polymerization
Prior art date
Application number
BR112012005280A
Other languages
English (en)
Other versions
BR112012005280A2 (pt
BR112012005280B1 (pt
Inventor
Alexandre Laurent
Denis Labarre
Laurence Moine
Laurent Bedouet
Michel Wassef
Nga Nguyen Van
Original Assignee
Hopitaux Paris Assist Publique
Centre Nat Rech Scient
Occlugel
Univ Paris Diderot Paris 7
Univ Paris Sud 11
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hopitaux Paris Assist Publique, Centre Nat Rech Scient, Occlugel, Univ Paris Diderot Paris 7, Univ Paris Sud 11 filed Critical Hopitaux Paris Assist Publique
Publication of BR112012005280A2 publication Critical patent/BR112012005280A2/pt
Publication of BR112012005280B1 publication Critical patent/BR112012005280B1/pt
Publication of BR112012005280B8 publication Critical patent/BR112012005280B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C08F290/02—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated end groups
    • C08F290/06—Polymers provided for in subclass C08G
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6925—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a microcapsule, nanocapsule, microbubble or nanobubble
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C08F290/02—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated end groups
    • C08F290/06—Polymers provided for in subclass C08G
    • C08F290/061—Polyesters; Polycarbonates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C08F290/02—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated end groups
    • C08F290/06—Polymers provided for in subclass C08G
    • C08F290/062—Polyethers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F299/00—Macromolecular compounds obtained by interreacting polymers involving only carbon-to-carbon unsaturated bond reactions, in the absence of non-macromolecular monomers
    • C08F299/02—Macromolecular compounds obtained by interreacting polymers involving only carbon-to-carbon unsaturated bond reactions, in the absence of non-macromolecular monomers from unsaturated polycondensates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L55/00—Compositions of homopolymers or copolymers, obtained by polymerisation reactions only involving carbon-to-carbon unsaturated bonds, not provided for in groups C08L23/00 - C08L53/00
    • C08L55/005—Homopolymers or copolymers obtained by polymerisation of macromolecular compounds terminated by a carbon-to-carbon double bond
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nanotechnology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Graft Or Block Polymers (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

polímero, composição farmacêutica e usos de uma composição farmacêutica a presente invenção está relacionada a um polímero obtido a partir da polimerização de: (i) pelo menos um monômero de fórmula (i) (ch2=cr1)co-k (i) em que: k representa 0-z ou nh-z, em que z representa (cr2r3)m-ch3, (ch2-ch2-o)m-h, (ch2-ch2-o)m-ch3, (ch2)m-n r4r5 com m representando um número inteiro de 1 a 30; r1, r2, r3, r4 e r5 representam independentemente h ou uma alquila c1-c6; e (ii) pelo menos um reticulador de copolímero em bloco biorreabsorvível.
BR112012005280A 2009-09-10 2010-09-09 Polímero e composição farmacêutica BR112012005280B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US24118309P 2009-09-10 2009-09-10
EP09305830A EP2295480A1 (en) 2009-09-10 2009-09-10 Implantable bio-resorbable polymer
US61/241,183 2009-09-10
EP09305830.3 2009-09-10
PCT/EP2010/063227 WO2011029867A1 (en) 2009-09-10 2010-09-09 Implantable bio-resorbable polymer

Publications (3)

Publication Number Publication Date
BR112012005280A2 BR112012005280A2 (pt) 2020-10-27
BR112012005280B1 BR112012005280B1 (pt) 2021-10-05
BR112012005280B8 true BR112012005280B8 (pt) 2021-10-26

Family

ID=41531626

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012005280A BR112012005280B8 (pt) 2009-09-10 2010-09-09 Polímero e composição farmacêutica

Country Status (13)

Country Link
US (1) US9320804B2 (pt)
EP (2) EP2295480A1 (pt)
JP (1) JP5792729B2 (pt)
KR (1) KR101585588B1 (pt)
CN (1) CN102597030B (pt)
AU (1) AU2010294246B2 (pt)
BR (1) BR112012005280B8 (pt)
CA (1) CA2773499C (pt)
ES (1) ES2472426T3 (pt)
IN (1) IN2012DN02064A (pt)
SG (1) SG179057A1 (pt)
WO (1) WO2011029867A1 (pt)
ZA (1) ZA201201752B (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8921429B2 (en) * 2010-11-23 2014-12-30 Howard University Biodegradable stealth polymeric particles fabricated using the macromonomer approach by free radical dispersion polymerization
ES2632769T3 (es) 2011-03-09 2017-09-15 Occlugel Polímero biorreabsorbible hinchable implantable
JP6063876B2 (ja) 2011-03-09 2017-01-18 オカルジェル 不安定な高分子を担持した移植用生体吸収性ポリマー
CN102304200B (zh) * 2011-05-27 2013-08-21 中国海洋石油总公司 一种交联聚合物微球及其制备方法
CN103709386B (zh) * 2012-10-09 2016-03-30 上海微创医疗器械（集团）有限公司 改性聚乳酸可降解支架及其制备方法
CN103113533B (zh) * 2013-02-01 2015-08-05 中国科学院长春应用化学研究所 聚乳酸共聚物及其制备方法、改性聚乳酸
JP6641265B2 (ja) 2013-09-19 2020-02-05 マイクロベンション インコーポレイテッドＭｉｃｒｏｖｅｎｔｉｏｎ， Ｉｎｃ． ポリマーフィルム
CN110279885B (zh) * 2013-09-19 2022-07-26 泰尔茂株式会社 聚合物颗粒
BR112016010067B1 (pt) 2013-11-08 2023-01-10 Terumo Corporation Partículas de polímero e métodos de preparação
CN105214145A (zh) * 2014-06-23 2016-01-06 李茂全 聚乳酸微球在出血性疾病中的应用
FR3024732B1 (fr) * 2014-08-08 2016-08-12 Snf Sas Polymere hydroxyalkyle hydrosoluble obtenu par procede de polymerisation en suspension inverse ou emulsion inverse
CN104558419B (zh) * 2014-09-27 2017-07-11 温州大学 一种环境敏感型环糊精衍生物水凝胶的制备方法
US9907880B2 (en) 2015-03-26 2018-03-06 Microvention, Inc. Particles
EP3411422A1 (en) * 2016-02-05 2018-12-12 The General Hospital Corporation Drug eluting polymer composed of biodegradable polymers applied to surface of medical device
EP3416626A4 (en) * 2016-02-17 2019-10-30 Biosphere Medical, Inc. MICROSPHERES CONTAINING THERAPEUTIC AGENTS AND ASSOCIATED METHODS OF USE
CA3029251A1 (en) * 2016-06-23 2017-12-28 The Regents Of The University Of Colorado, A Body Corporate Control of polymer network structures via nanogels
WO2018064389A1 (en) 2016-09-28 2018-04-05 Microvention, Inc. Polymer particles
CN106543992A (zh) * 2016-09-30 2017-03-29 成都西油华巍科技有限公司 一种钻井液用聚合物微球封堵剂及其制备方法
US11229604B2 (en) 2017-08-16 2022-01-25 Biosphere Medical, Inc. Microspheres containing therapeutic agents and related methods of use
CN111150879B (zh) * 2019-12-31 2022-06-17 华中科技大学鄂州工业技术研究院 一种促凝血和x光显影栓塞剂及其制备方法和应用
WO2022047544A1 (en) * 2020-09-04 2022-03-10 IP Cornerstone Pty Ltd Minimally invasive treatment of osteoarthritis and other conditions
CN112934198B (zh) * 2021-01-29 2022-07-08 浙江理工大学 一种环糊精多孔吸附材料及其制备方法与应用

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GB0131112D0 (en) * 2001-12-31 2002-02-13 Univ London Pharmacy Block copolymers
WO2005079856A1 (en) * 2004-02-23 2005-09-01 The University Of British Columbia Drug delivery compositions comprising hydrophobic polymers and amphipathic molecules
JP2005330246A (ja) * 2004-05-21 2005-12-02 Toray Ind Inc 膨潤性ヒドロゲルマトリックスを含む医薬組成物
WO2006045183A1 (en) * 2004-10-25 2006-05-04 The University Of British Columbia Polymer barrier compositions for surgical wounds
AU2006282042B2 (en) * 2005-06-17 2011-12-22 The University Of North Carolina At Chapel Hill Nanoparticle fabrication methods, systems, and materials
FI20060077L (fi) * 2006-01-26 2007-07-27 Seppaelae Jukka Veli Uudet biohajoavat polymeerit
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CN101265311A (zh) * 2008-05-07 2008-09-17 天津大学 Pvp-peg-pla壳层交联的纳米胶束的制备方法

Also Published As

Publication number Publication date
AU2010294246A1 (en) 2012-04-05
CN102597030A (zh) 2012-07-18
ES2472426T3 (es) 2014-07-01
BR112012005280A2 (pt) 2020-10-27
BR112012005280B1 (pt) 2021-10-05
US9320804B2 (en) 2016-04-26
US20120230937A1 (en) 2012-09-13
JP2013504538A (ja) 2013-02-07
CA2773499A1 (en) 2011-03-17
KR101585588B1 (ko) 2016-01-14
CA2773499C (en) 2017-12-05
EP2295480A1 (en) 2011-03-16
AU2010294246B2 (en) 2014-12-04
WO2011029867A1 (en) 2011-03-17
EP2475695A1 (en) 2012-07-18
JP5792729B2 (ja) 2015-10-14
KR20120099006A (ko) 2012-09-06
IN2012DN02064A (pt) 2015-08-21
ZA201201752B (en) 2012-11-28
SG179057A1 (en) 2012-04-27
EP2475695B1 (en) 2014-04-02
CN102597030B (zh) 2013-11-06

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Ipc: C08F 290/06 (2006.01), A61K 47/50 (2017.01)

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