BRPI0500480A - processo para a sìntese de (1s)-4,5-dimetóxi- 1-(metilaminometil)-benzociclobutano e sais de adição deste, e aplicação na sìntese de ivabradina e sais de adição desta com um ácido farmaceuticamente aceitável - Google Patents

processo para a sìntese de (1s)-4,5-dimetóxi- 1-(metilaminometil)-benzociclobutano e sais de adição deste, e aplicação na sìntese de ivabradina e sais de adição desta com um ácido farmaceuticamente aceitável

Info

Publication number
BRPI0500480A
BRPI0500480A BRPI0500480-2A BRPI0500480A BRPI0500480A BR PI0500480 A BRPI0500480 A BR PI0500480A BR PI0500480 A BRPI0500480 A BR PI0500480A BR PI0500480 A BRPI0500480 A BR PI0500480A
Authority
BR
Brazil
Prior art keywords
synthesis
addition salts
ivabradine
application
methylaminomethyl
Prior art date
Application number
BRPI0500480-2A
Other languages
English (en)
Inventor
Jean-Michel Lerestif
Isaac Gonzalez Blanco
Jean-Pierre Lecouve
Daniel Brigot
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of BRPI0500480A publication Critical patent/BRPI0500480A/pt
Publication of BRPI0500480B1 publication Critical patent/BRPI0500480B1/pt
Publication of BRPI0500480B8 publication Critical patent/BRPI0500480B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

"PROCESSO PARA A SìNTESE DE (1S)-4,5-DIMETóXI -1-(METILAMINOMETIL)-BENZOCICLOBUTANO E SAIS DE ADIçãO DESTE, E APLICAçãO NA SìNTESE DE IVABRADINA E SAIS DE ADIçãO DESTA COM UM áCIDO FARMACEUTICAMENTE ACEITáVEL". A presente invenção refere-se a um processo para a síntese do composto de fórmula (I): e aplicação na síntese de ivabradina, sais de adição desta com um ácido farmaceuticamente aceitável, e hidratos desta.
BRPI0500480A 2004-05-19 2005-02-17 processo para a síntese de ivabradina bem como processos para a resolução de amina e para a síntese de composto relacionado com a síntese de ivabradina BRPI0500480B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0405453 2004-05-19
FR0405453A FR2870537A1 (fr) 2004-05-19 2004-05-19 Nouveau procede de synthese du (1s)-4,5-dimethoxy-1-(methyl aminomethyl-)-benzocyclobutane et de ses sels d'addition, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Publications (3)

Publication Number Publication Date
BRPI0500480A true BRPI0500480A (pt) 2006-06-06
BRPI0500480B1 BRPI0500480B1 (pt) 2020-08-11
BRPI0500480B8 BRPI0500480B8 (pt) 2021-05-25

Family

ID=34941962

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0500480A BRPI0500480B8 (pt) 2004-05-19 2005-02-17 processo para a síntese de ivabradina bem como processos para a resolução de amina e para a síntese de composto relacionado com a síntese de ivabradina

Country Status (33)

