BR0312424A8 - derivados de pirazoloisoquinolinas para inibição de quinase indutora de nfkappab - Google Patents

derivados de pirazoloisoquinolinas para inibição de quinase indutora de nfkappab

Info

Publication number
BR0312424A8
BR0312424A8 BRPI0312424A BR0312424A BR0312424A8 BR 0312424 A8 BR0312424 A8 BR 0312424A8 BR PI0312424 A BRPI0312424 A BR PI0312424A BR 0312424 A BR0312424 A BR 0312424A BR 0312424 A8 BR0312424 A8 BR 0312424A8
Authority
BR
Brazil
Prior art keywords
pyrazoloisoquinolines
nfkappab
derivatives
kinase inhibition
inducing kinase
Prior art date
Application number
BRPI0312424A
Other languages
English (en)
Other versions
BR0312424A (pt
BRPI0312424A8 (pt
Inventor
Stefanie Flohr
Thorsten Naumann
Original Assignee
Aventis Pharma Gmbh
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh, Sanofi Aventis Deutschland filed Critical Aventis Pharma Gmbh
Publication of BR0312424A publication Critical patent/BR0312424A/pt
Publication of BR0312424A8 publication Critical patent/BR0312424A8/pt
Publication of BRPI0312424A8 publication Critical patent/BRPI0312424A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

"derivados de pirazoloisoquinolinas para inibição de quinase indutora de nfkappab". compostos da fórmula (i) são apropriados para a preparação de medicamentos para profilaxia e terapia de doenças, cujo desenvolvimento está relacionado com uma atividade reforçada de nik.
BRPI0312424A 2002-07-03 2003-06-20 Derivados de pirazoloisoquinolinas para inibição de quinase indutora de nfkappab BRPI0312424A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10229762A DE10229762A1 (de) 2002-07-03 2002-07-03 Pyrazoloisoquinolinenderivaten zur Inhibierung von NFkappaB-induzierende Kinase
PCT/EP2003/006500 WO2004005287A1 (de) 2002-07-03 2003-06-20 Pyrazoloisoquinolinenderivaten zur inhibierung von nfkappab-induzierende kinase

Publications (3)

Publication Number Publication Date
BR0312424A BR0312424A (pt) 2005-04-26
BR0312424A8 true BR0312424A8 (pt) 2016-02-16
BRPI0312424A8 BRPI0312424A8 (pt) 2016-02-16

Family

ID=29761582

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0312424A BRPI0312424A8 (pt) 2002-07-03 2003-06-20 Derivados de pirazoloisoquinolinas para inibição de quinase indutora de nfkappab

Country Status (12)

Country Link
US (1) US6841556B2 (pt)
EP (1) EP1519934B1 (pt)
JP (1) JP4603355B2 (pt)
AT (1) ATE373658T1 (pt)
AU (1) AU2003242737B2 (pt)
BR (1) BRPI0312424A8 (pt)
CA (1) CA2490571C (pt)
DE (2) DE10229762A1 (pt)
IL (1) IL165995A0 (pt)
MX (1) MXPA05000038A (pt)
TW (1) TW200418852A (pt)
WO (1) WO2004005287A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7132428B2 (en) * 2003-07-03 2006-11-07 Aventis Pharmaceuticals Inc. Pyrazoloisoquinoline derivative as kinase inhibitors for the treatment of various disorders
WO2006040645A1 (en) * 2004-10-11 2006-04-20 Ranbaxy Laboratories Limited N-(3,5-dichloropyridin-4-yl)-2,4,5-alkoxy and 2,3,4-alkoxy benzamide derivatives as pde-iv (phophodiesterase type-iv) inhibitors for the treatment of inflammatory diseases such as asthma
WO2009158011A1 (en) * 2008-06-26 2009-12-30 Amgen Inc. Alkynyl alcohols as kinase inhibitors
FR2944792B1 (fr) 2009-04-24 2011-05-20 Sanofi Aventis Derives de 1h-pyrazolo[4,3-c]isoquinoleines, leur preparation et leur application en therapeutique
EP2551670A1 (en) 2011-07-27 2013-01-30 Merck Patent GmbH NIK inhibitors cell-based assay
EP4169904A1 (en) 2021-10-25 2023-04-26 Yukin Therapeutics Substituted quinolines as improved nf-kb-inducing kinase (nik) inhibitors

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8419658D0 (en) * 1984-08-01 1984-09-05 Wellcome Found Nitrogen containing heterocyclic compounds
GB8600752D0 (en) * 1986-01-14 1986-02-19 Roussel Lab Ltd Chemical compounds
US4748246A (en) * 1987-05-07 1988-05-31 American Home Products Corporation Pyrazolo(4,3-c)quinolines
US5124337A (en) * 1991-05-20 1992-06-23 Schering Corporation N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme a:cholesterol acyl transferase
ES2111059T3 (es) * 1991-07-30 1998-03-01 Ciba Geigy Ag Derivados de hidroxilamina substituidos con heteroarilo como inhibidores de lipoxigenasa.
GB9322828D0 (en) * 1993-11-05 1993-12-22 Sandoz Ltd Organic compounds
ID16283A (id) * 1996-03-20 1997-09-18 Astra Pharma Prod Senyawa yang berguna dibidang farmasi
WO1999002528A1 (en) * 1997-07-09 1999-01-21 Astra Pharmaceuticals Ltd. Novel compounds
EP1134221A1 (en) * 2000-03-15 2001-09-19 Aventis Pharma Deutschland GmbH Substituted beta-carbolines as lkB kinase inhibitors
JP2002193938A (ja) * 2000-12-01 2002-07-10 Bayer Ag ４−アリールピリジン誘導体
CA2460939C (en) 2001-09-19 2008-07-29 Pharmacia Corporation Substituted pyrazolyl compounds for the treatment of inflammation

Also Published As

Publication number Publication date
CA2490571C (en) 2011-03-15
TW200418852A (en) 2004-10-01
CA2490571A1 (en) 2004-01-15
BR0312424A (pt) 2005-04-26
US6841556B2 (en) 2005-01-11
EP1519934A1 (de) 2005-04-06
AU2003242737B2 (en) 2009-01-22
MXPA05000038A (es) 2005-04-08
IL165995A0 (en) 2006-01-15
EP1519934B1 (de) 2007-09-19
WO2004005287A1 (de) 2004-01-15
WO2004005287A9 (de) 2004-03-04
US20040097541A1 (en) 2004-05-20
BRPI0312424A8 (pt) 2016-02-16
DE10229762A1 (de) 2004-01-22
AU2003242737A1 (en) 2004-01-23
JP4603355B2 (ja) 2010-12-22
JP2006513137A (ja) 2006-04-20
DE50308230D1 (de) 2007-10-31
ATE373658T1 (de) 2007-10-15

Similar Documents

Publication Publication Date Title
IL172942A0 (en) Pyrazoloisoquinoline derivatives as kinase inhibitors
DK1194425T3 (da) Substituerede benzimidazoler
ECSP055899A (es) Pirimidinas inhibidoras de chk, pdk y akt, su producción y su uso como agentes farmacéuticos
MY140074A (en) INDOLE DERIVATIVES OR BENZIMIDAZOLE DERIVATIVES FOR MODULATING IkB KINASE
UY27714A1 (es) 2 - heteroaril - pirimidinas inhibidoras de cdk, su preparación y su uso como medicamentos.
ATE408601T1 (de) Fredericamycin-derivate
HRP20020748A2 (en) Substituted beta-carbolines with ikb-kinase inhibiting activity
SV2004001459A (es) 2- (piridin-2-ilamino) -pirido [2,3-d]pirimidin-7-onas ref. pc20501
NO20054880L (no) Azaspiroalkanderivater som inhibitorer av metallproeaser
YU21702A (sh) Supstituisani indoli za moduliranje nfkb aktivnosti
UY27234A1 (es) Inhibidores novedosos de tirosina cinasa
PT1325011E (pt) Metodos e compostos para tratamento de doencas proliferativas
WO2002060375A3 (en) Diphenyl ether derivatives and their uses as heparanase inhibitors
BRPI0415390A (pt) compostos de pirazinona substituìda para o tratamento da inflamação
BR0312424A8 (pt) derivados de pirazoloisoquinolinas para inibição de quinase indutora de nfkappab
RS20050421A (en) Aminoindazole derivatives and use thereof as kinase inhibitors
PA8579401A1 (es) Derivados de 2,3-dihidro-isoindol-1-ona como inhibidores de mao-b
DK1553938T3 (da) Anvendelse af epothilonderivater til behandling af hyperparathyroidisme
DE50016023D1 (de) Neue stromelysin inhibitoren
CR7866A (es) Pirimidinas inhibidoras de chk, pdk y akt, su produccion y su uso como agentes farmaceuticos

Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH (DE)

Free format text: ALTERADO DE: AVENTIS PHARMA DEUTSCHLAND GMBH

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA: INT. CL. C07D 471/04; A61K 31/47, 29/00

Ipc: C07D 471/04 (2011.01), A61K 31/47 (2011.01), A61P

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements