BR0314966A - Processo para preparar um composto, e, composto - Google Patents

Processo para preparar um composto, e, composto

Info

Publication number
BR0314966A
BR0314966A BR0314966-8A BR0314966A BR0314966A BR 0314966 A BR0314966 A BR 0314966A BR 0314966 A BR0314966 A BR 0314966A BR 0314966 A BR0314966 A BR 0314966A
Authority
BR
Brazil
Prior art keywords
compound
protecting group
preparing
formula
removal
Prior art date
Application number
BR0314966-8A
Other languages
English (en)
Inventor
Paul Michael Murray
Jeremy Stephen Parker
Paul Schofield
Andrew Stocker
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR0314966A publication Critical patent/BR0314966A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

"PROCESSO PARA PREPARAR UM COMPOSTO, E, COMPOSTO". Um processo para preparar um composto de Fórmula (I) em que R^ 4^ e R^ 5^ são como definidos na especificação; e R^ 6^ é hidrogênio ou um grupo de proteção, processo este compreendendo a ciclização de um composto de Fórmula (II) em que R^ 4^, R^ 5^ e R^ 6^ são como definidos em relação à Fórmula (I) e R^ 7^ é um grupo de proteção-nitrogênio, e a remoção do grupo de proteção R^ 7^ e, em seguida, se desejado ou necessário, a remoção de qualquer grupo protetor R^ 6^, para obter-se o correspondente ácido carboxílico. Novos intermediários e o uso dos produtos da preparação de compostos farmacêuticos são também descritos e reivindicados.
BR0314966-8A 2002-10-03 2003-09-29 Processo para preparar um composto, e, composto BR0314966A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0222912.8A GB0222912D0 (en) 2002-10-03 2002-10-03 Novel process and intermediates
PCT/GB2003/004217 WO2004031194A1 (en) 2002-10-03 2003-09-29 Process and intermediates for the preparation of the thienopyrrole derivatives

Publications (1)

Publication Number Publication Date
BR0314966A true BR0314966A (pt) 2005-08-02

Family

ID=9945219

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0314966-8A BR0314966A (pt) 2002-10-03 2003-09-29 Processo para preparar um composto, e, composto

Country Status (13)

