BR0316020A - Composto, composição farmacêutica, uso de um composto, e, método para tratar um distúrbio - Google Patents
Composto, composição farmacêutica, uso de um composto, e, método para tratar um distúrbioInfo
- Publication number
- BR0316020A BR0316020A BR0316020-3A BR0316020A BR0316020A BR 0316020 A BR0316020 A BR 0316020A BR 0316020 A BR0316020 A BR 0316020A BR 0316020 A BR0316020 A BR 0316020A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- alkoxy
- halogen
- optionally substituted
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Abstract
"COMPOSTO, COMPOSIçãO FARMACêUTICA,USO DE UM COMPOSTO, E, MéTODO PARA TRATAR UM DISTúRBIO". Esta invenção fornece compostos não esteróides com afinidade para o receptor de androgênio e utilidade para tratamentos relacionados ao receptor de androgênio, tendo uma estrutura de acordo com a fórmula (1), em que X é S, SO OU S0~ 2~; R¬ 1¬ é uma estrutura monocíclica, hetero- ou homocíclica, saturada ou insaturada, de anel de 5 ou 6 membros, opcionalmente substituída com um ou mais substituintes selecionados do grupo consistindo de halogênio, CN, fluoroalquila (C1 -C4), nitro, alquila (C1C4), alcóxi (C1 -C4) ou fluoroalcóxi (C1 -C4); R¬ 2¬ é 2-nitrofenila, 2cianofenila, 2-hidroximetil-fenila, piridin-2-ila, piridin-2-il-N-óxido, 2benzamida, éster metílico de ácido 2-benzóico ou 2-metoxifenila; R¬ 3¬ é H, halogênio ou alquila (C1 -C4); R¬ 4¬ é H, OH, alcóxi (C1 -C4) ou halogênio; R¬ 5¬ é H, OH, alcóxi (C1-C4), NH~ 2~, CN, halogênio, fluoroalquila (C1-C4), NO~ 2~, hidroxialquila (C1 -C4), C0~ 2~H, C0~ 2~alquila C1 -C6, OU R¬ 5¬ é NHR¬ 6¬, em que R¬ 6¬ é acila C1-C6 opcionalmente substituída com um ou mais halogênios, S(O)~ 2~alquila (C1-C4) OU S(0)~ 2~arila opcionalmente substituída com alquila (C1 -C4) ou um ou mais halogênios, ou R¬ 5¬ é C(O)N(R¬ 8¬,R¬ 9¬), em que R¬ 8¬ e R¬ 9¬, cada um independentemente, são H, cicloalquila C~ 3~-C~ 6~, ou CH~ 2~R¬ 1¬O, em que R¬ 1¬O é H, alquila C~ 1~-C~ 5~, alquenila C~ 1~-C~ 5~, hidroxialquila C~ 1~-C~ 3~, alquiléster (C1C4) de carboxialquila (C1-C4), alcóxi C~ 1~-C~ 3~-alquila C~ 1~-C~ 3~, (mono- ou dialquila (C1 -C4))aminometila, (mono- ou dialquila (C1 -C4))aminocarbonila, ou um anel monociclico, homo- ou heterocíclico, aromático ou não aromático de 3, 4, 5 ou 6 membros, ou R¬ 8¬ e R¬ 9¬ formam, juntos com o N um anel heterocíclico saturado ou insaturado, opcionalmente substituído com alquila (C1 -C4) de 5 ou 6 membros; ou uma sua forma de sal ou hidrato.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42457902P | 2002-11-07 | 2002-11-07 | |
EP02079648 | 2002-11-07 | ||
PCT/EP2003/050783 WO2004041782A1 (en) | 2002-11-07 | 2003-11-03 | Indoles useful in the treatment of androgen-receptor related diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0316020A true BR0316020A (pt) | 2005-09-20 |
Family
ID=42635437
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0316020-3A BR0316020A (pt) | 2002-11-07 | 2003-11-03 | Composto, composição farmacêutica, uso de um composto, e, método para tratar um distúrbio |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP1585727B1 (pt) |
JP (1) | JP4643989B2 (pt) |
CN (1) | CN100391944C (pt) |
AT (1) | ATE469128T1 (pt) |
AU (1) | AU2003301853B2 (pt) |
BR (1) | BR0316020A (pt) |
CA (1) | CA2504907C (pt) |
ES (1) | ES2344836T3 (pt) |
NZ (1) | NZ539657A (pt) |
PL (1) | PL376728A1 (pt) |
RS (1) | RS20050340A (pt) |
RU (1) | RU2328484C2 (pt) |
TW (1) | TWI310032B (pt) |
UA (1) | UA79504C2 (pt) |
WO (1) | WO2004041782A1 (pt) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200602317A (en) | 2004-04-23 | 2006-01-16 | Akzo Nobel Nv | Novel androgens |
DE102004047272A1 (de) * | 2004-09-24 | 2006-04-06 | Schering Ag | Inhibitoren der löslichen Adenylatzyklase |
DE102005027274A1 (de) * | 2005-06-08 | 2006-12-14 | Schering Ag | Inhibitoren der löslichen Adenylatzyklase |
US7417066B2 (en) | 2005-06-08 | 2008-08-26 | Schering Ag | Inhibitors of soluble adenylate cyclase |
CN101203491A (zh) * | 2005-06-24 | 2008-06-18 | 伊莱利利公司 | 可用作雄激素受体调节剂的四氢咔唑衍生物(sarm) |
WO2007073231A1 (fr) * | 2005-12-23 | 2007-06-28 | Victor Lvovoch Limonov | Agent pour traiter des maladies tumorales, procede de fabrication correspondant et procede pour traiter des maladies tumorales |