Country Link
US (1) US6982350B2 (pt)
EP (1) EP1598333B1 (pt)
JP (1) JP4148952B2 (pt)
KR (1) KR100649289B1 (pt)
CN (1) CN1332933C (pt)
AR (1) AR047746A1 (pt)
AT (1) ATE342885T1 (pt)
AU (1) AU2005200883B2 (pt)
BR (1) BRPI0500480B8 (pt)
CA (1) CA2496708C (pt)
CY (1) CY1105826T1 (pt)
DE (1) DE602005000187T2 (pt)
DK (1) DK1598333T3 (pt)
EA (1) EA007746B1 (pt)
EG (1) EG23719A (pt)
ES (1) ES2275258T3 (pt)
FR (1) FR2870537A1 (pt)
GE (1) GEP20074135B (pt)
HK (1) HK1081945A1 (pt)
HR (1) HRP20060449T3 (pt)
MA (1) MA27640A1 (pt)
ME (1) ME01395B (pt)
MX (1) MXPA05005139A (pt)
MY (1) MY139475A (pt)
NO (1) NO330968B1 (pt)
NZ (1) NZ538329A (pt)
PL (1) PL1598333T3 (pt)
PT (1) PT1598333E (pt)
RS (1) RS50512B (pt)
SI (1) SI1598333T1 (pt)
UA (1) UA79482C2 (pt)
WO (1) WO2005123659A1 (pt)
ZA (1) ZA200501469B (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2097383B1 (en) * 2006-11-30 2012-02-08 Cadila Healthcare Limited Process for preparation of ivabradine hydrochloride
US8212026B2 (en) 2007-05-30 2012-07-03 Ind-Swift Laboratories Limited Process for the preparation of ivabradine hydrochloride and polymorph thereof
CN101434552B (zh) * 2007-11-16 2012-05-23 江苏恒瑞医药股份有限公司 4,5-二甲氧基-1-(甲基氨基甲基)-苯并环丁烷的拆分
FR2927900B1 (fr) * 2008-02-27 2010-09-17 Clariant Specialty Fine Chem Procede de preparation d'alpha-aminoacetals optiquement actifs.
FR2933975B1 (fr) * 2008-07-17 2011-02-18 Servier Lab Nouveau procede de preparation de benzocyclobutenes fonctionnalises,et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
FR2935381B1 (fr) 2008-08-29 2010-12-17 Servier Lab Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine
CN101671265B (zh) * 2008-09-12 2012-08-15 中国科学院上海药物研究所 一种苯并环丁烷类化合物及其制备方法与用途
WO2010072409A1 (en) * 2008-12-22 2010-07-01 Krka, D. D., Novo Mesto Process for preparation of ivabradine
FR2940287B1 (fr) * 2008-12-24 2010-12-24 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
FR2943667B1 (fr) * 2009-03-31 2011-05-06 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
ME00986B (me) * 2009-03-31 2012-06-20 Servier Lab Novi postupak sinteze ivabradina i njegovih adicionih soli sa farmaceutski prihvatljivom kiselinom
EP2902384B1 (en) 2010-02-12 2017-11-08 KRKA, D.D., Novo Mesto Form of ivabradine hydrochloride
HUP1000245A2 (en) 2010-05-07 2011-11-28 Richter Gedeon Nyrt Industrial process for the production ivabradin salts
CN102249937A (zh) * 2010-05-18 2011-11-23 上海京新生物医药有限公司 1-(s)-4,5-二甲氧基-1-甲胺基甲基-苯并环丁烷的制备方法
CN102372642B (zh) * 2011-07-04 2014-01-08 江苏宇田生物医药科技有限公司 (1s)-4,5-二甲氧基-1-[(甲基氨基)甲基]苯并环丁烷的制备方法
ITMI20111467A1 (it) * 2011-08-01 2013-02-02 Laboratorio Chimico Int Spa Procedimento per la preparazione di ivabradina e di suoi intermedi di sintesi
CN102408346B (zh) * 2011-10-31 2014-07-02 江苏阿尔法药业有限公司 一种4,5-二甲氧基-1-（甲基氨基甲基）-苯并环丁烷的制备方法
FR2984320B1 (fr) * 2011-12-20 2013-11-29 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2986804A1 (fr) 2012-02-09 2013-08-16 Servier Lab Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique ou de ses esters, et application a la synthese de l'ivabradine et de ses sels
FR2988720B1 (fr) * 2012-03-27 2014-03-14 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2993561B1 (fr) 2012-07-17 2014-10-31 Servier Lab Procede de synthese enzymatique de la (7s)-1-(3,4-dimethoxy bicyclo[4.2.0]octa-1,3,5-triene 7-yl) n-methyl methanamine, et application a la synthese de l'ivabradine et de ses sels
CN103848789B (zh) * 2012-11-29 2016-05-18 江苏恒瑞医药股份有限公司 一种伊伐布雷定的制备方法
FR3003859B1 (fr) * 2013-03-26 2015-03-13 Servier Lab "procede de synthese de derives de la 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one et application a la synthese de l'ivabradine"
FR3005658B1 (fr) * 2013-05-17 2015-04-24 Servier Lab "procede de synthese du 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable"
WO2015022702A2 (en) * 2013-08-10 2015-02-19 Ind-Swift Laboratories Limited Process for preparation of 4,5-dimethoxybenzene derivatives and use in the synthesis of ivabradine and salts thereof
CN103524360B (zh) * 2013-10-17 2015-09-30 安徽安腾药业有限责任公司 一种伊伐布雷定关键中间体的合成方法
JP6225998B2 (ja) * 2014-02-06 2017-11-08 宇部興産株式会社 インドリン化合物の製造方法
EP3101010A1 (en) 2015-06-03 2016-12-07 Urquima S.A. New method for the preparation of highly pure ivabradine base and salts thereof
CN110483312A (zh) * 2019-08-27 2019-11-22 北京阳光诺和药物研究有限公司 一种高纯度盐酸伊伐布雷定及其中间体的制备方法
CN115286577B (zh) * 2022-08-25 2023-10-20 江苏永安制药有限公司 一种盐酸伊伐布雷定及其中间体的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE52768B1 (en) * 1981-04-06 1988-02-17 Boots Co Ltd 1-arylcyclobutylalkylamine compounds useful as therapeutic agents
DE3119874A1 (de) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
EP0072061B1 (en) * 1981-08-05 1985-05-15 FISONS plc Amine derivatives, processes for their production and pharmaceutical compositions containing them
JP2823679B2 (ja) * 1990-05-08 1998-11-11 東レ株式会社 光学活性２―メチルピペラジンの製造方法
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
JPH083120A (ja) 1994-06-21 1996-01-09 Ajinomoto Co Inc アシル−アミノ酸とα−アリールアミンとの付加塩及びα−アリールアミンの光学分割法
JPH09208546A (ja) * 1995-11-29 1997-08-12 Ajinomoto Co Inc 新規置換ベンジルアミンの付加塩及びその光学分割法