Country Link
US (1) US7411074B2 (pt)
EP (1) EP1549654A1 (pt)
JP (1) JP2006505541A (pt)
KR (1) KR20050061503A (pt)
CN (1) CN100378106C (pt)
AU (1) AU2003269219A1 (pt)
BR (1) BR0314966A (pt)
CA (1) CA2500145A1 (pt)
GB (1) GB0222912D0 (pt)
MX (1) MXPA05003327A (pt)
NO (1) NO20051393L (pt)
WO (1) WO2004031194A1 (pt)
ZA (1) ZA200502340B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0205162D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205166D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205176D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205165D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205175D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205170D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0222909D0 (en) 2002-10-03 2002-11-13 Astrazeneca Ab Novel process and intermediates
CZ2006427A3 (cs) 2003-12-29 2006-11-15 Sepracor Inc. Pyrrolové a pyrazolové inhibitory DAAO
AU2007205114B2 (en) 2006-01-06 2012-11-08 Sunovion Pharmaceuticals Inc. Cycloalkylamines as monoamine reuptake inhibitors
ES2566479T3 (es) 2006-01-06 2016-04-13 Sunovion Pharmaceuticals Inc. Inhibidores de reabsorción de monoamina con base en tetralona
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7902252B2 (en) 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
US8669291B2 (en) 2007-05-31 2014-03-11 Sunovion Pharmaceuticals Inc. Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU364613A1 (ru) 1970-11-27 1972-12-28 Всесоюзный научно исследовательский химико фармацевтический институт имени С. Орджоникидзе Способ получения производных 2-аминотиено-
JPH01242587A (ja) * 1988-03-25 1989-09-27 Sankyo Co Ltd 縮環オキサゾロチエノピリミジン誘導体
GB9302622D0 (en) 1993-02-10 1993-03-24 Wellcome Found Heteroaromatic compounds
EP1088824B1 (en) 1999-09-30 2004-01-07 Pfizer Products Inc. Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors
JP2003512353A (ja) * 1999-10-19 2003-04-02 メルク エンド カムパニー インコーポレーテッド チロシンキナーゼ阻害剤
SE9903998D0 (sv) 1999-11-03 1999-11-03 Astra Ab New compounds
JP2001294572A (ja) 2000-02-09 2001-10-23 Dai Ichi Seiyaku Co Ltd 新規スルホニル誘導体
EP1136071A3 (en) 2000-03-22 2003-03-26 Pfizer Products Inc. Use of glycogen phosphorylase inhibitors
GB0017676D0 (en) 2000-07-19 2000-09-06 Angeletti P Ist Richerche Bio Inhibitors of viral polymerase
GB0021831D0 (en) * 2000-09-06 2000-10-18 Astrazeneca Ab Chemical compounds
MXPA03000966A (es) 2002-02-28 2003-09-04 Pfizer Prod Inc Agentes antidiabeticos.
GB0205166D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205165D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205162D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205176D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205170D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205175D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
JPWO2003091213A1 (ja) 2002-04-25 2005-09-02 アステラス製薬株式会社 新規なアミド誘導体又はその塩
US7226938B2 (en) 2002-09-06 2007-06-05 Janssen Pharmaceutica, N.V. Heterocyclic compounds
GB0222909D0 (en) 2002-10-03 2002-11-13 Astrazeneca Ab Novel process and intermediates
MXPA05004968A (es) 2002-11-07 2005-08-02 Pfizer Prod Inc N-(indol-z-carbonil)amidas como agentes anti-diabeticos.
US7098235B2 (en) 2002-11-14 2006-08-29 Bristol-Myers Squibb Co. Triglyceride and triglyceride-like prodrugs of glycogen phosphorylase inhibiting compounds
JP2004196702A (ja) 2002-12-18 2004-07-15 Yamanouchi Pharmaceut Co Ltd 新規なアミド誘導体又はその塩
CA2511493A1 (en) 2002-12-25 2004-07-15 Daiichi Pharmaceutical Co., Ltd. Diamine derivatives
EP1620427A1 (en) 2003-04-17 2006-02-01 Pfizer Products Inc. Carboxamide derivatives as anti-diabetic agents
CA2521962A1 (en) 2003-04-30 2004-11-11 Pfizer Products Inc. Anti-diabetic agents
WO2004113345A1 (ja) 2003-06-20 2004-12-29 Japan Tobacco Inc. 縮合ピロール化合物及びその医薬用途
GB0318464D0 (en) 2003-08-07 2003-09-10 Astrazeneca Ab Chemical compounds
GB0318463D0 (en) 2003-08-07 2003-09-10 Astrazeneca Ab Chemical compounds
GB0319759D0 (en) 2003-08-22 2003-09-24 Astrazeneca Ab Chemical compounds
GB0319690D0 (en) 2003-08-22 2003-09-24 Astrazeneca Ab Chemical compounds
WO2005020986A1 (en) 2003-08-29 2005-03-10 Astrazeneca Ab Heterocyclic amide derivatives which posses glycogen phosphorylase inhibitory activity
WO2005020985A1 (en) 2003-08-29 2005-03-10 Astrazeneca Ab Indolamide derivatives which possess glycogen phosphorylase inhibitory activity
GB0320422D0 (en) 2003-08-30 2003-10-01 Astrazeneca Ab Chemical compounds

Also Published As

Publication number Publication date
KR20050061503A (ko) 2005-06-22
JP2006505541A (ja) 2006-02-16
EP1549654A1 (en) 2005-07-06
AU2003269219A1 (en) 2004-04-23
CN1688587A (zh) 2005-10-26
CA2500145A1 (en) 2004-04-15
US20060035953A1 (en) 2006-02-16
MXPA05003327A (es) 2005-07-05
GB0222912D0 (en) 2002-11-13
US7411074B2 (en) 2008-08-12
NO20051393L (no) 2005-04-20
CN100378106C (zh) 2008-04-02
ZA200502340B (en) 2005-09-19
WO2004031194A1 (en) 2004-04-15

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]