DE102006014324B4 (de) * | 2006-03-23 | 2009-01-08 | Bayer Schering Pharma Aktiengesellschaft | Inhibitoren der löslichen Adenylatzyklase |
EP3412290B1 (en) | 2006-03-27 | 2021-03-03 | The Regents of The University of California | Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases |
EP2079466B1 (en) * | 2006-09-29 | 2014-01-15 | GlaxoSmithKline LLC | Substituted indole compounds |
US8268872B2 (en) | 2008-02-22 | 2012-09-18 | Radius Health, Inc. | Selective androgen receptor modulators |
ES2488990T3 (es) | 2008-02-22 | 2014-09-01 | Radius Health, Inc. | Moduladores selectivos del receptor de andrógenos |
EP2531029B1 (en) | 2010-02-04 | 2016-10-19 | Radius Health, Inc. | Selective androgen receptor modulators |
WO2011143469A1 (en) | 2010-05-12 | 2011-11-17 | Radius Health,Inc | Therapeutic regimens |
US8642632B2 (en) | 2010-07-02 | 2014-02-04 | Radius Health, Inc. | Selective androgen receptor modulators |
WO2012047617A1 (en) | 2010-09-28 | 2012-04-12 | Radius Health, Inc. | Selective androgen receptor modulators |
EP3834824A1 (en) | 2014-03-28 | 2021-06-16 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
US9421264B2 (en) | 2014-03-28 | 2016-08-23 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
WO2017223115A1 (en) | 2016-06-22 | 2017-12-28 | Radius Health, Inc. | Ar+ breast cancer treatment methods |
JP7481115B2 (ja) | 2017-01-05 | 2024-05-10 | ラジウス ファーマシューティカルズ,インコーポレイテッド | Rad1901-2hclの多形性形態 |
CN113861186B (zh) * | 2021-09-10 | 2023-08-25 | 浙江师范大学 | 基于异恶唑取代苯甲酰胺类衍生物及抗***癌药物应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ179580A (en) * | 1974-12-30 | 1978-04-03 | Mcneilab Inc | 2-or 3-(w-tertiaryaminoalkyl)-thioindoles and the corresponding sulfinyl and sulfonyl analogs |
US4059583A (en) * | 1975-11-13 | 1977-11-22 | Mcneil Laboratories, Incorporated | Substituted indoles |
GB9204365D0 (en) * | 1992-02-28 | 1992-04-08 | Pfizer Ltd | Indoles |
RU2337909C2 (ru) * | 2002-02-01 | 2008-11-10 | Ф.Хоффманн-Ля Рош Аг | Замещенные индолы и фармацевтическая композиция, обладающая агонистической активностью в отношении альфа-1a/l адренорецептора |
TW200401641A (en) * | 2002-07-18 | 2004-02-01 | Wyeth Corp | 1-Heterocyclylalkyl-3-sulfonylindole or-indazole derivatives as 5-hydroxytryptamine-6 ligands |
-
2003
- 2003-03-11 UA UAA200503773A patent/UA79504C2/uk unknown
- 2003-10-30 TW TW092130277A patent/TWI310032B/zh not_active IP Right Cessation
- 2003-11-03 AT AT03810458T patent/ATE469128T1/de not_active IP Right Cessation
- 2003-11-03 NZ NZ539657A patent/NZ539657A/en not_active IP Right Cessation
- 2003-11-03 AU AU2003301853A patent/AU2003301853B2/en not_active Ceased
- 2003-11-03 CA CA2504907A patent/CA2504907C/en not_active Expired - Fee Related
- 2003-11-03 BR BR0316020-3A patent/BR0316020A/pt not_active IP Right Cessation
- 2003-11-03 JP JP2004549180A patent/JP4643989B2/ja not_active Expired - Fee Related
- 2003-11-03 CN CNB2003801039507A patent/CN100391944C/zh not_active Expired - Fee Related
- 2003-11-03 WO PCT/EP2003/050783 patent/WO2004041782A1/en active Application Filing
- 2003-11-03 ES ES03810458T patent/ES2344836T3/es not_active Expired - Lifetime
- 2003-11-03 PL PL376728A patent/PL376728A1/pl not_active Application Discontinuation
- 2003-11-03 RU RU2005117374/04A patent/RU2328484C2/ru not_active IP Right Cessation
- 2003-11-03 RS YUP-2005/0340A patent/RS20050340A/sr unknown
- 2003-11-03 EP EP03810458A patent/EP1585727B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2504907C (en) | 2011-10-11 |
ATE469128T1 (de) | 2010-06-15 |
WO2004041782A1 (en) | 2004-05-21 |
CA2504907A1 (en) | 2004-05-21 |
RU2328484C2 (ru) | 2008-07-10 |
CN1714078A (zh) | 2005-12-28 |
JP2006507293A (ja) | 2006-03-02 |
PL376728A1 (pl) | 2006-01-09 |
RS20050340A (en) | 2007-06-04 |
NZ539657A (en) | 2008-04-30 |
EP1585727B1 (en) | 2010-05-26 |
AU2003301853B2 (en) | 2010-02-18 |
EP1585727A1 (en) | 2005-10-19 |
UA79504C2 (en) | 2007-06-25 |
TW200418793A (en) | 2004-10-01 |
AU2003301853A1 (en) | 2004-06-07 |
ES2344836T3 (es) | 2010-09-08 |
JP4643989B2 (ja) | 2011-03-02 |
TWI310032B (en) | 2009-05-21 |
CN100391944C (zh) | 2008-06-04 |
RU2005117374A (ru) | 2006-01-20 |
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