Also Published As

Publication number Publication date
ES2275258T3 (es) 2007-06-01
US20050261376A1 (en) 2005-11-24
NZ538329A (en) 2005-10-28
CA2496708C (fr) 2011-03-15
PL1598333T3 (pl) 2006-12-29
MY139475A (en) 2009-10-30
NO20050883L (no) 2005-11-21
NO20050883D0 (no) 2005-02-18
ME01395B (me) 2010-03-02
MXPA05005139A (es) 2005-11-24
BRPI0500480B1 (pt) 2020-08-11
ZA200501469B (en) 2005-11-30
GEP20074135B (en) 2007-06-25
US6982350B2 (en) 2006-01-03
KR20060042118A (ko) 2006-05-12
KR100649289B1 (ko) 2006-11-24
AU2005200883A1 (en) 2005-12-08
CY1105826T1 (el) 2011-02-02
EA200500239A1 (ru) 2005-12-29
WO2005123659A1 (fr) 2005-12-29
AR047746A1 (es) 2006-02-15
DE602005000187T2 (de) 2007-09-06
JP4148952B2 (ja) 2008-09-10
HRP20060449T3 (en) 2007-03-31
EA007746B1 (ru) 2006-12-29
JP2005330263A (ja) 2005-12-02
DK1598333T3 (da) 2007-02-12
AU2005200883B2 (en) 2010-07-15
CA2496708A1 (fr) 2005-11-19
MA27640A1 (fr) 2005-12-01
NO330968B1 (no) 2011-08-29
EP1598333A1 (fr) 2005-11-23
DE602005000187D1 (de) 2006-11-30
HK1081945A1 (en) 2006-05-26
PT1598333E (pt) 2007-01-31
FR2870537A1 (fr) 2005-11-25
EP1598333B1 (fr) 2006-10-18
RS50512B (sr) 2010-03-02
SI1598333T1 (sl) 2007-02-28
CN1699331A (zh) 2005-11-23
CN1332933C (zh) 2007-08-22
EG23719A (en) 2007-06-17
UA79482C2 (en) 2007-06-25
ATE342885T1 (de) 2006-11-15
BRPI0500480B8 (pt) 2021-05-25

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B06T Formal requirements before examination [chapter 6.20 patent gazette]
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Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
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