BR0312206A - Formulações de pélete esférico - Google Patents
Formulações de pélete esféricoInfo
- Publication number
- BR0312206A BR0312206A BR0312206-9A BR0312206A BR0312206A BR 0312206 A BR0312206 A BR 0312206A BR 0312206 A BR0312206 A BR 0312206A BR 0312206 A BR0312206 A BR 0312206A
- Authority
- BR
- Brazil
- Prior art keywords
- mixture
- pellets
- soluble
- water
- pellet formulations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
"FORMULAçõES DE PéLETE ESFéRICO". A presente invenção refere-se a um processo para preparar péletes esféricos compreendendo (a) um ingrediente ativo solúvel em água solúvel, livremente solúvel ou muito solúvel; e em particular tendo uma solubilidade em água de <242> 0,5 g/mL; (b) um agente de esferonização; (c) um lubrificante seco, o referido método compreendendo preparar uma mistura do ingrediente ativo, o agente de esferonização, o lubrificante seco; e uma quantidade de água que é menor do que 5%, p/p relativa ao peso total da mistura; extrusar a referida mistura para obter um extrusado; e esferonizar o extrusado para formar péletes esféricos. A invenção também refere-se aos péletes obtidos por este processo e formas de dosagem orais de liberação prolongada contendo os referidos péletes.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02077587 | 2002-06-27 | ||
| PCT/EP2003/006831 WO2004002398A2 (en) | 2002-06-27 | 2003-06-25 | Spherical pellet containing a water-soluble active ingredient |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0312206A true BR0312206A (pt) | 2005-04-12 |
Family
ID=29797247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0312206-9A BR0312206A (pt) | 2002-06-27 | 2003-06-25 | Formulações de pélete esférico |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20060153908A1 (pt) |
| EP (1) | EP1519704A2 (pt) |
| JP (1) | JP2005537240A (pt) |
| KR (1) | KR20050047507A (pt) |
| CN (1) | CN1662223A (pt) |
| AU (1) | AU2003257425A1 (pt) |
| BR (1) | BR0312206A (pt) |
| CA (1) | CA2489295A1 (pt) |
| IL (1) | IL165610A0 (pt) |
| MX (1) | MXPA05000018A (pt) |
| PL (1) | PL373148A1 (pt) |
| RU (1) | RU2336863C2 (pt) |
| WO (1) | WO2004002398A2 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8679533B2 (en) | 2002-07-25 | 2014-03-25 | Pharmacia Corporation | Pramipexole once-daily dosage form |
| EP2345407A1 (en) | 2004-08-13 | 2011-07-20 | Boehringer Ingelheim International GmbH | Extended release tablet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof |
| WO2006015943A2 (en) * | 2004-08-13 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Extended release pellet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof |
| WO2008109462A2 (en) * | 2007-03-02 | 2008-09-12 | Farnam Companies, Inc. | Sustained release pellets comprising wax-like material |
| ES2536736T3 (es) * | 2008-09-04 | 2015-05-28 | Farnam Companies, Inc. | Formulaciones masticables de liberación sostenida |
| CA2745456A1 (en) * | 2008-12-05 | 2010-06-10 | Bayer Animal Health Gmbh | Extrudate having spicular active substances |
| CN101670251B (zh) * | 2009-06-09 | 2012-01-04 | 中轻化工股份有限公司 | 一种圆球形阴离子表面活性剂的制造方法 |
| CN103040787A (zh) * | 2012-12-24 | 2013-04-17 | 蚌埠丰原涂山制药有限公司 | 一种阿奇霉素胶囊剂及其制备方法 |
| WO2016174664A1 (en) | 2015-04-29 | 2016-11-03 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
| US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
| WO2018087109A1 (de) | 2016-11-08 | 2018-05-17 | Grünenthal GmbH | Multipartikuläre arzneiform mit kontrollierter freisetzung von metamizol |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ260408A (en) * | 1993-05-10 | 1996-05-28 | Euro Celtique Sa | Controlled release preparation comprising tramadol |
| DE4413350A1 (de) * | 1994-04-18 | 1995-10-19 | Basf Ag | Retard-Matrixpellets und Verfahren zu ihrer Herstellung |
| DE19901692C2 (de) * | 1999-01-18 | 2002-06-20 | Gruenenthal Gmbh | Verfahren zur Herstellung von Pellets mit einem Gehalt von bis zu 90 Gew.% eines pharmazeutischen Wirkstoffes |
| HUP0203623A2 (hu) * | 1999-08-31 | 2003-02-28 | Grünenthal GmbH | Tramadol-szacharinátot tartalmazó, késleltetett hatású adagolási forma és alkalmazása |
| IL151475A0 (en) * | 2000-03-30 | 2003-04-10 | Bristol Myers Squibb Co | Beadlets containing stavudine |
| DE10108122A1 (de) * | 2001-02-21 | 2002-10-02 | Gruenenthal Gmbh | Arzneimittel auf Basis von Tramadol |
-
2003
- 2003-06-25 EP EP03761542A patent/EP1519704A2/en not_active Withdrawn
- 2003-06-25 BR BR0312206-9A patent/BR0312206A/pt not_active IP Right Cessation
- 2003-06-25 US US10/519,018 patent/US20060153908A1/en not_active Abandoned
- 2003-06-25 PL PL03373148A patent/PL373148A1/xx not_active Application Discontinuation
- 2003-06-25 RU RU2005101878/15A patent/RU2336863C2/ru not_active IP Right Cessation
- 2003-06-25 CA CA002489295A patent/CA2489295A1/en not_active Abandoned
- 2003-06-25 WO PCT/EP2003/006831 patent/WO2004002398A2/en active Application Filing
- 2003-06-25 MX MXPA05000018A patent/MXPA05000018A/es unknown
- 2003-06-25 KR KR1020047020922A patent/KR20050047507A/ko not_active Application Discontinuation
- 2003-06-25 CN CN03814767XA patent/CN1662223A/zh active Pending
- 2003-06-25 JP JP2004516724A patent/JP2005537240A/ja not_active Withdrawn
- 2003-06-25 AU AU2003257425A patent/AU2003257425A1/en not_active Abandoned
-
2004
- 2004-12-07 IL IL16561004A patent/IL165610A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2336863C2 (ru) | 2008-10-27 |
| RU2005101878A (ru) | 2005-06-27 |
| PL373148A1 (en) | 2005-08-22 |
| AU2003257425A1 (en) | 2004-01-19 |
| KR20050047507A (ko) | 2005-05-20 |
| CN1662223A (zh) | 2005-08-31 |
| MXPA05000018A (es) | 2005-04-08 |
| JP2005537240A (ja) | 2005-12-08 |
| IL165610A0 (en) | 2006-01-15 |
| US20060153908A1 (en) | 2006-07-13 |
| CA2489295A1 (en) | 2004-01-08 |
| WO2004002398A2 (en) | 2004-01-08 |
| EP1519704A2 (en) | 2005-04-06 |
| WO2004002398A3 (en) | 2004-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A E 8A ANUIDADE(S). |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2116 DE 26/07/2011. |