BR0318449A - processo para fabricação de (+)-(s)-clopidogrel bissulfato forma-i - Google Patents
processo para fabricação de (+)-(s)-clopidogrel bissulfato forma-iInfo
- Publication number
- BR0318449A BR0318449A BRPI0318449-8A BR0318449A BR0318449A BR 0318449 A BR0318449 A BR 0318449A BR 0318449 A BR0318449 A BR 0318449A BR 0318449 A BR0318449 A BR 0318449A
- Authority
- BR
- Brazil
- Prior art keywords
- forma
- manufacturing
- clopidogrel bisulfate
- manufacture
- present
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
"PROCESSO PARA FABRICAçãO DE (+)-(S)-CLOPIDOGREL BISSULFATO FORMA-I". A presente invenção refere-se a um novo processo para fabricação de um agente de inibição de agregação de plaquetas sangüíneas. Em particular, a presente invenção refere-se a um processo para a fabricação de bissulfato de metil-(+)-(S)-<244>-(2-clorofenil)-6,7-dihidrotieno¢3,2-c!piridina-S(4H)- acetato Forma-I.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2003/003104 WO2005012300A1 (en) | 2003-08-04 | 2003-08-04 | A novel process for the manufacture of (+)-(s)-clopidogrel bisulfate form-i |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0318449A true BR0318449A (pt) | 2006-08-01 |
Family
ID=34113359
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0318449-8A BR0318449A (pt) | 2003-08-04 | 2003-08-04 | processo para fabricação de (+)-(s)-clopidogrel bissulfato forma-i |
Country Status (9)
Country | Link |
---|---|
US (2) | US7291735B2 (pt) |
EP (1) | EP1651646B1 (pt) |
JP (1) | JP2007516934A (pt) |
AT (1) | ATE557028T1 (pt) |
AU (1) | AU2003253120A1 (pt) |
BR (1) | BR0318449A (pt) |
CA (1) | CA2534893A1 (pt) |
ES (1) | ES2387802T3 (pt) |
WO (1) | WO2005012300A1 (pt) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ297472B6 (cs) * | 2002-08-27 | 2006-12-13 | Zentiva, A.S. | Zpusob výroby clopidogrelu hydrogensulfátu krystalické formy I |
EP1651646B1 (en) * | 2003-08-04 | 2012-05-09 | Wockhardt Limited | A novel process for the manufacture of (+)-(s)-clopidogrel bisulfate form-i |
EP1680430B1 (en) * | 2003-11-03 | 2010-01-20 | Cadila Healthcare Ltd. | Processes for preparing form i of (s)-(+)- clopidogrel bisulfate |
US7999106B2 (en) * | 2004-04-19 | 2011-08-16 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Processes for the preparation of clopidogrel hydrogen sulfate polymorphic form I |
TW200640932A (en) * | 2005-02-24 | 2006-12-01 | Teva Pharma | Clopidogrel base suitable for pharmaceutical formulation and preparation thereof |
US7772398B2 (en) * | 2005-03-11 | 2010-08-10 | Dr. Reddy's Laboratories, Inc. | Process for making crystalline form I of clopidogrel hydrogen sulphate |
WO2007017886A1 (en) * | 2005-08-11 | 2007-02-15 | Arch Pharmalabs Limited | Novel process for preparation of clopidogrel bisulphate polymorphic form i |
US20090247569A1 (en) * | 2006-08-03 | 2009-10-01 | Claude Singer | Process for Preparing Clopidogrel Bisulphate |
SI22383A (sl) * | 2006-09-22 | 2008-04-30 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek sinteze klopidogrela in nove oblike njegovih farmacevtsko sprejemljivih soli |
PL382055A1 (pl) * | 2007-03-23 | 2008-09-29 | Koźluk Tomasz Nobilus Ent | Sposób wytwarzania formy krystalicznej 1 wodorosiarczanu klopidogrelu |
WO2008146249A1 (en) * | 2007-05-30 | 2008-12-04 | Wockhardt Research Centre | Processes for the preparation of clopidogrel |
EP2107061A1 (en) | 2008-04-02 | 2009-10-07 | Krka Tovarna Zdravil, D.D., Novo Mesto | Process for the preparation of optically enriched clopidogrel |
US20110118467A1 (en) * | 2008-06-24 | 2011-05-19 | Zach System S.P.A. | Process for the preparation of clopidogrel hydrogen sulfate crystalline form i |
WO2011042804A2 (en) | 2009-10-08 | 2011-04-14 | Jubliant Life Sciences Limited | An improved process for the preparation of clopidogrel hydrogen sulfate form i |
WO2011125069A1 (en) | 2010-03-22 | 2011-10-13 | Rpg Life Sciences Limited | A process for preparation of crystalline form i of clopidogrel bisulfate |
CN102796114A (zh) * | 2011-05-25 | 2012-11-28 | 浙江京新药业股份有限公司 | 一种制备(+)-(s-)-氯吡格雷硫酸氢盐1晶型的方法 |
WO2014118802A1 (en) | 2013-01-31 | 2014-08-07 | Pharmazell Gmbh | An improved process for the preparation of clopidogrel bisulfate form-i |
CN103193792A (zh) * | 2013-03-13 | 2013-07-10 | 广东中科药物研究有限公司 | 一种治疗缺血性心脑血管疾病的新化合物 |
KR101710922B1 (ko) | 2015-06-03 | 2017-02-28 | 경동제약 주식회사 | 클로피도그렐 황산염 결정형 i형의 제조방법 |
CN107337683B (zh) * | 2017-08-16 | 2019-08-16 | 中荣凯特(北京)生物科技有限公司 | 一种噻吩并吡啶类衍生物硫酸氢盐的晶型ⅱ及其制备方法和应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2779726B1 (fr) * | 1998-06-15 | 2001-05-18 | Sanofi Sa | Forme polymorphe de l'hydrogenosulfate de clopidogrel |
CZ297472B6 (cs) * | 2002-08-27 | 2006-12-13 | Zentiva, A.S. | Zpusob výroby clopidogrelu hydrogensulfátu krystalické formy I |
EP1651646B1 (en) * | 2003-08-04 | 2012-05-09 | Wockhardt Limited | A novel process for the manufacture of (+)-(s)-clopidogrel bisulfate form-i |
-
2003
- 2003-08-04 EP EP03817742A patent/EP1651646B1/en not_active Expired - Lifetime
- 2003-08-04 AT AT03817742T patent/ATE557028T1/de active
- 2003-08-04 JP JP2005507351A patent/JP2007516934A/ja not_active Abandoned
- 2003-08-04 CA CA002534893A patent/CA2534893A1/en not_active Abandoned
- 2003-08-04 WO PCT/IB2003/003104 patent/WO2005012300A1/en active Application Filing
- 2003-08-04 ES ES03817742T patent/ES2387802T3/es not_active Expired - Lifetime
- 2003-08-04 AU AU2003253120A patent/AU2003253120A1/en not_active Abandoned
- 2003-08-04 BR BRPI0318449-8A patent/BR0318449A/pt not_active IP Right Cessation
- 2003-08-04 US US10/564,364 patent/US7291735B2/en not_active Expired - Fee Related
-
2007
- 2007-09-06 US US11/896,853 patent/US7482453B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7291735B2 (en) | 2007-11-06 |
EP1651646A4 (en) | 2007-03-21 |
ATE557028T1 (de) | 2012-05-15 |
JP2007516934A (ja) | 2007-06-28 |
CA2534893A1 (en) | 2005-02-10 |
WO2005012300A1 (en) | 2005-02-10 |
US7482453B2 (en) | 2009-01-27 |
ES2387802T3 (es) | 2012-10-02 |
AU2003253120A1 (en) | 2005-02-15 |
EP1651646A1 (en) | 2006-05-03 |
US20060183907A1 (en) | 2006-08-17 |
EP1651646B1 (en) | 2012-05-09 |
US20080051581A1 (en) | 2008-02-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2073 DE 28/09/2010. |