BR0304213A - Processo para a sìntese industrial de ranelato de estrÈncio e os seus hidratos - Google Patents

Processo para a sìntese industrial de ranelato de estrÈncio e os seus hidratos

Info

Publication number
BR0304213A
BR0304213A BR0304213-8A BR0304213A BR0304213A BR 0304213 A BR0304213 A BR 0304213A BR 0304213 A BR0304213 A BR 0304213A BR 0304213 A BR0304213 A BR 0304213A
Authority
BR
Brazil
Prior art keywords
hydrates
strontium ranelate
industrial synthesis
synthesis
ranelate
Prior art date
Application number
BR0304213-8A
Other languages
English (en)
Inventor
Lucile Vaysse-Ludot
Jean-Pierre Lecouve
Pascal Langlois
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of BR0304213A publication Critical patent/BR0304213A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Inorganic Insulating Materials (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)

Abstract

"PROCESSO PARA A SìNTESE INDUSTRIAL DE RANELATO DE ESTRÈNCIO E OS SEUS HIDRATOS". Processo para a síntese industrial de ranelato de estróncio de fórmula (I): e seus hidratos.
BR0304213-8A 2002-09-24 2003-09-23 Processo para a sìntese industrial de ranelato de estrÈncio e os seus hidratos BR0304213A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0211763A FR2844795B1 (fr) 2002-09-24 2002-09-24 Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates

Publications (1)

Publication Number Publication Date
BR0304213A true BR0304213A (pt) 2004-08-31

Family

ID=29415189

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0304213-8A BR0304213A (pt) 2002-09-24 2003-09-23 Processo para a sìntese industrial de ranelato de estrÈncio e os seus hidratos

Country Status (38)

Country Link
US (1) US7214805B2 (pt)
EP (1) EP1403266B1 (pt)
JP (1) JP4136867B2 (pt)
KR (1) KR100551501B1 (pt)
CN (1) CN1212321C (pt)
AP (1) AP1910A (pt)
AR (1) AR041355A1 (pt)
AU (2) AU2003282179A1 (pt)
BR (1) BR0304213A (pt)
CA (1) CA2442878C (pt)
CR (1) CR7764A (pt)
CY (1) CY1115162T1 (pt)
DK (1) DK1403266T3 (pt)
EA (1) EA007489B1 (pt)
EC (1) ECSP055741A (pt)
ES (1) ES2478620T3 (pt)
FR (1) FR2844795B1 (pt)
GE (1) GEP20074215B (pt)
HK (1) HK1065791A1 (pt)
HR (1) HRP20050359B1 (pt)
IL (1) IL167316A (pt)
IS (1) IS7807A (pt)
MA (1) MA26102A1 (pt)
ME (1) ME00455B (pt)
MX (1) MXPA03008643A (pt)
MY (1) MY134921A (pt)
NO (1) NO328638B1 (pt)
NZ (1) NZ528402A (pt)
OA (1) OA12934A (pt)
PL (1) PL214400B1 (pt)
PT (1) PT1403266E (pt)
RS (2) RS20050240A (pt)
SG (1) SG110071A1 (pt)
SI (1) SI1403266T1 (pt)
TN (1) TNSN05087A1 (pt)
UA (1) UA79156C2 (pt)
WO (1) WO2004029036A1 (pt)
ZA (1) ZA200307409B (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1534305T3 (pl) * 2003-05-07 2007-03-30 Osteologix As Leczenie zaburzeń chrząstek i kości solami strontu rozpuszczalnymi w wodzie
PL1622630T3 (pl) * 2003-05-07 2013-01-31 Osteologix As Połączenia strontu w profilaktyce/leczeniu schorzeń tkanki chrzęstnej i/lub kostnej
KR101165614B1 (ko) * 2004-02-26 2012-07-18 오스테올로지스 에이에스 괴사성 골 질환의 예방 또는 치료에 사용하기 위한스트론튬 함유 화합물
US7589235B2 (en) * 2004-05-06 2009-09-15 Osteologix, A/S High yield and rapid synthesis methods for producing metallo-organic salts
MXPA06015187A (es) 2004-06-25 2007-09-27 Strontin Aps Composiciones que comprenden estroncio y vitamina d y usos de las mismas.
FR2875807B1 (fr) * 2004-09-30 2006-11-17 Servier Lab Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
CN100538672C (zh) * 2005-04-18 2009-09-09 索尼株式会社 控制设备和方法
CN100391955C (zh) * 2005-04-30 2008-06-04 河北医科大学 一种雷尼酸锶中间体的合成方法
WO2007020527A2 (en) * 2005-08-19 2007-02-22 Glenmark Pharmaceuticals Limited Process for the preparation of strontium ranelate
US20070292529A1 (en) * 2006-06-19 2007-12-20 Tabbiner Philip S Strontium compositions and methods of treating osteoporotic conditions
US20070292535A1 (en) * 2006-06-19 2007-12-20 Tabbiner Philip S Strontium compositions and methods of treating arthritic and or osteoporitic conditions
FR2921367B1 (fr) * 2007-09-26 2009-10-30 Servier Lab Nouveau procede de synthese du ranelate de strontium et de ses hydrates
US20120123131A1 (en) * 2008-08-22 2012-05-17 Koilpillai Joseph Prabahar Process for the preparation of strontium ranelate
HU228820B1 (en) 2010-01-14 2013-05-28 Richter Gedeon Nyrt Process for the preparation of distrontium ranelate
WO2011110597A1 (de) 2010-03-11 2011-09-15 Azad Pharmaceutical Ingredients Ag Verfahren zur herstellung von strontiumranelat
WO2011124992A1 (en) * 2010-03-24 2011-10-13 Actavis Group Ptc Ehf Substantially pure strontium ranelate
WO2013013003A1 (en) 2011-07-21 2013-01-24 Emory University Methods for treating inflamatory conditions and states, and cancers by antagonizing nf-kb activation
CN102321068B (zh) * 2011-08-01 2013-01-23 山东铂源药业有限公司 一种雷奈酸锶的制备方法
WO2013175270A1 (en) * 2012-05-25 2013-11-28 Fleming Laboratories Limited Improved process for the preparation of strontium ranelate hydrates and new polymorphic form of monohydrate
ES2505716T3 (es) 2013-01-21 2015-09-04 Galenicum Health S.L. Composiciones farmacéuticas que comprenden una sal de ácido
CN103319454B (zh) * 2013-06-14 2014-06-18 广东众生药业股份有限公司 一种高纯度雷尼酸四乙酯及其中间体的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2651497B1 (fr) * 1989-09-01 1991-10-25 Adir Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant.
FR2749759B1 (fr) * 1996-06-17 1999-11-26 Adir Utilisation de sels de strontium pour l'obtention de compositions pharmaceutiques destinees au traitement de l'arthrose
FR2844797B1 (fr) * 2002-09-24 2004-10-22 Servier Lab Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates
FR2844796A1 (fr) * 2002-09-24 2004-03-26 Servier Lab Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates

Also Published As

Publication number Publication date
CR7764A (es) 2005-10-06
AU2003248281A1 (en) 2004-04-08
HRP20050359A2 (en) 2005-06-30
NO328638B1 (no) 2010-04-12
EP1403266B1 (fr) 2014-04-09
RS53509B1 (en) 2015-02-27
WO2004029036A1 (fr) 2004-04-08
FR2844795B1 (fr) 2004-10-22
AP1910A (en) 2008-10-30
NZ528402A (en) 2004-07-30
NO20034235D0 (no) 2003-09-23
KR100551501B1 (ko) 2006-02-13
SG110071A1 (en) 2005-04-28
JP4136867B2 (ja) 2008-08-20
TNSN05087A1 (fr) 2007-05-14
PL214400B1 (pl) 2013-07-31
CN1496986A (zh) 2004-05-19
CA2442878C (fr) 2009-03-03
CN1212321C (zh) 2005-07-27
NO20034235L (no) 2004-03-25
OA12934A (en) 2006-10-13
KR20040026625A (ko) 2004-03-31
UA79156C2 (en) 2007-05-25
MA26102A1 (fr) 2004-04-01
IS7807A (is) 2005-04-19
CA2442878A1 (fr) 2004-03-24
MXPA03008643A (es) 2005-04-19
MY134921A (en) 2008-01-31
PT1403266E (pt) 2014-05-06
ECSP055741A (es) 2005-07-06
EP1403266A1 (fr) 2004-03-31
RS20050240A (en) 2007-06-04
ZA200307409B (en) 2004-07-07
SI1403266T1 (sl) 2014-06-30
DK1403266T3 (da) 2014-07-07
US7214805B2 (en) 2007-05-08
JP2004149516A (ja) 2004-05-27
HRP20050359B1 (hr) 2014-09-26
ES2478620T3 (es) 2014-07-22
GEP20074215B (en) 2007-10-10
AR041355A1 (es) 2005-05-11
ME00455B (me) 2011-10-10
EA200300925A1 (ru) 2004-04-29
US20040063972A1 (en) 2004-04-01
AU2003248281B2 (en) 2009-08-06
FR2844795A1 (fr) 2004-03-26
AP2005003256A0 (en) 2005-03-31
CY1115162T1 (el) 2016-12-14
EA007489B1 (ru) 2006-10-27
HK1065791A1 (en) 2005-03-04
PL362365A1 (en) 2004-04-05
AU2003282179A1 (en) 2004-04-19
IL167316A (en) 2008-08-07

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Legal Events

Date Code Title Description
B15K Others concerning applications: alteration of classification

Free format text: PARA INT.CL: C07D 333/38, A61P 19/10

Ipc: C07D 333/38 (2011.01)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06A Notification to applicant to reply to the report for non-patentability or inadequacy of the application [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements