BR0305100A - Processo para a preparação de olanzapina - Google Patents

Processo para a preparação de olanzapina

Info

Publication number
BR0305100A
BR0305100A BR0305100-5A BR0305100A BR0305100A BR 0305100 A BR0305100 A BR 0305100A BR 0305100 A BR0305100 A BR 0305100A BR 0305100 A BR0305100 A BR 0305100A
Authority
BR
Brazil
Prior art keywords
preparation
olanzapine
benzodiazepine
thieno
piperazinyl
Prior art date
Application number
BR0305100-5A
Other languages
English (en)
Inventor
Zbigniew Majka
Tomasz Stawinski
Justyna Rechnio
Maciej Wieczorek
Original Assignee
Adamed Sp Zoo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29997625&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0305100(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Adamed Sp Zoo filed Critical Adamed Sp Zoo
Publication of BR0305100A publication Critical patent/BR0305100A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE OLANZAPINA". A invenção refere-se a um processo para a preparação de olanzapina, processo esse que consiste na N-metilação de 2-metil-4-piperazin-1-il-10H-tieno[2,3b][1,5]benzodiazepina. A invenção relaciona-se igualmente com um novo composto intermediário, 2-metil-4-(4formil-1-piperazinil)-10H-tienol(2,3-b][1,5]-benzodiazepina da fórmula III e com um processo para a sua preparação.
BR0305100-5A 2002-06-20 2003-06-10 Processo para a preparação de olanzapina BR0305100A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PL354642A PL199016B1 (pl) 2002-06-20 2002-06-20 Sposób wytwarzania olanzapiny
PCT/IB2003/002181 WO2004000847A1 (en) 2002-06-20 2003-06-10 A process for the preparation of olanzapine and an intermediate therefor

Publications (1)

Publication Number Publication Date
BR0305100A true BR0305100A (pt) 2004-09-28

Family

ID=29997625

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0305100-5A BR0305100A (pt) 2002-06-20 2003-06-10 Processo para a preparação de olanzapina

Country Status (17)

Country Link
EP (2) EP1513845B2 (pt)
CN (1) CN100338069C (pt)
AT (2) ATE373664T1 (pt)
AU (1) AU2003240167A1 (pt)
BR (1) BR0305100A (pt)
DE (2) DE60316439T3 (pt)
ES (2) ES2289730T3 (pt)
HR (1) HRP20041075B1 (pt)
MX (1) MXPA04012200A (pt)
NO (1) NO328873B1 (pt)
PL (1) PL199016B1 (pt)
PT (2) PT1513845E (pt)
RU (1) RU2005101324A (pt)
SI (2) SI1513845T2 (pt)
TN (1) TNSN04226A1 (pt)
UA (1) UA76616C2 (pt)
WO (1) WO2004000847A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7323459B2 (en) 2002-12-24 2008-01-29 Teva Pharmaceutical Industries Ltd. Crystal forms, methods for their preparation and method for preparation of olanzapine
AR047461A1 (es) * 2004-01-27 2006-01-18 Synthon Bv Formacion, purificacion y uso de n-formilolanzapina
DE602005027308D1 (de) 2004-01-27 2011-05-19 Synthon Bv Stabile salze von olanzapin
AR048272A1 (es) * 2004-03-18 2006-04-12 Lek Pharmaceuticals Sintesis de 2 metil - 4- (4- metil -1- piperazinil) - 10 h- tieno ( 2,3-b) (1,5) benzodiazepina y sus sales, metodos para su preparacion, composiciones farmaceuticas que la contienen y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades mentales.
US8044196B2 (en) 2004-07-14 2011-10-25 Jubilant Organosys Limited Process for producing pure form of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine
PL198589B1 (pl) 2004-11-22 2008-06-30 Adamed Sp Z Oo Sposób wytwarzania N-demetyloolanzapiny
CN100383144C (zh) * 2006-09-11 2008-04-23 杭州盛美医药科技开发有限公司 一种奥氮平的中间体及其制备与应用
EP2292624A1 (en) 2009-07-20 2011-03-09 LEK Pharmaceuticals d.d. Process for the purification of olanzapine
CN102234285B (zh) * 2010-04-19 2013-06-12 江苏豪森药业股份有限公司 奥氮平的制备方法
CN102924470B (zh) * 2011-08-31 2014-12-03 江苏豪森药业股份有限公司 新颖的奥氮平的制备方法
CN102942573B (zh) * 2011-10-09 2015-03-25 连云港恒运医药科技有限公司 奥氮平的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7306069A (pt) † 1973-05-02 1974-11-05
SU629879A3 (ru) * 1974-11-26 1978-10-25 Лилли Индастриз Лимитед, (Фирма) Способ получени тиено(1,5) бензодиазепинов или их солей
US4115568A (en) † 1974-11-26 1978-09-19 Lilly Industries Limited Thieno[3,2-b]-[1,5]benzodiazepines
US5239071A (en) † 1989-11-21 1993-08-24 The B. F. Goodrich Company Process for methylating a hindered nitrogen atom in an inert non-aqueous solvent
GB9009229D0 (en) * 1990-04-25 1990-06-20 Lilly Industries Ltd Pharmaceutical compounds
DK55192D0 (da) † 1992-04-28 1992-04-28 Lundbeck & Co As H 1-piperazino-1,2-dihydroindenderivater
JP2002530341A (ja) 1998-11-23 2002-09-17 セプラコール， インク． デスメチルオランザピン組成物及び方法

Also Published As

Publication number Publication date
ES2291644T5 (es) 2011-02-15
CN100338069C (zh) 2007-09-19
ATE373664T1 (de) 2007-10-15
CN1662543A (zh) 2005-08-31
ATE371660T1 (de) 2007-09-15
SI1513845T2 (sl) 2011-01-31
DE60316047T2 (de) 2008-05-21
DE60316439T3 (de) 2011-05-05
PT1669359E (pt) 2007-10-16
HRP20041075B1 (en) 2008-05-31
MXPA04012200A (es) 2005-08-26
NO328873B1 (no) 2010-06-07
HRP20041075A2 (en) 2005-02-28
PT1513845E (pt) 2007-11-21
DE60316047D1 (de) 2007-10-11
SI1669359T1 (sl) 2007-12-31
RU2005101324A (ru) 2005-08-10
PL199016B1 (pl) 2008-08-29
ES2289730T3 (es) 2008-02-01
EP1669359B1 (en) 2007-08-29
DE60316439T2 (de) 2008-07-31
WO2004000847A1 (en) 2003-12-31
SI1513845T1 (sl) 2007-12-31
ES2291644T3 (es) 2008-03-01
TNSN04226A1 (en) 2007-03-12
PL354642A1 (en) 2003-12-29
UA76616C2 (en) 2006-08-15
EP1513845A1 (en) 2005-03-16
AU2003240167A1 (en) 2004-01-06
NO20040658L (no) 2004-02-13
DE60316439D1 (de) 2007-10-31
EP1669359A1 (en) 2006-06-14
EP1513845B1 (en) 2007-09-19
EP1513845B2 (en) 2010-11-03

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 11A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2258 DE 15/04/2014.