BR0310081A - Diaminotiazóis úteis como inibidores seletivos de cdk4 - Google Patents

Diaminotiazóis úteis como inibidores seletivos de cdk4

Info

Publication number
BR0310081A
BR0310081A BR0310081-2A BR0310081A BR0310081A BR 0310081 A BR0310081 A BR 0310081A BR 0310081 A BR0310081 A BR 0310081A BR 0310081 A BR0310081 A BR 0310081A
Authority
BR
Brazil
Prior art keywords
useful
treatment
diaminothiazoles
control
compounds
Prior art date
Application number
BR0310081-2A
Other languages
English (en)
Inventor
Xin-Jie Chu
Qingjie Ding
Nan Jiang
Kyungjin Kim
Allen John Lovey
Warren William Mccomas
John Guilfoyle Mullin Jr
Jefferson Wright Tilley
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0310081A publication Critical patent/BR0310081A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"DIAMINOTIAZóIS úTEIS COMO INIBIDORES SELETIVOS DE CDK4". A presente invenção refere-se a novos diaminotiazóis de fórmula Estes compostos inibem a cinase dependente de ciclina 4 (Cdk4) e são seletivos para Cdk2 e Cdk1. Estes comopstos e seus sais e ésteres farmaceuticamente aceitáveis têm atividade antiproliferativa e são úteis no tratamento ou controle de câncer, em particular tumores sólidos. Esta invenção também se refere a composições farmacêuticas contendo tais compostos e ao seu uso para a preparação de medicamentos para o tratamento e controle de câncer, mais particularmente o tratamento e controle de tumores de mama, pulmão e cólon e próstata.
BR0310081-2A 2002-05-17 2003-05-12 Diaminotiazóis úteis como inibidores seletivos de cdk4 BR0310081A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38151302P 2002-05-17 2002-05-17
PCT/EP2003/004939 WO2003097048A1 (en) 2002-05-17 2003-05-12 Diaminothiazoles

Publications (1)

Publication Number Publication Date
BR0310081A true BR0310081A (pt) 2005-02-15

Family

ID=29550137

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0310081-2A BR0310081A (pt) 2002-05-17 2003-05-12 Diaminotiazóis úteis como inibidores seletivos de cdk4

Country Status (16)

Country Link
US (1) US6818663B2 (pt)
EP (1) EP1507530B1 (pt)
JP (1) JP4308133B2 (pt)
KR (1) KR100619515B1 (pt)
CN (1) CN100400041C (pt)
AR (1) AR040078A1 (pt)
AT (1) ATE308323T1 (pt)
AU (1) AU2003232754B2 (pt)
BR (1) BR0310081A (pt)
CA (1) CA2485367A1 (pt)
DE (1) DE60302152T2 (pt)
ES (1) ES2251697T3 (pt)
MX (1) MXPA04011372A (pt)
PL (1) PL374581A1 (pt)
RU (1) RU2311414C2 (pt)
WO (1) WO2003097048A1 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004308079A1 (en) * 2003-12-24 2005-07-14 Bayer Cropscience Ag Plant growth regulation
US7211576B2 (en) * 2004-04-20 2007-05-01 Hoffmann-La Roche Inc. Diaminothiazoles
US7405220B2 (en) 2004-06-09 2008-07-29 Hoffmann-La Roche Inc. Pyrazolopyrimidines
US7705009B2 (en) * 2005-11-22 2010-04-27 Hoffman-La Roche Inc. 4-aminopyrimidine-5-thione derivatives
MX2009004791A (es) 2006-10-31 2009-08-19 Schering Corp Derivados de anilinopiperazina t metodos de uso de los mismos.
AU2007314342B2 (en) 2006-10-31 2013-02-21 Merck Sharp & Dohme Corp. Anilinopiperazine Derivatives and methods of use thereof
JP5270758B2 (ja) * 2008-08-12 2013-08-21 エア プロダクツ アンド ケミカルズ インコーポレイテッド パー（フェニルエチニル）アレーン誘導体を含有するポリマー組成物
CA3030689C (en) * 2010-08-24 2021-03-02 Gtx, Inc. Compounds for treatment of cancer
KR101616868B1 (ko) 2011-11-18 2016-04-29 델스퍼 엘피 유리전이온도가 높은 폴리머를 위한 가교 화합물
EP2986740B1 (en) 2013-04-16 2020-01-15 Memorial Sloan-Kettering Cancer Center Companion diagnostic for cdk4 inhibitors
WO2015051525A1 (en) * 2013-10-11 2015-04-16 Rhodia Operations Synthesis of acetal/ketal
WO2017156263A1 (en) 2016-03-09 2017-09-14 Memorial Sloan-Kettering Cancer Center Enigma and cdh18 as companion diagnostics for cdk4 inhibitors
WO2017158147A1 (en) 2016-03-18 2017-09-21 Savira Pharmaceuticals Gmbh Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
WO2018089902A1 (en) * 2016-11-13 2018-05-17 Apogee Biotechnology Corporation Diaminothiazole compounds, compositions and methods of use
CN110950848B (zh) * 2018-09-27 2024-03-26 徐诺药业 新型氨基吡唑类衍生物的合成与应用
EP3962945A1 (en) 2019-04-30 2022-03-09 Instituto de Medicina Molecular João Lobo Antunes Rank pathway inhibitors in combination with cdk inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP20032896B (en) * 1997-10-27 2003-02-25 Agouron Pharma 4-Aminothiazole Derivatives, Containing Them Pharmaceutical Compositions Inhibiting Cyclin-Dependent Kinases and Methods for Treatment
UA71971C2 (en) * 1999-06-04 2005-01-17 Agoron Pharmaceuticals Inc Diaminothiazoles, composition based thereon, a method for modulation of protein kinases activity, a method for the treatment of diseases mediated by protein kinases
WO2002012250A2 (en) * 2000-08-09 2002-02-14 Agouron Pharmaceuticals, Inc. Pyrazole-thiazole compounds, pharmaceutical compositions containing them, and methods of their use for inhibiting cyclin-dependent kinases
US6756374B2 (en) 2001-01-22 2004-06-29 Hoffmann-La Roche Inc. Diaminothiazoles having antiproliferative activity

Also Published As

Publication number Publication date
JP2005530783A (ja) 2005-10-13
DE60302152T2 (de) 2006-07-13
US6818663B2 (en) 2004-11-16
AU2003232754B2 (en) 2009-03-12
RU2004137110A (ru) 2005-08-20
AU2003232754A1 (en) 2003-12-02
EP1507530B1 (en) 2005-11-02
ATE308323T1 (de) 2005-11-15
CN1652780A (zh) 2005-08-10
JP4308133B2 (ja) 2009-08-05
MXPA04011372A (es) 2005-08-15
CA2485367A1 (en) 2003-11-27
US20040006058A1 (en) 2004-01-08
EP1507530A1 (en) 2005-02-23
AR040078A1 (es) 2005-03-16
ES2251697T3 (es) 2006-05-01
KR100619515B1 (ko) 2006-09-08
PL374581A1 (en) 2005-10-31
CN100400041C (zh) 2008-07-09
KR20050006261A (ko) 2005-01-15
RU2311414C2 (ru) 2007-11-27
WO2003097048A1 (en) 2003-11-27
DE60302152D1 (de) 2005-12-08

Similar Documents

Publication Publication Date Title
BR0310081A (pt) Diaminotiazóis úteis como inibidores seletivos de cdk4
BR0315912A (pt) Compostos pirimìdicos com atividade antiproliferativa (ii)
BRPI0409366A (pt) compostos de pirimido
NO20090631L (no) Morpholin pyrimidin derivativer anvendelige i behandlingen av proliferative lidelser
BRPI0606107A2 (pt) compostos farmacêuticos, seus proocessos de preparação, usos dos mesmos na fabricação de medicamento e composição farmacêutica compreendendo os referidos compostos
MX2007010072A (es) Derivados de piperidina antibacterianos.
BRPI0410563B8 (pt) compostos de pirazol-quinazolina, seus processos de preparação e composições farmacêuticas
BRPI0507644A (pt) pirazolopirimidinas como inibidores de cinase dependente de ciclina
BRPI0616987A2 (pt) pirazolopirimidinas como inibidores de cinase dependente de ciclina
BRPI0512588A (pt) derivados de uréia de pirimidina como inibidores de cinase
WO2002057261A3 (en) Diaminothiazoles and their use as inhibitors of cyclin-dependent kinase
NO20083250L (no) Antibakterielle pyrrolopyridiner, pyrrolopyrimidiner og pyrroloazepiner
TW200624431A (en) Phthalazinone derivatives, their manufacture and use as pharmaceutical agents
MXPA05007352A (es) Compuestos triciclicos inhibidores de proteina quinasa para mejorar la eficacia de agentes antineoplasicos y terapia de radiacion.
WO2012146933A1 (en) Cyprodinil for use in medicine
HRP20050689A2 (en) 4-aminopyrimidine-5-one
TW200510392A (en) Chemical compounds
WO2017040982A1 (en) Her3 ligands and uses thereof
BRPI0409882A (pt) compostos, composições farmacêuticas, método para o tratamento ou profilaxia de doenças, e, usos de compostos e de um ou mais compostos em combinação com outros compostos farmacologicamente ativos
TW200719899A (en) Tricyclic azole derivatives, their manufacture and use as pharmaceutical agents
EP2408776B1 (en) Use of a kinase inhibitor for the treatment of thymoma
ES2953005T3 (es) Tratamiento para el cáncer
BRPI0708307A2 (pt) combinação farmacêutica para administração simultánea, separada ou sequencial e usos de combinações farmacêuticas e de um inibidor do sìtio de fosforilação sobre os substratos de ck2 e um citostático farmaceuticamente aceitável
BRPI0520482A2 (pt) amidas do ácido 4-amino-tieno [3,2-c] piridina-7-carboxìlico
KR20200090771A (ko) 이중 mek 신호 전달 분해를 통한 암 치료

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 8A. ANUIDADES(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE AS 8A E 9A ANUIDADES.